Network Grants  
Ongoing Cancer Grants
  Recent Publications From Funded Grants  
:: Germ cell-specific heat shock protein 70-2 is expressed in cervical carcinoma and is involved in the growth, migration, and invasion of cervical cells
:: Identification of Potential Serum Biomarkers of Glioblastoma: Serum Osteopontin Levels Correlate with Poor Prognosis
:: Clinical significance of phosphatidyl inositol synthase overexpression in oral cancer
:: Beyond HPV: oncomirs as new players in cervical cancer
Cancer Types Sanctioned

Head/Neck Cancer

1. Gene therapy for head/neck cancer using combination therapy: Immuno-Cytokine therapy plus pro-drug activation therapy.  

Identification of Susceptibility Alleles for the Development of Head and Neck Cancer in Indian Population.


Development of Adenovirus Herpes simplex Thymidine Kinase/ Ganciclovir strategy for Head and Neck squamous cell carcinoma: Preclinical studies and large-scale preparation of clinical grade vector.


Phase II/III randomized placebo controlled clinical trial of curcumin in respectable stage III and IV squamous head and neck cancers (oral cancers).


Phase II trial of curcumin in advanced Head and Neck cancer treatment.


Brain Tumor

1. Isolation, Characterization of Gliomasphere forming cells from Glioblastoma Multiforme: Correlation with Prognostic Factors and Treatment Outcome.
2. Glioma serum biomarker discovery through proteomic approaches.
3. Study of the signaling cascades involved in the proliferation and differentiation of cancer stem cells in Glioblastoma.  

Cervical Cancer

1. Cytokine gene polymorphism in HPV associated cervical cancer.
2. Human papilloma viruses and prognosis of cervical neoplasia.
3. TLR expression profile in Langerhans and Dendritic Cells in invasive cervical cancer, cervical intraepithelial neoplasia and chronic cervicitis.
4. Delineation of Prognostic Biomarkers of progression of cervical cancer.
5. Regulatory T cells: a potential marker of progression of cervical precancer?
6. Molecular Pathology of Cervical Carcinogenesis.
7. Role of Transcription Factor STAT3 in Human Papillomavirus 16 (HPV16) – Induced Cervical Carcinogenesis.
8. Host-virus interactions at the genetic and epigenetic levels in HPV related cervical cancer in Indian women.

To study the immune response of T cell dominant synthetic peptides derived from HPV 16, using different adjuvants in a mouse model of cervical cancer.


Thyroid Cancer

1. Correlation between the expression of sex steroid receptor genes and tumor suppressor/inducer genes in human thyroid cancer tissues.  
2. Identification of biomarkers for thyroid malignancies in FNACs.
3. Expression of miR-200 family, miR-205 and cell surface proteins as markers of metastasis in thyroid tumors using real-time PCR and immunohistochemical analysis.  

Oral Cancer

1. Suppression of oral cancer-specific p53 mutants by SiRNA  
2. Studies on genetic susceptibility factors in oral cancer and precancer lesions with reference to metabolic and DNA repair genes.
3. Development and characterization of Autologous NKT Cell based Dendritic Cell Vaccine for Active Specific Immunotherapy of Oral Squamous Cell Carcinoma.
4. Study on the significance of Micro-RNA expression pattern in oral carcinoma.
5. Molecular ecology, molecular genetics and natural history of anterior tongue cancer in young adults without (or insignificant) tobacco exposure: can a distinct clinical entity be defined?
6. A study to evaluate the role of curcumin in oral premalignant lesions and gingivo-buccal cancers.
7. Cytomodulins in oral cancer therapy.
8. Loss of heterozygosity on specific chromosomal arms and influence of single nucleotide polymorphisms in XRCC1and XPD genes in oral and esophageal cancers induced by raw betel-nut in Meghalaya.
9. Study on the significance of Micro-RNA expression pattern in oral carcinoma. Phase-II: Validation of microarray results and assessment of its prognostic significance.
10. Identifying surface marker signature of oral cancer stem cells to develop a prognosis marker for oral squamous cell carcinoma using peptide-based CSC detection.
11. Salivary transcriptome and proteome for the diagnosis and prognosis of oral cancer.
12. Phase II/III, double blind, randomized, chemoprevention trial of curcumin in oral premalignant lesions.
13. Clinical and patho-biological effects of curcumin on oral leukoplakia: A double blind placebo controlled randomized trial.  

Nasopharyngeal Cancer

1. A comprehensive understanding of the Nasopharyngeal Carcinoma (NPC) in the North-Eastern Region of India.  
2. Immuno-genetic profile of nasopharyngeal cancer in a high-prevalence region of Northeast India.  

Breast Cancer

1. Designing of Methylation target arrays for Breast Cancer  
2. Role of osteopontin, a chemokine like protein in regulation of vascular endothelial growth factor dependent tumor growth and angiogenesis in breast cancer.
3. Altered Expression of tumor suppressor SMAR1 in breast cancer causes deregulation of cyclin D1.
4. Role of gap junctions in the bystander effect in breast cancer cells.
5. Study on gene expression and Hypermethylation profiles in early onset breast cancer.
6. Evaluation of circulating tumor DNA in serum of breast cancer patients.
7. Role of STAT3 as downstream mediator of steroid and epidermal growth factor pathways in breast cancer.
8. Analysis of Immunological parameters in breast tumors in the context of age at diagnosis.
9. Neuroendocrine-Immune interactions in mammary tumorigenesis.
10. Silencing of MTA1 gene as a strategy to inhibit tumor angiogenesis and metastasis; Role in breast cancer therapy.
11. Internal Ribosome Entry Site (IRES) mediated expression of endogenously produced carboxy-terminal domain of Connexin 43 (CT-Cx43): Status of expression in the breast cancer.
12. Embryonic zebrafish as a model system to study the expression and role of breast tumour kinase (brk/ptk6).
13. Evaluate the mechanism of resveratrol mediated apoptosis in cigarette smoke induced breast cancer.

Sequence dependent molecular action of ZD6474 with paclitaxel and radiation in progression and treatment of breast cancer.


Lung Cancer

1. Targeting human lung cancer: A preclinical and mechanistic investigation towards understanding lung metastasis.  
2. Role of poly N-acetyl lactosamine substituted ß1,6 branched N-oligosaccharides in facilitating organ specific metastasis of melanoma cells to the lungs.  

Esophageal Squamous Cell Carcinoma

1. Identification of novel esophageal squamous cell carcinoma (ESCC) genes by using a combination of array based CGH and gene expression microarrays.  
2. To study frequency and load of Human Papilloma Virus (HPV) in benign, pre-malignant (dysplastic) and malignant esophageal squamous epithelium by immunohistochemistry and real time PCR.  

Gastric Cancer

1. Functional genomic delineation of convolutions in Wnt signaling pathway for gastric cancer diagnostics.  

Colon Cancer

1. Tumor primordial cells in colorectal cancer: implications for surgical margins and minimal residual disease.  
2. Chemotherapeutic role of pronyl-lysine against 1,2-dimethylhydrazine induced colon cancer in male albino Wistar rats.
3. Study on the chemopreventive response of Dolastatin, a mollusc linear peptide of Indian Ocean origin in experimental colon cancer.  

Gallbladder Cancer

1 A study of Mutational and Histopathological risk factors for Gallbladder Cancer in patients with Gallstones.  

Pancreatic Cancer

1. Gene mutations in patients with chronic pancreatitis and their role in pathogenesis of malignant transformation.  
2. Investigating the role of P21 activated kinase 1 (Pak1) signaling in pancreatic adenocarcinoma (PDAC).  

Prostate Cancer

1. Evaluation of the potential of two monoclonal antibodies for treatment of androgen-independent prostatic carcinomas.  
2. Role of small molecule inhibitor(s) as targeted therapy in pancreatic and prostate cancers using in vitro and in vivo models.  

Uterine Cancer

1. Role of nuclear and mitochondrial genes in the aetiology of uterine leiomyomata (fibroids).  
2. Evaluation of curcumin in the management of advanced cancer cervix.
3. Investigation on the clearance of human papillomavirus infection in uterin cervix by BASANT, a polyherbal vaginal cream and curcumin.  

Ovarian Cancer

1. A DNA repair gene-potential marker for Ovarian cancer.  
2. Combination of P53, EGFR status and tumor grading in determining the outcome of early stage epithelial ovarian cancers.  

Bone/Soft tissue Sarcoma

1. Establishment of molecular cytogenetics in combination with protein markers for accurate diagnosis and prognostic prediction of bone and soft tissue sarcomas.  

Hemato-lymphoid system

1 Molecular monitoring of secondary mutations potentially involved in disease transformation of CML to CML-Blast Crisis.
2. Endothelial progenitor cells as biomarker of disease activity in multiple myeloma.  
3. To study the molecular biology of Multiple myeloma.  
4 Immunotherapy of drugs refractory leukemias and lymphomas expressing hCG or subunits by a highly specific recombinant chimeric antibody against ß-hCG linked to curcumin or other drugs.
5. Evaluation of Prognostic Value of FDG-PET after two cycles of Chemotherapy in Pediatric and Adolescent High Grade Lymphomas.
6. Assessment of therapeutic response of radiolabeled anti CD20 antibodies 131Iodine Rituximab & 90Yttrium Rituximab in diffuse large B cell non-Hodgkin’s lymphoma.
7. Designing of cost effective, quick and easy visualization method for detection of CML, AML and ALL leukemia patients using Molecular Beacons.  




India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.