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Samit Chattopadhyay, Ph.D.
Scientist F 
National Centre for Cell Science
NCCS Complex, Pune University Campus, Ganeshkhind
Pune - 411 007   
Phone: +91-20-25708113, 25708152
Fax: +91-20-25692259
Positions Held:
Position Affiliation Time Period
Scientist E National Centre for Cell Science, Pune, India 2003-Present
Scientist D National Centre for Cell Science, Pune, India 1998-2003
Instructor Massachusetts Institute of Technology, Boston, USA 1995-1998
Instructor University of Connecticut Health Center, Farmington, USA 1990-1995
Area of Specialization:
Molecular Biology
Research Summary:
Role of SMAR1 in cancer
Role of SMAR1 in modulating cell cycle arrest and apoptosis
Regulation of NF-kB mediated transactivation by SMAR1
Regulatory function of SMAR1 during IR induced DNA damage in cancer cells
SMAR1 represses HIV-1 LTR mediated transcription through chromatin remodeling
Role of SMAR1 in T helper cell differentiation
1. Malonia, S. K., Sinha, S., Lakshminarasimhan, P., Singh, K., Jalota-Badhwar, A., Rampalli, S., Kaul-Ghanekar, R. and Chattopadhyay, S.  Gene regulation by SMAR1: Role in cellular homeostasis and cancer. Biochimica et Biophysica Acta. 2011.  1815, 1-12. [PubMed]
2. Koppikar, S. J., Choudhari, A. S., Suryavanshi, S. A., Kumari, S., Chattopadhyay, S. and Kaul-Ghanekar, R.  Aqueous cinnamon extract (ACE-c) from the bark of Cinnamomum cassia causes apoptosis in human cervical cancer cell line (SiHa) through loss of mitochondrial membrane potential. BMC Cancer. 2010.  10, 210. [PubMed]
3. Pavithra, L., Sreenath, K., Singh, S. and Chattopadhyay, S.  Heat-shock protein 70 binds to a novel sequence in 5' UTR of tumor suppressor SMAR1 and regulates its mRNA stability upon Prostaglandin A2 treatment. FEBS Letters. 2010.  584, 1187-1192. [PubMed]
4. Sreenath, K., Pavithra, L., Singh, S., Sinha, S., Dash, P. K., Siddappa, N. B., Ranga, U., Mitra, D. and Chattopadhyay, S.  Nuclear matrix protein SMAR1 represses HIV-1 LTR mediated transcription through chromatin remodeling. Virology. 2010.  400, 76-85. [PubMed]
5. Singh, S., Sreenath, K., Pavithra, L., Roy, S. and Chattopadhyay, S.  SMAR1 regulates free radical stress through modulation of AKR1a4 enzyme activity. The International Journal of Biochemistry & Cell Biology. 2010.  42, 1105-1114. [PubMed]
6. Sinha, S., Malonia, S. K., Mittal, S. P., Singh, K., Kadreppa, S., Kamat, R., Mukhopadhyaya, R., Pal, J. K. and Chattopadhyay, S.  Coordinated regulation of p53 apoptotic targets BAX and PUMA by SMAR1 through an identical MAR element. The EMBO Journal. 2010.  29, 830-842. [PubMed]
7. Singh, K., Sinha, S., Malonia, S. K. and Chattopadhyay, S.  Tumor Necrosis Factor alpha (TNFalpha) regulates CD40 expression through SMAR1 phosphorylation. Biochemical and Biophysical Research Communications. 2010.  391, 1255-1261. [PubMed]
8. Nakka, K. K. and Chattopadhyay, S.  Modulation of chromatin by MARs and MAR binding oncogenic transcription factor SMAR1. Molecular and Cellular Biochemistry. 2010.  336, 75-84. [PubMed]
9. Kaul-Ghanekar, R., Singh, S., Mamgain, H., Jalota-Badhwar, A., Paknikar, K. M. and Chattopadhyay, S.  Tumor suppressor protein SMAR1 modulates the roughness of cell surface: combined AFM and SEM study. BMC Cancer. 2009.  9, 350. [PubMed]
10. Pavithra, L., Mukherjee, S., Sreenath, K., Kar, S., Sakaguchi, K., Roy, S. and Chattopadhyay, S.  SMAR1 forms a ternary complex with p53-MDM2 and negatively regulates p53-mediated transcription. Journal of Molecular Biology. 2009.  388, 691-702. [PubMed]
11. Singh, V. B., Pavithra, L., Chattopadhyay, S. and Pal, J. K.  Stress-induced overexpression of the heme-regulated eIF-2alpha kinase is regulated by Elk-1 activated through ERK pathway. Biochemical and Biophysical Research Communications. 2009.  379, 710-715. [PubMed]
12. Singh, K., Sinha, S., Malonia, S. K., Bist, P., Tergaonkar, V. and Chattopadhyay, S.  Tumor suppressor SMAR1 represses IkappaBalpha expression and inhibits p65 transactivation through matrix attachment regions. The Journal of Biological Chemistry. 2009.  284, 1267-1278. [PubMed]
13. Vatmurge, N. S., Hazra, B. G., Pore, V. S., Shirazi, F., Deshpande, M. V., Kadreppa, S., Chattopadhyay, S. and Gonnade, R. G.  Synthesis and biological evaluation of bile acid dimers linked with 1,2,3-triazole and bis-beta-lactam. Organic & Biomolecular Chemistry. 2008.  6, 3823-3830. [PubMed]
14. Pavithra, L., Singh, S., Sreenath, K. and Chattopadhyay, S.  Tumor suppressor SMAR1 downregulates Cytokeratin 8 expression by displacing p53 from its cognate site. The International Journal of Biochemistry & Cell Biology. 2009.  41, 862-871. [PubMed]
15. Bavikar, S. N., Salunke, D. B., Hazra, B. G., Pore, V. S., Dodd, R. H., Thierry, J., Shirazi, F., Deshpande, M. V., Kadreppa, S. and Chattopadhyay, S.  Synthesis of chimeric tetrapeptide-linked cholic acid derivatives: impending synergistic agents. Bioorganic & Medicinal Chemistry Letters. 2008.  18, 5512-5517. [PubMed]
16. Pavithra, L., Rampalli, S., Sinha, S., Sreenath, K., Pestell, R. G. and Chattopadhyay, S.  Stabilization of SMAR1 mRNA by PGA2 involves a stem loop structure in the 5' UTR. Nucleic Acids Research. 2007.  35, 6004-6016. [PubMed]
17. Singh, K., Mogare, D., Giridharagopalan, R. O., Gogiraju, R., Pande, G. and Chattopadhyay, S.  p53 target gene SMAR1 is dysregulated in breast cancer: its role in cancer cell migration and invasion. PloS One. 2007.  2, e660. [PubMed]
18. Chattopadhyay, S. and Pavithra, L.  MARs and MARBPs: key modulators of gene regulation and disease manifestation. Sub-cellular Biochemistry. 2007.  41, 213-230. [PubMed]
19. Jalota-Badhwar, A., Kaul-Ghanekar, R., Mogare, D., Boppana, R., Paknikar, K. M. and Chattopadhyay, S.  SMAR1-derived P44 peptide retains its tumor suppressor function through modulation of p53. The Journal of Biological Chemistry. 2007.  282, 9902-9913. [PubMed]
20. Sarkar, A., Kulkarni, A., Chattopadhyay, S., Mogare, D., Sharma, K. K., Singh, K. and Pal, J. K.  Lead-induced upregulation of the heme-regulated eukaryotic initiation factor 2alpha kinase is compromised by hemin in human K562 cells. Biochimica et Biophysica Acta. 2005.  1732, 15-22. [PubMed]
21. Rampalli, S., Pavithra, L., Bhatt, A., Kundu, T. K. and Chattopadhyay, S.  Tumor suppressor SMAR1 mediates cyclin D1 repression by recruitment of the SIN3/histone deacetylase 1 complex. Molecular and Cellular Biology. 2005.  25, 8415-8429. [PubMed]
22. Kulkarni, A., Ravi, D. S., Singh, K., Rampalli, S., Parekh, V., Mitra, D. and Chattopadhyay, S.  HIV-1 Tat modulates T-bet expression and induces Th1 type of immune response. Biochemical and Biophysical Research Communications. 2005.  329, 706-712. [PubMed]
23. Jalota, A., Singh, K., Pavithra, L., Kaul-Ghanekar, R., Jameel, S. and Chattopadhyay, S.  Tumor suppressor SMAR1 activates and stabilizes p53 through its arginine-serine-rich motif. The Journal of Biological Chemistry. 2005.  280, 16019-16029. [PubMed]
24. Kaul-Ghanekar, R., Majumdar, S., Jalota, A., Gulati, N., Dubey, N., Saha, B. and Chattopadhyay, S.  Abnormal V(D)J recombination of T cell receptor beta locus in SMAR1 transgenic mice. The Journal of Biological Chemistry. 2005.  280, 9450-9459. [PubMed]
25. Kaul-Ghanekar, R., Jalota, A., Pavithra, L., Tucker, P. and Chattopadhyay, S.  SMAR1 and Cux/CDP modulate chromatin and act as negative regulators of the TCRbeta enhancer (Ebeta). Nucleic Acids Research. 2004.  32, 4862-4875. [PubMed]
26. Kulkarni, A., Pavithra, L., Rampalli, S., Mogare, D., Babu, K., Shiekh, G., Ghosh, S. and Chattopadhyay, S.  HIV-1 integration sites are flanked by potential MARs that alone can act as promoters. Biochemical and Biophysical Research Communications. 2004.  322, 672-677. [PubMed]
27. Sarkar, A., Chattopadhyay, S., Kaul, R. and Pal, J. K.  Lead exposure and heat shock inhibit cell proliferation in human HeLa and K562 cells by inducing expression and activity of the heme-regulated eIF-2alpha kinase. Journal of Biochemistry, Molecular Biology, and Biophysics : JBMBB. 2002.  6, 391-396. [PubMed]
28. Rampalli, S., Kulkarni, A., Kumar, P., Mogare, D., Galande, S., Mitra, D. and Chattopadhyay, S.  Stimulation of Tat-independent transcriptional processivity from the HIV-1 LTR promoter by matrix attachment regions. Nucleic Acids Research. 2003.  31, 3248-3256. [PubMed]
29. Pavithra, L., Chavali, S. and Chattopadhyay, S. Nutritional epigenetics- impact on metabolic syndrome. Review in book chapter on Molecular Mechanisms of Epigenetics. CRC Press. (2010), In Press
30. Pavithra, L., Sreenath, K., Singh, S. and Chattopadhyay, S. Heat shock protein 70 binds to a novel sequence in 5’ UTR of tumor suppressor SMAR1 and regulates its mRNA stability upon PGA2 treatment. FEBS Letters, 19, 1187-92.
31 Kaul-Ghanekar, R., Singh, S., Mamgain, H., Jalota-Badhwar, A., Paknikar, K., M., and Chattopadhyay
SMAR1, Chattopadhyay S. SMAR1, a  phenotypic diagnostic marker for differentiation between cancerous and non-cancerous cells: combined AFM and SEM study. BMC Cancer, 2009, 9, 350.
32. Pavithra, L and Chattopadhyay, S. Chromatin and cancer: Reprogramming chaos in the cell. Natl. Acad. Sci. 2007, 30, 71-82.
33. Chattopadhyay, S. Anticancer protein identified, Nature News, 2003
34. Kaul, R., Mukherjee, S., Ahmed, F., Bhat, M. K., Chhipa, R., Galande, S. and Chattopadhyay, S. Direct interaction and activation of p53 by SMAR1 causes cell cycle arrest at G2/M phase and delays tumor growth in mice. International Journal of Cancer, 2003, 103, 606-615
35. Prasad, D. V., Parekh, V. V., Banerjee, P. P., Chattopadhyay, S., Kumar, A. and Mishra, G. C. (2002) the Th1-specific costimulatory molecule, m150, is a post-translational isoform of lysozyme-associated membrane protein-1. Journal of Immunology, 2002, 169, 1801-1809.
36. Chattopadhyay, S., Kaul, R., Charest, A., Houseman, D. and Chen, J.  SMAR1, a novel alternatively spliced gene product, binds to scaffold/ matrix associated region at TCRb locus.  Genomics, 2000, 68, 93.
37 Whitehurst, C., Chattopadhyay, S. and Chen, J. Control of V(D)J recombinational accessibility of the Db1 gene segment at the TCRb locus by a germline promoter. Immunity, 1999, 10, 1-20.
38. Chattopadhyay, S., Whitehurst, C., E. and Chen, J. A nuclear matrix attachment region (MAR) upstream of the T cell receptor gene enhancer binds Cux/ CDP and SATB1 and functions to repress transcription.  Journal of Biological Chemistry, 1998, 45, 29838-29846.
39 Chattopadhyay, S., Whitehurst, C., E., Schwenk, F. and Chen, J. Biochemical and functional analysis of chromatin changes of the T cell receptor ?gene locus during CD4-CD8- to CD4+CD8+ thymocyte differentiation.  Journal of Immunology,1998, 160, 1256-1267.
40 Das, A., Pal, M., Garcia, M. J., Crossley, R., Whalen, W., Wolska, K., Byrd, R. A., Court, D., Costantino, N., Mazzula, M., Rees, W., von Hippel, P., Chattopadhyay, S., DeVito, J. and Ghosh, B. Components of a multiprotein-RNA complex that controls transcription elongation in E. coli phage lambda.  Methods in Enzymology, 1996, 274, 374-402.
41 Chattopadhyay, S., Hung, S. C., Das, A and Gottesman. M. E. Interaction between the phage HK022 Nun protein and the nut RNA of phage lambda. Proceedings of the National Academy of Sciences, USA, 1995, 92: 12131-12135.
42 Chattopadhyay, S., Garcia, M.J. and Das, A. Bipartite function of a small RNA hairpin in transcription antitermination in bacteriophage lambda. Proceedings of the National Academy of Sciences, USA, 1995, 92, 4061-4065.
43. Chattopadhyay, S. and Ghosh, R.K. The cloning and expression of transfer RNA gene cluster of Vibrio eltor phage e4.  Virology, 1989, 171, 114.
44. Nair, B., Oku,Y., Takeda,Y., Ghosh, A., Ghosh, R.K., Chattopadhyay, S., Pal, S. C., Kaper, B.J., Takeda, T. Toxin profiles of vibrio cholerae  Non-01 from environmental sources in Calcutta, India. Applied and Environmental Microbiology, 1988, 54, 3180.
45. Chattopadhyay, S. and Ghosh, R.K. Characterization of the transfer RNA coded by Vibrio eltor phage e4. Virology, 1988, 165, 606.
46. Chattopadhyay, S. and Ghosh, R.K.  Localization of the transfer RNA gene on the physical map of Vibrio eltor  phage e4. Virology, 1988, 162, 337.
47. Chattopadhyay, S., Kinchington, D. and Ghosh, R.K.Characterization of Vibrio eltor typing phages: Properties of the eltor phage e4. Journal of General Virology, 1987, 68, 1411-1416.


My CV:   Download
Ph.D. Indian Institute of Chemical Biology, Jadavpur, Kolkata
Honors and Awards
2004, Certificate Chromatin: Folded Secrets Unfolded, ACTREC, Mumbai
2003, Certificate for being invited speaker: DNA Double Helix, NCCS
2000-2002, HIV-gene therapy, Jay Vigyan Mission project Award, DBT
1990-1995, Awarded NIH Research Scientist and Instructor UCONN. USA
Fellow of Indian Academy of Science
Fellow of National Academy of Science
Fellow, Maharastra Academy of Science
2006, Guha Research Conference
Thesis Committee member and examiner, ACTREC, Navi Mumbai
The American Society for Biochemistry and Molecular Biology,USA
Molecular Immunology Forum
Indian Society of Cell Biology
Board member, Indian Society for Developmental Biologists
  Last modified on : Mar 4, 2011
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