CV of Dr. Samit Chattopadhyay



Name:                                                Samit Chattopadhyay

Present designation:                     Scientist-E

Address:                                           National Center for Cell Science

Ganeshkhind, Pune 411007

Phone: 20 2569 0922; Fax: 20 2569 2259


Academic qualifications:


B. Sc, 1980, Calcutta University, Ranked 3rd in the University

M. Sc. 1984, Calcutta University, Ranked 2nd in the University with a specialization in Cytogenetics.

Ph. D: 1989, Indian Institute of Chemical Biology, Jadavpur, Kolkata

Instructor: 1990-95, UCONN Health Center, Farmington, USA, Specialization in Viral Transcription

Instructor: 1995-98. MIT, Boston, Working on T cell development aspects

Scientist-D, 1998-2003, National Centre for Cell Science, Pune; Chromatin and Cancer

Scientist-E, 2003 till date, National Centre for Cell Science, Gene regulation and Transcription during breast cancer.



·    Member of  “The American Society for Biochemistry
and Molecular Biology (ASBMB), USA”


·    Member of Molecular Immunology Forum (MIF)

·    Member of Maharashtra Academy of Science (MAS)

·    Life member of Society of Indian Cell Biology

·    Board member of Indian Society for Development Biologists (ISDB)

·    Thesis Committee member and examiner, ACTREC, Navi Mumbai

·    Member of Guha Rsearch Conference (GRC)


Awards won:  

·    Awarded JRF from ICMR and SRF from CSIR (1984-1989) 

·    Awarded NIH Research Scientist and Instructor UCONN. USA (1990-95)

·    Jay Vigyan Mission project Award, DBT, HIV-gene therapy (2000-2002)

·    Certificate for being invited speaker: DNA Double Helix; NCCS, 2003

·    Certificate Chromatin: Folded Secrets Unfolded; 2004, ACTREC, Mumbai



Publications from NCCS:


1.      Rampalli, S., Pavithra, L., Bhatt A., Tapas K. Kundu and Chattopadhyay, S. (2005) Tumor suppressor SMAR1 mediates Cyclin D1 repression by recruitment of SIN3/HDAC1 complex. Molecular and Cellular Biology 25(19): 8415-8416.

2.      Jalota A, Singh K, Pavithra L, Kaul R, Jameel S, Chattopadhyay S. (2005) Tumor suppressor SMAR1 activates and stabilizes p53 through its arginine-serine (RS) rich motif. Journal of Biological Chemistry, 280 (16), 16019-16029.


3.      Kaul-Ghanekar, R., Majumdar, S., Jalota, A., Gulati, N., Dubey, N., Saha, B., Chattopadhyay, S. (2005) Abnormal V(D)J Recombination of T Cell Receptor {beta} Locus in SMAR1 Transgenic Mice. Journal of Biological Chemistry, 280 (10): 9450-9459.


4.      Kulkarni, A, Ravi, D. S., Singh, K., Rampalli, S., Parekh, V., Mitra, D., Chattopadhyay, S. (2005) HIV-1 Tat modulates T-bet expression and induces Th1 type of immune response Biochemical and Biophysical Research Communication. 329 (2): 706-712.


  1. Kaul-Ghanekar, R., Jalota, A., L. Pavithra, Tucker, P. and Chattopadhyay, S. (2004) SMAR1 and Cux/CDP modulate chromatin and act as negative regulators of the TCR enhancer (E). Nucleic Acids Research, 32; 16: 4862-4875.


  1. Kulkarni, A., Pavithra L, Rampalli, S., Mogare, D., Babu, K. Shiekh, G., Ghosh, S. and Chattopadhyay, S. (2004) HIV-1 integration sites are flanked by potential MARs that alone can act as promoters. Biochemical and Biophysical Research Communication, 322; 7672-77.


  1. Rampalli, S., Kulkarni, A., Kumar, P., Mogare D., Galande, S., Mitra, D and Chattopadhyay, S. (2003) Stimulation of Tat independent transcriptional processivity from the HIV-1 LTR promoter by Matrix Attachment Regions.  Nucleic Acids Research, 31, 3248-3256.


  1. Kaul, R., Mukherjee, S., Ahmed, F., Bhat, M. K., Chhipa, R., Galande, S. and Chattopadhyay, S. (2003) Direct interaction and activation of p53 by SMAR1 causes cell cycle arrest at G2/M phase and delays tumor growth in mice.  International Journal of Cancer, 103 (5), 606-615.


  1. Prasad, D. V., Parekh, V. V., Banerjee, P. P., Chattopadhyay, S and Mishra, G. C. (2002) the Th1-specific costimulatory molecule, M150, is a post-translational isoform of lysozyme-associated membrane protein-1. Journal of Immunology, 169 (4): 1801-1809.


  1. S. Chattopadhyay (2003) Anticancer protein identified., September issue 2003, Nature News, London.


  1. Chattopadhyay S., Kaul R. Charest A., Houseman, D. and Chen, J.  (2000) SMAR1, a novel alternatively spliced gene product, binds to scaffold/ matrix associated region at TCR locus. Genomics, 68, 93-98.


  1. Whitehurst, C., Chattopadhyay, S. and Chen, J.  (2000) Control of V(D)J recombinational accessibility of the D1 gene segment at the TCR locus by a germline promoter.  Immunity, 10, 1-20.


Other Publications:


  1. Chattopadhyay, S., Whitehurst, C., E., Schwenk, F. and Chen, J.  (1998a) Biochemical and functional analysis of chromatin changes of the T cell receptor gene locus during CD4-CD8- to CD4+CD8+ thymocyte differentiation.  Journal of Immunology, 160, 1256.


  1. Chattopadhyay, S., Whitehurst, C., E. and Chen, J. (1998b) A nuclear matrix attachment region (MAR) upstream of the T cell receptor  gene enhancer binds Cux/ CDP and SATB1 and functions to repress transcription. Journal of Biological Chemistry, 45, 29838.


15. Das, A., Pal, M., Garcia, M. J., Crossley, R., Whalen, W., Wolska, K., Byrd, R. A., Court, D., Costantino, N., Mazzula, M., Rees, W., von Hippel, P., Chattopadhyay, S., DeVito, J. and Ghosh, B., (1996) Components of a multiprotein-RNA complex that controls transcription elongation in E. coli phage lambda.  Methods in Enzymology, 274: 374. 


  1. Chattopadhyay, S., Hung, S. C., Das, A and Gottesman. M. E. (1995a) Interaction between the phage HK022 Nun protein and the nut RNA of phage lambda. PNAS, USA, 92: 12131.


  1. Chattopadhyay, S., Garcia, M.J. and Das, A. (1995b)  Bipartite function of a small RNA hairpin in transcription antitermination in bacteriophage lambda. PNAS, USA, 92: 4061.


  1. Chattopadhyay, S., Garcia, J., Lazinski, D. and Das, A. (1991) Molecular basis of nut site recognition. Journal of Cellular Biochemistry, 15: 246. 


19. Chattopadhyay, S. and Ghosh, R.K. (1989) The cloning and expression of transfer RNA gene cluster of Vibrio eltor  phage e4.  Virology, 171: 114. 


20. Nair, B., Oku,Y., Takeda,Y., Ghosh, A., Ghosh, R.K., Chattopadhyay, S., Pal, S. C., Kaper, B.J., Takeda, T. (1988) Toxin profiles of vibrio cholerae  Non-01 from environmental sources in Calcutta, India. Applied and Environmental Microbiology , 54: 3180. 


21. Chattopadhyay, S. and Ghosh, R.K. (1988) Characterization of the transfer RNA coded by Vibrio eltor phage e4Virology, 165: 606.


22. Chattopadhyay, S. and Ghosh, R.K. (1988) Localization of the transfer RNA gene on the physical map of Vibrio eltor  phage e4Virology, 162: 337.


23. Chattopadhyay, S., Kinchington, D. and Ghosh, R.K. (1987) Characterization of Vibrio eltor typing phages: Properties of the eltor  phage e4. J. Gen.Virology, 68: 1411-1416.