INCREDB ID : 9
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Surekha M. Zingde, Ph.D.
Deputy Director 
 
Advanced Centre for Treatment Research and Education in Cancer
Cancer Research Institute
Tata Memorial Centre, Kharghar
Navi Mumbai - 410 210   
Maharashtra   
 
E-mail: szingde@actrec.gov.in
Phone: +91-22-27405034, 27405000, extn. 5344, 5345
Fax: +91-22-27405095
 
URL: http://actrec.gov.in/pi-webpages/SurekhaZingde/smz-index.htm
 
Positions Held:
Position Affiliation Time Period
Deputy Director Advanced Centre for Treatment, Research and Education in Cancer, Navi Mumbai, India 2001-Present
Scientific Officer H Advanced Centre for Treatment Research and Education in Cancer, Tata Memorial Centre Present
Scientific Officer C Advanced Centre for Treatment Research and Education in Cancer, Tata Memorial Centre 1979
Visiting Fellow Tata Institute of Fundamental Research, Mumbai, India 1977
 
Area of Specialization:
Molecular Biology
Biochemistry
Research Summary:
Profiling of oral tumors by proteomics and immunoproteomics towards discovery of biomarkers and therapeutic targets
Biochemistry & Molecular Biology of granulocyte membrane proteins
Signal transduction in Granulocytes, Protein Kinase C in erythrocytes
 
Publications:
1. Kamal, A., Dastagiri, D., Ramaiah, M. J., Bharathi, E. V., Reddy, J. S., Balakishan, G., Sarma, P., Pushpavalli, S. N., Pal-Bhadra, M., Juvekar, A., Sen, S. and Zingde, S.  Synthesis, anticancer activity and mitochondrial mediated apoptosis inducing ability of 2,5-diaryloxadiazole-pyrrolobenzodiazepine conjugates. Bioorganic & Medicinal Chemistry. 2010.  18, 6666-6677. [PubMed]
2. Tabassum, S., Khan, R. A., Arjmand, F., Juvekar, A. S. and Zingde, S. M.  Synthesis of carbohydrate-conjugate heterobimetallic Cu(II)-Sn(2)(IV) and Zn(II)-Sn(2)(IV) complexes; their interactions with CT DNA and nucleotides; DNA cleavage, in-vitro cytotoxicity. European Journal of Medicinal Chemistry. 2010.  45, 4797-4806. [PubMed]
3. Kamal, A., Reddy, J. S., Ramaiah, M. J., Dastagiri, D., Bharathi, E. V., Azhar, M. A., Sultana, F., Pushpavalli, S. N., Pal-Bhadra, M., Juvekar, A., Sen, S. and Zingde, S.  Design, synthesis and biological evaluation of 3,5-diaryl-isoxazoline/isoxazole-pyrrolobenzodiazepine conjugates as potential anticancer agents. European Journal of Medicinal Chemistry. 2010.  45, 3924-3937. [PubMed]
4. Tabassum, S., Khan, R. A., Arjmand, F., Juvekar, A. S. and Zingde, S. M.  Synthesis of carbohydrate-conjugate heterobimetallic Cu(II)-Sn(2)(IV) and Zn(II)-Sn(2)(IV) complexes; their interactions with CT DNA and nucleotides; DNA cleavage, in-vitro cytotoxicity. European Journal of Medicinal Chemistry. 2010.  45, 4797-4806. [PubMed]
5. Kamal, A., Bharati E. V., Ramaiah, M. J., Dastagiri, D., Reddy, J. S., Viswanath, A., Sultana, F., Pushpavalli, S.N., Pal-Bhadra, M., Srivastava, H.K., Sastry, N.G., Juvekar, A., Sen, S., Zingde, S. Quinazolinone linked pyrrolo[2,1-c][1,4]benzodiazepine(PBD conjugates: Design, synthesis and biological evaluation as anticancer agents. Bioorganic & Medicinal Chemistry. 2010. 18, 526-542.
6. Kamal A, K. Reddy, S.K., Naseer, M., Khan, A., Rajesh, V.C., Shetti, R.N.C., Ramaiah, M.J., Pushpavalli, S.N., Srinivas, C., Pal-Bhadra, M, Chourasia, M., G. Sastry, N.G., Juvekar, A., Zingde, S., Madan Barkume, M.Synthesis, DNA-binding ability and anticancer activity of benzothiazole/benzoxazole-pyrrolo[2,1-c][1,4]benzodiazepine conjugates.Bioorganic & Medicinal Chemistry. 2010. 18, 4747–4761.
7. Govekar, R. B., D'Cruz, A. K., Alok, P., Agarwal, J., Dinshaw, K. A., Chinoy, R. F., Gadewal, N., Kannan, S., Sirdeshmukh, R., Sundaram, C. S., Malgundkar, S. A., Kane, S. V. and Zingde, S. M.  Proteomic profiling of cancer of the gingivo-buccal complex: Identification of new differentially expressed markers. Proteomics - Clinical Applications. 2009.  3, 1451-1462. [PubMed]
8. Shukla, S., Pranay, A., D'Cruz, A. K., Chaturvedi, P., Kane, S. V. and Zingde, S. M.  Immunoproteomics reveals that cancer of the tongue and the gingivobuccal complex exhibit differential autoantibody response. Cancer Biomarkers. 2009.  5, 127-135. [PubMed]
9. Kamal, A., Shankaraiah, N., Devaiah, V., Laxma, R., Juvekar, A., Sen, S., Kurian, N. and Zingde, S.  Synthesis of 1,2,3-triazole-linked pyrrolobenzodiazepine conjugates employing 'click' chemistry: DNA-binding affinity and anticancer activity. Bioorganic & Medicinal Chemistry Letters. 2008.  18, 1468-1473. [PubMed]
10. Kamal, A., Ramu, R., Tekumalla, V., Khanna, G. B., Barkume, M. S., Juvekar, A. S. and Zingde, S. M.  Remarkable DNA binding affinity and potential anticancer activity of pyrrolo[2,1-c][1,4]benzodiazepine-naphthalimide conjugates linked through piperazine side-armed alkane spacers. Bioorganic & Medicinal Chemistry. 2008.  16, 7218-7224. [PubMed]
11. Kamal, A., Kumar, P. P., Seshadri, B. N., Srinivas, O., Kumar, M. S., Sen, S., Kurian, N., Juvekar, A. S. and Zingde, S. M.  Phosphonate-linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates: synthesis, DNA-binding affinity and cytotoxicity. Bioorganic & Medicinal Chemistry. 2008.  16, 3895-3906. [PubMed]
12. Sawant, S. S., Zingde, S. M. and Vaidya, M. M.  Cytokeratin fragments in the serum: their utility for the management of oral cancer. Oral Oncology. 2008.  44, 722-732. [PubMed]
13. Kamal, A., Khan, M.N., Reddy, K.S., Ahmed, S.K., Kumar, M.S., Juvekar, A., Sen, A. and Zingde, S. 1,2,4 Benzothiadazine linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates: Synthesis, DNA-binding affinity and cytotoxicity. Biorganic and Medicinal Chemistry letters. 2007. 17,5345-5348.
14. Kamal, A., Ramu, R., Tekumalla, V., Khanna, G.B., Barkume, M.S., Juvekar, A.S. and  Zingde, S.M. Synthesis, DNA-binding affinity and cytotoxicity studies of pyrrolo[2,1-c][1,4]benzodiazepine –anthroquinone conjugates, Bioorganic & Medicinal Chemistry. 2007. 15, 6868-6875.
15. Shukla, S., Govekar, R. B., Sirdeshmukh, R., Sundaram, C. S., D'Cruz, A. K., Pathak, K. A., Kane, S. V. and Zingde, S. M.  Tumor antigens eliciting autoantibody response in cancer of gingivo-buccal complex. Proteomics - Clinical Applications. 2007.  1, 1592-1604. [PubMed]
16. Kamal, A., Ramu, R., Tekumalla, V., Khanna, G. B., Barkume, M. S., Juvekar, A. S. and Zingde, S. M.  Synthesis, DNA binding, and cytotoxicity studies of pyrrolo[2,1-c][1,4]benzodiazepine-anthraquinone conjugates. Bioorganic & Medicinal Chemistry. 2007.  15, 6868-6875. [PubMed]
17. Govekar, R.B. and ZingdeS.M. Cancer proteomics: How far we are from the clinics? International Journal of Human Genetics. 2007. 7, 91-97.
18. Gadewal, N.S. and Zingde, S.M. Database and interactome map of genes involved in oral cancer. Online Journal of Bioinformatics. 2007. 8, 41-44.
19. Warawdekar, U. M., Zingde, S. M., Iyer, K. S., Jagannath, P., Mehta, A. R. and Mehta, N. G.  Elevated levels and fragmented nature of cellular fibronectin in the plasma of gastrointestinal and head and neck cancer patients. Clinica Chimica Acta. 2006.  372, 83-93. [PubMed]
20. West, C. M., McKay, M. J., Holscher, T., Baumann, M., Stratford, I. J., Bristow, R. G., Iwakawa, M., Imai, T., Zingde, S. M., Anscher, M. S., Bourhis, J., Begg, A. C., Haustermans, K., Bentzen, S. M. and Hendry, J. H.  Molecular markers predicting radiotherapy response: report and recommendations from an International Atomic Energy Agency technical meeting. International Journal of Radiation Oncology, Biology, Physics. 2005.  62, 1264-1273. [PubMed]
21. Balasubramanian, N., Advani, S. H. and Zingde, S. M.  Protein kinase C isoforms in normal and leukemic neutrophils: altered levels in leukemic neutrophils and changes during myeloid maturation in chronic myeloid leukemia. Leukemia Research. 2002.  26, 67-81. [PubMed]
22. Govekar, R. B. and Zingde, S. M.  Protein kinase C isoforms in human erythrocytes. Annals of Hematology. 2001.  80, 531-534. [PubMed]
23. Zingde, S. M. Cancer Genes. Current Science. 2001. 81, 508-514.
24. Balasubramanian, N., Advani, S. H. and Zingde, S. M.  Protein kinase C isoforms in normal and chronic myeloid leukemic neutrophils. Distinct signal for PKC alpha by immunodetection on PVDF membrane, decreased expression of PKC alpha and increased expression of PKC delta in leukemic neutrophils. Leukemia Research. 1998.  22, 597-604. [PubMed]
25. Zingde, S. M. The neutrophil in chronic myeloid leukemia: Molecular analysis of chemotaxis, endocytosis and adhesion. The Cancer Journal. 1998. 11, 167-175.
26. Balasubramanian, N. and Zingde, S. M.  Even highly homologous proteins vary in their affinity for different blotting membranes. BioTechniques. 1997.  23, 390-392. [PubMed]
27. Kant, A. M., Advani, S. H. and Zingde, S. M.  Heterogeneity in the expression of Fc gammaRIII in morphologically mature granulocytes from patients with chronic myeloid leukemia. Leukemia Research. 1997.  21, 225-234. [PubMed]
28. Vijayan, K. V., Advani, S. H. and Zingde, S. M.  Chronic myeloid leukemic granulocytes exhibit reduced and altered binding to P-selectin: modification in the CD15 antigens and sialylation. Leukemia Research. 1997.  21, 59-65. [PubMed]
29. Kant, A. M., Advani, S. H. and Zingde, S. M.  Actin mRNA is not lowered in chronic myeloid leukemic granulocytes. Leukemia Research. 1996.  20, 739-741. [PubMed]
30. Vijayan, V. K. and Zingde, S. M.  Heat-treated bovine serum albumin is a better blocking reagent for adhesion studies. BioTechniques. 1995.  18, 430-432. [PubMed]
31. Mehta, P., Zingde, S., Advani, S., Desai, H. and Gothoskar, B.  Protein 1a: a major wheat germ agglutinin binding protein on the surface of human granulocytes associated with the cytoskeleton. Molecular and Cellular Biochemistry. 1995.  144, 153-165. [PubMed]
32. Vijayan, V. K., Advani, S. H. and Zingde, S. M.  Chronic myeloid leukemic granulocytes exhibit decreased adhesion to fibronectin. Leukemia Research. 1994.  18, 877-879. [PubMed]
33. Batliwalla, F., Advani, S., Gothoskar, B. and Zingde, S.  Differential phosphorylation in normal and leukemic granulocytes in response to phorbol 12-myristate 13-acetate. Leukemia Research. 1994.  18, 327-336. [PubMed]
34. Karnik, M. P., Nair, C. N., Zingde, S. M., Gothoskar, B. P., Zachariah, L., Barbhaya, S. and Advani, S. H.  Use of polyclonal anti-myeloperoxidase antibody in myeloid lineage determination. The Indian Journal of Medical Research. 1994.  100, 272-276. [PubMed]
35. Desai, H., Zingde, S., Advani, S. and Gothoskar, B.  Differential phosphorylation--cause for defective internalization of aggregated IgG by chronic myeloid leukemic granulocytes? Leukemia Research. 1992.  16, 235-245. [PubMed]
36. Hingorani, R., Zingde, S. M., Tankkar, A., Advani, S. H. and Gothoskar, B. P.  A major concanavalin-A-binding cell surface protein from normal and leukemic granulocytes: isolation and characterization. Annals of Hematology. 1992.  65, 175-183. [PubMed]
37. Monteiro, J., Advani, S., Gothoskar, B. and Zingde, S. Decreased expression of FcRIII mRNA in leukemic granulocytes. FEBS Letters. 1992.300, 105-107.
38. Shirsat, N. V., Zingde, S. M., Advani, S. H. and Gothoskar, B. P.  The receptor for IgG on human normal and chronic myeloid leukemic granulocytes: functional and biochemical characterization. Cancer Biochemistry Biophysics. 1989.  10, 235-245. [PubMed]
39. Zingde, S. M., Advani, S. H. and Gothoskar, B. P.  Plasma membrane proteins from human normal and chronic myeloid leukemic granulocytes: identification and partial characterization of the concanavalin A-binding and detergent resistant proteins. Blut. 1987.  55, 89-100. [PubMed]
40. Zingde, S. M., Anklesaria, P. N., Advani, S. H., Bhisey, A. N. and Gothoskar, B. P.  Differential endocytosis of fluorescein iso-thiocyanate-concanavalin A by normal and chronic myeloid leukemic granulocytes. Blut. 1987.  55, 81-88. [PubMed]
41. Zingde, S. M., Shirsat, N. V. and Gothoskar, B. P.  Peptide mapping of proteins in gel bands after partial cleavage with acidic cyanogen bromide vapors. Analytical Biochemistry. 1986.  155, 10-13. [PubMed]
42. Zingde, S. M., Mungikar, A. M., Chhajlani, V., Advani, S. H. and Gothoskar, B. P.  Plasma membranes from normal and chronic myeloid leukemic granulocytes: isolation and two-dimensional polyacrylamide gel electrophoretic analysis. Cancer Biochemistry Biophysics. 1985.  7, 333-342. [PubMed]
43. Chhajlani, V., Zingde, S., Adwani, S. and Gothoskar, B.  Circulating immune complexes in chronic myeloid leukemia: turbidimetric measurement and two-dimensional electrophoretic analysis. Leukemia Research. 1983.  7, 565-573. [PubMed]
44. Mungikar, A. M., Zingde, S. M., Advani, S. H. and Gothoskar, B. P.  Mixed function oxidase enzymes in human normal granulocytes and chronic myeloid leukemia cells. I. Detection and estimation. Biochemical Medicine. 1983.  30, 181-187. [PubMed]
45. Zingde, S.M., Rodrigues, V., Joshi, S.M. and Krishnan, K.S. Molecular properties of Drosophila acetyl-cholinesterase. Journal of Neurochemistry. 1983. 41, 1243-1252.
46. Zingde, S. M. and Gothoskar, B. P.  Identification of a receptor for IgG on human granulocytes. FEBS Letters. 1982.  139, 317-320. [PubMed]
47. Laursen, R. A., L'Italien, J. J., Nagarkatti, S. and Miller, D. L.  The amino acid sequence of elongation factor Tu of Escherichia coli. The complete sequence. The Journal of Biological Chemistry. 1981.  256, 8102-8109. [PubMed]
48. Arai, K., Clark, B. F., Duffy, L., Jones, M. D., Kaziro, Y., Laursen, R. A., L'Italien, J., Miller, D. L., Nagarkatti, S., Nakamura, S., Nielsen, K. M., Petersen, T. E., Takahashi, K. and Wade, M.  Primary structure of elongation factor Tu from Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 1980.  77, 1326-1330. [PubMed]
49. S.M.Zingde and K.S.Krishnan. The acetylcholinesterase from Drosophila melanogaster in Development and Neurobiology of Drosophila. Basic Life Sciences. 1980. Vol. 16 (Ed. O.Siddiqi, P.Babu,, L.M.Hall and J.C.Hall). Plenum Press, New York, pp.305-311.
50. D.L.Miller, S.Nagarkatti, R.A.Laursen, J.Parker and J.D.Friesen.  comparison of the activities of the products of the two genes for elongation factor Tu. Molecular & General Genetics : MGG. 1978.  159, 57-62. [PubMed]
51. Laursen, R. A., Nagarkatti, S. and Miller, D. L.  Amino acid sequence of elongation factor Tu. Characterization and alignment of the cyanogen bromide fragments and location of the cysteine residues. FEBS Letters. 1977.  80, 103-106. [PubMed]
52. Pedersen, S., Blumenthal, R. M., Reeh, S., Russell, L. B., Lemaux, P., Laursen, R. A., Nagarkatti, S. and Friesen, J. D.  A mutant of Escherichia coli with an altered elongation factor Tu. Proceedings of the National Academy of Sciences of the United States of America. 1976.  73, 1698-1701. [PubMed]

 
Book Chapters:
S.M.Zingde and K.S.Krishnan. The acetylcholinesterase from Drosophila melanogaster in Development and Neurobiology of Drosophila. In: Basic Life Sciences. Siddiqi, O., Babu, P., L.M.Hall, L.M. and Hall,J.C.. Eds. Plenum Press, New York, 1980. Vol. 16. pp.305-311.
Venkatesh, T.R., Zingde, S.M. and Krishnan, K.S. Isolation and characterization of membranes from Drosophila melanogaster in Development and Neurobiology of Drosophila. In: Basic Life Sciences. Siddiqi, O., Babu, P., L.M.Hall, L.M. and Hall,J.C.. Eds. Plenum Press, New York, 1980. Vol. 16. pp.313-321.
 
Grant Support:
Project Title Role Funding Agency Sanction Number Sanction Date
Screening of anticancer drugs from the sea Principal Investigator Ministry of Earth Sciences, India 2007-2012
Post translational modifications of Cytokeratin 8 and 18: Potential biomarkers for cancer of buccal mucosa Principal Investigator Lady Tata Memorial Trust, India 2008-2011
Study of tumor antigens eliciting humoral immune response in oral cancer Council of Scientific and Industrial Research, Government of India 2007-2010
Curcumin clinical trials in cancer Co-Investigator Department of Biotechnology, Government of India 2009-2014
Design of novel anticancer drugs and analysis of their therapeutic potential by in vitro and invivo studies Co-Investigator Department of Biotechnology, Government of India 2007-2010
An in vivo study to evaluate the role of curcumins in oral premalignant lesions and gingivo-buccal cancers Co-Investigator Department of Biotechnology, Government of India 2006-2008
Design, synthesis and biological evaluation of new hybrids based on Pyrrolo[2,1- c][1,4] benzodiazepines Co-Investigator Department of Biotechnology, Government of India 2006-2009
To confirm the role of Protein kinase C delta in aggregation of Band 3 in CML erythrocytes Co-Investigator 2006-2009
An in vivo study to evaluate the role of curcumins in oral premalignant lesions and gingivo-buccal cancers Co-Investigator Department of Biotechnology, Government of India 2007-2009
Study of tumor antigens which elicit humoral immune response in oral cancer Principal Investigator Council of Scientific and Industrial Research, Government of India 2007-2010
New targets and markers for cancer using genomics and proteomics Principal Investigator Council of Scientific and Industrial Research, Government of India 2001-2006
Adhesion of normal and leukemic granulocytes to Fibronectin Principal Investigator Lady Tata Memorial Trust, India 1995-2000
Studies on Protein Kinase C isoforms in normal and leukemic granulocytes Principal Investigator Council of Scientific and Industrial Research, Government of India 27/58/95-EMR-II 1995-1999
The major concanavalin A binding membrane protein from normal and leukemic granulocytes : Expression in relation to maturity Principal Investigator Department of Science & Technology, Government of India SP/SO/D81/89 1990-1994
Plasma membrane proteins from normal and leukemic granulocytes: Isolation, biochemical characterization and gene cloning Principal Investigator Department of Science & Technology, Government of India SP/SO/D64/86 1987-1990

 
 
My CV:   Download
 
Education 
::
M.Sc. in Chemistry, Indian Institute of Technology, Bombay, India
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Ph.D. in Chemistry, Boston University, Boston, USA, 1972-1977
Honors and Awards
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Joint Secretary and founder member of the Proteomics Society-India
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Fellow of the Maharashtra Academy of Sciences and the Sigma Xi, USA
Member
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Member of CSIR, Department of Biotechnology, Lady Tata Memorial Trust and Board of Research in Nuclear Sciences of the Department of Atomic Energy
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Member of the Research & Recognition Committee in Biochemistry of the University of Mumbai and Board of Studies in Life Sciences of the Homi Bhabha National Institute
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Member of the executive committee of the Indian Society of Cell Biology
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Vice President of the Indian Association of Cancer Research
Type of Neoplasms
 
Head and Neck
Oral cavity
  Last modified on : Mar 6, 2011
India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.