Ashok K. Varma, Ph.D.
Advanced Centre for Treatment Research and Education in Cancer
Varma Lab
KS 101, Tata Memorial Centre, Kharghar
Navi Mumbai - 410 210
Maharashtra
E-mail: avarma@actrec.gov.in
Phone: +91-22-27405000, Extn. 5112, 5331
Fax: +91-22-27405085
URL: http://www.actrec.gov.in/pi-webpages/AshokVarma/varma-index.htm
Positions Held:
Position Affiliation Time Period
Principal Investigator
Advanced Centre for Treatment, Research and Education in Cancer, Navi Mumbai, India
Present
Area of Specialization:
Proteomics
Oncology
Research Summary:
Three dimensional structural characterization of functional domain of breast cancer associated domain-1 and mapping of cancer causing mutations in an Indian family
Structural mechanism to understand I-kappa-B kinase epsilon as a potential target for cancer therapy
Structural basis of fanconi anemia protein
Phospho ERK1/2 binding analysis with SmaV and structural characterization
Structural and binding analysis of human alpha 3 (IV) NC1 to integrin receptors
Structural integrity of checkpoint kinase 1/2 in tumorigenesis
Structural and binding analysis of mediator of DNA damage checkpoint protein 1 with phosphopeptide that regulate its DNA damage function
Cell signaling and biophysical interaction analysis with ephrin receptor B2
Publications:
1.
Patil, R., Das, S., Stanley, A., Yadav, L., Sudhakar, A. and Varma, A. K. Optimized hydrophobic interactions and hydrogen bonding at the target-ligand interface leads the pathways of drug-designing. PloS One. 2010. 5, e12029. [PubMed]
2.
Gunther, S., Varma, A. K. , Moza, B., Kasper, K. J., Wyatt, A. W., Zhu, P., Rahman, A. K., Li, Y., Mariuzza, R. A., McCormick, J. K. and Sundberg, E. J. A novel loop domain in superantigens extends their T cell receptor recognition site. Journal of Molecular Biology. 2007. 371, 210-221. [PubMed]
3.
Birrane, G., Varma, A. K. , Soni, A. and Ladias, J. A. Crystal structure of the BARD1 BRCT domains. Biochemistry. 2007. 46, 7706-7712. [PubMed]
4.
Brouillard, J. N., Gunther, S., Varma, A. K. , Gryski, I., Herfst, C. A., Rahman, A. K., Leung, D. Y., Schlievert, P. M., Madrenas, J., Sundberg, E. J. and McCormick, J. K. Crystal structure of the streptococcal superantigen SpeI and functional role of a novel loop domain in T cell activation by group V superantigens. Journal of Molecular Biology. 2007. 367, 925-934. [PubMed]
5.
Moza, B., Varma, A. K. , Buonpane, R. A., Zhu, P., Herfst, C. A., Nicholson, M. J., Wilbuer, A. K., Seth, N. P., Wucherpfennig, K. W., McCormick, J. K., Kranz, D. M. and Sundberg, E. J. Structural basis of T-cell specificity and activation by the bacterial superantigen TSST-1. The EMBO Journal. 2007. 26, 1187-1197. [PubMed]
6.
Varma, A. K. , Brown, R. S., Birrane, G. and Ladias, J. A. Structural basis for cell cycle checkpoint control by the BRCA1-CtIP complex. Biochemistry. 2005. 44, 10941-10946. [PubMed]
7.
Jabeen, T., Sharma, S., Singh, N., Singh, R. K., Verma, A. K. , Paramasivam, M., Srinivasan, A. and Singh, T. P. Structure of the zinc-induced heterodimer of two calcium-free isoforms of phospholipase A2 from Naja naja sagittifera at 2.7 angstroms resolution. Acta Crystallographica. Section D, Biological Crystallography. 2005. 61, 302-308. [PubMed]
8.
Raghavan, S., Reddy, S. R., Tony, K. A., Kumar, C. h. N., Varma, A. K. and Nangia, A. Sulfinyl group as an intramolecular nucleophile: synthesis of bromohydrins from beta-methyl-gamma,delta-unsaturated sulfoxides with high 1,2-asymmetric induction. The Journal of Organic Chemistry. 2002. 67, 5838-5841. [PubMed]
9.
Varma, A. K. , Nangia, A., Desiraju, G. R., Giri, V. S. and Jaisankar, P. Hydrogen bonding in two tetracyclic indole alkaloids. Acta Crystallographica. Section C, Crystal Structure Communications. 2001. 57, 97-99. [PubMed]
10.
Bhushan, A., Mishra, V., Varma, A., K. , Yadav, S., Sharma, R., S., Babu, C., R. and Singh, T., P., Crystal structure of a ribosome inactivating viscumin from Indian Viscumin album at 2.8 Å resolution. Acta Crystallography , 2002. A58, C288.
11.
Varma, A., K. , Tiwari, R., K., Crystallographic studies of antibacterial biomolecules “Sulphonamides”. J.T.R.Chem , 1999, 6(2), 1-8.
12.
Varma, A., K. , Tiwari, R., K. Refinement of the crystal structure of a p-amino benzene sulfonamides. J.T.R.Chem , 1999, 6(1), 1-8.
13.
Varma, A., K. , Tiwari, R., K., Crystal structure of a 1:1 complex between sulphonamides and salicylic acid. J.T.R.Chem , 1999, 6(1), 13-21.
Last modified on : Mar 4, 2011