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Ashok K. Varma, Ph.D.
Principal Investigator 
Advanced Centre for Treatment Research and Education in Cancer
Varma Lab
KS 101, Tata Memorial Centre, Kharghar
Navi Mumbai - 410 210   
Phone: +91-22-27405000, Extn. 5112, 5331
Fax: +91-22-27405085
Positions Held:
Position Affiliation Time Period
Principal Investigator Advanced Centre for Treatment, Research and Education in Cancer, Navi Mumbai, India Present
Area of Specialization:
Research Summary:
Three dimensional structural characterization of functional domain of breast cancer associated domain-1 and mapping of cancer causing mutations in an Indian family
Structural mechanism to understand I-kappa-B kinase epsilon as a potential target for cancer therapy
Structural basis of fanconi anemia protein
Phospho ERK1/2 binding analysis with SmaV and structural characterization
Structural and binding analysis of human alpha 3 (IV) NC1 to integrin receptors
Structural integrity of checkpoint kinase 1/2 in tumorigenesis
Structural and binding analysis of mediator of DNA damage checkpoint protein 1 with phosphopeptide that regulate its DNA damage function
Cell signaling and biophysical interaction analysis with ephrin receptor B2
1. Patil, R., Das, S., Stanley, A., Yadav, L., Sudhakar, A. and Varma, A. K.  Optimized hydrophobic interactions and hydrogen bonding at the target-ligand interface leads the pathways of drug-designing. PloS One. 2010.  5, e12029. [PubMed]
2. Gunther, S., Varma, A. K., Moza, B., Kasper, K. J., Wyatt, A. W., Zhu, P., Rahman, A. K., Li, Y., Mariuzza, R. A., McCormick, J. K. and Sundberg, E. J.  A novel loop domain in superantigens extends their T cell receptor recognition site. Journal of Molecular Biology. 2007.  371, 210-221. [PubMed]
3. Birrane, G., Varma, A. K., Soni, A. and Ladias, J. A.  Crystal structure of the BARD1 BRCT domains. Biochemistry. 2007.  46, 7706-7712. [PubMed]
4. Brouillard, J. N., Gunther, S., Varma, A. K., Gryski, I., Herfst, C. A., Rahman, A. K., Leung, D. Y., Schlievert, P. M., Madrenas, J., Sundberg, E. J. and McCormick, J. K.  Crystal structure of the streptococcal superantigen SpeI and functional role of a novel loop domain in T cell activation by group V superantigens. Journal of Molecular Biology. 2007.  367, 925-934. [PubMed]
5. Moza, B., Varma, A. K., Buonpane, R. A., Zhu, P., Herfst, C. A., Nicholson, M. J., Wilbuer, A. K., Seth, N. P., Wucherpfennig, K. W., McCormick, J. K., Kranz, D. M. and Sundberg, E. J.  Structural basis of T-cell specificity and activation by the bacterial superantigen TSST-1. The EMBO Journal. 2007.  26, 1187-1197. [PubMed]
6. Varma, A. K., Brown, R. S., Birrane, G. and Ladias, J. A.  Structural basis for cell cycle checkpoint control by the BRCA1-CtIP complex. Biochemistry. 2005.  44, 10941-10946. [PubMed]
7. Jabeen, T., Sharma, S., Singh, N., Singh, R. K., Verma, A. K., Paramasivam, M., Srinivasan, A. and Singh, T. P.  Structure of the zinc-induced heterodimer of two calcium-free isoforms of phospholipase A2 from Naja naja sagittifera at 2.7 angstroms resolution. Acta Crystallographica. Section D, Biological Crystallography. 2005.  61, 302-308. [PubMed]
8. Raghavan, S., Reddy, S. R., Tony, K. A., Kumar, C. h. N., Varma, A. K. and Nangia, A.  Sulfinyl group as an intramolecular nucleophile: synthesis of bromohydrins from beta-methyl-gamma,delta-unsaturated sulfoxides with high 1,2-asymmetric induction. The Journal of Organic Chemistry. 2002.  67, 5838-5841. [PubMed]
9. Varma, A. K., Nangia, A., Desiraju, G. R., Giri, V. S. and Jaisankar, P.  Hydrogen bonding in two tetracyclic indole alkaloids. Acta Crystallographica. Section C, Crystal Structure Communications. 2001.  57, 97-99. [PubMed]
10. Bhushan, A., Mishra, V., Varma, A., K., Yadav, S., Sharma, R., S., Babu, C., R. and Singh, T., P., Crystal structure of a ribosome inactivating viscumin from Indian Viscumin album at 2.8 Å resolution. Acta Crystallography, 2002. A58, C288.
11. Varma, A., K., Tiwari, R., K., Crystallographic studies of antibacterial biomolecules “Sulphonamides”. J.T.R.Chem, 1999, 6(2), 1-8.
12. Varma, A., K., Tiwari, R., K. Refinement of the crystal structure of a p-amino benzene sulfonamides. J.T.R.Chem, 1999, 6(1), 1-8.
13. Varma, A., K., Tiwari, R., K., Crystal structure of a 1:1 complex between sulphonamides and salicylic acid. J.T.R.Chem , 1999, 6(1), 13-21.


  Last modified on : Mar 4, 2011
India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.