INCREDB ID : 79
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Alok Chandra Bharati, Ph.D.
Scientist D 
 
Institute of Cytology and Preventive Oncology
I-7, Sector-39
Noida - 201 301   
Uttar Pradesh   
 
E-mail: bhartiac@icmr.org.in, alokchandrab@yahoo.com
Phone: +91-120-2579471, 72
Fax: +91-120-2579473
 
URL: http://icmr.nic.in/icmrsql/biodata.asp?expno=00011694
 
Positions Held:
Position Affiliation Time Period
Scientist D Institute of Cytology and Preventive Oncology, Noida, India Present
Senior Research Officer All India Institue of Medical Sciences, New Delhi, India 2003-2004
 
Area of Specialization:
Molecular Biology
Research Summary:
Immunology
 
Publications:
1. Kumar, S., Guleria, R., Mohan, A., Singh, V., Bharti, A. C. and Das, B. C.  Efficacy of Plasma TGF-beta1 Level in Predicting Therapeutic Efficacy and Prognosis in Patients with Advanced Non-Small Cell Lung Cancer. Cancer Investigation. 2011.  [PubMed]
2. Hedau, S., Kumar, U., Hussain, S., Shukla, S., Pande, S., Jain, N., Tyagi, A., Despande, T., Bhat, D., Mir, M. M., Chakrabvarty, S., Singh, Y. M., Kumar, R., Somasundaram, K., Bharti, A. C. and Das, B. C.  Breast cancer and human papillomavirus infection: No evidence of HPV etiology of breast cancer in Indian women. BMC Cancer. 2011.  11, 27. [PubMed]
3. Shukla, S., Shishodia, G., Mahata, S., Hedau, S., Pandey, A., Bhambhani, S., Batra, S., Basir, S. F., Das, B. C. and Bharti, A. C.  Aberrant expression and constitutive activation of STAT3 in cervical carcinogenesis: implications in high-risk human papillomavirus infection. Molecular Cancer. 2010.  9, 282. [PubMed]
4. Chaudhary, A. K., Pandya, S., Mehrotra, R., Bharti, A. C., Singh, M. and Singh, M.  Comparative study between the Hybrid Capture II test and PCR based assay for the detection of human papillomavirus DNA in oral submucous fibrosis and oral squamous cell carcinoma. Virology Journal. 2010.  7, 253. [PubMed]
5. Chaudhary, A. K., Pandya, S., Mehrotra, R., Bharti, A. C., Jain, S. and Singh, M.  Functional polymorphism of the MMP-1 promoter (-1607 1G/2G) in potentially malignant and malignant head and neck lesions in an Indian population. Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility To Chemicals. 2010.  15, 684-692. [PubMed]
6. Shukla, S., Bharti, A. C., Mahata, S., Hussain, S., Hedau, S., Sharma, R., Pillai, M. R., Krishna, S., Chiplunkar, S., Tongaonkar, H. and Das, B. C.  Application of a multiplex PCR to cervical cells collected by a paper smear for the simultaneous detection of all mucosal human papillomaviruses (HPVs) and typing of high-risk HPV types 16 and 18. Journal of Medical Microbiology. 2010.  59, 1303-1310. [PubMed]
7. Chaudhary, A. K., Singh, M., Bharti, A. C., Singh, M., Shukla, S., Singh, A. K. and Mehrotra, R.  Synergistic effect of stromelysin-1 (matrix metalloproteinase-3) promoter (-1171 5A->6A) polymorphism in oral submucous fibrosis and head and neck lesions. BMC Cancer. 2010.  10, 369. [PubMed]
8. Kumar, S., Guleria, R., Singh, V., Mohan, A., Bharti, A. C. and Das, B. C.  Lack of utility of plasma TNF-alpha level in predicting therapeutic efficacy in patients with advanced non-small cell lung cancer. Cytokine. 2010.  51, 245-248. [PubMed]
9. Bharti, A. C., Panigrahi, A., Sharma, P. K., Gupta, N., Kumar, R., Shukla, S., Bhowmik, D. M., Agarwal, S. K., Guleria, S. and Mehra, N. K.  Clinical relevance of curcumin-induced immunosuppression in living-related donor renal transplant: an in vitro analysis. Experimental and Clinical Transplantation. 2010.  8, 161-171. [PubMed]
10. Kumar, S., Guleria, R., Mohan, A., Singh, V., Ali, A., Bharti, A. C. and Das, B. C.  Utility of plasma tumour necrosis factor-alpha and transforming growth factor-beta1 as predictors of survival and treatment outcome in advanced non-small cell lung carcinoma. Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility To Chemicals. 2010.  15, 446-453. [PubMed]
11. Kumar, S., Guleria, R., Singh, V., Bharti, A. C., Mohan, A. and Das, B. C.  Plasma DNA level in predicting therapeutic efficacy in advanced nonsmall cell lung cancer. The European Respiratory Journal. 2010.  36, 885-892. [PubMed]
12. Kumar, S., Guleria, R., Singh, V., Bharti, A. C., Mohan, A. and Das, B. C.  Efficacy of circulating plasma DNA as a diagnostic tool for advanced non-small cell lung cancer and its predictive utility for survival and response to chemotherapy. Lung Cancer. 2010.  70, 211-217. [PubMed]
13. Chaudhary, A. K., Singh, M., Bharti, A. C., Asotra, K., Sundaram, S. and Mehrotra, R.  Genetic polymorphisms of matrix metalloproteinases and their inhibitors in potentially malignant and malignant lesions of the head and neck. Journal of Biomedical Science. 2010.  17, 10. [PubMed]
14. Kumar, S., Guleria, R., Singh, V., Bharti, A. C., Mohan, A. and Das, B. C.  Plasma nucleosome levels might predict response to therapy in patients with advanced non-small-cell lung cancer. Clinical Lung Cancer. 2010.  11, 36-44. [PubMed]
15. Kumar, S., Guleria, R., Singh, V., Bharti, A. C., Mohan, A. and Das, B. C.  Efficacy of plasma vascular endothelial growth factor in monitoring first-line chemotherapy in patients with advanced non-small cell lung cancer. BMC Cancer. 2009.  9, 421. [PubMed]
16. Bharti, A. C., Shukla, S., Mahata, S., Hedau, S. and Das, B. C.  Anti-human papillomavirus therapeutics: facts & future. The Indian Journal of Medical Research. 2009.  130, 296-310. [PubMed]
17. Shukla, S., Bharti, A. C., Mahata, S., Hussain, S., Kumar, R., Hedau, S. and Das, B. C.  Infection of human papillomaviruses in cancers of different human organ sites. The Indian Journal of Medical Research. 2009.  130, 222-233. [PubMed]
18. Das, B. C., Bharti, A. C. and Bharadwaj, M.  Human papillomavirus & cervical cancer: looking ahead. The Indian Journal of Medical Research. 2009.  130, 210-211. [PubMed]
19. Hussain, S., Bharti, A. C., Salam, I., Bhat, M. A., Mir, M. M., Hedau, S., Siddiqi, M. A., Basir, S. F. and Das, B. C.  Transcription factor AP-1 in esophageal squamous cell carcinoma: alterations in activity and expression during human Papillomavirus infection. BMC Cancer. 2009.  9, 329. [PubMed]
20. Mishra, A., Bharti, A. C., Saluja, D. and Das, B. C.  Transactivation and expression patterns of Jun and Fos/AP-1 super-family proteins in human oral cancer. International Journal of Cancer. 2010.  126, 819-829. [PubMed]
21. Shukla, S., Bharti, A. C., Hussain, S., Mahata, S., Hedau, S., Kailash, U., Kashyap, V., Bhambhani, S., Roy, M., Batra, S., Talwar, G. P. and Das, B. C.  Elimination of high-risk human papillomavirus type HPV16 infection by 'Praneem' polyherbal tablet in women with early cervical intraepithelial lesions. Journal of Cancer Research and Clinical Oncology. 2009.  135, 1701-1709. [PubMed]
22. Salam, I., Hussain, S., Mir, M. M., Dar, N. A., Abdullah, S., Siddiqi, M. A., Lone, R. A., Zargar, S. A., Sharma, S., Hedau, S., Basir, S. F., Bharti, A. C. and Das, B. C.  Aberrant promoter methylation and reduced expression of p16 gene in esophageal squamous cell carcinoma from Kashmir valley: a high-risk area. Molecular and Cellular Biochemistry. 2009.  332, 51-58. [PubMed]
23. Sobti, R. C., Singh, N., Hussain, S., Suri, V., Bharti, A. C. and Das, B. C.  Overexpression of STAT3 in HPV-mediated cervical cancer in a north Indian population. Molecular and Cellular Biochemistry. 2009.  330, 193-199. [PubMed]
24. Tekade, R. K., Dutta, T., Tyagi, A., Bharti, A. C., Das, B. C. and Jain, N. K.  Surface-engineered dendrimers for dual drug delivery: a receptor up-regulation and enhanced cancer targeting strategy. Journal of Drug Targeting. 2008.  16, 758-772. [PubMed]
25. Mishra, A., Bharti, A. C., Varghese, P., Saluja, D. and Das, B. C.  Differential expression and activation of NF-kappaB family proteins during oral carcinogenesis: Role of high risk human papillomavirus infection. International Journal of Cancer. 2006.  119, 2840-2850. [PubMed]
26. Bharti, A. C., Takada, Y. and Aggarwal, B. B.  PARP cleavage and caspase activity to assess chemosensitivity. Methods in Molecular Medicine. 2005.  111, 69-78. [PubMed]
27. Bharti, A. C. and Aggarwal, B. B.  Ranking the role of RANK ligand in apoptosis. Apoptosis. 2004.  9, 677-690. [PubMed]
28. Bharti, A. C., Takada, Y. and Aggarwal, B. B.  Curcumin (diferuloylmethane) inhibits receptor activator of NF-kappa B ligand-induced NF-kappa B activation in osteoclast precursors and suppresses osteoclastogenesis. Journal of Immunology. 2004.  172, 5940-5947. [PubMed]
29. Bharti, A. C., Shishodia, S., Reuben, J. M., Weber, D., Alexanian, R., Raj-Vadhan, S., Estrov, Z., Talpaz, M. and Aggarwal, B. B.  Nuclear factor-kappaB and STAT3 are constitutively active in CD138+ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis. Blood. 2004.  103, 3175-3184. [PubMed]
30. Bharti, A. C., Takada, Y., Shishodia, S. and Aggarwal, B. B.  Evidence that receptor activator of nuclear factor (NF)-kappaB ligand can suppress cell proliferation and induce apoptosis through activation of a NF-kappaB-independent and TRAF6-dependent mechanism. The Journal of Biological Chemistry. 2004.  279, 6065-6076. [PubMed]
31. Aggarwal, B. B., Shishodia, S., Ashikawa, K. and Bharti, A. C.  The role of TNF and its family members in inflammation and cancer: lessons from gene deletion. Current Drug Targets. Inflammation and Allergy. 2002.  1, 327-341. [PubMed]
32. Bharti, A. C., Donato, N. and Aggarwal, B. B.  Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells. Journal of Immunology. 2003.  171, 3863-3871. [PubMed]
33. Aggarwal, B. B., Kumar, A. and Bharti, A. C.  Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Research. 2003.  23, 363-398. [PubMed]
34. Bharti, A. C. and Singh, S. M.  Inhibition of macrophage nitric oxide production by gangliosides derived from a spontaneous T cell lymphoma: the involved mechanisms. Nitric Oxide : Biology and Chemistry. 2003.  8, 75-82. [PubMed]
35. Bharti, A. C. and Aggarwal, B. B.  Chemopreventive agents induce suppression of nuclear factor-kappaB leading to chemosensitization. Annals of the New York Academy of Sciences. 2002.  973, 392-395. [PubMed]
36. Ashikawa, K., Majumdar, S., Banerjee, S., Bharti, A. C., Shishodia, S. and Aggarwal, B. B.  Piceatannol inhibits TNF-induced NF-kappaB activation and NF-kappaB-mediated gene expression through suppression of IkappaBalpha kinase and p65 phosphorylation. Journal of Immunology. 2002.  169, 6490-6497. [PubMed]
37. Bharti, A. C., Donato, N., Singh, S. and Aggarwal, B. B.  Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis. Blood. 2003.  101, 1053-1062. [PubMed]
38. Bharti, A. C. and Aggarwal, B. B.  Nuclear factor-kappa B and cancer: its role in prevention and therapy. Biochemical Pharmacology. 2002.  64, 883-888. [PubMed]
39. Bharti, A. C. and Singh, S. M.  Gangliosides derived from a T cell lymphoma inhibit bone marrow cell proliferation and differentiation. International Immunopharmacology. 2001.  1, 155-165. [PubMed]
40. Bharti, A. C. and Singh, S. M.  Induction of apoptosis in bone marrow cells by gangliosides produced by a T cell lymphoma. Immunology Letters. 2000.  72, 39-48. [PubMed]

 
 
Education 
::
M.Sc. Delhi University
::
Ph.D. Banaras Hindu University, Varanasi, Uttar Pradesh, India
Member
::
Indian Immunology Society
  Last modified on : Mar 4, 2011
India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.