INCREDB ID : 7
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Girish B. Maru, Ph.D.
Principal Investigator 
 
Advanced Centre for Treatment Research and Education in Cancer
KS 217, Tata Memorial Centre, Kharghar
Navi Mumbai - 410 208   
Maharashtra   
 
E-mail: gmaru@actrec.gov.in
Phone: +91-22-27405022
Fax: +91-22-27405085
 
URL: http://actrec.gov.in/pi-webpages/GirishMaru/maru-gbm.htm
 
Positions Held:
Position Affiliation Time Period
Principal Investigator Advanced Centre for Treatment, Research and Education in Cancer, Navi Mumbai, India Present
Visiting Scientist International Agency for Research on Cancer, Lyon, France 1987-1989
Post Doctoral Fellowship Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester, UK 1980-1981
 
Area of Specialization:
Cancer Biology
Research Summary:
Evaluation of mechanism(s) of action(s) of environmental agents
Evaluation of carcinogenic/mutagenic/ genotoxic or cancer preventive (chemopreventive) activity of environmental agents
 
Publications:
1. Thapliyal, R., Dolas, S. S., Pakhale, S. S. and Maru, G. B.  Evaluation of DNA damage in mice topically exposed to total particulate matter from mainstream and sidestream smoke from cigarettes and bidis. Mutagenesis. 2004.  19, 413-421. [PubMed]
2. Krishnan, R., Raghunathan, R. and Maru, G. B.  Effect of polymeric black tea polyphenols on benzo(a)pyrene [B(a)P]-induced cytochrome P4501A1 and 1A2 in mice. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 2005.  35, 671-682. [PubMed]
3. Krishnan, R. and Maru, G. B.  Inhibitory effect(s) of polymeric black tea polyphenols on the formation of B(a)P-derived DNA adducts in mouse skin. Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society For Environmental Toxicology and Cancer. 2005.  24, 79-90. [PubMed]
4. Thapliyal, R., Naresh, K. N., Rao, K. V. and Maru, G. B.  Inhibition of nitrosodiethylamine-induced hepatocarcinogenesis by dietary turmeric in rats. Toxicology Letters. 2003.  139, 45-54. [PubMed]
6. Thapliyal, R. and Maru, G. B.  Inhibition of cytochrome P450 isozymes by curcumins in vitro and in vivo. Food and Chemical Toxicology. 2001.  39, 541-547. [PubMed]
7. Thapliyal, R., Deshpande, S. S. and Maru, G. B.  Effects of turmeric on the activities of benzo(a)pyrene-induced cytochrome P-450 isozymes. Journal of Environmental Pathology, Toxicology and Oncology . 2001.  20, 59-63. [PubMed]
8. Deshpande, S. S., Lalitha, V. S., Ingle, A. D., Raste, A. S., Gadre, S. G. and Maru, G. B.  Subchronic oral toxicity of turmeric and ethanolic turmeric extract in female mice and rats. Toxicology Letters. 1998.  95, 183-193. [PubMed]
9. Kandarkar, S. V., Sawant, S. S., Ingle, A. D., Deshpande, S. S. and Maru, G. B.  Subchronic oral hepatotoxicity of turmeric in mice--histopathological and ultrastructural studies. Indian Journal of Experimental Biology. 1998.  36, 675-679. [PubMed]
10. Pakhale, S. S. and Maru, G. B.  Distribution of major and minor alkaloids in tobacco, mainstream and sidestream smoke of popular Indian smoking products. Food and Chemical Toxicology. 1998.  36, 1131-1138. [PubMed]
11. Deshpande, S. S., Ingle, A. D. and Maru, G. B.  Chemopreventive efficacy of curcumin-free aqueous turmeric extract in 7,12-dimethylbenz[a]anthracene-induced rat mammary tumorigenesis. Cancer Letters. 1998.  123, 35-40. [PubMed]
12. Deshpande, S. S., Ingle, A. D. and Maru, G. B.  Inhibitory effects of curcumin-free aqueous turmeric extract on benzo[a]pyrene-induced forestomach papillomas in mice. Cancer Letters. 1997.  118, 79-85. [PubMed]
13. Deshpande, S. S. and Maru, G. B.  Effects of curcumin on the formation of benzo[a]pyrene derived DNA adducts in vitro. Cancer Letters. 1995.  96, 71-80. [PubMed]
14. Dolas, S., S., Pakhale, S., S. and Maru, G., B., Levels of phenols in mainstream and sidestream smoke of Indian smoking products. Tobacco Reserch. 2005, 31: 1-12.
15. Krishnan., R. and Maru, G., B., Isolation and analyses of polymeric polyphenols fractions from black tea. Food Chemistry.2006, 94: 331-340.
16. Krishnan., R. and Maru, G., B., Inhibitory effect(s) of polymeric black tea polyphenols fractions on the formation of [3H]-B(a)P-derived DNA adducts. J. Agri. Food Chem. 2004, 52: 4261-4269.
18. Thapliyal, R., Deshpande, S., S. and Maru., G., B. Mechanisms of turmeric-mediated protective effects against benzo(a)pyrene-derived DNA adducts. Cancer Letter.2002, 176: 77-87.
19. Dolas., S., S., Pakhale, S., S. and Maru., G.,B. Yields of hydrogen cyanide in mainstream and sidestream smoke of popular Indian smoking products. Tobacco Res. 27: 63-72.
20. Pakhale, S., S., Dolas., S., S. and Maru., G., B., Determination of alkaloids, nitrate, nitrite, moisture and pH in tobacco varieties from different parts of India. Tobacco Reserch.1998, 23:11-18.
22. Pakhale., S., S., Dolas., S., S. and Maru., G., B.,  The distribution of total particulate matter (TPM) and nicotine between mainstream and sidestream smoke in bidis and cigarettes. Anal. Lett.,1997, 30: 383-394.
23. Pakhale., S., S., Dolas.,  S., S. and Maru., G., B. Determination of alkaloids, nitrate, nitrite, moisture and pH in tobacco varieties from different parts of India. Tobacco Res.1997, 23: 11-18.

 

Book Chapters:
Bhisey, RA., Ramchandani, AG., and Sirsat, SM. Tumor promoter 12-0-tetradecanoylphorbol-13-acetate - (TPA) enhances methylcholanthrene (MCA) induced mouse skin tumorigenesis. In: Chemical Carcinogenesis and Mutagenesis. Editors. Reddi OS & Reddy PP. Institute of Genetics and Hospital for Genetic Diseases, Hyderabad, Osmania University, 1988. pp. 1-3.
Pakhale, SS., and Maru, GB. Analysis of tobacco and its products .In: “Techniques in Cancer Research: A Laboratory Manual”, Editors. Deo, MG., Seshadri, R., Mulherkar, R., Mukhopadhyay, R., and Bhisey, AN. National Institute of Science Communication, New Delhi. 1997. pp. 342-347.
Maru, GB. Measurement of DNA single strand breaks and cross links. In: “Techniques in Cancer Research: A Laboratory Manual,” Editors. Deo, MG., Seshadri, R., Mulherkar, R., Mukhopadhyay, R., and Bhisey, AN. National Institute of Science Communication New Delhi. 1997. pp. 326-329.
Ramchandani, AG., and Bhisey, RA. Assessment of carcinogenicity. In: “Techniques in Cancer Research: A Laboratory Manual”, Editors. Deo, MG., Seshadri, R., Mulherkar, R., Mukhopadhyay, R., and Bhisey, AN. National Institute of Science Communication, New Delhi. 1997. pp. 333-335.
Maru, GB. 32 P-post labelling analysis of DNA adducts. In: “Techniques in Cancer Research : A Laboratory Manual”, Editors. Deo, MG., Seshadri, R., Mulherkar, R., Mukhopadhyay, R., and Bhisey, AN. National Institute of Science Communication, New Delhi. 1997. pp. 316-326.
Pakhale, SS., and Maru, GB. A) Analysis of tobacco and its products for alkaloids, tobacco specific nitroasamines and nitrate/nitrite. B} Assessement of human exposure to tobacco I} Determination of carboxy haemoglobin as biological indicator of tobacco smoke exposure. II} Determination of nicotine and cotinine in physiogical fluids by gas chromatography. In: ‘Techniques in Cancer Research: A Laboratory Manual’.Editors. Deo, MG., Sheshadri, R., Mulherkar, R., Mukhopadhyaya, R. Cancer Reseach Institute, Tata Memorial Centre, Mumbai. India. 1995.
Sarkar, S., Bhide, MB., Bhide, AM., Raghavan, S., Maru, GB., and Bhide, SV. Transplacental exposure of human foetuses to nicotine/ cotinine in masheri addict mothers and consequent loss of weight in babies at birth. In: “Nitroso Compounds: Biological mechanisms, exposures and cancer etiology”. Editors. O’Neil, IK., and Bartsch, H. IARC Technical Report No. 11, IARC, Lyon, France.1992. p. 32.
Lahiri, M., Maru, GB., Amonkar, AJ., and Bhide, SV. Modulation of benzo(a)pyrene induced DNA damage by some chemopreventive agents. In: “Chemoprevention of Cancer”. Editors.Bhide, SV., and Maru, GB. Omega Scientific Publishers, New Delhi. 1991. pp. 152-161.
Maru, GB., Castegnaro, M., and Bartsch, H. Evaluation of DNA damage in rats treated with tobacco-specific nitrosamines by 32p adduct assay. In: “N-Nitrosocompounds - Biology and Chemistry”. Editors. Bhide, SV., and Rao, KVK. Omega Scientific Publishers, New Delhi.1990. pp. 207-214.
Friesen, M., Maru, GB., Bussachini, V., Bartsch, H., Nair, UJ., Nair, J., and Floyd, RA. Formation of reactive oxygen species and 8-hydroxy-2’deoxyguanosine in DNA in vitro with betelquid ingredients. In: “Detection methods for DNA damaging Agents in man: Applications in cancer epidemiology and prevention”. Editors. Bartsch, H., Hemminki, K., and O’Neill, I. IARC Publ. No. 89, International Agency for Research on Cancer, Lyon. 1989. pp. 417-421.
Jayant, K. and Pakhale, SS. Toxic constituents in bidi smoke. In: ‘Tobacco and Health: The Indian Scene’. Editors. Sanghvi, LD., and Notani, P. UICC Workshop, Tata Memorial Centre, Bombay, India. 1989. pp. 101-110.
Bhisey, RA., Ramchandani, AG., and Veturkar, PL. Is conversion to propagation sensitivity a crucial step in enhanced expression of MCA-induced neoplasia? In: Theories of Carcinogenesis, Editor.Iverson OH, Hemisphere Publ. Corpn., Washington. 1988. pp. 318- 319.
 
Grant Support:
Project Title Role Funding Agency Sanction Number Sanction Date
Comparison of sensitivity of SENCAR, Swiss albino, Swiss bare and transgenic K14-EF mice to skin carcinogenesis
Evaluation of carcinogenic potential and mechanism/s of action of pan masala / gutkha Principal Investigator
Evaluation of mechanism(s) of turmeric/ curcumin-mediated chemoprevention and validation of biomarkers for drug effect measurements Principal Investigator Indian Council of Medical Research
Investigations on chemopreventive efficacy of black tea (Camelia sinensis): the popular beverage in India Principal Investigator

 

 
 
Education 
::
M.Sc. in Biochemistry, M. S. University, Baroda, India
::
Ph.D. in Biochemistry, University of Mumbai, Mumbai, India
Honors and Awards
::
1986, Invited expert member in “WHO Task Group Meeting” on ‘Environmental Health criteria for 1,2 dichloroethane and hydrazine’, Geneva
::
1987-1989, Visiting Scientist, International Agency for Research on Cancer (IARC), Lyon, France
::
1987, Invited expert member in “WHO Study Group Meeting” on Smokeless Tobacco, Geneva
  Last modified on : Mar 5, 2011
India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.