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Sudhir Krishna, M.B.B.S., Ph.D.
National Centre for Biological Sciences
Cellular Organization and Signalling Lab
Tata Institute of Fundamental Research, GKVK, Bellary Road
Bangalore - 560 065   
Positions Held:
Position Affiliation Time Period
Professor National Centre for Biological Sciences, Tata Institute of Fundemental Research, Bangalore, India 1998-Present
Associate Professor National Centre for Biological Sciences, Tata Institute of Fundemental Research, Bangalore, India 1992-1998
Research fellow Massachusetts General Hospital, Harvard Medical School, Harvard University, MA, Boston, USA
Area of Specialization:
Signal transduction
Stem cell biology
Research Summary:
Cellular organisation and signaling
Notch signaling in human cancers: molecular mechanisms and clinical translation
1. Shukla, S., Bharti, A. C., Mahata, S., Hussain, S., Hedau, S., Sharma, R., Pillai, M. R., Krishna, S., Chiplunkar, S., Tongaonkar, H. and Das, B. C.  Application of a multiplex PCR to cervical cells collected by a paper smear for the simultaneous detection of all mucosal human papillomaviruses (HPVs) and typing of high-risk HPV types 16 and 18. Journal of Medical Microbiology. 2010.  59, 1303-1310. [PubMed]
2. Jayshree, R. S., Sreenivas, A., Tessy, M. and Krishna, S.  Cell intrinsic & extrinsic factors in cervical carcinogenesis. The Indian Journal of Medical Research. 2009.  130, 286-295. [PubMed]
3. Srivastava, S. and Krishna, S.  Cancer stem cells: an approach to identify newer therapeutic targets. Journal of Stem Cells. 2009.  4, 123-131. [PubMed]
4. Adurthi, S., Krishna, S., Mukherjee, G., Bafna, U. D., Devi, U. and Jayshree, R. S.  Regulatory T cells in a spectrum of HPV-induced cervical lesions: cervicitis, cervical intraepithelial neoplasia and squamous cell carcinoma. American Journal of Reproductive Immunology. 2008.  60, 55-65. [PubMed]
5. Ramdass, B., Maliekal, T. T., Lakshmi, S., Rehman, M., Rema, P., Nair, P., Mukherjee, G., Reddy, B. K., Krishna, S. and Radhakrishna, P.  Coexpression of Notch1 and NF-kappaB signaling pathway components in human cervical cancer progression. Gynecologic Oncology. 2007.  104, 352-361. [PubMed]
6. Subramanyam, D. and Krishna, S.  c-Myc substitutes for Notch1-CBF1 functions in cooperative transformation with papillomavirus oncogenes. Virology. 2006.  347, 191-198. [PubMed]
7. Veeraraghavalu, K., Subbaiah, V. K., Srivastava, S., Chakrabarti, O., Syal, R. and Krishna, S.  Complementation of human papillomavirus type 16 E6 and E7 by Jagged1-specific Notch1-phosphatidylinositol 3-kinase signaling involves pleiotropic oncogenic functions independent of CBF1;Su(H);Lag-1 activation. Journal of Virology. 2005.  79, 7889-7898. [PubMed]
8. Mcavoy, B. R., Fulcher, G. R., Amerena, J. V., Conner, G. W., Beltrame, J. F., Hankey, G. J., Keech, A. C., Lloyd, B. L., Neale, M. L., Pollock, C. A., Sudhir, K., Waltham, R. D. and West, M. J.  An evidence based clinical aid for cardiovascular disease--what do GPs think? Australian Family Physician. 2005.  34, 297-298. [PubMed]
9. Ayyub, C., Sen, A., Gonsalves, F., Badrinath, K., Bhandari, P., Shashidhara, L. S., Krishna, S. and Rodrigues, V.  Cullin-5 plays multiple roles in cell fate specification and synapse formation during Drosophila development. Developmental Dynamics. 2005.  232, 865-875. [PubMed]
10. Veeraraghavalu, K., Pett, M., Kumar, R. V., Nair, P., Rangarajan, A., Stanley, M. A. and Krishna, S.  Papillomavirus-mediated neoplastic progression is associated with reciprocal changes in JAGGED1 and manic fringe expression linked to notch activation. Journal of Virology. 2004.  78, 8687-8700. [PubMed]
11. Chakrabarti, O., Veeraraghavalu, K., Tergaonkar, V., Liu, Y., Androphy, E. J., Stanley, M. A. and Krishna, S.  Human papillomavirus type 16 E6 amino acid 83 variants enhance E6-mediated MAPK signaling and differentially regulate tumorigenesis by notch signaling and oncogenic Ras. Journal of Virology. 2004.  78, 5934-5945. [PubMed]
12. Sade, H., Krishna, S. and Sarin, A.  The anti-apoptotic effect of Notch-1 requires p56lck-dependent, Akt/PKB-mediated signaling in T cells. The Journal of Biological Chemistry. 2004.  279, 2937-2944. [PubMed]
13. Nair, P., Somasundaram, K. and Krishna, S.  Activated Notch1 inhibits p53-induced apoptosis and sustains transformation by human papillomavirus type 16 E6 and E7 oncogenes through a PI3K-PKB/Akt-dependent pathway. Journal of Virology. 2003.  77, 7106-7112. [PubMed]
14. Chakrabarti, O. and Krishna, S.  Molecular interactions of 'high risk' human papillomaviruses E6 and E7 oncoproteins: implications for tumour progression. Journal of Biosciences. 2003.  28, 337-348. [PubMed]


Grant Support:
Project Title Role Funding Agency Sanction Number Sanction Date
Regulation of RhoC by Notch1 during cervical carcinoma progression
Notch1 and TGF-β crosstalk in EMT during carcinoma progression
Cancer stem-like cells and role of Notch1 signaling
Notch signaling in human hematological cancers


M.B.B.S. St. Johns Medical College, Bangalore, India
Ph.D. University of Cambridge, UK
Honors and Awards
British Lepra Foundation prize
Cambridge Nehru Scholarship
Rockefeller Biotechnology Career Fellowship
  Last modified on : May 2, 2012
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