INCREDB ID : 69
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Sudhir Krishna, M.B.B.S., Ph.D.
Professor 
 
National Centre for Biological Sciences
Cellular Organization and Signalling Lab
Tata Institute of Fundamental Research, GKVK, Bellary Road
Bangalore - 560 065   
Karnataka   
 
E-mail: skrishna@ncbs.res.in
 
URL: http://ncbs.res.in/skrishna
 
Positions Held:
Position Affiliation Time Period
Professor National Centre for Biological Sciences, Tata Institute of Fundemental Research, Bangalore, India 1998-Present
Associate Professor National Centre for Biological Sciences, Tata Institute of Fundemental Research, Bangalore, India 1992-1998
Research fellow Massachusetts General Hospital, Harvard Medical School, Harvard University, MA, Boston, USA
 
Area of Specialization:
Oncology
Signal transduction
Stem cell biology
Research Summary:
Cellular organisation and signaling
Notch signaling in human cancers: molecular mechanisms and clinical translation
 
Publications:
1. Shukla, S., Bharti, A. C., Mahata, S., Hussain, S., Hedau, S., Sharma, R., Pillai, M. R., Krishna, S., Chiplunkar, S., Tongaonkar, H. and Das, B. C.  Application of a multiplex PCR to cervical cells collected by a paper smear for the simultaneous detection of all mucosal human papillomaviruses (HPVs) and typing of high-risk HPV types 16 and 18. Journal of Medical Microbiology. 2010.  59, 1303-1310. [PubMed]
2. Jayshree, R. S., Sreenivas, A., Tessy, M. and Krishna, S.  Cell intrinsic & extrinsic factors in cervical carcinogenesis. The Indian Journal of Medical Research. 2009.  130, 286-295. [PubMed]
3. Srivastava, S. and Krishna, S.  Cancer stem cells: an approach to identify newer therapeutic targets. Journal of Stem Cells. 2009.  4, 123-131. [PubMed]
4. Adurthi, S., Krishna, S., Mukherjee, G., Bafna, U. D., Devi, U. and Jayshree, R. S.  Regulatory T cells in a spectrum of HPV-induced cervical lesions: cervicitis, cervical intraepithelial neoplasia and squamous cell carcinoma. American Journal of Reproductive Immunology. 2008.  60, 55-65. [PubMed]
5. Ramdass, B., Maliekal, T. T., Lakshmi, S., Rehman, M., Rema, P., Nair, P., Mukherjee, G., Reddy, B. K., Krishna, S. and Radhakrishna, P.  Coexpression of Notch1 and NF-kappaB signaling pathway components in human cervical cancer progression. Gynecologic Oncology. 2007.  104, 352-361. [PubMed]
6. Subramanyam, D. and Krishna, S.  c-Myc substitutes for Notch1-CBF1 functions in cooperative transformation with papillomavirus oncogenes. Virology. 2006.  347, 191-198. [PubMed]
7. Veeraraghavalu, K., Subbaiah, V. K., Srivastava, S., Chakrabarti, O., Syal, R. and Krishna, S.  Complementation of human papillomavirus type 16 E6 and E7 by Jagged1-specific Notch1-phosphatidylinositol 3-kinase signaling involves pleiotropic oncogenic functions independent of CBF1;Su(H);Lag-1 activation. Journal of Virology. 2005.  79, 7889-7898. [PubMed]
8. Mcavoy, B. R., Fulcher, G. R., Amerena, J. V., Conner, G. W., Beltrame, J. F., Hankey, G. J., Keech, A. C., Lloyd, B. L., Neale, M. L., Pollock, C. A., Sudhir, K., Waltham, R. D. and West, M. J.  An evidence based clinical aid for cardiovascular disease--what do GPs think? Australian Family Physician. 2005.  34, 297-298. [PubMed]
9. Ayyub, C., Sen, A., Gonsalves, F., Badrinath, K., Bhandari, P., Shashidhara, L. S., Krishna, S. and Rodrigues, V.  Cullin-5 plays multiple roles in cell fate specification and synapse formation during Drosophila development. Developmental Dynamics. 2005.  232, 865-875. [PubMed]
10. Veeraraghavalu, K., Pett, M., Kumar, R. V., Nair, P., Rangarajan, A., Stanley, M. A. and Krishna, S.  Papillomavirus-mediated neoplastic progression is associated with reciprocal changes in JAGGED1 and manic fringe expression linked to notch activation. Journal of Virology. 2004.  78, 8687-8700. [PubMed]
11. Chakrabarti, O., Veeraraghavalu, K., Tergaonkar, V., Liu, Y., Androphy, E. J., Stanley, M. A. and Krishna, S.  Human papillomavirus type 16 E6 amino acid 83 variants enhance E6-mediated MAPK signaling and differentially regulate tumorigenesis by notch signaling and oncogenic Ras. Journal of Virology. 2004.  78, 5934-5945. [PubMed]
12. Sade, H., Krishna, S. and Sarin, A.  The anti-apoptotic effect of Notch-1 requires p56lck-dependent, Akt/PKB-mediated signaling in T cells. The Journal of Biological Chemistry. 2004.  279, 2937-2944. [PubMed]
13. Nair, P., Somasundaram, K. and Krishna, S.  Activated Notch1 inhibits p53-induced apoptosis and sustains transformation by human papillomavirus type 16 E6 and E7 oncogenes through a PI3K-PKB/Akt-dependent pathway. Journal of Virology. 2003.  77, 7106-7112. [PubMed]
14. Chakrabarti, O. and Krishna, S.  Molecular interactions of 'high risk' human papillomaviruses E6 and E7 oncoproteins: implications for tumour progression. Journal of Biosciences. 2003.  28, 337-348. [PubMed]

 
Grant Support:
Project Title Role Funding Agency Sanction Number Sanction Date
Regulation of RhoC by Notch1 during cervical carcinoma progression
Notch1 and TGF-β crosstalk in EMT during carcinoma progression
Cancer stem-like cells and role of Notch1 signaling
Notch signaling in human hematological cancers

 
 
 
Education 
::
M.B.B.S. St. Johns Medical College, Bangalore, India
::
Ph.D. University of Cambridge, UK
Honors and Awards
::
British Lepra Foundation prize
::
Cambridge Nehru Scholarship
::
Rockefeller Biotechnology Career Fellowship
  Last modified on : May 2, 2012
India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.