Ganesh Nagaraju, Ph.D.
Indian Institute of Science
Department of Biochemistry
C. V. Raman Avenue
Bangalore - 560 012
Karnataka
E-mail: nganesh@biochem.iisc.ernet.in, ganesh_him@yahoo.co.in
Phone: +91-80-22932473
Fax: +91-80-23600814
URL: http://biochem.iisc.ernet.in/ganesh.htm
Positions Held:
Position Affiliation Time Period
Post Doctoral Fellowship
Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, USA
2003-2007
Area of Specialization:
Cancer Genomics
Research Summary:
RAD51 paralogs in Fanconi anemia and breast cancer
Fanconi anemia proteins in sister chromatid recombination
ATM and ATR kinase in DNA damage response and HR
RAD51 paralogs in DNA damage signaling and HR
Mycobacterium tuberculosis and DNA repair
Publications:
1.
Somyajit, K., Subramanya, S. and Nagaraju, G. RAD51C: a novel cancer susceptibility gene is linked to Fanconi anemia and breast cancer. Carcinogenesis. 2010. 31, 2031-2038. [PubMed]
2.
Nagaraju, G. , Hartlerode, A., Kwok, A., Chandramouly, G. and Scully, R. XRCC2 and XRCC3 regulate the balance between short- and long-tract gene conversions between sister chromatids. Molecular and Cellular Biology. 2009. 29, 4283-4294. [PubMed]
3.
Xie, A., Hartlerode, A., Stucki, M., Odate, S., Puget, N., Kwok, A., Nagaraju, G. , Yan, C., Alt, F. W., Chen, J., Jackson, S. P. and Scully, R. Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair. Molecular Cell. 2007. 28, 1045-1057. [PubMed]
4.
Nagaraju, G. and Scully, R. Minding the gap: the underground functions of BRCA1 and BRCA2 at stalled replication forks. DNA Repair. 2007. 6, 1018-1031. [PubMed]
5.
Nagaraju, G. , Odate, S., Xie, A. and Scully, R. Differential regulation of short- and long-tract gene conversion between sister chromatids by Rad51C. Molecular and Cellular Biology. 2006. 26, 8075-8086. [PubMed]
6.
Scully, R., Xie, A. and Nagaraju, G. Molecular functions of BRCA1 in the DNA damage response. Cancer Biology & Therapy. 2004. 3, 521-527. [PubMed]
7.
Ganesh, N. and Muniyappa, K. Mycobacterium smegmatis RecA protein is structurally similar to but functionally distinct from Mycobacterium tuberculosis RecA. Proteins. 2003. 53, 6-17. [PubMed]
8.
Datta, S., Krishna, R., Ganesh, N. , Chandra, N. R., Muniyappa, K. and Vijayan, M. Crystal structures of Mycobacterium smegmatis RecA and its nucleotide complexes. Journal of Bacteriology. 2003. 185, 4280-4284. [PubMed]
9.
Ganesh, N. and Muniyappa, K. Characterization of DNA strand transfer promoted by Mycobacterium smegmatis RecA reveals functional diversity with Mycobacterium tuberculosis RecA. Biochemistry. 2003. 42, 7216-7225. [PubMed]
10.
Datta, S., Ganesh, N. , Chandra, N. R., Muniyappa, K. and Vijayan, M. Structural studies on MtRecA-nucleotide complexes: insights into DNA and nucleotide binding and the structural signature of NTP recognition. Proteins. 2003. 50, 474-485. [PubMed]
11.
Venkatesh, R., Ganesh, N. , Guhan, N., Reddy, M. S., Chandrasekhar, T. and Muniyappa, K. RecX protein abrogates ATP hydrolysis and strand exchange promoted by RecA: insights into negative regulation of homologous recombination. Proceedings of the National Academy of Sciences of the United States of America. 2002. 99, 12091-12096. [PubMed]
12.
Muniyappa, K., Vaze, M. B., Ganesh, N. , Sreedhar, R., Guhan, N. and Venkatesh, R. Comparative genomics of Mycobacterium tuberculosis and Escherichia coli for recombination (rec) genes. Microbiology. 2000. 146 ( Pt 9), 2093-2095. [PubMed]
13.
Datta, S., Prabu, M. M., Vaze, M. B., Ganesh, N. , Chandra, N. R., Muniyappa, K. and Vijayan, M. Crystal structures of Mycobacterium tuberculosis RecA and its complex with ADP-AlF(4): implications for decreased ATPase activity and molecular aggregation. Nucleic Acids Research. 2000. 28, 4964-4973. [PubMed]
Education
::
Ph.D.
Indian Institute of Science, Bangalore, India