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Kumaravel Somasundaram, Ph.D.
Associate Professor 
Indian Institute of Science
Department of Microbiology and Cell Biology
CV Raman Avenue
Bangalore - 560 012   
Phone: +91-80-22932973, 23607171
Fax: +91-80-23602697
Area of Specialization:
Molecular Oncology
Research Summary:
Prognostic value of p53 status in glioma
p53, an important determinant of chemosensitivity of cancer cells against deacetylase inhibitor treatment
Regulation of p73 by adenovirus oncogene E1A
p73 for the treatment of cervical cancer
Functional analysis of BRCA1 gene
BRCA1 and BRCA2 involvement in breast cancer among Indian women
Regulation and functional analysis of activator protein 2a in cancer
1. Kumar, D. M., Thota, B., Shinde, S. V., Prasanna, K. V., Hegde, A. S., Arivazhagan, A., Chandramouli, B. A., Santosh, V. and Somasundaram, K.  Proteomic identification of haptoglobin alpha2 as a glioblastoma serum biomarker: implications in cancer cell migration and tumor growth. Journal of Proteome Research. 2010.  9, 5557-5567. [PubMed]
2. Rao, S. A., Santosh, V. and Somasundaram, K.  Genome-wide expression profiling identifies deregulated miRNAs in malignant astrocytoma. Modern Pathology. 2010.  23, 1404-1417. [PubMed]
3. Ladha, J., Donakonda, S., Agrawal, S., Thota, B., Srividya, M. R., Sridevi, S., Arivazhagan, A., Thennarasu, K., Balasubramaniam, A., Chandramouli, B. A., Hegde, A. S., Kondaiah, P., Somasundaram, K., Santosh, V. and Rao, S. M.  Glioblastoma-specific protein interaction network identifies PP1A and CSK21 as connecting molecules between cell cycle-associated genes. Cancer Research. 2010.  70, 6437-6447. [PubMed]
4. Sreekanthreddy, P., Srinivasan, H., Kumar, D. M., Nijaguna, M. B., Sridevi, S., Vrinda, M., Arivazhagan, A., Balasubramaniam, A., Hegde, A. S., Chandramouli, B. A., Santosh, V., Rao, M. R., Kondaiah, P. and Somasundaram, K.  Identification of potential serum biomarkers of glioblastoma: serum osteopontin levels correlate with poor prognosis. Cancer Epidemiology, Biomarkers & Prevention. 2010.  19, 1409-1422. [PubMed]
5. Santosh, V., Arivazhagan, A., Sreekanthreddy, P., Srinivasan, H., Thota, B., Srividya, M. R., Vrinda, M., Sridevi, S., Shailaja, B. C., Samuel, C., Prasanna, K. V., Thennarasu, K., Balasubramaniam, A., Chandramouli, B. A., Hegde, A. S., Somasundaram, K., Kondaiah, P. and Rao, M. R.  Grade-specific expression of insulin-like growth factor-binding proteins-2, -3, and -5 in astrocytomas: IGFBP-3 emerges as a strong predictor of survival in patients with newly diagnosed glioblastoma. Cancer Epidemiology, Biomarkers & Prevention. 2010.  19, 1399-1408. [PubMed]
6. Das, S., Sinha, S., Britto, R., Somasundaram, K. and Samuelson, A. G.  Cytotoxicity of half sandwich ruthenium(II) complexes with strong hydrogen bond acceptor ligands and their mechanism of action. Journal of Inorganic Biochemistry. 2010.  104, 93-104. [PubMed]
7. Somasundaram, K., Nijaguna, M. B. and Kumar, D. M.  Serum proteomics of glioma: methods and applications. Expert Review of Molecular Diagnostics. 2009.  9, 695-707. [PubMed]
8. Vaidyanathan, K., Lakhotia, S., Ravishankar, H. M., Tabassum, U., Mukherjee, G. and Somasundaram, K.  BRCA1 and BRCA2 germline mutation analysis among Indian women from south India: identification of four novel mutations and high-frequency occurrence of 185delAG mutation. Journal of Biosciences. 2009.  34, 415-422. [PubMed]
9. Kothari, V., Joshi, G., Nama, S., Somasundaram, K. and Mulherkar, R.  HDAC inhibitor valproic acid enhances tumor cell kill in adenovirus-HSVtk mediated suicide gene therapy in HNSCC xenograft mouse model. International Journal of Cancer. Journal International Du Cancer. 2010.  126, 733-742. [PubMed]
10. Somasundaram K.  HPV vaccine: end to women's major health problem? The Indian Journal of Medical Research. 2008.  127, 511-513. [PubMed]
11. Reddy, P. S., Umesh, S., Thota, B., Tandon, A., Pandey, P., Hegde, A. S., Balasubramaniam, A., Chandramouli, B. A., Santosh, V., Rao, M. R., Kondaiah, P. and Somasundaram, K.  PBEF1/NAmPRTase/Visfatin: a potential malignant astrocytoma/glioblastoma serum marker with prognostic value. Cancer Biology & Therapy. 2008.  7, 663-668. [PubMed]
12. Suvasini, R. and Somasundaram, K.  Safe and efficient gene therapy--delivery makes all the difference. Cancer Biology & Therapy. 2008.  7, 225-227. [PubMed]
13. Reddy, S. P., Britto, R., Vinnakota, K., Aparna, H., Sreepathi, H. K., Thota, B., Kumari, A., Shilpa, B. M., Vrinda, M., Umesh, S., Samuel, C., Shetty, M., Tandon, A., Pandey, P., Hegde, S., Hegde, A. S., Balasubramaniam, A., Chandramouli, B. A., Santosh, V., Kondaiah, P., Somasundaram, K. and Rao, M. R.  Novel glioblastoma markers with diagnostic and prognostic value identified through transcriptome analysis. Clinical Cancer Research. 2008.  14, 2978-2987. [PubMed]
14. Rajendiran, V., Murali, M., Suresh, E., Sinha, S., Somasundaram, K. and Palaniandavar, M.  Mixed ligand ruthenium(II) complexes of bis(pyrid-2-yl)-/bis(benzimidazol-2-yl)-dithioether and diimines: study of non-covalent DNA binding and cytotoxicity. Dalton Transactions. 2008.  , 148-163. [PubMed]
15. Britto, R., Umesh, S., Hegde, A. S., Hegde, S., Santosh, V., Chandramouli, B. A. and Somasundaram, K.  Shift in AP-2alpha localization characterizes astrocytoma progression. Cancer Biology & Therapy. 2007.  6, 413-418. [PubMed]
16. Mungamuri, S. K., Yang, X., Thor, A. D. and Somasundaram, K.  Survival signaling by Notch1: mammalian target of rapamycin (mTOR)-dependent inhibition of p53. Cancer Research. 2006.  66, 4715-4724. [PubMed]
17. Wajapeyee, N., Britto, R., Ravishankar, H. M. and Somasundaram, K.  Apoptosis induction by activator protein 2alpha involves transcriptional repression of Bcl-2. The Journal of Biological Chemistry. 2006.  281, 16207-16219. [PubMed]
18. Das, S. and Somasundaram, K.  Therapeutic potential of an adenovirus expressing p73 beta, a p53 homologue, against human papilloma virus positive cervical cancer in vitro and in vivo. Cancer Biology & Therapy. 2006.  5, 210-217. [PubMed]
19. Wajapeyee, N., Raut, C. G. and Somasundaram, K.  Activator protein 2alpha status determines the chemosensitivity of cancer cells: implications in cancer chemotherapy. Cancer Research. 2005.  65, 8628-8634. [PubMed]
20. Somasundaram, K., Reddy, S. P., Vinnakota, K., Britto, R., Subbarayan, M., Nambiar, S., Hebbar, A., Samuel, C., Shetty, M., Sreepathi, H. K., Santosh, V., Hegde, A. S., Hegde, S., Kondaiah, P. and Rao, M. R.  Upregulation of ASCL1 and inhibition of Notch signaling pathway characterize progressive astrocytoma. Oncogene. 2005.  24, 7073-7083. [PubMed]
21. Sanghamitra, N. J., Phatak, P., Das, S., Samuelson, A. G. and Somasundaram, K.  Mechanism of cytotoxicity of copper(I) complexes of 1,2-bis(diphenylphosphino)ethane. Journal of Medicinal Chemistry. 2005.  48, 977-985. [PubMed]
22. Joseph, J., Wajapeyee, N. and Somasundaram, K.  Role of p53 status in chemosensitivity determination of cancer cells against histone deacetylase inhibitor sodium butyrate. International Journal of Cancer. Journal International Du Cancer. 2005.  115, 11-18. [PubMed]
23. Das, S., Nama, S., Antony, S. and Somasundaram, K.  p73 beta-expressing recombinant adenovirus: a potential anticancer agent. Cancer Gene Therapy. 2005.  12, 417-426. [PubMed]
24. Britto, R. and Somasundaram, K.  Ribozyme's potential in cervical cancer control. Cancer Biology & Therapy. 2004.  3, 1135-1136. [PubMed]
25. Joseph, J., Mudduluru, G., Antony, S., Vashistha, S., Ajitkumar, P. and Somasundaram, K.  Expression profiling of sodium butyrate (NaB)-treated cells: identification of regulation of genes related to cytokine signaling and cancer metastasis by NaB. Oncogene. 2004.  23, 6304-6315. [PubMed]
26. Wajapeyee, N. and Somasundaram, K.  Pharmacogenomics in breast cancer: current trends and future directions. Current Opinion in Molecular Therapeutics. 2004.  6, 296-301. [PubMed]
27. Das, S., El-Deiry, W. S. and Somasundaram, K.  Efficient growth inhibition of HPV 16 E6-expressing cells by an adenovirus-expressing p53 homologue p73beta. Oncogene. 2003.  22, 8394-8402. [PubMed]
28. Wajapeyee, N. and Somasundaram, K.  Cell cycle arrest and apoptosis induction by activator protein 2alpha (AP-2alpha) and the role of p53 and p21WAF1/CIP1 in AP-2alpha-mediated growth inhibition. The Journal of Biological Chemistry. 2003.  278, 52093-52101. [PubMed]
29. Lakhotia, S. and Somasundaram, K.  Conformation-sensitive gel electrophoresis for detecting BRCA1 mutations. Methods in Molecular Biology. 2003.  223, 403-412. [PubMed]
30. Somasundaram, K., Das, S., Lakhotia, S. and Wajapeyee, N.  Analysis of gene promoter regulation by tumor suppressor genes. Methods in Molecular Biology. 2003.  223, 101-116. [PubMed]
31. Nair, P., Somasundaram, K. and Krishna, S.  Activated Notch1 inhibits p53-induced apoptosis and sustains transformation by human papillomavirus type 16 E6 and E7 oncogenes through a PI3K-PKB/Akt-dependent pathway. Journal of Virology. 2003.  77, 7106-7112. [PubMed]
32. Somasundaram K.  Stable RNA interference (RNAi) in mammalian cells. Cancer Biology & Therapy. 2003.  2, 211-212. [PubMed]
33. Somasundaram K.  Breast cancer gene 1 (BRCA1): role in cell cycle regulation and DNA repair--perhaps through transcription. Journal of Cellular Biochemistry. 2003.  88, 1084-1091. [PubMed]
34. Das, S., El-Deiry, W. S. and Somasundaram, K.  Regulation of the p53 homolog p73 by adenoviral oncogene E1A. The Journal of Biological Chemistry. 2003.  278, 18313-18320. [PubMed]
35. Phatak, P., Selvi, S. K., Divya, T., Hegde, A. S., Hegde, S. and Somasundaram, K.  Alterations in tumour suppressor gene p53 in human gliomas from Indian patients. Journal of Biosciences. 2002.  27, 673-678. [PubMed]
36. Kumar, B. V., Lakhotia, S., Ankathil, R., Madhavan, J., Jayaprakash, P. G., Nair, M. K. and Somasundaram, K.  Germline BRCA1 mutation analysis in Indian breast/ovarian cancer families. Cancer Biology & Therapy. 2002.  1, 18-21. [PubMed]


Book Chapters:
Smita Lakhotia and Kumaravel Somasundaram , Conformation Sensitive Gel Electrophoresis for detecting BRCA1 mutations. In Methods in Molecular Biology, Vol. 223: Tumor Suppressor Genes: Regulation, Function, and Medicinal Applications. Ed. W. S. El-Deiry, Humana Press Inc., Totowa, NJ 2:2003, 403-414
Kumaravel Somasundaram, Sanjeev Das, Smita Lakhotia and Narendra Wajapeyee Analysis of gene promoter regulation by Tumor Suppressor Genes. In Methods in Molecular Biology, Vol. 223: Tumor Suppressor Genes: Regulation, Function, and Medicinal Applications. Ed, W. S. El-Deiry, Humana Press Inc., Totowa, NJ 2:2003, 101-116
Honors and Awards
2006, National Bioscience award for Career Development
  Last modified on : Mar 4, 2011
India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.