INCREDB ID : 65
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Tapas K. Kundu, Ph.D.
Professor 
 
Jawaharlal Nehru Centre for Advanced Scientific Research
Transcription and Disease Lab
Molecular Biology and Genetics Unit, Jakkur
Bangalore - 560 064   
Karnataka   
 
E-mail: tapas@jncasr.ac.in
Phone: +91-80-22082840, +91-80-22082841
Fax: +91-80-22082766
 
URL: http://www.jncasr.ac.in/faculty_templates/default/index.php?menu_id=1&user_id=20&page_id=97
 
Positions Held:
Position Affiliation Time Period
Professor Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India 2009-Present
Associate Professor Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India 2004-2009
Assistant Professor Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India 1999-2004
Post Doctoral Fellowship The Rockefeller University, New-York, USA 1996-1999
Research Associate National Institute of Genetics, Mishima, Japan 1995-1996
 
Area of Specialization:
Molecular Biology
Transcriptomics
Research Summary:
The mechanism of transcription regulation through chromatin in humans, with special reference to diseases and cancer
The regulation of p53 function by nonhistone chromatin associated proteins
Role of higher order chromatin structure and histone chaperones in transcription regulation
Functional genomics of transcriptional coactivators
Small molecule modulators of histone modifying enzymes, which may serve as lead compounds for the treatment of asthma, cardiac hypertrophy, AIDS, and cancer
 
Publications:
1. Kundu T. K.  Small molecule modulators of chromatin and coactivators. Biochimica et Biophysica Acta. 2010.  1799, 669-670. [PubMed]
2. Arif, M., Senapati, P., Shandilya, J. and Kundu, T. K.  Protein lysine acetylation in cellular function and its role in cancer manifestation. Biochimica et Biophysica Acta. 2010.  1799, 702-716. [PubMed]
3. Selvi, B. R., Mohankrishna, D. V., Ostwal, Y. B. and Kundu, T. K.  Small molecule modulators of histone acetylation and methylation: a disease perspective. Biochimica et Biophysica Acta. 2010.  1799, 810-828. [PubMed]
4. Selvi, B. R., Cassel, J. C., Kundu, T. K. and Boutillier, A. L.  Tuning acetylation levels with HAT activators: therapeutic strategy in neurodegenerative diseases. Biochimica et Biophysica Acta. 2010.  1799, 840-853. [PubMed]
5. Arif, M., Vedamurthy, B. M., Choudhari, R., Ostwal, Y. B., Mantelingu, K., Kodaganur, G. S. and Kundu, T. K.  Nitric oxide-mediated histone hyperacetylation in oral cancer: target for a water-soluble HAT inhibitor, CTK7A. Chemistry & Biology. 2010.  17, 903-913. [PubMed]
6. Arif, M., Selvi, B. R. and Kundu, T. K.  Lysine acetylation: the tale of a modification from transcription regulation to metabolism. Chembiochem : A European Journal of Chemical Biology. 2010.  11, 1501-1504. [PubMed]
7. Karthigeyan, D., Prasad, S. B., Shandilya, J., Agrawal, S. and Kundu, T. K.  Biology of Aurora A kinase: Implications in cancer manifestation and therapy. Medicinal Research Reviews. 2010.  [PubMed]
8. Das, C., Gadad, S. S. and Kundu, T. K.  Human positive coactivator 4 controls heterochromatinization and silencing of neural gene expression by interacting with REST/NRSF and CoREST. Journal of Molecular Biology. 2010.  397, 1-12. [PubMed]
9. Gadad, S. S., Shandilya, J., Kishore, A. H. and Kundu, T. K.  NPM3, a member of the nucleophosmin/nucleoplasmin family, enhances activator-dependent transcription. Biochemistry. 2010.  49, 1355-1357. [PubMed]
10. Selvi, B. R., Batta, K., Kishore, A. H., Mantelingu, K., Varier, R. A., Balasubramanyam, K., Pradhan, S. K., Dasgupta, D., Sriram, S., Agrawal, S. and Kundu, T. K.  Identification of a novel inhibitor of coactivator-associated arginine methyltransferase 1 (CARM1)-mediated methylation of histone H3 Arg-17. The Journal of Biological Chemistry. 2010.  285, 7143-7152. [PubMed]
11. Pradeepa, M. M., Nikhil, G., Hari, K., Bharath, G. N., Kundu, T. K. and Rao, M. R.  Acetylation of transition protein 2 (TP2) by KAT3B (p300) alters its DNA condensation property and interaction with putative histone chaperone NPM3. The Journal of Biological Chemistry. 2009.  284, 29956-29967. [PubMed]
12. Shandilya, J., Swaminathan, V., Gadad, S. S., Choudhari, R., Kodaganur, G. S. and Kundu, T. K.  Acetylated NPM1 localizes in the nucleoplasm and regulates transcriptional activation of genes implicated in oral cancer manifestation. Molecular and Cellular Biology. 2009.  29, 5115-5127. [PubMed]
13. Ravindra, K. C., Selvi, B. R., Arif, M., Reddy, B. A., Thanuja, G. R., Agrawal, S., Pradhan, S. K., Nagashayana, N., Dasgupta, D. and Kundu, T. K.  Inhibition of lysine acetyltransferase KAT3B/p300 activity by a naturally occurring hydroxynaphthoquinone, plumbagin. The Journal of Biological Chemistry. 2009.  284, 24453-24464. [PubMed]
14. Gadad, S. S., Shandilya, J., Swaminathan, V. and Kundu, T. K.  Histone chaperone as coactivator of chromatin transcription: role of acetylation. Methods in Molecular Biology. 2009.  523, 263-278. [PubMed]
15. Selvi, R. B. and Kundu, T. K.  Reversible acetylation of chromatin: implication in regulation of gene expression, disease and therapeutics. Biotechnology Journal. 2009.  4, 375-390. [PubMed]
16. Selvi, B., Pradhan, S. K., Shandilya, J., Das, C., Sailaja, B. S., Shankar, G., Gadad, S. S., Reddy, A., Dasgupta, D. and Kundu, T. K.  Sanguinarine interacts with chromatin, modulates epigenetic modifications, and transcription in the context of chromatin. Chemistry & Biology. 2009.  16, 203-216. [PubMed]
17. Noothi, S. K., Kombrabail, M., Kundu, T. K., Krishnamoorthy, G. and Rao, B. J.  Enhanced DNA dynamics due to cationic reagents, topological states of dsDNA and high mobility group box 1 as probed by PicoGreen. The FEBS Journal. 2009.  276, 541-551. [PubMed]
18. Arif, M., Pradhan, S. K., Thanuja, G. R., Vedamurthy, B. M., Agrawal, S., Dasgupta, D. and Kundu, T. K.  Mechanism of p300 specific histone acetyltransferase inhibition by small molecules. Journal of Medicinal Chemistry. 2009.  52, 267-277. [PubMed]
19. Batta, K., Yokokawa, M., Takeyasu, K. and Kundu, T. K.  Human transcriptional coactivator PC4 stimulates DNA end joining and activates DSB repair activity. Journal of Molecular Biology. 2009.  385, 788-799. [PubMed]
20. Selvi, B. R., Jagadeesan, D., Suma, B. S., Nagashankar, G., Arif, M., Balasubramanyam, K., Eswaramoorthy, M. and Kundu, T. K.  Intrinsically fluorescent carbon nanospheres as a nuclear targeting vector: delivery of membrane-impermeable molecule to modulate gene expression in vivo. Nano Letters. 2008.  8, 3182-3188. [PubMed]
21. Kumar, G. V., Selvi, R., Kishore, A. H., Kundu, T. K. and Narayana, C.  Surface-enhanced Raman spectroscopic studies of coactivator-associated arginine methyltransferase 1. The Journal of Physical Chemistry. B. 2008.  112, 6703-6707. [PubMed]
22. Kishore, A. H., Vedamurthy, B. M., Mantelingu, K., Agrawal, S., Reddy, B. A., Roy, S., Rangappa, K. S. and Kundu, T. K.  Specific small-molecule activator of Aurora kinase A induces autophosphorylation in a cell-free system. Journal of Medicinal Chemistry. 2008.  51, 792-797. [PubMed]
23. Arif, M., Kumar, G. V., Narayana, C. and Kundu, T. K.  Autoacetylation induced specific structural changes in histone acetyltransferase domain of p300: probed by surface enhanced Raman spectroscopy. The Journal of Physical Chemistry. B. 2007.  111, 11877-11879. [PubMed]
24. Batta, K. and Kundu, T. K.  Activation of p53 function by human transcriptional coactivator PC4: role of protein-protein interaction, DNA bending, and posttranslational modifications. Molecular and Cellular Biology. 2007.  27, 7603-7614. [PubMed]
25. Mantelingu, K., Reddy, B. A., Swaminathan, V., Kishore, A. H., Siddappa, N. B., Kumar, G. V., Nagashankar, G., Natesh, N., Roy, S., Sadhale, P. P., Ranga, U., Narayana, C. and Kundu, T. K.  Specific inhibition of p300-HAT alters global gene expression and represses HIV replication. Chemistry & Biology. 2007.  14, 645-657. [PubMed]
26. Kishore, A. H., Batta, K., Das, C., Agarwal, S. and Kundu, T. K.  p53 regulates its own activator: transcriptional co-activator PC4, a new p53-responsive gene. The Biochemical Journal. 2007.  406, 437-444. [PubMed]
27. Swaminathan, V., Reddy, B. A., Ruthrotha, S., Sukanya, M. S. and Kundu, T. K.  Small molecule modulators in epigenetics: implications in gene expression and therapeutics. Sub-cellular Biochemistry. 2007.  41, 397-428. [PubMed]
28. Batta, K., Das, C., Gadad, S., Shandilya, J. and Kundu, T. K.  Reversible acetylation of non histone proteins: role in cellular function and disease. Sub-cellular Biochemistry. 2007.  41, 193-212. [PubMed]
29. Shandilya, J., Gadad, S., Swaminathan, V. and Kundu, T. K.  Histone chaperones in chromatin dynamics: implications in disease manifestation. Sub-cellular Biochemistry. 2007.  41, 111-124. [PubMed]
30. Boulard, M., Bouvet, P., Kundu, T. K. and Dimitrov, S.  Histone variant nucleosomes: structure, function and implication in disease. Sub-cellular Biochemistry. 2007.  41, 71-89. [PubMed]
31. Mantelingu, K., Kishore, A. H., Balasubramanyam, K., Kumar, G. V., Altaf, M., Swamy, S. N., Selvi, R., Das, C., Narayana, C., Rangappa, K. S. and Kundu, T. K.  Activation of p300 histone acetyltransferase by small molecules altering enzyme structure: probed by surface-enhanced Raman spectroscopy. The Journal of Physical Chemistry. B. 2007.  111, 4527-4534. [PubMed]
32. Das, C., Hizume, K., Batta, K., Kumar, B. R., Gadad, S. S., Ganguly, S., Lorain, S., Verreault, A., Sadhale, P. P., Takeyasu, K. and Kundu, T. K.  Transcriptional coactivator PC4, a chromatin-associated protein, induces chromatin condensation. Molecular and Cellular Biology. 2006.  26, 8303-8315. [PubMed]
33. Pavan, K., Ashok, R., Arif, M., Kundu, T. K. and Narayana, C.  Surface-enhanced Raman scattering studies of human transcriptional coactivator p300. The Journal of Physical Chemistry. B. 2006.  110, 16787-16792. [PubMed]
34. Varier, R. A. and Kundu, T. K.  Chromatin modifications (acetylation/ deacetylation/ methylation) as new targets for HIV therapy. Current Pharmaceutical Design. 2006.  12, 1975-1993. [PubMed]
35. Rampalli, S., Pavithra, L., Bhatt, A., Kundu, T. K. and Chattopadhyay, S.  Tumor suppressor SMAR1 mediates cyclin D1 repression by recruitment of the SIN3/histone deacetylase 1 complex. Molecular and Cellular Biology. 2005.  25, 8415-8429. [PubMed]
36. Swaminathan, V., Kishore, A. H., Febitha, K. K. and Kundu, T. K.  Human histone chaperone nucleophosmin enhances acetylation-dependent chromatin transcription. Molecular and Cellular Biology. 2005.  25, 7534-7545. [PubMed]
37. Das, C. and Kundu, T. K.  Transcriptional regulation by the acetylation of nonhistone proteins in humans -- a new target for therapeutics. IUBMB Life. 2005.  57, 137-149. [PubMed]
38. Davidson, S. M., Townsend, P. A., Carroll, C., Yurek-George, A., Balasubramanyam, K., Kundu, T. K., Stephanou, A., Packham, G., Ganesan, A. and Latchman, D. S.  The transcriptional coactivator p300 plays a critical role in the hypertrophic and protective pathways induced by phenylephrine in cardiac cells but is specific to the hypertrophic effect of urocortin. Chembiochem : A European Journal of Chemical Biology. 2005.  6, 162-170. [PubMed]
39. Sadasivam, S., Gupta, S., Radha, V., Batta, K., Kundu, T. K. and Swarup, G.  Caspase-1 activator Ipaf is a p53-inducible gene involved in apoptosis. Oncogene. 2005.  24, 627-636. [PubMed]
40. Balasubramanyam, K., Varier, R. A., Altaf, M., Swaminathan, V., Siddappa, N. B., Ranga, U. and Kundu, T. K.  Curcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. The Journal of Biological Chemistry. 2004.  279, 51163-51171. [PubMed]
41. Varier, R. A., Swaminathan, V., Balasubramanyam, K. and Kundu, T. K.  Implications of small molecule activators and inhibitors of histone acetyltransferases in chromatin therapy. Biochemical Pharmacology. 2004.  68, 1215-1220. [PubMed]
42. Balasubramanyam, K., Altaf, M., Varier, R. A., Swaminathan, V., Ravindran, A., Sadhale, P. P. and Kundu, T. K.  Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression. The Journal of Biological Chemistry. 2004.  279, 33716-33726. [PubMed]
43. Banerjee, S., Kumar, B. R. and Kundu, T. K.  General transcriptional coactivator PC4 activates p53 function. Molecular and Cellular Biology. 2004.  24, 2052-2062. [PubMed]
44. Banerjee, S. and Kundu, T. K.  The acidic C-terminal domain and A-box of HMGB-1 regulates p53-mediated transcription. Nucleic Acids Research. 2003.  31, 3236-3247. [PubMed]
45. Balasubramanyam, K., Swaminathan, V., Ranganathan, A. and Kundu, T. K.  Small molecule modulators of histone acetyltransferase p300. The Journal of Biological Chemistry. 2003.  278, 19134-19140. [PubMed]
46. Kar, S., Sakaguchi, K., Shimohigashi, Y., Samaddar, S., Banerjee, R., Basu, G., Swaminathan, V., Kundu, T. K. and Roy, S.  Effect of phosphorylation on the structure and fold of transactivation domain of p53. The Journal of Biological Chemistry. 2002.  277, 15579-15585. [PubMed]
47. Chatterjee, S., Gadad, S., S., and Kundu, T.,K., Atomic Force Microscopy: A tool to unveil the mystery of Biological Systems. Resonance, 2010, 15: 622-42.
48. Selvi, R.,B., Krishna, D.,V., Ostwal, Y.,B., and Kundu, T.,K., Modulators of Chromatin modifying enzymes in transcription and disease – A Connotation to Epigenetic Therapy. BiochimIca and Biophysica Acta., 2010, 1799(10-12): 810-28
49. Karthigeyan,D.,Benakaprasad,S.,B., Shandilya,  Jayasha, Kundu, T.,K., . Biology of Aurora Kinase A: Implications in Cancer Manifestation and Therapy. Med Res Rev. (In press)
50. Kishore, H.,A., and Kundu T.,K., Transcription Through Chromatin- Link to Diseases and Therapeutics. Resonance. 2004, 9(11):23-38.
51. Kishore, A.,H., and Kundu, T.,K.,Transcription Through Chromatin-Dynamic Organization of Genes. Resonance, 2003, 8(11): 78-93
52. Kundu, T.,K. and Rao, M.,R.,S., CpG in chromatin organization and gene expression. Journal of Biochemistry. 2009, 125: 217-222.
53. Kundu, T., K., Virupaksha, T., K., Sudharshana, L. and Dana, S., Lectins as phylogenetic markers of Vigna spp. Biochem System Ecology. 1993, 21(4): 499-504.
54. Kundu, T., K. and Rao, M., R., S., Characterization of zinc-metalloprotein nature of rat spermatidal protein TP2. FEBS letters. 1994, 351(1): 6-10.
55. Kundu, T., K. and Rao, M., R., S., DNA condensation by the rat spermatidal protein TP2 shows GC-rich sequence preference and is zinc dependent. Biochemistry. 1995, 34(15): 5143-5150.
56. Martinez, E., Palhan, V., B., Tjeruberg, A., Laymer, E., S., Gamper, A., M., Kundu, T., K., Chait, B., T. and Roeder, R., G.,Human STAGA complex induce chromatin mediated transcription and DNA repair activity. Mol Cell Biology. 2001,  21(20): 6782-6795.
57.  Kumar, P., B., R., Swaminathan, V., Banerjee, S., and Kundu, T.,K., p300-Mediated acetylation of human transcriptional coactivator is inhibited by phosphorylation. Journal of Biological Chemistry. 2001, 276(20): 16804-16809.
58. Kundu, T., K., Palhan, V., Wang, Z., An, W., Cole, P.,A. and Roeder, R.,G., Activator  dependent transcription from a chromatin template involving targeted histone acetylation by  p300. Molecular Cell. 2000 6(3): 551-561.
59. Lau, O., D., Kundu, T.,K., Soccio, R.,E., Khalil, E., M., Vassilev, A., Nakatani, Y., Roeder, R., G. and Cole, P., A., HATs off: Selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF.  Molecular Cell. 2000, 5(3): 589-595.
60. Hsieh, Y., J., Kundu, T., K., Wang, Z., Kovelman, R. and Roeder, R.,G., The TFIIIC90 subunit of TFIIIC interacts with multiple components of RNA polymerase III machinery contains a histone-specific acetyltransferase activity. Mol Cell Biology. 1999, 19(11):7697-7704.
61. Kundu, T., K., Wang, Z. and Roeder, R., G.,. Human TFIIIC relieves chromatin-mediated repression of RNA polymerase III transcription and contains an intrinsic histone acetyltransferase activity. Mol Cell Biology. 1999, 19(2): 1605-1615.
62. Martinez, E., Kundu, T., K., Fu, J.. and Roeder, R., G., A human SPT3- TAFII31-GCN5-L acetylase complex distinct from transcription factor IID. Journal of Biological Chemistry. 1998, 273(37): 23781-23785.
63. Kundu, T., K., Kusano, S. and Ishihama A., Promoter selectivity of Escherichia coli RNA polymerase sF holoenzyme involved in transcription of flagellar and chemotaxis genes. Journal of Bacteriology.1997, 179(13): 4264-4269.
64. Kundu, T., K. and Rao, M., R., S., Zinc dependent recognition of a human CpG island sequence by the mammalian spermatidal protein TP2. Biochemistry.1996, 35(49): 15626-15632.
65. Kundu, T., K., Meetei, A., R. and Srinath, B., R., A method for in vivo [32P]phosphate labelling of testis proteins. Journal of  Biochemical and  Biophysical Methods.,1995, 30(2-3):185-189.

 

Book Chapters:
Tapas K. Kundu and Dipak Dasgupta, Chromatin and Disease , 2007, Springer Publications.
Tapas K. Kundu, Epigenetics: Development and Disease.
Tapas K. Kundu, BBA: Gene Regulatory Mechanisms (Special issue) Small molecule modulators of chromatin and co-activators.
Gadad SS, Shandilya J, Swaminathan V and Kundu TK: Histone chaperone as coactivator of chromatin transcription: Role of acetylation. Chromatin Protocols (Humana Press) 2009, 523(2):263-278.
Batta K, Das C, Gadad S, Shandilya J and Kundu TK: Reversible acetylation of Non Histone proteins: Role in cellular function and disease. Subcell Biochem. 2007, 41:193-212. Chromatin and Disease (Springer).
Shandilya J, Gadad S, Swaminathan V and Kundu TK. Histone chaperones in chromatin dynamics: Implication in disease manifestation. Subcell Biochem.2007, 41:111-24. Chromatin and Disease (Springer)
Boulard M, Bouvet P, Kundu TK and Dimitrov S. : Histone variant nucleosomes: structure, function and implication in disease. Subcell Biochem.2007, 41:71-89. Chromatin and Disease (Springer)
Swaminathan V, Ashok Reddy BA, Selvi RB, Sukanya MS and Kundu TK.: Small Molecule Modulators in Epigenetics: Implication in gene expression and therapeutics. Subcell Biochem.2007, 41:397-428. Chromatin and Disease (Springer)
Krishna DV, Selvi BR and Kundu TK : Turning histone acetylation off and on; small molecule modulators of histone acetylation. Epigenomics and Diseases (Cambridge Press) (In process), 2010.
 
 
Education 
::
M.Sc. Univesity of Agricultutal sciences, GKVK, Bangalore, 1990-1995
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Ph.D. in Biochemistry , 1987-1989
Honors and Awards
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2010, Tohoku Medical Society, Tohoku University, Japan, Lecture Medal
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2008, National Academy of Science, India- Reliance Industries Platinum Jubilee Award
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2005-08, India-France ARCUS-INDIA grant for collaborative research Fellowship
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Shanti Swarup Bhatnagar prize from CSIR, Govt. of India
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2004-05, National Bioscience award for career development, DBT, Govt. of India
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2005, International Union Against Cancer, Fellowship, Switzerland
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2001, Human Frontier Science Programme Organization, Fellowship, France
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2001, International Union Against Cancer, Fellowship, Switzerland
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1996, COE Visiting Scientist fellowship from MONBUSHO, Government of Japan
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1995, Giri Memorial Award for best thesis in Biochemistry, IISc. India
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1993, International Council of Scientific Union Award, India
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1990, Gold Medal for securing first position in M.Sc., G.K.V.K, Bangalore, India
Member
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Society of Biological Chemists, India
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Society of Biological Chemists Executive Commitee
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American Chemical Society
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American Society for Molecular Biology and Biochemistry
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Guha Research Conference
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The National Academy of Sciences, India
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American Society for Microbiology
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Indian Academy of Sciences
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Nature reader panel
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Elected Fellow of Indian National Science Academy
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Elected Fellow of Indian Academy of Sciences
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International Union Against Cance
  Last modified on : Mar 4, 2011
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