Shubhada V. Chiplunkar, Ph.D.
Advanced Centre for Treatment Research and Education in Cancer
Chiplunkar Lab
Khanolkar Shodhika, Tata Memorial Centre, Sector-22, Kharghar
Navi Mumbai - 410 210
Maharashtra
E-mail: schiplunkar@actrec.gov.in
Phone: +91-22-27405032
Fax: +91-22-27412894
URL: http://actrec.gov.in/pi-webpages/ShubhaChiplunkar/Home.html
Positions Held:
Position Affiliation Time Period
Principal Investigator
Advanced Centre for Treatment, Research and Education in Cancer, Navi Mumbai, India
Present
Post Doctoral Fellowship
Max Planck Institute for Immunology, Freiburg, Germany
1984-1986
Area of Specialization:
Immunology
Research Summary:
Understanding the immunobiology of γδ T cells with reference to anti–tumor immunity
Mechanism of immune dysfunction in patients– Role of CD3–zeta chain and Cox
Clonality of TCR and immunoglobulin genes in leukemias and lymphomas
Crosstalk of NKT cells and regulatory T cells
Publications:
1.
Dhar, S. and Chiplunkar, S. V. Lysis of aminobisphosphonate-sensitized MCF-7 breast tumor cells by Vgamma9Vdelta2 T cells. Cancer Immunity. 2010. 10, 10. [PubMed]
2.
Shukla, S., Bharti, A. C., Mahata, S., Hussain, S., Hedau, S., Sharma, R., Pillai, M. R., Krishna, S., Chiplunkar, S. , Tongaonkar, H. and Das, B. C. Application of a multiplex PCR to cervical cells collected by a paper smear for the simultaneous detection of all mucosal human papillomaviruses (HPVs) and typing of high-risk HPV types 16 and 18. Journal of Medical Microbiology. 2010. 59, 1303-1310. [PubMed]
3.
Pillai, R. M., Babu, J. M., Jissa, V. T., Lakshmi, S., Chiplunkar, S. V. , Patkar, M., Tongaonkar, H., Reddy, K. B., Chakka, K. N., Siddiqui, M., Roychoudury, S., Abraham, P., Peedicayil, A., Gnanamony, M., Subashini, J., Ram, T. S., Dey, B., Singh, N., Singh, A., Jain, S. K. and Jayshree, R. S. Region-wise distribution of high-risk human papillomavirus types in squamous cell carcinomas of the cervix in India. International Journal of Gynecological Cancer . 2010. 20, 1046-1051. [PubMed]
4.
Chiplunkar, S. , Dhar, S., Wesch, D. and Kabelitz, D. gammadelta T cells in cancer immunotherapy: current status and future prospects. Immunotherapy. 2009. 1, 663-678. [PubMed]
5.
Patel, S. and Chiplunkar, S. Host immune responses to cervical cancer. Current Opinion in Obstetrics & Gynecology. 2009. 21, 54-59. [PubMed]
6.
Kulkarni, D. P., Wadia, P. P., Pradhan, T. N., Pathak, A. K. and Chiplunkar, S. V. Mechanisms involved in the down-regulation of TCR zeta chain in tumor versus peripheral blood of oral cancer patients. International Journal of Cancer. 2009. 124, 1605-1613. [PubMed]
7.
Wadia, P., Rao, D., Pradhan, T., Pathak, A. and Chiplunkar, S. Impaired lymphocyte responses and their restoration in oral cancer patients expressing distinct TCR variable region. Cancer Investigation. 2008. 26, 471-480. [PubMed]
8.
Bhairavabhotla, R. K., Verm, V., Tongaonkar, H., Shastri, S., Dinshaw, K. and Chiplunkar, S. Role of IL-10 in immune suppression in cervical cancer. Indian Journal of Biochemistry & Biophysics. 2007. 44, 350-356. [PubMed]
9.
Patel, S. and Chiplunkar, S. Role of cyclooxygenase-2 in tumor progression and immune regulation in lung cancer. Indian Journal of Biochemistry & Biophysics. 2007. 44, 419-428. [PubMed]
10.
Chiplunkar S. V. Immunology in India. European Journal of Immunology. 2007. 37, 2675-2679. [PubMed]
11.
Atre, N., Thomas, L., Mistry, R., Pathak, K. and Chiplunkar, S. Role of nitric oxide in heat shock protein induced apoptosis of gammadeltaT cells. International Journal of Cancer. 2006. 119, 1368-1376. [PubMed]
12.
Wadia, P., Atre, N., Pradhan, T., Mistry, R. and Chiplunkar, S. Heat shock protein induced TCR gammadelta gene rearrangements in patients with oral cancer. Oral Oncology. 2005. 41, 175-182. [PubMed]
13.
Kode, J., Dudhal, N., Banavali, S., Advani, S. and Chiplunkar, S. Clonal T-cell receptor gamma and delta gene rearrangements in T-cell acute lymphoblastic leukemia at diagnosis: predictor of prognosis and response to chemotherapy. Leukemia & Lymphoma. 2004. 45, 125-133. [PubMed]
14.
Dadke, D., Jaganath, P., Krishnamurthy, S. and Chiplunkar, S. The detection of HBV antigens and HBx-transcripts in an Indian fibrolamellar carcinoma patient: a case study. Liver. 2002. 22, 87-91. [PubMed]
15.
Thomas, M. L., Badwe, R. A., Deshpande, R. K., Samant, U. C. and Chiplunkar, S. V. Role of adhesion molecules in recruitment of Vdelta1 T cells from the peripheral blood to the tumor tissue of esophageal cancer patients. Cancer Immunol Immunotherapy. 2001. 50, 218-225. [PubMed]
16.
Chiplunkar, S.V. The immune system and cancer. Current Science . 2001. 81(5), 542-546.
17.
Pichan, D., Thomas, M. L., Damodaran, A., Fakih, A. R. and Chiplunkar, S. V. Characterization of tumor-associated antigens on human oral squamous cell carcinomas using monoclonal antibody 3F8E3. Tumori. 2000. 86, 64-69. [PubMed]
18.
Kode, J., Advani, S. and Chiplunkar, S. T-cell receptor gamma and delta gene rearrangements in T-cell acute lymphoblastic leukemia in Indian patients. Leukemia & Lymphoma. 2000. 36, 331-338. [PubMed]
19.
Thomas, M. L., Samant, U. C., Deshpande, R. K. and Chiplunkar, S. V. gammadelta T cells lyse autologous and allogenic oesophageal tumours: involvement of heat-shock proteins in the tumour cell lysis. Cancer Immunol Immunotherapy. 2000. 48, 653-659. [PubMed]
20.
Kode, J.A., Dudhal, N.V., Banavali, S.D., Chiplunkar, S.V. T-cell receptor and junctional region gene rearrangements as diagnostic and prognostic biomarker for T-cell Acute Lymphoblastic Leukemia. Leukemia and Lymphoma . 2000. 47(4),769-70.
21.
Chatterjee, S., Singh, S., Sohoni, R., Kattige, V., Deshpande, C., Chiplunkar, S. Kumar, N. and Sharma, S. Characterization of domains of the phosphoriboprotein PO of Plasmodium falciparum. Molecular Biochemical Parasitology . 2000. 107,143-154
Education
::
Ph.D.
University of Mumbai, Mumbai, India
Member
::
Indian Immunological Society
::
Indian Society of Cell Biology
::
American Association of Indian Scientists in Cancer Research
Type of Neoplasms
Head and Neck
Oral cavity
Female genital system
Cervix