INCREDB ID : 58
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Ramadasan Kuttan, Ph.D.
Research Director 
 
Amala Cancer Research Center
Department of Biochemistry
Amala Nagar
Thrissur - 680 555   
Kerala   
 
E-mail: amalacancerresearch@gmail.com
Phone: +91-487-2307950
Mobile: +91-9447123071
Fax: +91-487-2307868
 
URL: http://amalaims.org/cancer_research_centre_amala_facultiesandstaff.php
 
Area of Specialization:
Molecular Biology
Publications:
1. Sindhu, E. R., Firdous, A. P., Preethi, K. C. and Kuttan, R.  Carotenoid lutein protects rats from paracetamol-, carbon tetrachloride- and ethanol-induced hepatic damage. The Journal of Pharmacy and Pharmacology. 2010.  62, 1054-1060. [PubMed]
2. Harikumar, K. B., Kuttan, G. and Kuttan, R.  Inhibition of viral carcinogenesis by Phyllanthus amarus. Integrative Cancer Therapies. 2009.  8, 254-260. [PubMed]
3. Sunila, E. S., Kuttan, R., Preethi, K. C. and Kuttan, G.  Dynamized preparations in cell culture. Evidence-based Complementary and Alternative Medicine . 2009.  6, 257-263. [PubMed]
4. Harikumar, K. B., Kuttan, G. and Kuttan, R.  Phyllanthus amarus inhibits cell growth and induces apoptosis in Dalton's lymphoma ascites cells through activation of caspase-3 and downregulation of Bcl-2. Integrative Cancer Therapies. 2009.  8, 190-194. [PubMed]
5. Sabu, M. C. and Kuttan, R.  Antidiabetic and antioxidant activity of Terminalia belerica. Roxb. Indian Journal of Experimental Biology. 2009.  47, 270-275. [PubMed]
6. Preethi, K. C. and Kuttan, R.  Hepato and reno protective action of Calendula officinalis L. flower extract. Indian Journal of Experimental Biology. 2009.  47, 163-168. [PubMed]
7. Preethi, K. C., Kuttan, G. and Kuttan, R.  Anti-inflammatory activity of flower extract of Calendula officinalis Linn. and its possible mechanism of action. Indian Journal of Experimental Biology. 2009.  47, 113-120. [PubMed]
8. Preethi, K. C. and Kuttan, R.  Wound healing activity of flower extract of Calendula officinalis. Journal of Basic and Clinical Physiology and Pharmacology. 2009.  20, 73-79. [PubMed]
9. Preethi, K. C., Nair, C. K. and Kuttan, R.  Clastogenic potential of Ruta graveolens extract and a homeopathic preparation in mouse bone marrow cells. Asian Pacific Journal of Cancer Prevention. 2008.  9, 763-769. [PubMed]
10. Chandran, P. K. and Kuttan, R.  Effect of Calendula officinalis Flower Extract on Acute Phase Proteins, Antioxidant Defense Mechanism and Granuloma Formation During Thermal Burns. Journal of Clinical Biochemistry and Nutrition. 2008.  43, 58-64. [PubMed]
11. Tharakan, S. T., Kuttan, G., Kuttan, R., Kesavan, M., Austin, S. r. and Rajagopalan, K.  Immunostimulatory action of AC II--an ayurvedic formulation useful in HIV. Indian Journal of Experimental Biology. 2008.  46, 47-51. [PubMed]
12. Harikumar, K. B., Nimita, C. V., Preethi, K. C., Kuttan, R., Shankaranarayana, M. L. and Deshpande, J.  Toxicity profile of lutein and lutein ester isolated from marigold flowers (Tagetes erecta). International Journal of Toxicology. 2008.  27, 1-9. [PubMed]
13. Harikumar, K. B., Kuttan, G. and Kuttan, R.  Inhibition of progression of erythroleukemia induced by Friend virus in BALB/c mice by natural products--berberine, curcumin and picroliv. Journal of Experimental Therapeutics & Oncology. 2008.  7, 275-284. [PubMed]
14. Harikumar, K. B. and Kuttan, R.  An extract of Phyllanthus amarus protects mouse chromosomes and intestine from radiation induced damages. Journal of Radiation Research. 2007.  48, 469-476. [PubMed]
15. Es, S., Kuttan, G., Kc, P. and Kuttan, R.  Effect of homeopathic medicines on transplanted tumors in mice. Asian Pacific Journal of Cancer Prevention. 2007.  8, 390-394. [PubMed]
16. Kuttan, G., Kumar, K. B., Guruvayoorappan, C. and Kuttan, R.  Antitumor, anti-invasion, and antimetastatic effects of curcumin. Advances in Experimental Medicine and Biology. 2007.  595, 173-184. [PubMed]
17. Kumar, K. B., Sunila, E. S., Kuttan, G., Preethi, K. C., Venugopal, C. N. and Kuttan, R.  Inhibition of chemically induced carcinogenesis by drugs used in homeopathic medicine. Asian Pacific Journal of Cancer Prevention. 2007.  8, 98-102. [PubMed]
18. Tharakan, S. T., Kuttan, G., Kuttan, R., Kesavan, M., Austin, S. and Rajagopalan, K.  Effect of AC II, an herbal formulation in cyclophosphamide-induced immunosuppression in BALB/c mice--Implication in HIV treatment. Immunological Investigations. 2007.  36, 147-157. [PubMed]
19. Preethi, K. C., Kuttan, G. and Kuttan, R.  Anti-tumour activity of Ruta graveolens extract. Asian Pacific Journal of Cancer Prevention. 2006.  7, 439-443. [PubMed]
20. Hari, K. and Kuttan, R.  Inhibition of drug metabolizing enzymes (cytochrome P450) in vitro as well as in vivo by Phyllanthus amarus SCHUM & THONN. Biological & Pharmaceutical Bulletin. 2006.  29, 1310-1313. [PubMed]
21. Raphael, K. R., Sabu, M., Kumar, K. H. and Kuttan, R.  Inhibition of N-Methyl N'-nitro-N-nitrosoguanidine (MNNG) induced gastric carcinogenesis by Phyllanthus amarus extract. Asian Pacific Journal of Cancer Prevention. 2006.  7, 299-302. [PubMed]
22. Swarnam, J., Sreekanth, K. S., Hareesh, P., Sabu, M. C. and Kuttan, R.  Effect of Smoke Shield-a herbal formulation on the mutagenicity and oxidative stress produced by cigarette smoke in rats. Journal of Experimental & Clinical Cancer Research. 2005.  24, 297-304. [PubMed]
23. Kumar, K. B. and Kuttan, R.  Chemoprotective activity of an extract of Phyllanthus amarus against cyclophosphamide induced toxicity in mice. Phytomedicine. 2005.  12, 494-500. [PubMed]
24. Harikumar, K. B., Jesil, A. M., Sabu, M. C. and Kuttan, R.  A preliminary assessment of the acute and subchronic toxicity profile of phase2: an alpha-amylase inhibitor. International Journal of Toxicology. 2005.  24, 95-102. [PubMed]
25. Hari, K., Sabu, M. C., Lima, P. S. and Kuttan, R.  Modulation of haematopoetic system and antioxidant enzymes by Emblica officinalis gaertn and its protective role against gamma-radiation induced damages in mice. Journal of Radiation Research. 2004.  45, 549-555. [PubMed]
26. Kuttan, R., Kuttan, G., Joseph, S., Ajith, T. A., Mohan, M. and Srimal, R. C.  Antimutagenicity of herbal detoxification formula Smoke Shield against environmental mutagens. Journal of Experimental & Clinical Cancer Research : CR. 2004.  23, 61-68. [PubMed]
27. Kumar, K. B. and Kuttan, R.  Protective effect of an extract of Phyllanthus amarus against radiation-induced damage in mice. Journal of Radiation Research. 2004.  45, 133-139. [PubMed]
28. Sabu, M. C. and Kuttan, R.  Antidiabetic activity of Aegle marmelos and its relationship with its antioxidant properties. Indian Journal of Physiology and Pharmacology. 2004.  48, 81-88. [PubMed]
29. Raphael, K. R. and Kuttan, R.  Inhibition of experimental gastric lesion and inflammation by Phyllanthus amarus extract. Journal of Ethnopharmacology. 2003.  87, 193-197. [PubMed]
30. Rajeshkumar, N. V., Pillai, M. R. and Kuttan, R.  Induction of apoptosis in mouse and human carcinoma cell lines by Emblica officinalis polyphenols and its effect on chemical carcinogenesis. Journal of Experimental & Clinical Cancer Research : CR. 2003.  22, 201-212. [PubMed]
31. Sreekanth, K. S., Sabu, M. C., Varghese, L., Manesh, C., Kuttan, G. and Kuttan, R.  Antioxidant activity of Smoke Shield in-vitro and in-vivo. The Journal of Pharmacy and Pharmacology. 2003.  55, 847-853. [PubMed]
32. Rajeshkumar, N. V. and Kuttan, R.  Modulation of carcinogenic response and antioxidant enzymes of rats administered with 1,2-dimethylhydrazine by Picroliv. Cancer Letters. 2003.  191, 137-143. [PubMed]
33. Sabu, M. C., Smitha, K. and Kuttan, R.  Anti-diabetic activity of green tea polyphenols and their role in reducing oxidative stress in experimental diabetes. Journal of Ethnopharmacology. 2002.  83, 109-116. [PubMed]
34. Raphael, K. R., Sabu, M. C. and Kuttan, R.  Hypoglycemic effect of methanol extract of Phyllanthus amarus Schum & Thonn on alloxan induced diabetes mellitus in rats and its relation with antioxidant potential. Indian Journal of Experimental Biology. 2002.  40, 905-909. [PubMed]
35. Sabu, M. C. and Kuttan, R.  Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property. Journal of Ethnopharmacology. 2002.  81, 155-160. [PubMed]
36. Rajeshkumar, N. V., Joy, K. L., Kuttan, G., Ramsewak, R. S., Nair, M. G. and Kuttan, R.  Antitumour and anticarcinogenic activity of Phyllanthus amarus extract. Journal of Ethnopharmacology. 2002.  81, 17-22. [PubMed]
37. Raphael, K. R., Ajith, T. A., Joseph, S. and Kuttan, R.  Anti-mutagenic activity of Phyllanthus amarus Schum & Thonn in vitro as well as in vivo. Teratogenesis, Carcinogenesis, and Mutagenesis. 2002.  22, 285-291. [PubMed]
38. Rekha, P. S., Kuttan, G. and Kuttan, R.  Effect of brahma rasayana on antioxidant system after radiation. Indian Journal of Experimental Biology. 2001.  39, 1173-1175. [PubMed]
39. Rajeshkumar, N. V. and Kuttan, R.  Cancare-a herbal formulation inhibits chemically induced tumours in experimental animals. Indian Journal of Experimental Biology. 2001.  39, 654-659. [PubMed]
40. Rekha, P. S., Kuttan, G. and Kuttan, R.  Effect of Brahma Rasayana on antioxidant systems and cytokine levels in mice during cyclophosphamide administration. Journal of Experimental & Clinical Cancer Research : CR. 2001.  20, 219-223. [PubMed]
41. Rekha, P. S., Kuttan, G. and Kuttan, R.  Antioxidant activity of brahma rasayana. Indian Journal of Experimental Biology. 2001.  39, 447-452. [PubMed]
42. Jose, J. K., Kuttan, G. and Kuttan, R.  Antitumour activity of Emblica officinalis. Journal of Ethnopharmacology. 2001.  75, 65-69. [PubMed]
43. Anis, K. V., Rajeshkumar, N. V. and Kuttan, R.  Inhibition of chemical carcinogenesis by berberine in rats and mice. The Journal of Pharmacy and Pharmacology. 2001.  53, 763-768. [PubMed]
44. Rajeshkumar, N. V. and Kuttan, R.  Protective effect of Picroliv, the active constituent of Picrorhiza kurroa, against chemical carcinogenesis in mice. Teratogenesis, Carcinogenesis, and Mutagenesis. 2001.  21, 303-313. [PubMed]
45. Rajeshkumar, N. V. and Kuttan, R.  Inhibition of N-nitrosodiethylamine-induced hepatocarcinogenesis by Picroliv. Journal of Experimental & Clinical Cancer Research : CR. 2000.  19, 459-465. [PubMed]
46. Rajeshkumar, N. V. and Kuttan, R.  Phyllanthus amarus extract administration increases the life span of rats with hepatocellular carcinoma. Journal of Ethnopharmacology. 2000.  73, 215-219. [PubMed]
47. Rekha, P. S., Kuttan, G. and Kuttan, R.  Effect of herbal preparation, brahma rasayana, in amelioration of radiation induced damage. Indian Journal of Experimental Biology. 2000.  38, 999-1002. [PubMed]
48. Jose, J. K. and Kuttan, R.  Hepatoprotective activity of Emblica officinalis and Chyavanaprash. Journal of Ethnopharmacology. 2000.  72, 135-140. [PubMed]
49. Antony, S., Kuttan, R. and Kuttan, G.  Role of natural killer cells in iscador mediated inhibition of metastasis by adoptive immunotherapy. Immunological Investigations. 2000.  29, 219-231. [PubMed]
50. Joy, K. L., Rajeshkumar, N. V., Kuttan, G. and Kuttan, R.  Effect of Picrorrhiza kurroa extract on transplanted tumours and chemical carcinogenesis in mice. Journal of Ethnopharmacology. 2000.  71, 261-266. [PubMed]
51. Joy, K. L., Kuttan, G. and Kuttan, R.  Antioxidant and anticarcinogenic activity of Lycovin--an indigenous herbal preparation. Indian Journal of Experimental Biology. 1999.  37, 1177-1181. [PubMed]
52. Joy, K. L. and Kuttan, R.  Anti-diabetic activity of Picrorrhiza kurroa extract. Journal of Ethnopharmacology. 1999.  67, 143-148. [PubMed]
53. Antony, S., Kuttan, R. and Kuttan, G.  Immunomodulatory activity of curcumin. Immunological Investigations. 1999.  28, 291-303. [PubMed]
54. Joseph, C. D., Praveenkumar, V., Kuttan, G. and Kuttan, R.  Myeloprotective effect of a non-toxic indigenous preparation Rasayana in cancer patients receiving chemotherapy and radiation therapy. A pilot study. Journal of Experimental & Clinical Cancer Research. 1999.  18, 325-329. [PubMed]
55. Menon, L. G., Kuttan, R. and Kuttan, G.  Anti-metastatic activity of curcumin and catechin. Cancer Letters. 1999.  141, 159-165. [PubMed]
56. Jeena, K. J., Joy, K. L. and Kuttan, R.  Effect of Emblica officinalis, Phyllanthus amarus and Picrorrhiza kurroa on N-nitrosodiethylamine induced hepatocarcinogenesis. Cancer Letters. 1999.  136, 11-16. [PubMed]
57. Antony, S., Kuttan, R. and Kuttan, G.  Inhibition of lung metastasis by adoptive immunotherapy using Iscador. Immunological Investigations. 1999.  28, 1-8. [PubMed]
58. Kumar, V. P., Kuttan, R. and Kuttan, G.  Effect of "rasayanas", a herbal drug preparation on immune responses and its significance in cancer treatment. Indian Journal of Experimental Biology. 1999.  37, 27-31. [PubMed]
59. Kumar, V. P., Kuttan, R. and Kuttan, G.  Effect of "rasayanas" a herbal drug preparation on cell-mediated immune responses in tumour bearing mice. Indian Journal of Experimental Biology. 1999.  37, 23-26. [PubMed]
60. Thresiamma, K. C., George, J. and Kuttan, R.  Protective effect of curcumin, ellagic acid and bixin on radiation induced genotoxicity. Journal of Experimental & Clinical Cancer Research : CR. 1998.  17, 431-434. [PubMed]
61. Menon, L. G., Kuttan, R., Nair, M. G., Chang, Y. C. and Kuttan, G.  Effect of isoflavones genistein and daidzein in the inhibition of lung metastasis in mice induced by B16F-10 melanoma cells. Nutrition and Cancer. 1998.  30, 74-77. [PubMed]
62. Praveenkumar, V., Kuttan, R. and Kuttan, G.  Immunopotentiating activity of septilin. Indian Journal of Experimental Biology. 1997.  35, 1319-1323. [PubMed]
63. Menon, L. G., Kuttan, R. and Kuttan, G.  Effect of rasayanas in the inhibition of lung metastasis induced by B16F-10 melanoma cells. Journal of Experimental & Clinical Cancer Research : CR. 1997.  16, 365-368. [PubMed]
64. Antony, S., Kuttan, R. and Kuttan, G.  Effect of viscum album in the inhibition of lung metastasis in mice induced by B16F10 melanoma cells. Journal of Experimental & Clinical Cancer Research : CR. 1997.  16, 159-162. [PubMed]
65. Soni, K. B., Lahiri, M., Chackradeo, P., Bhide, S. V. and Kuttan, R.  Protective effect of food additives on aflatoxin-induced mutagenicity and hepatocarcinogenicity. Cancer Letters. 1997.  115, 129-133. [PubMed]
66. Kuttan, G., Menon, L. G., Antony, S. and Kuttan, R.  Anticarcinogenic and antimetastatic activity of Iscador. Anti-cancer Drugs. 1997.  8 Suppl 1, S15-6. [PubMed]
67. George, J. and Kuttan, R.  Mutagenic, carcinogenic and cocarcinogenic activity of cashewnut shell liquid. Cancer Letters. 1997.  112, 11-16. [PubMed]
68. Thresiamma, K. C. and Kuttan, R.  Inhibition of liver fibrosis by ellagic acid. Indian Journal of Physiology and Pharmacology. 1996.  40, 363-366. [PubMed]
69. George, J. and Kuttan, R.  Lack of induction of chromosome aberrations and micronuclei by N-(1,3-dimethylbutyl)-N-phenylparaphenylenediamine in mouse bone marrow cells. Mutation Research. 1996.  370, 191-194. [PubMed]
70. Anto, R. J., George, J., Babu, K. V., Rajasekharan, K. N. and Kuttan, R.  Antimutagenic and anticarcinogenic activity of natural and synthetic curcuminoids. Mutation Research. 1996.  370, 127-131. [PubMed]
71. Thresiamma, K. C., George, J. and Kuttan, R.  Protective effect of curcumin, ellagic acid and bixin on radiation induced toxicity. Indian Journal of Experimental Biology. 1996.  34, 845-847. [PubMed]
72. Kuttan, G., Menon, L. G. and Kuttan, R.  Prevention of 20-methylcholanthrene-induced sarcoma by a mistletoe extract, Iscador. Carcinogenesis. 1996.  17, 1107-1109. [PubMed]
73. George, J. and Kuttan, R.  Studies on clastogenic and carcinogenic potency of tetramethyl thiuram disulphide. Cancer Letters. 1995.  97, 213-216. [PubMed]
74. Anto, R. J., Sukumaran, K., Kuttan, G., Rao, M. N., Subbaraju, V. and Kuttan, R.  Anticancer and antioxidant activity of synthetic chalcones and related compounds. Cancer Letters. 1995.  97, 33-37. [PubMed]
75. Soudamini, K. K., Unnikrishnan, M. C., Sukumaran, K. and Kuttan, R.  Mutagenicity and anti-mutagenicity of selected spices. Indian Journal of Physiology and Pharmacology. 1995.  39, 347-353. [PubMed]
76. Menon, L. G., Kuttan, R. and Kuttan, G.  Inhibition of lung metastasis in mice induced by B16F10 melanoma cells by polyphenolic compounds. Cancer Letters. 1995.  95, 221-225. [PubMed]
77. Ruby, A. J., Kuttan, G., Babu, K. D., Rajasekharan, K. N. and Kuttan, R.  Anti-tumour and antioxidant activity of natural curcuminoids. Cancer Letters. 1995.  94, 79-83. [PubMed]
78. Sukumaran, K. and Kuttan, R.  Inhibition of tobacco-induced mutagenesis by eugenol and plant extracts. Mutation Research. 1995.  343, 25-30. [PubMed]
79. Sukumaran, K., Unnikrishnan, M. C. and Kuttan, R.  Inhibition of tumour promotion in mice by eugenol. Indian Journal of Physiology and Pharmacology. 1994.  38, 306-308. [PubMed]
80. Praveenkumar, V., Kuttan, R. and Kuttan, G.  Chemoprotective action of Rasayanas against cyclosphamide toxicity. Tumori. 1994.  80, 306-308. [PubMed]
81. Kuttan, G. and Kuttan, R.  Reduction of leukopenia in mice by "viscum album" administration during radiation and chemotherapy. Tumori. 1993.  79, 74-76. [PubMed]
82. Soni, K. B. and Kuttan, R.  Effect of oral curcumin administration on serum peroxides and cholesterol levels in human volunteers. Indian Journal of Physiology and Pharmacology. 1992.  36, 273-275. [PubMed]
83. Soudamini, K. K., Unnikrishnan, M. C., Soni, K. B. and Kuttan, R.  Inhibition of lipid peroxidation and cholesterol levels in mice by curcumin. Indian Journal of Physiology and Pharmacology. 1992.  36, 239-243. [PubMed]
84. Kuttan, G. and Kuttan, R.  Immunological mechanism of action of the tumor reducing peptide from mistletoe extract (NSC 635089) cellular proliferation. Cancer Letters. 1992.  66, 123-130. [PubMed]
85. Soni, K. B., Rajan, A. and Kuttan, R.  Reversal of aflatoxin induced liver damage by turmeric and curcumin. Cancer Letters. 1992.  66, 115-121. [PubMed]
86. Kuttan, G. and Kuttan, R.  Immunomodulatory activity of a peptide isolated from Viscum album extract (NSC 635 089). Immunological Investigations. 1992.  21, 285-296. [PubMed]
87. Sukumaran, K. and Kuttan, R.  Screening of 11 ferns for cytotoxic and antitumor potential with special reference to Pityrogramma calomelanos. Journal of Ethnopharmacology. 1991.  34, 93-96. [PubMed]
88. Unnikrishnan, M. C. and Kuttan, R.  Tumour reducing and anticarcinogenic activity of selected spices. Cancer Letters. 1990.  51, 85-89. [PubMed]
89. Kuttan, G., Vasudevan, D. M. and Kuttan, R.  Effect of a preparation from Viscum album on tumor development in vitro and in mice. Journal of Ethnopharmacology. 1990.  29, 35-41. [PubMed]
90. Unnikrishnan, M. C., Soudamini, K. K. and Kuttan, R.  Chemoprotection of garlic extract toward cyclophosphamide toxicity in mice. Nutrition and Cancer. 1990.  13, 201-207. [PubMed]
91. Kuttan, G., Vasudevan, D. M. and Kuttan, R.  Presence of a receptor for the active component of Iscador in ascites fluid of tumour bearing mice. Cancer Letters. 1989.  48, 223-227. [PubMed]
92. Soudamini, K. K. and Kuttan, R.  Inhibition of chemical carcinogenesis by curcumin. Journal of Ethnopharmacology. 1989.  27, 227-233. [PubMed]
93. Kuttan, G., Vasudevan, D. M. and Kuttan, R.  Isolation and identification of a tumour reducing component from mistletoe extract (Iscador). Cancer Letters. 1988.  41, 307-314. [PubMed]
94. Unnikrishnan, M. C. and Kuttan, R.  Cytotoxicity of extracts of spices to cultured cells. Nutrition and Cancer. 1988.  11, 251-257. [PubMed]
95. Kuttan R.  Effect of gold thiomalate on cell proliferation and collagen synthesis of synovial cells in culture. Indian Journal of Physiology and Pharmacology. 1987.  31, 245-249. [PubMed]

 
 
Education 
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Ph.D.
  Last modified on : Dec 17, 2015
India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.