Girija Kuttan, Ph.D.
Amala Institute of Medical Sciences
Department of Immunology
Amala Nagar
Thrissur - 680 555
Kerala
E-mail: amalacanceresearch@gmail.com, girijakuttan@gmail.com
Phone: +91-487-2304190
Mobile: +91-9495923071
URL: http://amalaims.org/cancer_research_centre_amala_facultiesandstaff.php
Area of Specialization:
Immunopharmacology
Publications:
1.
Pratheeshkumar, P. and Kuttan, G . Vernolide-A inhibits tumour specific angiogenesis by regulating proinflammatory cytokines, VEGF, MMPs and TIMP. European Journal of Pharmacology. 2011. [PubMed]
2.
Pratheeshkumar, P. and Kuttan, G . Effect of vernolide-A, a sesquiterpene lactone from Vernonia cinerea L., on cell-mediated immune response in B16F-10 metastatic melanoma-bearing mice. Immunopharmacology and Immunotoxicology. 2011. [PubMed]
3.
Pratheeshkumar, P. and Kuttan, G . Cardiospermum halicacabum inhibits Cyclophosphamide Induced Immunosupression and Oxidative Stress in Mice and also Regulates iNOS and COX-2 Gene Expression in LPS Stimulated Macrophages. Asian Pacific Journal of Cancer Prevention : APJCP. 2010. 11, 1245-1252. [PubMed]
4.
Hamsa, T. P. and Kuttan, G . Ipomoea obscura ameliorates cyclophosphamide-induced toxicity by modulating the immune system and levels of proinflammatory cytokine and GSH. Canadian Journal of Physiology and Pharmacology. 2010. 88, 1042-1053. [PubMed]
5.
Pratheeshkumar, P. and Kuttan, G . Vernonia cinerea Less. Inhibits Tumor Cell Invasion and Pulmonary Metastasis in C57BL/6 Mice. Integrative Cancer Therapies. 2010. [PubMed]
6.
Hamsa, T. P. and Kuttan, G . Anti-angiogenic activity of Ipomoea obscura extract and Ipobscurine-A. Immunopharmacology and Immunotoxicology. 2010. [PubMed]
7.
Siveen, K. S. and Kuttan, G . Immunomodulatory and antitumor activity of Aerva lanata ethanolic extract. Immunopharmacology and Immunotoxicology. 2010. [PubMed]
8.
Hamsa, T. P. and Kuttan, G . Tinospora cordifolia ameliorates urotoxic effect of cyclophosphamide by modulating GSH and cytokine levels. Experimental and Toxicologic Pathology . 2010. [PubMed]
9.
Pratheeshkumar, P. and Kuttan, G . Protective role of Vernonia cinerea L. against gamma radiation-induced immunosupression and oxidative stress in mice. Human & Experimental Toxicology. 2010. [PubMed]
10.
Hamsa, T. P. and Kuttan, G . Protective role of Ipomoea obscura (L.) on cyclophosphamide-induced uro- and nephrotoxicities by modulating antioxidant status and pro-inflammatory cytokine levels. Inflammopharmacology. 2010. [PubMed]
11.
Hamsa, T. P. and Kuttan, G . Harmine inhibits tumour specific neo-vessel formation by regulating VEGF, MMP, TIMP and pro-inflammatory mediators both in vivo and in vitro. European Journal of Pharmacology. 2010. 649, 64-73. [PubMed]
12.
Pratheeshkumar, P. and Kuttan, G . Ameliorative action of Vernonia cinerea L. on cyclophosphamide-induced immunosuppression and oxidative stress in mice. Inflammopharmacology. 2010. 18, 197-207. [PubMed]
13.
Hamsa, T. P. and Kuttan, G . Evaluation of the Anti-inflammatory and Anti-tumor Effect of Ipomoea obscura (L) and Its Mode of Action Through the Inhibition of Pro Inflammatory Cytokines, Nitric Oxide and COX-2. Inflammation. 2010. [PubMed]
14.
Kanjoormana, M. and Kuttan, G . Antiangiogenic activity of ursolic acid. Integrative Cancer Therapies. 2010. 9, 224-235. [PubMed]
15.
Pratheeshkumar, P. and Kuttan, G . Modulation of immune response by Vernonia cinerea L. inhibits the proinflammatory cytokine profile, iNOS, and COX-2 expression in LPS-stimulated macrophages. Immunopharmacology and Immunotoxicology. 2011. 33, 73-83. [PubMed]
16.
Harikumar, K. B., Kuttan, G . and Kuttan, R. Inhibition of viral carcinogenesis by Phyllanthus amarus. Integrative Cancer Therapies. 2009. 8, 254-260. [PubMed]
17.
Manu, K. A. and Kuttan, G . Immunomodulatory activities of Punarnavine, an alkaloid from Boerhaavia diffusa. Immunopharmacology and Immunotoxicology. 2009. 31, 377-387. [PubMed]
18.
Siveen, K. S. and Kuttan, G . Role of macrophages in tumour progression. Immunology Letters. 2009. 123, 97-102. [PubMed]
19.
Preethi, K. C., Kuttan, G . and Kuttan, R. Anti-inflammatory activity of flower extract of Calendula officinalis Linn. and its possible mechanism of action. Indian Journal of Experimental Biology. 2009. 47, 113-120. [PubMed]
20.
Kumar, P. P. and Kuttan, G . Vernonia cinerea L. scavenges free radicals and regulates nitric oxide and proinflammatory cytokines profile in carrageenan induced paw edema model. Immunopharmacology and Immunotoxicology. 2009. 31, 94-102. [PubMed]
21.
Harikumar, K. B., Kuttan, G . and Kuttan, R. Inhibition of progression of erythroleukemia induced by Friend virus in BALB/c mice by natural products--berberine, curcumin and picroliv. Journal of Experimental Therapeutics & Oncology. 2008. 7, 275-284. [PubMed]
22.
Harikumar, K. B., Kuttan, G . and Kuttan, R. Phyllanthus amarus inhibits cell growth and induces apoptosis in Dalton's lymphoma ascites cells through activation of caspase-3 and downregulation of Bcl-2. Integrative Cancer Therapies. 2009. 8, 190-194. [PubMed]
23.
Manu, K. A. and Kuttan, G . Anti-metastatic potential of Punarnavine, an alkaloid from Boerhaavia diffusa Linn. Immunobiology. 2009. 214, 245-255. [PubMed]
24.
Manu, K. A. and Kuttan, G . Punarnavine induces apoptosis in B16F-10 melanoma cells by inhibiting NF-kappaB signaling. Asian Pacific Journal of Cancer Prevention : APJCP. 2009. 10, 1031-1037. [PubMed]
25.
Guruvayoorappan, C. and Kuttan, G . Amentoflavone stimulates apoptosis in B16F-10 melanoma cells by regulating bcl-2, p53 as well as caspase-3 genes and regulates the nitric oxide as well as proinflammatory cytokine production in B16F-10 melanoma cells, tumor associated macrophages and peritoneal macrophages. Journal of Experimental Therapeutics & Oncology. 2008. 7, 207-218. [PubMed]
26.
Guruvayoorappan, C. and Kuttan, G . 13 cis-retinoic acid regulates cytokine production and inhibits angiogenesis by disrupting endothelial cell migration and tube formation. Journal of Experimental Therapeutics & Oncology. 2008. 7, 173-182. [PubMed]
27.
Sunila, E. S., Kuttan, R., Preethi, K. C. and Kuttan, G . Dynamized preparations in cell culture. Evidence-based Complementary and Alternative Medicine. 2009. 6, 257-263. [PubMed]
28.
Guruvayoorappan, C. and Kuttan, G . Protective effect of Biophytum sensitivum (L.) DC on radiation-induced damage in mice. Immunopharmacology and Immunotoxicology. 2008. 30, 815-835. [PubMed]
29.
Hamsa, T. P. and Kuttan, G . Ipomoea obscura (L.) enhances the functions of immunological effector cells, inhibits proinflammatory cytokines and nitric oxide production by LPS induced macrophages. Immunopharmacology and Immunotoxicology. 2009. 31, 222-229. [PubMed]
30.
Tharakan, S. T., Kuttan, G ., Kuttan, R., Kesavan, M., Austin, S. r. and Rajagopalan, K. Immunostimulatory action of AC II--an ayurvedic formulation useful in HIV. Indian Journal of Experimental Biology. 2008. 46, 47-51. [PubMed]
31.
Guruvayoorappan, C. and Kuttan, G. Amentoflavone inhibits experimental tumor metastasis through a regulatory mechanism involving MMP-2, MMP-9, prolyl hydroxylase, lysyl oxidase, VEGF, ERK-1, ERK-2, STAT-1, NM23 and cytokines in lung tissues of C57BL/6 mice. Immunopharmacology and Immunotoxicology. 2008. 30, 711-727. [PubMed]
32.
Guruvayoorappan, C., Pradeep, C. R. and Kuttan, G. 13-cis-retinoic acid induces apoptosis by modulating caspase-3, bcl-2, and p53 gene expression and regulates the activation of transcription factors in B16F-10 melanoma cells. Journal of Environmental Pathology, Toxicology and Oncology . 2008. 27, 197-207. [PubMed]
33.
Guruvayoorappan, C. and Kuttan, G. (+)-Catechin inhibits tumour angiogenesis and regulates the production of nitric oxide and TNF-alpha in LPS-stimulated macrophages. Innate Immunity. 2008. 14, 160-174. [PubMed]
34.
Manu, K. A. and Kuttan, G . Ursolic acid induces apoptosis by activating p53 and caspase-3 gene expressions and suppressing NF-kappaB mediated activation of bcl-2 in B16F-10 melanoma cells. International Immunopharmacology. 2008. 8, 974-981. [PubMed]
35.
Guruvayoorappan, C. and Kuttan, G . Anti-metastatic effect of Biophytum sensitivum is exerted through its cytokine and immunomodulatory activity and its regulatory effect on the activation and nuclear translocation of transcription factors in B16F-10 melanoma cells. Journal of Experimental Therapeutics & Oncology. 2008. 7, 49-63. [PubMed]
36.
Manu, K. A. and Kuttan, G . Boerhaavia diffusa stimulates cell-mediated immune response by upregulating IL-2 and downregulating the pro-inflammatory cytokines and GM-CSF in B16F-10 metastatic melanoma bearing mice. Journal of Experimental Therapeutics & Oncology. 2008. 7, 17-29. [PubMed]
37.
Guruvayoorappan, C. and Kuttan, G . Rutin inhibits nitric oxide and tumor necrosis factor-alpha production in lipopolysaccharide and concanavalin-a stimulated macrophages. Drug Metabolism and Drug Interactions. 2007. 22, 263-278. [PubMed]
38.
Guruvayoorappan, C., Pradeep, C. R. and Kuttan, G. 13 Cis-retinoic acid mediates apoptosis in Dalton's lymphoma ascites cells by regulating gene expression. Journal of Basic and Clinical Physiology and Pharmacology. 2007. 18, 267-276. [PubMed]
39.
Guruvayoorappan, C. and Kuttan, G . Biophytum sensitivum (L.) DC inhibits tumor cell invasion and metastasis through a mechanism involving regulation of MMPs, prolyl hydroxylase, lysyl oxidase, nm23, ERK-1, ERK-2, STAT-1, and proinflammatory cytokine gene expression in metastatic lung tissue. Integrative Cancer Therapies. 2008. 7, 42-50. [PubMed]
40.
Guruvayoorappan, C. and Kuttan, G . Methanol extract of Biophytum sensitivum alters the cytokine profile and inhibits iNOS and COX-2 expression in LPS/Con A stimulated macrophages. Drug and Chemical Toxicology. 2008. 31, 175-188. [PubMed]
41.
Es, S., Kuttan, G ., Kc, P. and Kuttan, R. Effect of homeopathic medicines on transplanted tumors in mice. Asian Pacific Journal of Cancer Prevention : APJCP. 2007. 8, 390-394. [PubMed]
42.
Manu, K. A. and Kuttan, G . Effect of Punarnavine, an alkaloid from Boerhaavia diffusa, on cell-mediated immune responses and TIMP-1 in B16F-10 metastatic melanoma-bearing mice. Immunopharmacology and Immunotoxicology. 2007. 29, 569-586. [PubMed]
43.
Thejass, P. and Kuttan, G . Inhibition of endothelial cell differentiation and proinflammatory cytokine production during angiogenesis by allyl isothiocyanate and phenyl isothiocyanate. Integrative Cancer Therapies. 2007. 6, 389-399. [PubMed]
44.
Manu, K. A., Leyon, P. V. and Kuttan, G . Studies on the protective effects of Boerhaavia diffusa L. against gamma radiation induced damage in mice. Integrative Cancer Therapies. 2007. 6, 381-388. [PubMed]
45.
Guruvayoorappan, C. and Kuttan, G . Apoptotic effect of Biophytum sensitivum on B16F-10 cells and its regulatory effects on nitric oxide and cytokine production on tumor-associated macrophages. Integrative Cancer Therapies. 2007. 6, 373-380. [PubMed]
46.
Guruvayoorappan, C. and Kuttan, G . Amentoflavone, a biflavonoid from Biophytum sensitivum augments lymphocyte proliferation, natural killer cell and antibody dependent cellular cytotoxicity through enhanced production of IL-2 and IFN-gamma and restrains serum sialic acid and gamma glutamyl transpeptidase production in tumor - bearing animals. Journal of Experimental Therapeutics & Oncology. 2007. 6, 285-295. [PubMed]
47.
Guruvayoorappan, C. and Kuttan, G . Beta-carotene inhibits tumor-specific angiogenesis by altering the cytokine profile and inhibits the nuclear translocation of transcription factors in B16F-10 melanoma cells. Integrative Cancer Therapies. 2007. 6, 258-270. [PubMed]
48.
Guruvayoorappan, C. and Kuttan, G . Evaluation of the chemoprotective effect of Biophytum sensitivum (L.) DC extract against cyclophosphamide induced toxicity in Swiss albino mice. Drug Metabolism and Drug Interactions. 2007. 22, 131-150. [PubMed]
49.
Kuttan, G ., Kumar, K. B., Guruvayoorappan, C. and Kuttan, R. Antitumor, anti-invasion, and antimetastatic effects of curcumin. Advances in Experimental Medicine and Biology. 2007. 595, 173-184. [PubMed]
50.
Guruvayoorappan, C. and Kuttan, G . Anti-angiogenic effect of Biophytum sensitivum is exerted through its cytokine modulation activity and inhibitory activity against VEGF mRNA expression, endothelial cell migration and capillary tube formation. Journal of Experimental Therapeutics & Oncology. 2007. 6, 241-250. [PubMed]
51.
Guruvayoorappan, C. and Kuttan, G . Effect of amentoflavone on the inhibition of pulmonary metastasis induced by B16F-10 melanoma cells in C57BL/6 mice. Integrative Cancer Therapies. 2007. 6, 185-197. [PubMed]
52.
Kumar, K. B., Sunila, E. S., Kuttan, G ., Preethi, K. C., Venugopal, C. N. and Kuttan, R. Inhibition of chemically induced carcinogenesis by drugs used in homeopathic medicine. Asian Pacific Journal of Cancer Prevention : APJCP. 2007. 8, 98-102. [PubMed]
53.
Guruvayoorappan, C. and Kuttan, G . Immunomodulatory and antitumor activity of Biophytum sensitivum extract. Asian Pacific Journal of Cancer Prevention : APJCP. 2007. 8, 27-32. [PubMed]
54.
Tharakan, S. T., Kuttan, G ., Kuttan, R., Kesavan, M., Austin, S. and Rajagopalan, K. Effect of AC II, an herbal formulation in cyclophosphamide-induced immunosuppression in BALB/c mice--Implication in HIV treatment. Immunological Investigations. 2007. 36, 147-157. [PubMed]
55.
Guruvayoorappan, C., Afira, A. H. and Kuttan, G. Antioxidant potential of Biophytum sensitivum extract in vitro and in vivo. Journal of Basic and Clinical Physiology and Pharmacology. 2006. 17, 255-267. [PubMed]
56.
Thejass, P. and Kuttan, G . Antiangiogenic activity of Diallyl Sulfide (DAS). International Immunopharmacology. 2007. 7, 295-305. [PubMed]
57.
Thejass, P. and Kuttan, G . Inhibition of angiogenic differentiation of human umbilical vein endothelial cells by diallyl disulfide (DADS). Life Sciences. 2007. 80, 515-521. [PubMed]
58.
Thejass, P. and Kuttan, G . Allyl isothiocyanate (AITC) and phenyl isothiocyanate (PITC) inhibit tumour-specific angiogenesis by downregulating nitric oxide (NO) and tumour necrosis factor-alpha (TNF-alpha) production. Nitric Oxide : Biology and Chemistry. 2007. 16, 247-257. [PubMed]
59.
Preethi, K. C., Kuttan, G . and Kuttan, R. Anti-tumour activity of Ruta graveolens extract. Asian Pacific Journal of Cancer Prevention : APJCP. 2006. 7, 439-443. [PubMed]
60.
Tharakan, S. T., Kuttan, G . and Kuttan, R. Effect of AC II, a herbal formulation on radiation-induced immunosuppression in mice. Indian Journal of Experimental Biology. 2006. 44, 719-725. [PubMed]
61.
Sheeja, K. and Kuttan, G . Protective effect of Andrographis paniculata and andrographolide on cyclophosphamide-induced urothelial toxicity. Integrative Cancer Therapies. 2006. 5, 244-251. [PubMed]
62.
Ramnath, V., Kuttan, G . and Kuttan, R. Effect of abrin on cell-mediated immune responses in mice. Immunopharmacology and Immunotoxicology. 2006. 28, 259-268. [PubMed]
63.
Chittezhath, M. and Kuttan, G . Radioprotective activity of naturally occurring organosulfur compounds. Tumori. 2006. 92, 163-169. [PubMed]
64.
Thejass, P. and Kuttan, G . Antimetastatic activity of Sulforaphane. Life Sciences. 2006. 78, 3043-3050. [PubMed]
65.
Sreekanth, K. S., Sabu, M. C., Varghese, L., Manesh, C., Kuttan, G . and Kuttan, R. Antioxidant activity of Smoke Shield in-vitro and in-vivo. The Journal of Pharmacy and Pharmacology. 2003. 55, 847-853. [PubMed]
66.
Vayalil, P. K., Kuttan, G . and Kuttan, R. Protective effects of Rasayanas on cyclophosphamide- and radiation-induced damage. Journal of Alternative and Complementary Medicine. 2002. 8, 787-796. [PubMed]
67.
Ramnath, V., Kuttan, G . and Kuttan, R. Immunopotentiating activity of abrin, a lectin from Abrus precatorius Linn. Indian Journal of Experimental Biology. 2002. 40, 910-913. [PubMed]
68.
Vayalil, P. K., Kuttan, G . and Kuttan, R. Rasayanas: evidence for the concept of prevention of diseases. The American Journal of Chinese Medicine. 2002. 30, 155-171. [PubMed]
69.
Ramnath, V., Kuttan, G . and Kuttan, R. Antitumour effect of abrin on transplanted tumours in mice. Indian Journal of Physiology and Pharmacology. 2002. 46, 69-77. [PubMed]
70.
Rajeshkumar, N. V., Joy, K. L., Kuttan, G ., Ramsewak, R. S., Nair, M. G. and Kuttan, R. Antitumour and anticarcinogenic activity of Phyllanthus amarus extract. Journal of Ethnopharmacology. 2002. 81, 17-22. [PubMed]
Last modified on : Mar 4, 2011