Ramkumar  Hariharan,                               Ph.D. 
                               
                              Scientist B   
                           
                         
                                  
         
                                                    
                                                    
                            Rajiv Gandhi Centre for Biotechnology 
                           
                                                                                                        
                            Thycaud, Poojappura 
                           
                                                    
                            Thiruvananthapuram - 695 014                                 
                           
                                                    
                            Kerala                                 
                           						  
                                                            
                           
                                                    
                            E-mail: rmhariharan@rgcb.res.in 
                           
                                                                              
                            Phone: +91-471-2529488 
                           
                          
                               
                           
                          
                            URL:   http://rgcb.res.in/departments/cancer_research/ramkumar-hariharan/profile.html  
                           
                          
                          						  
                              
                           
						  
	                             
                            Positions Held:  
                           
                                                    
                            
                                
                                  Position  
                                  Affiliation  
                                  Time Period   
                                 
                                                                
                                  Scientist B   
                                  Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India 
                                  
								  2008-Present 
                                 
                                                                
                                  Visiting Scientist  
                                  RIKEN Advanced Science Institute, Yokohama, Japan 
                                  
								   
                                 
                                                            
 
                           
                          
                              
                           
                                                                              
                            Area of Specialization:  
                           
                          
                          
                          
  
     
    Bioinformatics 
   
    
                          
                        
                           
                           
                         
                         
                                                    
                                                    
                          
                             
                           
                                                    
                             Research Summary:  
                           
                                                    
                            
                                                                
                                   
                                  Computational genomics and systems biology 
                                 
                                                            
 
                           
                          
                              
                           
                                                    
                            Publications:  
                           
                          
                            
	
		
			
				1. 
			
				Sreekumar, E., Issac, A., Nair, S., Hariharan, R ., Janki, M. B., Arathy, D. S., Regu, R., Mathew, T., Anoop, M., Niyas, K. P. and Pillai, M. R.  Genetic characterization of 2006-2008 isolates of Chikungunya virus from Kerala, South India, by whole genome sequence analysis. Virus Genes.  2010.  40, 14-27. [PubMed]  
		 
		
			
				2. 
			
				Hariharan, R. , Babu, J. M., P, R. and Pillai, M. R.  Mutational analysis of Smad7 in human cervical cancer. Oncology Reports.  2009.  21, 1001-1004. [PubMed]  
		 
		
			
				3. 
			
				Krishnan, A., Hariharan, R ., Nair, S. A. and Pillai, M. R.  Fluoxetine mediates G0/G1 arrest by inducing functional inhibition of cyclin dependent kinase subunit (CKS)1. Biochemical Pharmacology.  2008.  75, 1924-1934. [PubMed]  
		 
		
			
				4. 
			
				Hariharan, R . and Pillai, M. R.  Structure-function relationship of inhibitory Smads: Structural flexibility contributes to functional divergence. Proteins.  2008.  71, 1853-1862. [PubMed]  
		 
		
			
				5. 
			
				Joy, S., Nair, P. S., Hariharan, R . and Pillai, M. R.  Detailed comparison of the protein-ligand docking efficiencies of GOLD, a commercial package and ArgusLab, a licensable freeware. In Silico Biology.  2006.  6, 601-605. [PubMed]  
		 
		
			
				6. 
			
				Ramachandran, S., Ramadas, K., Hariharan, R ., Rejnish, K. and Radhakrishna, P.  Single nucleotide polymorphisms of DNA repair genes XRCC1 and XPD and its molecular mapping in Indian oral cancer. Oral Oncology.  2006.  42, 350-362. [PubMed]  
		 
		
			
				7. 
			
				Hariharan, R . and Pillai, M. R.  Homology modeling of the DNA-binding domain of human Smad5: a molecular model for inhibitor design. Journal of Molecular Graphics & Modelling.  2006.  24, 271-277. [PubMed]  
		 
		
			
				8. 
			
				Pillai, M. R., Hariharan, R. , Babu, J. M., Lakshmi, S., Chiplunkar, S. V., Patkar, M., Tongaonkar, H., Dinshaw, K., Jayshree, R. S., Reddy, B. K., Siddiqui, M., Roychoudury, S., Saha, B., Abraham, P., Gnanamony, M., Peedicayil, A., Subhashini, J., Ram, T. S., Dey, B., Sharma, C., Jain, S. K. and Singh, N.  Molecular variants of HPV-16 associated with cervical cancer in Indian population. International Journal of Cancer. Journal International Du Cancer.  2009.  125, 91-103. [PubMed]  
		 
	 
	 
  
                           
                         
                                                    
                            Grant Support:  
                           
                                                    
                            
                                
                                  Project Title  
                                  Role  
                                  Funding Agency   
                                  Sanction Number  
                                  Sanction Date  
                                 
                                                                
                                  Studying the role of microRNAs in etiologically diverse oral carcinomas 
                                   
                                  Department of Science & Technology, Government of India 
                                   
                                  
                                  
								  
								  
								  
								  
								  
								  
								  
								  2009-2012								   
                                 
                                                                
                                  To develop vaccines against Classical Swine Fever and delivery through conjugated nanoparticles 
                                  Co-Investigator 
                                  Department of Biotechnology, Government of India 
                                   
                                  
                                  
								  
								  
								  
								  
								  
								  
								  
								  2008-2014								   
                                 
                                                              
                                 
 
                           
                          
                              
                           
                                                
 
                      
                          
                            
                                                                 
                                   
                             
                            
                                
                             
                            
                              
                                  
                                     
                                   
                                  
                                                                            
                                        
                                                                                    
                                            Education  
 
                                           
                                                                                    
                                            :: 
 
                                            M.Sc.                                                    in Biotechnology, 				
				 
                                                    University of Kerala                                                                        
 
                                           
                                                                                    
                                            :: 
 
                                            Ph.D.                                                    in Biotechnology, 				
				 
                                                    University of Kerala                                                                        
 
                                           
                                                                                    
                                            Honors and Awards  
 
                                           
                                                                                    
                                            :: 
 
                                            Researcher Exchange Program award by the British Council to undertake collaborative work with Oxford University, UK       
 
                                           
                                                                                    
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                                            Visiting Scientist to RIKEN Advanced Science Institute, Yokohama, Japan