S.  Sreeja,                               Ph.D. 
                               
                              Scientist C  
                           
                         
                                  
         
                                                    
                                                    
                            Rajiv Gandhi Centre for Biotechnology 
                           
                                                                                                        
                            Thycaud, Poojappura 
                           
                                                    
                            Thiruvananthapuram - 695 014                                 
                           
                                                    
                            Kerala                                 
                           						  
                                                            
                           
                                                    
                            E-mail: ssreeja@rgcb.res.in 
                           
                                                                              
                            Phone: +91-471-2529474 
                           
                          
                               
                           
                          
                            URL:   http://rgcb.res.in/departments/cancer_research/s-sreeja/profile.html  
                           
                          
                          						  
                              
                           
						  
	                             
                            Positions Held:  
                           
                                                    
                            
                                
                                  Position  
                                  Affiliation  
                                  Time Period   
                                 
                                                                
                                  Scientist C  
                                  Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India 
                                  
								  2005-Present 
                                 
                                                                
                                  Scientist B   
                                  Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India 
                                  
								  2001-2005 
                                 
                                                                
                                  Research Officer  
                                  Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India 
                                  
								  1993-2001 
                                 
                                                                
                                  Research Assistant  
                                  Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India 
                                  
								  1992-1993 
                                 
                                                            
 
                           
                          
                              
                           
                                                                              
                            Area of Specialization:  
                           
                          
                          
                          
  
     
    Biotechnology 
   
    
                          
                        
                           
                           
                         
                         
                                                    
                                                    
                          
                             
                           
                                                    
                             Research Summary:  
                           
                                                    
                            
                                                                
                                   
                                  Differential gene expression in breast tumor tissue at different stages of menstrual cycle 
                                 
                                                                
                                   
                                  Screening of dietary estrogens for its selective estrogen receptor modulatory (SERM) activity 
                                 
                                                            
 
                           
                          
                              
                           
                                                    
                            Publications:  
                           
                          
                            
	
		
			
				1. 
			
				Sreeja, S. , Anju, V. S. and Sreeja, S.  In vitro estrogenic activities of fenugreek Trigonella foenum graecum seeds. The Indian Journal of Medical Research.  2010.  131, 814-819. [PubMed]  
		 
		
			
				2. 
			
				Sreeja, S . and Sreeja, S.  An in vitro study on antiproliferative and antiestrogenic effects of Boerhaavia diffusa L. extracts. Journal of Ethnopharmacology.  2009.  126, 221-225. [PubMed]  
		 
		
			
				3. 
			
				Jacob, J., Sebastian, K. S., Devassy, S., Priyadarsini, L., Farook, M. F., Shameem, A., Mathew, D., Sreeja, S . and Thampan, R. V.  Membrane estrogen receptors: genomic actions and post transcriptional regulation. Molecular and Cellular Endocrinology.  2006.  246, 34-41. [PubMed]  
		 
		
			
				4. 
			
				Sreeja, S . and Thampan, R.  Functional roles of plasma membrane localized estrogen receptors. Indian Journal of Experimental Biology.  2003.  41, 740-747. [PubMed]  
		 
		
			
				5. 
			
				Sebastian, T., Sreeja, S . and Thampan, R. V.  Import and export of nuclear proteins: focus on the nucleocytoplasmic movements of two different species of mammalian estrogen receptor. Molecular and Cellular Biochemistry.  2004.  260, 91-102. [PubMed]  
		 
		
			
				6. 
			
				Sreeja, S . and Thampan, R. V.  Proteins which mediate the nuclear entry of goat uterine non activated estrogen receptor (naER) following naER internalization from the plasma membrane. Molecular and Cellular Biochemistry.  2004.  259, 141-148. [PubMed]  
		 
		
			
				7. 
			
				Sreeja, S . and Thampan, R. V.  Estradiol-mediated internalisation of the non-activated estrogen receptor from the goat uterine plasma membrane: identification of the proteins involved. Molecular and Cellular Biochemistry.  2004.  259, 131-140. [PubMed]  
		 
		
			
				8. 
			
				Govind, A. P., Sreeja, S . and Thampan, R. V.  Proteins that mediate the nuclear entry of the goat uterine estrogen receptor activation factor (E-RAF): identification of a molecular basis for the inhibitory effect of progesterone on estrogen action. Journal of Cellular Biochemistry.  2003.  89, 108-119. [PubMed]  
		 
		
			
				9. 
			
				Govind, A. P., Sreeja, S.  and Thampan, R. V.  Estradiol dependent anchoring of the goat uterine estrogen receptor activation factor (E-RAF) at the endoplasmic reticulum by a 55 kDa anchor protein (ap55). Journal of Cellular Biochemistry.  2003.  89, 94-107. [PubMed]  
		 
		
			
				10. 
			
				Thampan, R. V., Zafar, A., Imam, N. S., Sreeja, S ., Suma, K. and Vairamani, M.  Cholesterol inhibits the nuclear entry of estrogen receptor activation factor (E-RAF) and its dimerization with the nonactivated estrogen receptor (naER) in goat uterus. Journal of Cellular Biochemistry.  2000.  77, 382-395. [PubMed]  
		 
		
			
				11. 
			
				Aneef J and S.Sreeja . Phytoestrogens: An overview. The Icfai University journal of Biotechnology .2009. 3, 48-60. 
		 
	 
	 
  
                           
                         
                                                
 
                      
                          
                            
                                                                 
                                   
                             
                            
                                
                             
                            
                              
                                  
                                     
                                   
                                  
                                                                            
                                        
                                                                                    
                                            Education  
 
                                           
                                                                                    
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                                            Ph.D.                                                    in Biotechnology, 				
				 
                                                    University of Kerala                                                                        
 
                                           
                                                                                    
                                            Member 
 
                                           
                                                                                    
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                                            SBTI