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Priya Srinivas, Ph.D.
Scientist E-I 
 
Rajiv Gandhi Centre for Biotechnology
Thycaud, Poojappura
Thiruvananthapuram - 695 014   
Kerala   
 
E-mail: priyasrinivas@rgcb.res.in
Phone: +91-471-2529495
 
URL: http://rgcb.res.in/departments/cancer_research/priya-srinivas/profile.html
 
Positions Held:
Position Affiliation Time Period
Scientist E-I Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India 2000-Present
Visiting Scientist Mayo Clinic, Rochester, Minnesotta, USA 2009-2010
 
Area of Specialization:
Molecular Biology
Research Summary:
Functional characterization of plant derived quinones and their combinations- studying the molecular signature of apoptosis using in vivo strategies
Isolation, characterization and therapeutic interventions of breast cancer stem cells from BRCA1 knockout mouse models
Designing of metal based anticancer molecules functionally mimicking standard chemotherapeutic agents
 
Publications:
1. Somasundaram, V. and Srinivas, P.  Insights into the targeted elimination of BRCA1-defective cancer stem cells. Medicinal Research Reviews. 2010.  [PubMed]
2. Thasni, K. A., Rojini, G., Rakesh, S. N., Ratheeshkumar, T., Babu, M. S., Srinivas, G., Banerji, A. and Srinivas, P.  Genistein induces apoptosis in ovarian cancer cells via different molecular pathways depending on Breast Cancer Susceptibility gene-1 (BRCA1) status. European Journal of Pharmacology. 2008.  588, 158-164. [PubMed]
3. Babykutty, S., Padikkala, J., Sathiadevan, P. P., Vijayakurup, V., Azis, T. K., Srinivas, P. and Gopala, S.  Apoptosis induction of Centella asiatica on human breast cancer cells. African Journal of Traditional, Complementary, and Alternative Medicines : African Networks On Ethnomedicines. 2008.  6, 9-16. [PubMed]
4. Nair, S., Nair, R. R., Srinivas, P., Srinivas, G. and Pillai, M. R.  Radiosensitizing effects of plumbagin in cervical cancer cells is through modulation of apoptotic pathway. Molecular Carcinogenesis. 2008.  47, 22-33. [PubMed]
5. Srinivas, G., Babykutty, S., Sathiadevan, P. P. and Srinivas, P.  Molecular mechanism of emodin action: transition from laxative ingredient to an antitumor agent. Medicinal Research Reviews. 2007.  27, 591-608. [PubMed]
6. Srinivas, P., Gopinath, G., Banerji, A., Dinakar, A. and Srinivas, G.  Plumbagin induces reactive oxygen species, which mediate apoptosis in human cervical cancer cells. Molecular Carcinogenesis. 2004.  40, 201-211. [PubMed]
7. Srinivas, G., Annab, L. A., Gopinath, G., Banerji, A. and Srinivas, P.  Antisense blocking of BRCA1 enhances sensitivity to plumbagin but not tamoxifen in BG-1 ovarian cancer cells. Molecular Carcinogenesis. 2004.  39, 15-25. [PubMed]
8. Srinivas, G., Anto, R. J., Srinivas, P., Vidhyalakshmi, S., Senan, V. P. and Karunagaran, D.  Emodin induces apoptosis of human cervical cancer cells through poly(ADP-ribose) polymerase cleavage and activation of caspase-9. European Journal of Pharmacology. 2003.  473, 117-125. [PubMed]
9. Madhavan, M., Srinivas, P., Abraham, E., Ahmed, I., Vijayalekshmi, N. R. and Balaram, P.  Down regulation of endothelial adhesion molecules in node positive breast cancer: possible failure of host defence mechanism. Pathology Oncology Research. 2002.  8, 125-128. [PubMed]
10. Thasni, K. A., Rakesh, S., Rojini, G., Ratheeshkumar, T., Srinivas, G. and Priya, S.  Estrogen-dependent cell signaling and apoptosis in BRCA1-blocked BG1 ovarian cancer cells in response to plumbagin and other chemotherapeutic agents. Annals of Oncology. 2008.  19, 696-705. [PubMed]
11. Madhavan, M., Srinivas, P., Abraham, E., Ahmed, I., Mathew, A., Vijayalekshmi, N. R. and Balaram, P.  Cadherins as predictive markers of nodal metastasis in breast cancer. Modern Pathology. 2001.  14, 423-427. [PubMed]
12. Madhavan, M., Srinivas, P., Abraham, E., Ahmed, I., Vijayalekshmi, N. R. and Balaram, P.  Down regulation of endothelial adhesion molecules in node positive breast cancer: possible failure of host defence mechanism. Pathology Oncology Research. 2002.  8, 125-128. [PubMed]
13. Srinivas, P., Madhavan, M., Ahamed, I., Abraham, E., Vijayalakshmy, N. R. and Balaram, P.  Nm23H1 and p53 proteins are differentially correlated to metastasis in breast carcinoma. Neoplasma. 2002.  49, 225-230. [PubMed]
14. Srinivas, P., Abraham, E., Ahamed, I., Madhavan, M., Vijayalakshmi, N. R., Nair, M. K. and Balaram, P.  Apoptotic index: use in predicting recurrence in breast cancer patients. Journal of Experimental & Clinical Cancer Research. 2002.  21, 233-238. [PubMed]
15. T.R. Cibin, G. Srinivas, D. Gayathri Devi, Priya Srinivas and Annie Abraham. Antioxidant and Antiproliferative Effects of Flavonoids from Emilia sonchifolia Linn on Human Cancer Cells. International Journal of Pharmacology. 2006. 2, 520-524.
16. Hasni K A, Rakesh S Nair, Rojini G, Ratheesh kumar T, Srinivas Gopal, Asoke Banerjj, Priya Srinivas. Naphthaquinones - Promising anticancer agents against breast and ovarian cancer treatment. (Abstract) - Breast Cancer Research and Treatment,2007, Vol 106, Supplement 1.
17. T.R. Cibin,G.Srinvas, D. Gayathri Devi, Priya Srinivas and Annie Abraham. Antioxidant and Antiproliferative Effects of Flavonoids from Emilia sonchifolia Linn on Human Cancer Cells. International Journal of Pharmacology. 2006. 2, 520-524.

 
Grant Support:
Project Title Role Funding Agency Sanction Number Sanction Date
Mechanisms of anticancer activity of emodin/aloe emodin: effects on cell growth, angiogenesis and metastasis in human colon cancer cells. Co-PI Department of Atomic Energy, Government of India
Studies on matrix metalloproteinsase (MMP) gene transcription by nitric oxide: mechanism of MMP gene induction in human colon cancer cells. Co-PI Department of Biotechnology, Government of India
Molecular evidence for potential use of plumbagin in brca1 blocked/ mutated cancers. Investigator Department of Biotechnology, Government of India
Effects of phytoestrogens (emodin & genistein) on BRCA1 blocked ovarian cancer cells. Principal Investigator Indian Council of Medical Research, Goverment of India
Potential role of plumbagin as an anticancer agent in brca1 blocked ovarian cancer cells: comparison with standard chemotherapeutic agents Principal Investigator Department of Science & Technology, Government of India
Selective gene expression by plumbagin in BRCA1 blocked ovarian cancer cells: An analysis by subtractive hybridization Principal Investigator Kerala State Council for Science Technology and Environment, Government of Kerala, India

 
 
 
Education 
::
M.Sc. Mahatma Gandhi University, Kerala
::
Ph.D. Regional Cancer Centre, University of Kerala,Thiruvananthapuram, India
Honors and Awards
::
2008, DBT Overseas Fellowship 2008-09
::
2008, AACR-NCI International Investigator Opportunity Grants in recognition of the need to globalize cancer research and to equalize the exchange of scientific knowledge -- presented at AACR meeting at Washington DC
::
2004, DST Young Scientist Project (Fast Track Scheme)
Member
::
Biotechnology Research Society of India
::
Society for Biotechnologists, India
::
Third World Organization for Women in Science
::
American Association for Cancer Research
Type of Neoplasms
Breast
Female, Male
Gastrointestinal tract
Colon
Female genital system
Ovaries
  Last modified on : Mar 4, 2011
India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.