INCREDB ID : 52
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S. Asha Nair, Ph.D.
Scientist E-I 
 
Rajiv Gandhi Centre for Biotechnology
Thycaud, Poojappura
Thiruvananthapuram - 695 014   
Kerala   
 
E-mail: sasha@rgcb.res.in
Phone: +91-471-2529501
 
URL: http://rgcb.res.in/departments/cancer_research/s-asha-nair/profile.html
 
Positions Held:
Position Affiliation Time Period
Scientist E-I Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India 2006-Present
Post Doctoral Fellowship MD Anderson Cancer Centre, Houston, Texas, USA. 2005-2005
Research fellow Harvard Medical School, Boston, USA 2004-2004
Principal Investigator Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India 2001-2004
Post Doctoral Fellowship Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India 1999-2001
 
Area of Specialization:
Oncology
Research Summary:
Identification of tumor primordial cells in colorectal cancers
Validation of a new molecular target CKS1 in cancer therapeutics
Investigation of functional role of CKS1 in oral tumor initiation and progression
Molecular profiling of SMURF2 in breast cancer
Peroxisomal proliferator activated receptor gamma role as a breast cancer promoter or tumor inhibitor
In vitro studies of novel sensitizers for photodynamic therapy
 
Publications:
1. Krishnan, V., Krishnan, A., Remya, R., Ravikumar, K. K., Nair, S. A., Shibli, S. M., Varma, H. K., Sukumaran, K. and Kumar, K. J.  Development and evaluation of two PVD-coated beta-titanium orthodontic archwires for fluoride-induced corrosion protection. Acta Biomaterialia. 2010.  [PubMed]
2. Ramshid, P. K., Jagadeeshan, S., Krishnan, A., Mathew, M., Nair, S. A. and Pillai, M. R.  Synthesis and in vitro evaluation of some isatin-thiazolidinone hybrid analogues as anti-proliferative agents. Medicinal Chemistry. 2010.  6, 306-312. [PubMed]
3. Krishnan, A., Nair, S. A. and Pillai, M. R.  Loss of cks1 homeostasis deregulates cell division cycle. Journal of Cellular and Molecular Medicine. 2010.  14, 154-164. [PubMed]
4. Krishnan, A., Hariharan, R., Nair, S. A. and Pillai, M. R.  Fluoxetine mediates G0/G1 arrest by inducing functional inhibition of cyclin dependent kinase subunit (CKS)1. Biochemical Pharmacology. 2008.  75, 1924-1934. [PubMed]
5. Krishnan, A., Nair, S. A. and Pillai, M. R.  Biology of PPAR gamma in cancer: a critical review on existing lacunae. Current Molecular Medicine. 2007.  7, 532-540. [PubMed]
6. Carcinogenesis program In: Cervical Cancer in Developing Countries (eds-Bhattathiri VN, Rajan B, Blake P, Nair MK), Trivandrum, Regional Cancer Centre Publication division, 1993 pp 34-38.
7. Lakshmi S., S Asha Nair, Jayasree K., Jayaprakash P. G., Rajalekshmy T. N., Kannan S., Pillai M. R. Argyrophilic nucleolar organizer regions (AgNORs) in inflammatory, premalignant and malignant lesions of the uterine cervix. Cancer Letter. 1993, 71: 197-201.
8. S Asha Nair, Kannan S., Lakshmi S., Nair M. K., and Pillai. M. R. The basement membrane and its role in cancer.Journal of Experimental & Clinical Cancer Reserch.1994, 13: 195-201.
9. Lakshmi S., Pillai M. R., S Asha Nair, Jayaprakash P. J., and Nair M. K.Cancer of the uterine cervix: integration of molecular evaluation into management strategy and the concept of biological staging. Currerent Science.1995, 68: 45-52.
10. S Asha Nair, Lakshmi S., Kannan S., Nair M. K., and Pillai M. R.Cytokeratins and tumor progression in the uterine cervix. Journal of Experimental & Clinical Cancer.1995, 14: 131-138
11. Lakshmi S., Pillai M. R., Rajalekshmy T. N., Gopalakrishnan K., Nandini V. R., S Asha Nair, and Nair M.K.Human papillomavirus infection and cervical pre-cancer implications for management and control. Journal of Experimental & Clinical Cancer Research.1995, 68: 45-52.
12. S Asha Nair, Nair M. B., Jayaprakash P. J., Rajalekshmy T. N., Nair M. K., and Pillai M. R.Involucrin and tumor progression in the uterine cervix. Pathobiology.1997, 64: 333-338.
13. S Asha Nair, Nair M. B., Jayaprakash P. J., Rajalekshmy T. N., Nair M. K., and Pillai M. R.Increased expression of cytokeratins 14, 18 and 19 correlates with tumor progression in the uterine cervix. Pathobiology.1997, 65: 100-107.
14. S Asha Nair, Nair M. B., Jayaprakash P. J., Rajalekshmy T. N., Nair M. K., and Pillai M. R.The basement membrane and tumor progression in the uterine cervix.General and Diagnostic Pathology.1997, 142: 297-303.
15. S Asha Nair, Nair M. B., Jayaprakash P. J., Rajalekshmy T. N., Nair M. K., and Pillai M. R.Cytokeratin and the evaluation of tumor differentiation in squamous lesions of the uterine cervix .General and Diagnostic Pathology. 1997, 143:15-22.
16. S Asha Nair, Nair M. B., Jayaprakash P. J., Rajalekshmy T. N., Nair M. K., and Pillai M. R. Ras and c-myc oncoproteins during tumor progression in the uterine cervix. Tumorigenesis.1998, 84: 583-588.
17. D. Karunagaran and S Asha Nair. Relevance of Rel signaling in cancer Amala Research Bulletin.2001, 21: 1-3.
18. S Asha Nair, Venkatraman M., Malieckal TT., Nair M., and Karunagaran D.NF-B Is Constitutively Activated In High Grade Squamous Intraepithelial Lesions and Squamous Cell Carcinomas of the Human Uterine Cervix. Oncogene.2003, 22: 50-58.
19. S Asha Nair, Karunagaran D., Nair M. B., and Sudhakara P. R.Changes in matrix metalloproteinase and their endogenous inhibitors during tumor progression in the uterine cervix. Journal of Cancer Research and Clinical Oncology.2003, 129: 123-131.
20. Malieckal TT., Antony ML., S Asha Nair, Paulmurugan R., and Karunagaran D. (Loss of expression, and mutations of smad 2 and smad 4 in human cervical cancer. Oncogene.2003, 22: 4889-4892.
21. Smitha VB., Vinesh Kumar TP., Ayswaria Deepti.,S Asha Nair, Devarajan Karunagaran., and Ruby John Anto.Sensitization of taxol-induced apoptosis by curcumin involves down-regulation of Nuclear Factor-B and the serine/threonine kinase Akt and is independent of tubulin polymerization. Journal Biological Chemistry.2005, 280(8):6301-8.
22. Manickam Venkatraman, Ruby John Anto,S Asha Nair, Merina Varghese and Devarajan Karunagaran.Biological and chemical inhibitors of NF-?B sensitize SiHa cells to cisplatin-induced apoptosis. Molecular Carcinogenesis.2005, 44(1):51-59.
23. Bharat B. Aggarwal, Gautam Sethi,S Asha Nair and Haruyo Ichikawa.Nuclear Factor (NF)-
24. Bharat B. Aggarwal, Haruyo Ichikawa, Kwang Seok Ahn, Gautam Sethi, S Asha Nair , Santhosh K Sandur, Indra Bhatt and Shishir Shishodia.TNF Superfamily: The Holy Grail in Molecular Medicine.2005.

 
 
Education 
::
M.Sc. in Zoology, University of Kerala
::
Ph.D. in Tumor Biology, RCC -University of Kerala
Honors and Awards
::
DST Young Scientist Award
Member
::
Society of Biological Chemists
::
Indian Association for Cancer Research
::
Society for Biotechnologists-India
Type of Neoplasms
Gastrointestinal tract
Colon
  Last modified on : Mar 4, 2011
India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.