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Bushra Ateeq, Ph.D.
Assistant Professor 
Indian Institute of Technology
Department of Biological Sciences & Bioengineering
Kanpur - 208 016   
Phone: +91 512 2594083
Fax: +91 512 2594010
Area of Specialization:
Molecular Oncology and therapeutics


1. Khan, A. P., Rajendiran, T. M., Ateeq, B., Asangani, I. A., Athanikar, J. N., Yocum, A. K., Mehra, R., Siddiqui, J., Palapattu, G., Wei, J. T., Michailidis, G., Sreekumar, A. and Chinnaiyan, A. M.  The role of sarcosine metabolism in prostate cancer progression. Neoplasia. 2013.  15, 491-501. [PubMed]
2. Wang, R., Asangani, I. A., Chakravarthi, B. V., Ateeq, B., Lonigro, R. J., Cao, Q., Mani, R. S., Camacho, D. F., McGregor, N., Schumann, T. E., Jing, X., Menawat, R., Tomlins, S. A., Zheng, H., Otte, A. P., Mehra, R., Siddiqui, J., Dhanasekaran, S. M., Nyati, M. K., Pienta, K. J., Palanisamy, N., Kunju, L. P., Rubin, M. A., Chinnaiyan, A. M. and Varambally, S.  Role of transcriptional corepressor CtBP1 in prostate cancer progression. Neoplasia. 2012.  14, 905-914. [PubMed]
3. Wang, X. S., Shankar, S., Dhanasekaran, S. M., Ateeq, B., Sasaki, A. T., Jing, X., Robinson, D., Cao, Q., Prensner, J. R., Yocum, A. K., Wang, R., Fries, D. F., Han, B., Asangani, I. A., Cao, X., Li, Y., Omenn, G. S., Pflueger, D., Gopalan, A., Reuter, V. E., Kahoud, E. R., Cantley, L. C., Rubin, M. A., Palanisamy, N., Varambally, S. and Chinnaiyan, A. M.  Characterization of KRAS rearrangements in metastatic prostate cancer. Cancer Discovery. 2011.  1, 35-43. [PubMed]
4. Ateeq, B., Tomlins, S. A., Laxman, B., Asangani, I. A., Cao, Q., Cao, X., Li, Y., Wang, X., Feng, F. Y., Pienta, K. J., Varambally, S. and Chinnaiyan, A. M.  Therapeutic targeting of SPINK1-positive prostate cancer. Science Translational Medicine. 2011.  3, 72ra17. [PubMed]
5. Brenner, J. C., Ateeq, B., Li, Y., Yocum, A. K., Cao, Q., Asangani, I. A., Patel, S., Wang, X., Liang, H., Yu, J., Palanisamy, N., Siddiqui, J., Yan, W., Cao, X., Mehra, R., Sabolch, A., Basrur, V., Lonigro, R. J., Yang, J., Tomlins, S. A., Maher, C. A., Elenitoba-Johnson, K. S., Hussain, M., Navone, N. M., Pienta, K. J., Varambally, S., Feng, F. Y. and Chinnaiyan, A. M.  Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer. Cancer Cell. 2011.  19, 664-678. [PubMed]
6. Grasso, C. S., Wu, Y. M., Robinson, D. R., Cao, X., Dhanasekaran, S. M., Khan, A. P., Quist, M. J., Jing, X., Lonigro, R. J., Brenner, J. C., Asangani, I. A., Ateeq, B., Chun, S. Y., Siddiqui, J., Sam, L., Anstett, M., Mehra, R., Prensner, J. R., Palanisamy, N., Ryslik, G. A., Vandin, F., Raphael, B. J., Kunju, L. P., Rhodes, D. R., Pienta, K. J., Chinnaiyan, A. M. and Tomlins, S. A.  The mutational landscape of lethal castration-resistant prostate cancer. Nature. 2012.  487, 239-243. [PubMed]
7. Robinson, D. R., Kalyana-Sundaram, S., Wu, Y. M., Shankar, S., Cao, X., Ateeq, B., Asangani, I. A., Iyer, M., Maher, C. A., Grasso, C. S., Lonigro, R. J., Quist, M., Siddiqui, J., Mehra, R., Jing, X., Giordano, T. J., Sabel, M. S., Kleer, C. G., Palanisamy, N., Natrajan, R., Lambros, M. B., Reis-Filho, J. S., Kumar-Sinha, C. and Chinnaiyan, A. M.  Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer. Nature Medicine. 2011.  17, 1646-1651. [PubMed]
8. Asangani, I. A., Ateeq, B., Cao, Q., Dodson, L., Pandhi, M., Kunju, L. P., Mehra, R., Lonigro, R. J., Siddiqui, J., Palanisamy, N., Wu, Y. M., Cao, X., Kim, J. H., Zhao, M., Qin, Z. S., Iyer, M. K., Maher, C. A., Kumar-Sinha, C., Varambally, S. and Chinnaiyan, A. M.  Characterization of the EZH2-MMSET histone methyltransferase regulatory axis in cancer. Molecular Cell. 2013.  49, 80-93. [PubMed]
9. Cao, Q., Mani, R. S., Ateeq, B., Dhanasekaran, S. M., Asangani, I. A., Prensner, J. R., Kim, J. H., Brenner, J. C., Jing, X., Cao, X., Wang, R., Li, Y., Dahiya, A., Wang, L., Pandhi, M., Lonigro, R. J., Wu, Y. M., Tomlins, S. A., Palanisamy, N., Qin, Z., Yu, J., Maher, C. A., Varambally, S. and Chinnaiyan, A. M.  Coordinated regulation of polycomb group complexes through microRNAs in cancer. Cancer Cell. 2011.  20, 187-199. [PubMed]
10. Palanisamy, N., Ateeq, B., Kalyana-Sundaram, S., Pflueger, D., Ramnarayanan, K., Shankar, S., Han, B., Cao, Q., Cao, X., Suleman, K., Kumar-Sinha, C., Dhanasekaran, S. M., Chen, Y. B., Esgueva, R., Banerjee, S., LaFargue, C. J., Siddiqui, J., Demichelis, F., Moeller, P., Bismar, T. A., Kuefer, R., Fullen, D. R., Johnson, T. M., Greenson, J. K., Giordano, T. J., Tan, P., Tomlins, S. A., Varambally, S., Rubin, M. A., Maher, C. A. and Chinnaiyan, A. M.  Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma. Nature Medicine. 2010.  16, 793-798. [PubMed]
11. Varambally, S., Cao, Q., Mani, R. S., Shankar, S., Wang, X., Ateeq, B., Laxman, B., Cao, X., Jing, X., Ramnarayanan, K., Brenner, J. C., Yu, J., Kim, J. H., Han, B., Tan, P., Kumar-Sinha, C., Lonigro, R. J., Palanisamy, N., Maher, C. A. and Chinnaiyan, A. M.  Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer. Science. 2008.  322, 1695-1699. [PubMed]
12. Rhodes, D. R., Ateeq, B., Cao, Q., Tomlins, S. A., Mehra, R., Laxman, B., Kalyana-Sundaram, S., Lonigro, R. J., Helgeson, B. E., Bhojani, M. S., Rehemtulla, A., Kleer, C. G., Hayes, D. F., Lucas, P. C., Varambally, S. and Chinnaiyan, A. M.  AGTR1 overexpression defines a subset of breast cancer and confers sensitivity to losartan, an AGTR1 antagonist. Proceedings of the National Academy of Sciences of the United States of America. 2009.  106, 10284-10289. [PubMed]
13. Wu, Y. M., Su, F., Kalyana-Sundaram, S., Khazanov, N., Ateeq, B., Cao, X., Lonigro, R. J., Vats, P., Wang, R., Lin, S. F., Cheng, A. J., Kunju, L. P., Siddiqui, J., Tomlins, S. A., Wyngaard, P., Sadis, S., Roychowdhury, S., Hussain, M. H., Feng, F. Y., Zalupski, M. M., Talpaz, M., Pienta, K. J., Rhodes, D. R., Robinson, D. R. and Chinnaiyan, A. M.  Identification of targetable FGFR gene fusions in diverse cancers. Cancer Discovery. 2013.  3, 636-647. [PubMed]
14. Ateeq, B., Tomlins, S. A. and Chinnaiyan, A. M.  AGTR1 as a therapeutic target in ER-positive and ERBB2-negative breast cancer cases. Cell Cycle. 2009.  8, 3794-3795. [PubMed]
15. Ateeq, B., Vellaichamy, A., Tomlins, S. A., Wang, R., Cao, Q., Lonigro, R. J., Pienta, K. J. and Varambally, S.  Role of dutasteride in pre-clinical ETS fusion-positive prostate cancer models. The Prostate. 2012.  72, 1542-1549. [PubMed]
16. Rabbani, S. A., Ateeq, B., Arakelian, A., Valentino, M. L., Shaw, D. E., Dauffenbach, L. M., Kerfoot, C. A. and Mazar, A. P.  An anti-urokinase plasminogen activator receptor antibody (ATN-658) blocks prostate cancer invasion, migration, growth, and experimental skeletal metastasis in vitro and in vivo. Neoplasia. 2010.  12, 778-788. [PubMed]
17. Ateeq, B., Unterberger, A., Szyf, M. and Rabbani, S. A.  Pharmacological inhibition of DNA methylation induces proinvasive and prometastatic genes in vitro and in vivo. Neoplasia. 2008.  10, 266-278. [PubMed]
18. Sen, S., Ateeq, B., Sharma, H., Datta, P., Gupta, S. D., Bal, S., Kumar, A. and Singh, N.  Molecular profiling of genes in squamous cell lung carcinoma in Asian Indians. Life Sciences. 2008.  82, 772-779. [PubMed]
19. Ateeq, B., Farah, M. A. and Ahmad, W.  Evidence of apoptotic effects of 2,4-D and butachlor on walking catfish, Clarias batrachus, by transmission electron microscopy and DNA degradation studies. Life Sciences. 2006.  78, 977-986. [PubMed]
20. Ateeq, B., Abul, F. and Ahmad, W.  Detection of DNA damage by alkaline single cell gel electrophoresis in 2,4-dichlorophenoxyacetic-acid- and butachlor-exposed erythrocytes of Clarias batrachus. Ecotoxicology and Environmental Safety. 2005.  62, 348-354. [PubMed]
21. Ateeq, B., Abul, f., Niamat, A. l. i. and Ahmad, W.  Induction of micronuclei and erythrocyte alterations in the catfish Clarias batrachus by 2,4-dichlorophenoxyacetic acid and butachlor. Mutation Research. 2002.  518, 135-144. [PubMed]
22. Farah, M. A., Ateeq, B., Ali, M. N., Sabir, R. and Ahmad, W.  Studies on lethal concentrations and toxicity stress of some xenobiotics on aquatic organisms. Chemosphere. 2004.  55, 257-265. [PubMed]
23. Ateeq, B., Abul, F., Niamat, A. l. i. and Ahmad, W.  Clastogenicity of pentachlorophenol, 2,4-D and butachlor evaluated by Allium root tip test. Mutation Research. 2002.  514, 105-113. [PubMed]
24. Farah, M. A., Ateeq, B., Ali, M. N. and Ahmad, W.  Evaluation of genotoxicity of PCP and 2,4-D by micronucleus test in freshwater fish Channa punctatus. Ecotoxicology and Environmental Safety. 2003.  54, 25-29. [PubMed]
25. Farah, M. A., Ateeq, B. and Ahmad, W.  Antimutagenic effect of neem leaves extract in freshwater fish, Channa punctatus evaluated by cytogenetic tests. The Science of the Total Environment. 2006.  364, 200-214. [PubMed]
26. Ahmad, W., Ali, M. N., Farah, M. A. and Ateeq, B.  Computerized automated morphometric assay including frequency estimation of pentachlorophenol induced nuclear anomalies (micronucleus) in catfish Heteropneustes fossilis. Chromosoma. 2002.  110, 570-574. [PubMed]


Grant Support:
Project Title Role Funding Agency Sanction Number Sanction Date
Role of SPINK1 in Cancer Progression: Regulatory Mechanisms and Therapeutic Target Potential Principal Investigator Wellcome Trust-DBT India Alliance


Ph.D. in Genetics, Aligarh Muslim University, Aligarh, India
Honors and Awards
Ramanujan fellowship From Department of Science and Technology, India (Declined)
Wellcome Trust-DBT India Alliance Intermediate Award
2011, AACR Women in Cancer Research Scholar Award at the annual meeting of American Association of Cancer Research, Orlando, FL
2009, Young Investigator Award from Expedition Inspiration Fund for Breast Cancer Research, Ketchum, Idaho, USA
Genentech Postdoctoral Award from the Genentech Foundation, South San Francisco, CA
American Association for Cancer Research, AACR
Indian Association for Cancer Research, IACR
Environmental Mutagen Society of India, EMSI
  Last modified on : Dec 10, 2015
India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.