INCREDB ID : 474
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Bushra Ateeq, Ph.D.
Assistant Professor 
 
Indian Institute of Technology
Department of Biological Sciences & Bioengineering
Kanpur - 208 016   
 
E-mail: bushra@iitk.ac.in
Phone: +91 512 2594083
Fax: +91 512 2594010
 
URL: http://iitk.ac.in/new/bushra-ateeq
 
Area of Specialization:
Molecular Oncology and therapeutics
Publications:

 

1. Khan, A. P., Rajendiran, T. M., Ateeq, B., Asangani, I. A., Athanikar, J. N., Yocum, A. K., Mehra, R., Siddiqui, J., Palapattu, G., Wei, J. T., Michailidis, G., Sreekumar, A. and Chinnaiyan, A. M.  The role of sarcosine metabolism in prostate cancer progression. Neoplasia. 2013.  15, 491-501. [PubMed]
2. Wang, R., Asangani, I. A., Chakravarthi, B. V., Ateeq, B., Lonigro, R. J., Cao, Q., Mani, R. S., Camacho, D. F., McGregor, N., Schumann, T. E., Jing, X., Menawat, R., Tomlins, S. A., Zheng, H., Otte, A. P., Mehra, R., Siddiqui, J., Dhanasekaran, S. M., Nyati, M. K., Pienta, K. J., Palanisamy, N., Kunju, L. P., Rubin, M. A., Chinnaiyan, A. M. and Varambally, S.  Role of transcriptional corepressor CtBP1 in prostate cancer progression. Neoplasia. 2012.  14, 905-914. [PubMed]
3. Wang, X. S., Shankar, S., Dhanasekaran, S. M., Ateeq, B., Sasaki, A. T., Jing, X., Robinson, D., Cao, Q., Prensner, J. R., Yocum, A. K., Wang, R., Fries, D. F., Han, B., Asangani, I. A., Cao, X., Li, Y., Omenn, G. S., Pflueger, D., Gopalan, A., Reuter, V. E., Kahoud, E. R., Cantley, L. C., Rubin, M. A., Palanisamy, N., Varambally, S. and Chinnaiyan, A. M.  Characterization of KRAS rearrangements in metastatic prostate cancer. Cancer Discovery. 2011.  1, 35-43. [PubMed]
4. Ateeq, B., Tomlins, S. A., Laxman, B., Asangani, I. A., Cao, Q., Cao, X., Li, Y., Wang, X., Feng, F. Y., Pienta, K. J., Varambally, S. and Chinnaiyan, A. M.  Therapeutic targeting of SPINK1-positive prostate cancer. Science Translational Medicine. 2011.  3, 72ra17. [PubMed]
5. Brenner, J. C., Ateeq, B., Li, Y., Yocum, A. K., Cao, Q., Asangani, I. A., Patel, S., Wang, X., Liang, H., Yu, J., Palanisamy, N., Siddiqui, J., Yan, W., Cao, X., Mehra, R., Sabolch, A., Basrur, V., Lonigro, R. J., Yang, J., Tomlins, S. A., Maher, C. A., Elenitoba-Johnson, K. S., Hussain, M., Navone, N. M., Pienta, K. J., Varambally, S., Feng, F. Y. and Chinnaiyan, A. M.  Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer. Cancer Cell. 2011.  19, 664-678. [PubMed]
6. Grasso, C. S., Wu, Y. M., Robinson, D. R., Cao, X., Dhanasekaran, S. M., Khan, A. P., Quist, M. J., Jing, X., Lonigro, R. J., Brenner, J. C., Asangani, I. A., Ateeq, B., Chun, S. Y., Siddiqui, J., Sam, L., Anstett, M., Mehra, R., Prensner, J. R., Palanisamy, N., Ryslik, G. A., Vandin, F., Raphael, B. J., Kunju, L. P., Rhodes, D. R., Pienta, K. J., Chinnaiyan, A. M. and Tomlins, S. A.  The mutational landscape of lethal castration-resistant prostate cancer. Nature. 2012.  487, 239-243. [PubMed]
7. Robinson, D. R., Kalyana-Sundaram, S., Wu, Y. M., Shankar, S., Cao, X., Ateeq, B., Asangani, I. A., Iyer, M., Maher, C. A., Grasso, C. S., Lonigro, R. J., Quist, M., Siddiqui, J., Mehra, R., Jing, X., Giordano, T. J., Sabel, M. S., Kleer, C. G., Palanisamy, N., Natrajan, R., Lambros, M. B., Reis-Filho, J. S., Kumar-Sinha, C. and Chinnaiyan, A. M.  Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer. Nature Medicine. 2011.  17, 1646-1651. [PubMed]
8. Asangani, I. A., Ateeq, B., Cao, Q., Dodson, L., Pandhi, M., Kunju, L. P., Mehra, R., Lonigro, R. J., Siddiqui, J., Palanisamy, N., Wu, Y. M., Cao, X., Kim, J. H., Zhao, M., Qin, Z. S., Iyer, M. K., Maher, C. A., Kumar-Sinha, C., Varambally, S. and Chinnaiyan, A. M.  Characterization of the EZH2-MMSET histone methyltransferase regulatory axis in cancer. Molecular Cell. 2013.  49, 80-93. [PubMed]
9. Cao, Q., Mani, R. S., Ateeq, B., Dhanasekaran, S. M., Asangani, I. A., Prensner, J. R., Kim, J. H., Brenner, J. C., Jing, X., Cao, X., Wang, R., Li, Y., Dahiya, A., Wang, L., Pandhi, M., Lonigro, R. J., Wu, Y. M., Tomlins, S. A., Palanisamy, N., Qin, Z., Yu, J., Maher, C. A., Varambally, S. and Chinnaiyan, A. M.  Coordinated regulation of polycomb group complexes through microRNAs in cancer. Cancer Cell. 2011.  20, 187-199. [PubMed]
10. Palanisamy, N., Ateeq, B., Kalyana-Sundaram, S., Pflueger, D., Ramnarayanan, K., Shankar, S., Han, B., Cao, Q., Cao, X., Suleman, K., Kumar-Sinha, C., Dhanasekaran, S. M., Chen, Y. B., Esgueva, R., Banerjee, S., LaFargue, C. J., Siddiqui, J., Demichelis, F., Moeller, P., Bismar, T. A., Kuefer, R., Fullen, D. R., Johnson, T. M., Greenson, J. K., Giordano, T. J., Tan, P., Tomlins, S. A., Varambally, S., Rubin, M. A., Maher, C. A. and Chinnaiyan, A. M.  Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma. Nature Medicine. 2010.  16, 793-798. [PubMed]
11. Varambally, S., Cao, Q., Mani, R. S., Shankar, S., Wang, X., Ateeq, B., Laxman, B., Cao, X., Jing, X., Ramnarayanan, K., Brenner, J. C., Yu, J., Kim, J. H., Han, B., Tan, P., Kumar-Sinha, C., Lonigro, R. J., Palanisamy, N., Maher, C. A. and Chinnaiyan, A. M.  Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer. Science. 2008.  322, 1695-1699. [PubMed]
12. Rhodes, D. R., Ateeq, B., Cao, Q., Tomlins, S. A., Mehra, R., Laxman, B., Kalyana-Sundaram, S., Lonigro, R. J., Helgeson, B. E., Bhojani, M. S., Rehemtulla, A., Kleer, C. G., Hayes, D. F., Lucas, P. C., Varambally, S. and Chinnaiyan, A. M.  AGTR1 overexpression defines a subset of breast cancer and confers sensitivity to losartan, an AGTR1 antagonist. Proceedings of the National Academy of Sciences of the United States of America. 2009.  106, 10284-10289. [PubMed]
13. Wu, Y. M., Su, F., Kalyana-Sundaram, S., Khazanov, N., Ateeq, B., Cao, X., Lonigro, R. J., Vats, P., Wang, R., Lin, S. F., Cheng, A. J., Kunju, L. P., Siddiqui, J., Tomlins, S. A., Wyngaard, P., Sadis, S., Roychowdhury, S., Hussain, M. H., Feng, F. Y., Zalupski, M. M., Talpaz, M., Pienta, K. J., Rhodes, D. R., Robinson, D. R. and Chinnaiyan, A. M.  Identification of targetable FGFR gene fusions in diverse cancers. Cancer Discovery. 2013.  3, 636-647. [PubMed]
14. Ateeq, B., Tomlins, S. A. and Chinnaiyan, A. M.  AGTR1 as a therapeutic target in ER-positive and ERBB2-negative breast cancer cases. Cell Cycle. 2009.  8, 3794-3795. [PubMed]
15. Ateeq, B., Vellaichamy, A., Tomlins, S. A., Wang, R., Cao, Q., Lonigro, R. J., Pienta, K. J. and Varambally, S.  Role of dutasteride in pre-clinical ETS fusion-positive prostate cancer models. The Prostate. 2012.  72, 1542-1549. [PubMed]
16. Rabbani, S. A., Ateeq, B., Arakelian, A., Valentino, M. L., Shaw, D. E., Dauffenbach, L. M., Kerfoot, C. A. and Mazar, A. P.  An anti-urokinase plasminogen activator receptor antibody (ATN-658) blocks prostate cancer invasion, migration, growth, and experimental skeletal metastasis in vitro and in vivo. Neoplasia. 2010.  12, 778-788. [PubMed]
17. Ateeq, B., Unterberger, A., Szyf, M. and Rabbani, S. A.  Pharmacological inhibition of DNA methylation induces proinvasive and prometastatic genes in vitro and in vivo. Neoplasia. 2008.  10, 266-278. [PubMed]
18. Sen, S., Ateeq, B., Sharma, H., Datta, P., Gupta, S. D., Bal, S., Kumar, A. and Singh, N.  Molecular profiling of genes in squamous cell lung carcinoma in Asian Indians. Life Sciences. 2008.  82, 772-779. [PubMed]
19. Ateeq, B., Farah, M. A. and Ahmad, W.  Evidence of apoptotic effects of 2,4-D and butachlor on walking catfish, Clarias batrachus, by transmission electron microscopy and DNA degradation studies. Life Sciences. 2006.  78, 977-986. [PubMed]
20. Ateeq, B., Abul, F. and Ahmad, W.  Detection of DNA damage by alkaline single cell gel electrophoresis in 2,4-dichlorophenoxyacetic-acid- and butachlor-exposed erythrocytes of Clarias batrachus. Ecotoxicology and Environmental Safety. 2005.  62, 348-354. [PubMed]
21. Ateeq, B., Abul, f., Niamat, A. l. i. and Ahmad, W.  Induction of micronuclei and erythrocyte alterations in the catfish Clarias batrachus by 2,4-dichlorophenoxyacetic acid and butachlor. Mutation Research. 2002.  518, 135-144. [PubMed]
22. Farah, M. A., Ateeq, B., Ali, M. N., Sabir, R. and Ahmad, W.  Studies on lethal concentrations and toxicity stress of some xenobiotics on aquatic organisms. Chemosphere. 2004.  55, 257-265. [PubMed]
23. Ateeq, B., Abul, F., Niamat, A. l. i. and Ahmad, W.  Clastogenicity of pentachlorophenol, 2,4-D and butachlor evaluated by Allium root tip test. Mutation Research. 2002.  514, 105-113. [PubMed]
24. Farah, M. A., Ateeq, B., Ali, M. N. and Ahmad, W.  Evaluation of genotoxicity of PCP and 2,4-D by micronucleus test in freshwater fish Channa punctatus. Ecotoxicology and Environmental Safety. 2003.  54, 25-29. [PubMed]
25. Farah, M. A., Ateeq, B. and Ahmad, W.  Antimutagenic effect of neem leaves extract in freshwater fish, Channa punctatus evaluated by cytogenetic tests. The Science of the Total Environment. 2006.  364, 200-214. [PubMed]
26. Ahmad, W., Ali, M. N., Farah, M. A. and Ateeq, B.  Computerized automated morphometric assay including frequency estimation of pentachlorophenol induced nuclear anomalies (micronucleus) in catfish Heteropneustes fossilis. Chromosoma. 2002.  110, 570-574. [PubMed]
 

 
Grant Support:
Project Title Role Funding Agency Sanction Number Sanction Date
Role of SPINK1 in Cancer Progression: Regulatory Mechanisms and Therapeutic Target Potential Principal Investigator Wellcome Trust-DBT India Alliance

 
 
 
Education 
::
Ph.D. in Genetics, Aligarh Muslim University, Aligarh, India
Honors and Awards
::
Ramanujan fellowship From Department of Science and Technology, India (Declined)
::
Wellcome Trust-DBT India Alliance Intermediate Award
::
2011, AACR Women in Cancer Research Scholar Award at the annual meeting of American Association of Cancer Research, Orlando, FL
::
2009, Young Investigator Award from Expedition Inspiration Fund for Breast Cancer Research, Ketchum, Idaho, USA
::
Genentech Postdoctoral Award from the Genentech Foundation, South San Francisco, CA
Member
::
American Association for Cancer Research, AACR
::
Indian Association for Cancer Research, IACR
::
Environmental Mutagen Society of India, EMSI
  Last modified on : Dec 10, 2015
India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.