INCREDB ID : 465
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P. Ajitkumar, Ph.D.
Associate Professor 
 
Indian Institute of Science
Department of Microbiology and Cell Biology
Banglore - 560 -012   
Karnataka   
 
E-mail: ajit@mcbl.iisc.ernet.in
Phone: 080 - 2293 2344
 
URL: http://mcbl.iisc.ernet.in/ajitkumar/research.html
 
Publications:
1. Roy, S. and Ajitkumar, P.  Transcriptional analysis of the principal cell division gene, ftsZ, of Mycobacterium tuberculosis. Journal of Bacteriology. 2005.  187, 2540-2550. [PubMed]
2. Roy, S., Mir, M. A., Anand, S. P., Niederweis, M. and Ajitkumar, P.  Identification and semi-quantitative analysis of Mycobacterium tuberculosis H37Rv ftsZ gene-specific promoter activity-containing regions. Research in Microbiology. 2004.  155, 817-826. [PubMed]
3. Roy, S., Vijay, S., Arumugam, M., Anand, D., Mir, M. and Ajitkumar, P.  Mycobacterium tuberculosis expresses ftsE gene through multiple transcripts. Current Microbiology. 2011.  62, 1581-1589. [PubMed]
4. Roy, S., Narayana, Y., Balaji, K. N. and Ajitkumar, P.  Highly fluorescent GFPm 2+ -based genome integration-proficient promoter probe vector to study Mycobacterium tuberculosis promoters in infected macrophages. Microbial Biotechnology. 2012.  5, 98-105. [PubMed]
5. Roy, S., Anand, D., Vijay, S., Gupta, P. and Ajitkumar, P.  The ftsZ Gene of Mycobacterium smegmatis is expressed Through Multiple Transcripts. The Open Microbiology Journal. 2011.  5, 43-53. [PubMed]
6. Vijay, S., Anand, D. and Ajitkumar, P.  Unveiling unusual features of formation of septal partition and constriction in mycobacteria--an ultrastructural study. Journal of Bacteriology. 2012.  194, 702-707. [PubMed]
7. Anand, S. P., Rajeswari, H., Gupta, P., Srinivasan, R., Indi, S. and Ajitkumar, P.  A C-terminal deletion mutant of Mycobacterium tuberculosis FtsZ shows fast polymerization in vitro. Microbiology. 2004.  150, 1119-1121. [PubMed]
8. Gupta, P., Rajeswari, H., Arumugam, M., Mishra, S., Bhagavat, R., Anand, P., Chandra, N., Srinivasan, R., Indi, S. and Ajitkumar, P.  Mycobacterium tuberculosis FtsZ requires at least one arginine residue at the C-terminal end for polymerization in vitro. Acta Biochimica et Biophysica Sinica. 2010.  42, 58-69. [PubMed]
9. Gupta, P., Srinivasan, R., Rajeswari, H., Indi, S. and Ajitkumar, P.  In vitro polymerization of Mycobacterium leprae FtsZ OR Mycobacterium tuberculosis FtsZ is revived or abolished, respectively, by reciprocal mutation of a single residue. Biochemical and Biophysical Research Communications. 2008.  368, 445-452. [PubMed]
10. Mir, M. A., Rajeswari, H. S., Veeraraghavan, U. and Ajitkumar, P.  Molecular characterisation of ABC transporter type FtsE and FtsX proteins of Mycobacterium tuberculosis. Archives of Microbiology. 2006.  185, 147-158. [PubMed]
11. Gupta, P., Anand, S. P., Srinivasan, R., Rajeswari, H., Indi, S. and Ajitkumar, P.  The C-terminally truncated MtFtsZ-DeltaC169 mutant of Mycobacterium tuberculosis FtsZ shows GTPase and GTP-induced, GTP-specific polymerization activities in vitro. Microbiology. 2004.  150, 3906-3908. [PubMed]
12. Anilkumar, G., Chauhan, M. M. and Ajitkumar, P.  Cloning and expression of the gene coding for FtsH protease from Mycobacterium tuberculosis H37Rv. Gene. 1998.  214, 7-11. [PubMed]
13. Srinivasan, R., Rajeswari, H. and Ajitkumar, P.  Analysis of degradation of bacterial cell division protein FtsZ by the ATP-dependent zinc-metalloprotease FtsH in vitro. Microbiological Research. 2008.  163, 21-30. [PubMed]
14. Srinivasan, R., Rajeswari, H., Bhatt, B. N., Indi, S. and Ajitkumar, P.  GTP/GDP binding stabilizes bacterial cell division protein FtsZ against degradation by FtsH protease in vitro. Biochemical and Biophysical Research Communications. 2007.  357, 38-43. [PubMed]
15. Mishra, S., Bhagavat, R., Chandra, N., Vijayarangan, N., Rajeswari, H. and Ajitkumar, P.  Cloning, expression, purification, and biochemical characterisation of the FIC motif containing protein of Mycobacterium tuberculosis. Protein Expression and Purification. 2012.  86, 58-67. [PubMed]
16. Anilkumar, G., Srinivasan, R. and Ajitkumar, P.  Genomic organization and in vivo characterization of proteolytic activity of FtsH of Mycobacterium smegmatis SN2. Microbiology. 2004.  150, 2629-2639. [PubMed]
17. Chaturvedi, R., Bansal, K., Narayana, Y., Kapoor, N., Sukumar, N., Togarsimalemath, S. K., Chandra, N., Mishra, S., Ajitkumar, P., Joshi, B., Katoch, V. M., Patil, S. A. and Balaji, K. N.  The multifunctional PE_PGRS11 protein from Mycobacterium tuberculosis plays a role in regulating resistance to oxidative stress. The Journal of Biological Chemistry. 2010.  285, 30389-30403. [PubMed]
18. Srinivasan, R., Anilkumar, G., Rajeswari, H. and Ajitkumar, P.  Functional characterization of AAA family FtsH protease of Mycobacterium tuberculosis. FEMS Microbiology Letters. 2006.  259, 97-105. [PubMed]
19. Kumar, P., Krishna, K., Srinivasan, R., Ajitkumar, P. and Varshney, U.  Mycobacterium tuberculosis and Escherichia coli nucleoside diphosphate kinases lack multifunctional activities to process uracil containing DNA. DNA Repair. 2004.  3, 1483-1492. [PubMed]
20. Anilkumar, G., Srinivasan, R., Anand, S. P. and Ajitkumar, P.  Bacterial cell division protein FtsZ is a specific substrate for the AAA family protease FtsH. Microbiology. 2001.  147, 516-517. [PubMed]
21. Mishra, S., Anand, D., Vijayarangan, N. and Ajitkumar, P.  An accurate method for the qualitative detection and quantification of mycobacterial promoter activity. The Open Microbiology Journal. 2013.  7, 1-5. [PubMed]
22. Arumugam, M. and Ajitkumar, P.  Histidine 117 in the His-Gly-Ser-Asp motif is Required for the Biochemical Activities of Nucleoside Diphosphate Kinase of Mycobacterium smegmatis. The Open Biochemistry Journal. 2012.  6, 71-77. [PubMed]
23. Joseph, J., Mudduluru, G., Antony, S., Vashistha, S., Ajitkumar, P. and Somasundaram, K.  Expression profiling of sodium butyrate (NaB)-treated cells: identification of regulation of genes related to cytokine signaling and cancer metastasis by NaB. Oncogene. 2004.  23, 6304-6315. [PubMed]
24. Marathe, S. A., Kumar, R., Ajitkumar, P., Nagaraja, V. and Chakravortty, D.  Curcumin reduces the antimicrobial activity of ciprofloxacin against Salmonella typhimurium and Salmonella typhi. The Journal of Antimicrobial Chemotherapy. 2013.  68, 139-152. [PubMed]
25. Arumugam, M. and Ajitkumar, P.  Heat and SDS insensitive NDK dimers are largely stabilised by hydrophobic interaction to form functional hexamer in Mycobacterium smegmatis. Acta Biochimica Polonica. 2013.  60, 199-207. [PubMed]
26. Joshi, C. V., Supriya, P. and Ajitkumar, P.  Growth inhibition of human promonocytic leukaemic U937 cells by interferon gamma is irreversible and not cell cycle phase-specific. Cytokine. 1999.  11, 673-678. [PubMed]
27. Vashistha, S., Patil, S., Joshi, C. and Ajitkumar, P.  Determination of growth inhibitory action point of interferon gamma on WISH cells in cell cycle progression and the window of responsiveness of the cells to the interferon. Cytokine. 2007.  37, 108-118. [PubMed]
28. Supriya, P., Joshi, C. V. and Ajitkumar, P.  IFN-gamma inhibits growth of WISH cells in a cell cycle phase-specific manner. Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. 1998.  18, 215-217. [PubMed]
29. Nathenson, S. G., Kesari, K., Sheil, J. M. and Ajitkumar, P.  Use of mutants to analyze regions on the H-2Kb molecule for interaction with immune receptors. Cold Spring Harbor Symposia On Quantitative Biology. 1989.  54 Pt 1, 521-528. [PubMed]
30. Ajitkumar, P., Geier, S. S., Kesari, K. V., Borriello, F., Nakagawa, M., Bluestone, J. A., Saper, M. A., Wiley, D. C. and Nathenson, S. G.  Evidence that multiple residues on both the alpha-helices of the class I MHC molecule are simultaneously recognized by the T cell receptor. Cell. 1988.  54, 47-56. [PubMed]
31. Ajitkumar, P. and Cherayil, J. D.  Presence of 2-methylthioribosyl-trans-zeatin in Azotobacter vinelandii tRNA. Journal of Bacteriology. 1985.  162, 752-755. [PubMed]
32. Ajitkumar, P. and Cherayil, J. D.  Thionucleosides in transfer ribonucleic acid: diversity, structure, biosynthesis, and function. Microbiological Reviews. 1988.  52, 103-113. [PubMed]
33. Ajitkumar, P., Barkema, H. W., Zadoks, R. N., Morck, D. W., van, d. e. r. and De, B.  High-resolution melt analysis for species identification of coagulase-negative staphylococci derived from bovine milk. Diagnostic Microbiology and Infectious Disease. 2013.  75, 227-234. [PubMed]
34. Ajitkumar, P., Barkema, H. W. and De, B.  Rapid identification of bovine mastitis pathogens by high-resolution melt analysis of 16S rDNA sequences. Veterinary Microbiology. 2012.  155, 332-340. [PubMed]
35. Aravindhan, V., Christy, A. J., Roy, S., Ajitkumar, P., Narayanan, P. R. and Narayanan, S.  Mycobacterium tuberculosis groE promoter controls the expression of the bicistronic groESL1 operon and shows differential regulation under stress conditions. FEMS Microbiology Letters. 2009.  292, 42-49. [PubMed]
 

 
 
Education 
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Ph.D.
  Last modified on : Dec 9, 2015
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