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Annapoorni Rangarajan, Ph.D.
Assistant Professor 
Indian Institute of Science
Molecular Reproduction, Development & Genetics
Banglore - 560 012   
Phone: 080-22933263
Research Summary:
Stem Cells and Cancer
1.Sharma, A., Rangarajan, A. and Dighe, R. R.  Antibodies against the extracellular domain of human Notch1 receptor reveal the critical role of epidermal-growth-factor-like repeats 25-26 in ligand binding and receptor activation. The Biochemical Journal. 2013.  449, 519-530. [PubMed]
2.Arya, N., Sardana, V., Saxena, M., Rangarajan, A. and Katti, D. S.  Recapitulating tumour microenvironment in chitosan-gelatin three-dimensional scaffolds: an improved in vitro tumour model. Journal of the Royal Society, Interface / the Royal Society. 2012.  9, 3288-3302. [PubMed]
3.Sharma, A., Paranjape, A. N., Rangarajan, A. and Dighe, R. R.  A monoclonal antibody against human Notch1 ligand-binding domain depletes subpopulation of putative breast cancer stem-like cells. Molecular Cancer Therapeutics. 2012.  11, 77-86. [PubMed]
4.Mittal, S., Subramanyam, D., Dey, D., Kumar, R. V. and Rangarajan, A.  Cooperation of Notch and Ras/MAPK signaling pathways in human breast carcinogenesis. Molecular Cancer. 2009.  8, 128. [PubMed]
5.Kumar, S. H. and Rangarajan, A.  Simian virus 40 small T antigen activates AMPK and triggers autophagy to protect cancer cells from nutrient deprivation. Journal of Virology. 2009.  83, 8565-8574. [PubMed]
6.Dey, D., Saxena, M., Paranjape, A. N., Krishnan, V., Giraddi, R., Kumar, M. V., Mukherjee, G. and Rangarajan, A.  Phenotypic and functional characterization of human mammary stem/progenitor cells in long term culture. PloS One. 2009.  4, e5329. [PubMed]
7.Bheeshmachar, G., Purushotaman, D., Sade, H., Gunasekharan, V., Rangarajan, A. and Sarin, A.  Evidence for a role for notch signaling in the cytokine-dependent survival of activated T cells. Journal of Immunology. 2006.  177, 5041-5050. [PubMed]
8.Rangarajan, A., Hong, S. J., Gifford, A. and Weinberg, R. A.  Species- and cell type-specific requirements for cellular transformation. Cancer Cell. 2004.  6, 171-183. [PubMed]
9.Veeraraghavalu, K., Pett, M., Kumar, R. V., Nair, P., Rangarajan, A., Stanley, M. A. and Krishna, S.  Papillomavirus-mediated neoplastic progression is associated with reciprocal changes in JAGGED1 and manic fringe expression linked to notch activation. Journal of Virology. 2004.  78, 8687-8700. [PubMed]
10.Rangarajan, A. and Weinberg, R. A.  Opinion: Comparative biology of mouse versus human cells: modelling human cancer in mice. Nature Reviews. Cancer. 2003.  3, 952-959. [PubMed]
11.Watnick, R. S., Cheng, Y. N., Rangarajan, A., Ince, T. A. and Weinberg, R. A.  Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis. Cancer Cell. 2003.  3, 219-231. [PubMed]
  Last modified on : Dec 6, 2013
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