INCREDB ID : 455
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Sathees C Raghavan, Ph.D.
Associate Professor 
 
Indian Institute of Science
Department of Biochemistry
Bangalore - 560 012   
Karnataka   
 
E-mail: sathees@biochem.iisc.ernet.in
Phone: +91-80-22932473
Fax: +91-80-23600814
 
URL: http://biochem.iisc.ernet.in/sathees.htm
 
Positions Held:
Position Affiliation Time Period
Post Doctoral Fellow University of Southern California, Los Angeles, USA 1999-2006
 
Research Summary:
Cancer Genetics, Genomic instability, DNA repair and recombination
 
Publications:
1. Nambiar, M., Srivastava, M., Gopalakrishnan, V., Sankaran, S. K. and Raghavan, S. C.  G-quadruplex structures formed at the HOX11 breakpoint region contribute to its fragility during t(10;14) translocation in T-cell leukemia. Molecular and Cellular Biology. 2013.  33, 4266-4281. [PubMed]
2. Kavitha, C. V., Nambiar, M., Narayanaswamy, P. B., Thomas, E., Rathore, U., Ananda, K., Choudhary, B., Rangappa, K. S. and Raghavan, S. C.  Propyl-2-(8-(3,4-difluorobenzyl)-2',5'-dioxo-8-azaspiro[bicyclo[3.2.1] octane-3,4'-imidazolidine]-1'-yl) acetate induces apoptosis in human leukemia cells through mitochondrial pathway following cell cycle arrest. PloS One. 2013.  8, e69103. [PubMed]
3. Sahu, U., Sidhar, H., Ghate, P. S., Advirao, G. M., Raghavan, S. C. and Giri, R. K.  A Novel Anticancer Agent, 8-Methoxypyrimido[4',5':4,5]thieno(2,3-) Quinoline-4(3H)-One Induces Neuro 2a Neuroblastoma Cell Death through p53-Dependent, Caspase-Dependent and -Independent Apoptotic Pathways. PloS One. 2013.  8, e66430. [PubMed]
4. Gurupadaswamy, H. D., Girish, V., Kavitha, C. V., Raghavan, S. C. and Khanum, S. A.  Synthesis and evaluation of 2,5-di(4-aryloylaryloxymethyl)-1,3,4-oxadiazoles as anti-cancer agents. European Journal of Medicinal Chemistry. 2013.  63, 536-543. [PubMed]
5. Srivastava, M., Nambiar, M., Sharma, S., Karki, S. S., Goldsmith, G., Hegde, M., Kumar, S., Pandey, M., Singh, R. K., Ray, P., Natarajan, R., Kelkar, M., De, A., Choudhary, B. and Raghavan, S. C.  An inhibitor of nonhomologous end-joining abrogates double-strand break repair and impedes cancer progression. Cell. 2012.  151, 1474-1487. [PubMed]
6. Somasagara, R. R., Hegde, M., Chiruvella, K. K., Musini, A., Choudhary, B. and Raghavan, S. C.  Extracts of strawberry fruits induce intrinsic pathway of apoptosis in breast cancer cells and inhibits tumor progression in mice. PloS One. 2012.  7, e47021. [PubMed]
7. Nishana, M. and Raghavan, S. C.  Role of recombination activating genes in the generation of antigen receptor diversity and beyond. Immunology. 2012.  137, 271-281. [PubMed]
8. Gopalakrishnan, V. and Raghavan, S. C.  Sequence and structural basis for chromosomal fragility during translocations in cancer. Future Oncology. 2012.  8, 1121-1134. [PubMed]
9. Hegde, M., Karki, S. S., Thomas, E., Kumar, S., Panjamurthy, K., Ranganatha, S. R., Rangappa, K. S., Choudhary, B. and Raghavan, S. C.  Novel levamisole derivative induces extrinsic pathway of apoptosis in cancer cells and inhibits tumor progression in mice. PloS One. 2012.  7, e43632. [PubMed]
10. Nambiar, M. and Raghavan, S. C.  Chromosomal translocations among the healthy human population: implications in oncogenesis. Cellular and Molecular Life Sciences : CMLS. 2013.  70, 1381-1392. [PubMed]
11. Nishana, M. and Raghavan, S. C.  A non-B DNA can replace heptamer of V(D)J recombination when present along with a nonamer: implications in chromosomal translocations and cancer. The Biochemical Journal. 2012.  448, 115-125. [PubMed]
12. Katapadi, V. K., Nambiar, M. and Raghavan, S. C.  Potential G-quadruplex formation at breakpoint regions of chromosomal translocations in cancer may explain their fragility. Genomics. 2012.  100, 72-80. [PubMed]
13. Chiruvella, K. K., Sebastian, R., Sharma, S., Karande, A. A., Choudhary, B. and Raghavan, S. C.  Time-dependent predominance of nonhomologous DNA end-joining pathways during embryonic development in mice. Journal of Molecular Biology. 2012.  417, 197-211. [PubMed]
14. Nambiar, M. and Raghavan, S. C.  Mechanism of fragility at BCL2 gene minor breakpoint cluster region during t(14;18) chromosomal translocation. The Journal of Biological Chemistry. 2012.  287, 8688-8701. [PubMed]
15. Sharma, S., Panjamurthy, K., Choudhary, B., Srivastava, M., Shahabuddin, M., Giri, R., Advirao, G. M. and Raghavan, S. C.  A novel DNA intercalator, 8-methoxy pyrimido[4',5':4,5]thieno (2,3-b)quinoline-4(3H)-one induces apoptosis in cancer cells, inhibits the tumor progression and enhances lifespan in mice with tumor. Molecular Carcinogenesis. 2013.  52, 413-425. [PubMed]
16. Choudhary, B., Karande, A. A. and Raghavan, S. C.  Telomere and telomerase in stem cells: relevance in ageing and disease. Frontiers in Bioscience. 2012.  4, 16-30. [PubMed]
17. Vinaya, K., Kavitha, C. V., Prasanna, D. S., Chandrappa, S., Ranganatha, S. R., Raghavan, S. C. and Rangappa, K. S.  Synthesis and antileukemic activity of novel 2-(4-(2,4-dimethoxybenzoyl)phenoxy)-1-(4-(3-(piperidin-4-yl)propyl)piperidin-1-yl )ethanone derivatives. Chemical Biology & Drug Design. 2012.  79, 360-367. [PubMed]
18. Naik, A. K. and Raghavan, S. C.  Differential reaction kinetics, cleavage complex formation, and nonamer binding domain dependence dictate the structure-specific and sequence-specific nuclease activity of RAGs. Journal of Molecular Biology. 2012.  415, 475-488. [PubMed]
19. Purohit, M. N., Panjamurthy, K., Elango, S., Hebbar, K., Mayur, Y. C. and Raghavan, S. C.  In-vitro cytotoxicity and cell cycle analysis of two novel bis-1,2, 4-triazole derivatives: 1,4-bis[5-(5-mercapto-1,3,4-oxadiazol-2-yl-methyl)-thio-4-(p-tolyl)-1,2,4-triazol -3-yl]-butane (MNP-14) and 1,4-bis[5-(carbethoxy-methyl)-thio-4-(p-ethoxy phenyl)-1,2,4-triazol-3-yl]-butane (MNP-16). Nucleosides, Nucleotides & Nucleic Acids. 2011.  30, 873-885. [PubMed]
20. Vinaya, K., Kavitha, C. V., Chandrappa, S., Prasanna, D. S., Raghavan, S. C. and Rangappa, K. S.  Synthesis and antileukemic activity of novel 4-(3-(piperidin-4-yl) propyl)piperidine derivatives. Chemical Biology & Drug Design. 2011.  78, 622-630. [PubMed]
21. Nambiar, M. and Raghavan, S. C.  How does DNA break during chromosomal translocations? Nucleic Acids Research. 2011.  39, 5813-5825. [PubMed]
22. Karki, S. S., Panjamurthy, K., Kumar, S., Nambiar, M., Ramareddy, S. A., Chiruvella, K. K. and Raghavan, S. C.  Synthesis and biological evaluation of novel 2-aralkyl-5-substituted-6-(4'-fluorophenyl)-imidazo[2,1-b][1,3,4]thiadiazole derivatives as potent anticancer agents. European Journal of Medicinal Chemistry. 2011.  46, 2109-2116. [PubMed]
23. Sharma, S. and Raghavan, S. C.  Nonhomologous DNA end joining in cell-free extracts. Journal of Nucleic Acids. 2010.  2010. [PubMed]
24. Nambiar, M., Goldsmith, G., Moorthy, B. T., Lieber, M. R., Joshi, M. V., Choudhary, B., Hosur, R. V. and Raghavan, S. C.  Formation of a G-quadruplex at the BCL2 major breakpoint region of the t(14;18) translocation in follicular lymphoma. Nucleic Acids Research. 2011.  39, 936-948. [PubMed]
25. Prasanna, D. S., Kavitha, C. V., Vinaya, K., Ranganatha, S. R., Raghavan, S. C. and Rangappa, K. S.  Synthesis and identification of a new class of antileukemic agents containing 2-(arylcarboxamide)-(S)-6-amino-4,5,6,7-tetrahydrobenzo[d]thiazole. European Journal of Medicinal Chemistry. 2010.  45, 5331-5336. [PubMed]
26. Moorthy, B. T., Ravi, S., Srivastava, M., Chiruvella, K. K., Hemlal, H., Joy, O. and Raghavan, S. C.  Novel rhodanine derivatives induce growth inhibition followed by apoptosis. Bioorganic & Medicinal Chemistry Letters. 2010.  20, 6297-6301. [PubMed]
27. Chiruvella, K. K., Panjamurthy, K., Choudhary, B., Joy, O. and Raghavan, S. C.  Methyl angolensate from callus of Indian redwood induces cytotoxicity in human breast cancer cells. International Journal of Biomedical Science : IJBS. 2010.  6, 182-194. [PubMed]
28. Kumar, T. S., Kari, V., Choudhary, B., Nambiar, M., Akila, T. S. and Raghavan, S. C.  Anti-apoptotic protein BCL2 down-regulates DNA end joining in cancer cells. The Journal of Biological Chemistry. 2010.  285, 32657-32670. [PubMed]
29. Kavitha, C. V., Choudhary, B., Raghavan, S. C. and Muniyappa, K.  Differential regulation of MRN (Mre11-Rad50-Nbs1) complex subunits and telomerase activity in cancer cells. Biochemical and Biophysical Research Communications. 2010.  399, 575-580. [PubMed]
30. Sharma, S., Choudhary, B. and Raghavan, S. C.  Efficiency of nonhomologous DNA end joining varies among somatic tissues, despite similarity in mechanism. Cellular and Molecular Life Sciences : CMLS. 2011.  68, 661-676. [PubMed]
31. Shahabuddin, M. S., Nambiar, M., Advirao, G. M. and Raghavan, S. C.  Intercalative pyrimido[4',5':4,5]thieno(2,3-b)quinolines induce apoptosis in leukemic cells: a comparative study of methoxy and morpholino substitution. Investigational New Drugs. 2011.  29, 873-882. [PubMed]
32. Ravi, S., Chiruvella, K. K., Rajesh, K., Prabhu, V. and Raghavan, S. C.  5-Isopropylidene-3-ethyl rhodanine induce growth inhibition followed by apoptosis in leukemia cells. European Journal of Medicinal Chemistry. 2010.  45, 2748-2752. [PubMed]
33. Chiruvella, K. K. and Raghavan, S. C.  A natural compound, methyl angolensate, induces mitochondrial pathway of apoptosis in Daudi cells. Investigational New Drugs. 2011.  29, 583-592. [PubMed]
34. Shahabuddin, M. S., Nambiar, M., Moorthy, B. T., Naik, P. L., Choudhary, B., Advirao, G. M. and Raghavan, S. C.  A novel structural derivative of natural alkaloid ellipticine, MDPSQ, induces necrosis in leukemic cells. Investigational New Drugs. 2011.  29, 523-533. [PubMed]
35. Naik, A. K., Lieber, M. R. and Raghavan, S. C.  Cytosines, but not purines, determine recombination activating gene (RAG)-induced breaks on heteroduplex DNA structures: implications for genomic instability. The Journal of Biological Chemistry. 2010.  285, 7587-7597. [PubMed]
36. Ranganatha, S. R., Kavitha, C. V., Vinaya, K., Prasanna, D. S., Chandrappa, S., Raghavan, S. C. and Rangappa, K. S.  Synthesis and cytotoxic evaluation of novel 2-(4-(2,2,2-trifluoroethoxy)-3-methylpyridin-2-ylthio)-1H-benzo[d]imidazole derivatives. Archives of Pharmacal Research. 2009.  32, 1335-1343. [PubMed]
37. Gowda, N. R., Kavitha, C. V., Chiruvella, K. K., Joy, O., Rangappa, K. S. and Raghavan, S. C.  Synthesis and biological evaluation of novel 1-(4-methoxyphenethyl)-1H-benzimidazole-5-carboxylic acid derivatives and their precursors as antileukemic agents. Bioorganic & Medicinal Chemistry Letters. 2009.  19, 4594-4600. [PubMed]
38. Prasanna, D. S., Kavitha, C. V., Raghava, B., Vinaya, K., Ranganatha, S. R., Raghavan, S. C. and Rangappa, K. S.  Synthesis and identification of a new class of (S)-2,6-diamino-4,5,6,7-tetrahydrobenzo[d]thiazole derivatives as potent antileukemic agents. Investigational New Drugs. 2010.  28, 454-465. [PubMed]
39. Nambiar, M. and Raghavan, S. C.  Prevalence and analysis of t(14;18) and t(11;14) chromosomal translocations in healthy Indian population. Annals of Hematology. 2010.  89, 35-43. [PubMed]
40. Chandrappa, S., Kavitha, C. V., Shahabuddin, M. S., Vinaya, K., Ananda, K., Ranganatha, S. R., Raghavan, S. C. and Rangappa, K. S.  Synthesis of 2-(5-((5-(4-chlorophenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)ace tic acid derivatives and evaluation of their cytotoxicity and induction of apoptosis in human leukemia cells. Bioorganic & Medicinal Chemistry. 2009.  17, 2576-2584. [PubMed]
41. Shahabuddin, M. S., Nambiar, M., Choudhary, B., Advirao, G. M. and Raghavan, S. C.  A novel DNA intercalator, butylamino-pyrimido[4',5':4,5]selenolo(2,3-b)quinoline, induces cell cycle arrest and apoptosis in leukemic cells. Investigational New Drugs. 2010.  28, 35-48. [PubMed]
42. Tsai, A. G., Lu, H., Raghavan, S. C., Muschen, M., Hsieh, C. L. and Lieber, M. R.  Human chromosomal translocations at CpG sites and a theoretical basis for their lineage and stage specificity. Cell. 2008.  135, 1130-1142. [PubMed]
43. Chiruvella, K. K., Kari, V., Choudhary, B., Nambiar, M., Ghanta, R. G. and Raghavan, S. C.  Methyl angolensate, a natural tetranortriterpenoid induces intrinsic apoptotic pathway in leukemic cells. FEBS Letters. 2008.  582, 4066-4076. [PubMed]
44. Kavitha, C. V., Nambiar, M., Ananda, K., Choudhary, B., Muniyappa, K., Rangappa, K. S. and Raghavan, S. C.  Novel derivatives of spirohydantoin induce growth inhibition followed by apoptosis in leukemia cells. Biochemical Pharmacology. 2009.  77, 348-363. [PubMed]
45. Shahabuddin, M. S., Gopal, M. and Raghavan, S. C.  Intercalating, cytotoxic, antitumour activity of 8-chloro and 4-morpholinopyrimido [4',5':4,5]thieno(2,3-b)quinolines. Journal of Photochemistry and Photobiology. B, Biology. 2009.  94, 13-19. [PubMed]
46. Ananda, K., Kavitha, C. V., Vinaya, K., Benaka, P., Thimmegowda, N. R., Chandrappa, S., Raghavan, S. C. and Rangappa, K. S.  Synthesis and in vitro cytotoxic evaluation of novel diazaspiro bicyclo hydantoin derivatives in human leukemia cells: a SAR study. Investigational New Drugs. 2009.  27, 327-337. [PubMed]
47. Nambiar, M., Kari, V. and Raghavan, S. C.  Chromosomal translocations in cancer. Biochimica et Biophysica Acta. 2008.  1786, 139-152. [PubMed]
48. Nambiar, M., Choudhary, B., Rao, C. R. and Raghavan, S. C.  Amplification of chromosomal translocation junctions from paraffin-embedded tissues of follicular lymphoma patients. Biomedical Materials. 2008.  3, 034103. [PubMed]
49. Lieber, M. R., Raghavan, S. C. and Yu, K.  Mechanistic aspects of lymphoid chromosomal translocations. Journal of the National Cancer Institute. Monographs. 2008.  , 8-11. [PubMed]
50. Naik, A. K. and Raghavan, S. C.  P1 nuclease cleavage is dependent on length of the mismatches in DNA. DNA Repair. 2008.  7, 1384-1391. [PubMed]
51. Chiruvella, K. K., Mohammed, A., Dampuri, G., Ghanta, R. G. and Raghavan, S. C.  Phytochemical and Antimicrobial Studies of Methyl Angolensate and Luteolin-7-O-glucoside Isolated from Callus Cultures of Soymida febrifuga. International Journal of Biomedical Science : IJBS. 2007.  3, 269-278. [PubMed]
52. Raghavan, S. C. and Lieber, M. R.  DNA structure and human diseases. Frontiers in Bioscience : A Journal and Virtual Library. 2007.  12, 4402-4408. [PubMed]
53. Raghavan, S. C., Gu, J., Swanson, P. C. and Lieber, M. R.  The structure-specific nicking of small heteroduplexes by the RAG complex: implications for lymphoid chromosomal translocations. DNA Repair. 2007.  6, 751-759. [PubMed]
54. Raghavan, S. C., Tsai, A., Hsieh, C. L. and Lieber, M. R.  Analysis of non-B DNA structure at chromosomal sites in the mammalian genome. Methods in Enzymology. 2006.  409, 301-316. [PubMed]
55. Lieber, M. R., Yu, K. and Raghavan, S. C.  Roles of nonhomologous DNA end joining, V(D)J recombination, and class switch recombination in chromosomal translocations. DNA Repair. 2006.  5, 1234-1245. [PubMed]
56. Raghavan, S. C. and Lieber, M. R.  DNA structures at chromosomal translocation sites. BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. 2006.  28, 480-494. [PubMed]
57. Raghavan, S. C., Tong, J. and Lieber, M. R.  Hybrid joint formation in human V(D)J recombination requires nonhomologous DNA end joining. DNA Repair. 2006.  5, 278-285. [PubMed]
58. Raghavan, S. C., Hsieh, C. L. and Lieber, M. R.  Both V(D)J coding ends but neither signal end can recombine at the bcl-2 major breakpoint region, and the rejoining is ligase IV dependent. Molecular and Cellular Biology. 2005.  25, 6475-6484. [PubMed]
59. Raghavan, S. C., Swanson, P. C., Ma, Y. and Lieber, M. R.  Double-strand break formation by the RAG complex at the bcl-2 major breakpoint region and at other non-B DNA structures in vitro. Molecular and Cellular Biology. 2005.  25, 5904-5919. [PubMed]
60. Raghavan, S. C., Chastain, P., Lee, J. S., Hegde, B. G., Houston, S., Langen, R., Hsieh, C. L., Haworth, I. S. and Lieber, M. R.  Evidence for a triplex DNA conformation at the bcl-2 major breakpoint region of the t(14;18) translocation. The Journal of Biological Chemistry. 2005.  280, 22749-22760. [PubMed]
61. Raghavan, S. C. and Raman, M. J.  Nonhomologous end joining of complementary and noncomplementary DNA termini in mouse testicular extracts. DNA Repair. 2004.  3, 1297-1310. [PubMed]
62. Raghavan, S. C., Houston, S., Hegde, B. G., Langen, R., Haworth, I. S. and Lieber, M. R.  Stability and strand asymmetry in the non-B DNA structure at the bcl-2 major breakpoint region. The Journal of Biological Chemistry. 2004.  279, 46213-46225. [PubMed]
63. Raghavan, S. C. and Lieber, M. R.  Chromosomal translocations and non-B DNA structures in the human genome. Cell Cycle. 2004.  3, 762-768. [PubMed]
64. Raghavan, S. C., Swanson, P. C., Wu, X., Hsieh, C. L. and Lieber, M. R.  A non-B-DNA structure at the Bcl-2 major breakpoint region is cleaved by the RAG complex. Nature. 2004.  428, 88-93. [PubMed]
 
 
Education 
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Ph.D.
  Last modified on : Dec 5, 2013
India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.