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Padma Shastry, Ph.D.
Scientist G 
National Centre for Cell Science
NCCS Complex, Pune University Campus
Pune - 411 007   
Phone: +91-020-25708108
Fax: +91-020-25692259
Research Summary:
Mechanisms of drug resistance and sensitivity in gliomas using monolayers (2D) and multicellular spheroids (MCS) cultured cells
1. Pujari, R., Eligar, S. M., Kumar, N., Barkeer, S., Reddy, V., Swamy, B. M., Inamdar, S. R. and Shastry, P.  Rhizoctonia Bataticola Lectin (RBL) Induces Caspase-8-Mediated Apoptosis in Human T-Cell Leukemia Cell Lines but Not in Normal CD3 and CD34 Positive Cells. PloS One. 2013.  8, e79311. [PubMed]
2. Shah, R. D., Jagtap, J. C., Mruthyunjaya, S., Shelke, G. V., Pujari, R., Das, G. and Shastry, P.  Sodium valproate potentiates staurosporine-induced apoptosis in neuroblastoma cells via Akt/survivin independently of HDAC inhibition. Journal of Cellular Biochemistry. 2013.  114, 854-863. [PubMed]
3. Londhe, J. S., Devasagayam, T. P., Foo, L. Y., Shastry, P. and Ghaskadbi, S. S.  Geraniin and amariin, ellagitannins from Phyllanthus amarus, protect liver cells against ethanol induced cytotoxicity. Fitoterapia. 2012.  83, 1562-1568. [PubMed]
4. Inamdar, S. R., Savanur, M. A., Eligar, S. M., Chachadi, V. B., Nagre, N. N., Chen, C., Barclays, M., Ingle, A., Mahajan, P., Borges, A., Shastry, P., Kalraiya, R. D., Swamy, B. M., Rhodes, J. M. and Yu, L. G.  The TF-antigen binding lectin from Sclerotium rolfsii inhibits growth of human colon cancer cells by inducing apoptosis in vitro and suppresses tumor growth in vivo. Glycobiology. 2012.  22, 1227-1235. [PubMed]
5. Pujari, R., Eligar, S. M., Kumar, N., Nagre, N. N., Inamdar, S. R., Swamy, B. M. and Shastry, P.  CD45-mediated signaling pathway is involved in Rhizoctonia bataticola lectin (RBL)-induced proliferation and Th1/Th2 cytokine secretion in human PBMC. Biochemical and Biophysical Research Communications. 2012.  419, 708-714. [PubMed]
6. Lokwani, D., Shah, R., Mokale, S., Shastry, P. and Shinde, D.  Development of energetic pharmacophore for the designing of 1,2,3,4-tetrahydropyrimidine derivatives as selective cyclooxygenase-2 inhibitors. Journal of Computer-aided Molecular Design. 2012.  26, 267-277. [PubMed]
7. Mruthyunjaya, S., Rumma, M., Ravibhushan, G., Anjali, S. and Padma, S.  c-Jun/AP-1 transcription factor regulates laminin-1-induced neurite outgrowth in human bone marrow mesenchymal stem cells: role of multiple signaling pathways. FEBS Letters. 2011.  585, 1915-1922. [PubMed]
8. Das, G., Shiras, A., Shanmuganandam, K. and Shastry, P.  Rictor regulates MMP-9 activity and invasion through Raf-1-MEK-ERK signaling pathway in glioma cells. Molecular Carcinogenesis. 2011.  50, 412-423. [PubMed]
9. Kale, A., Kale, S., Yadav, P., Gholap, H., Pasricha, R., Jog, J. P., Lefez, B., Hannoyer, B., Shastry, P. and Ogale, S.  Magnetite/CdTe magnetic-fluorescent composite nanosystem for magnetic separation and bio-imaging. Nanotechnology. 2011.  22, 225101. [PubMed]
10. Nagre, N. N., Chachadi, V. B., Eligar, S. M., Shubhada, C., Pujari, R., Shastry, P., Swamy, B. M. and Inamdar, S. R.  Purification and characterization of a mitogenic lectin from cephalosporium, a pathogenic fungus causing mycotic keratitis. Biochemistry Research International. 2010.  2010, 854656. [PubMed]
11. Pujari, R., Nagre, N. N., Chachadi, V. B., Inamdar, S. R., Swamy, B. M. and Shastry, P.  Rhizoctonia bataticola lectin (RBL) induces mitogenesis and cytokine production in human PBMC via p38 MAPK and STAT-5 signaling pathways. Biochimica et Biophysica Acta. 2010.  1800, 1268-1275. [PubMed]
12. Nagre, N. N., Chachadi, V. B., Sundaram, P. M., Naik, R. S., Pujari, R., Shastry, P., Swamy, B. M. and Inamdar, S. R.  A potent mitogenic lectin from the mycelia of a phytopathogenic fungus, Rhizoctonia bataticola, with complex sugar specificity and cytotoxic effect on human ovarian cancer cells. Glycoconjugate Journal. 2010.  27, 375-386. [PubMed]
13. Mruthyunjaya, S., Manchanda, R., Godbole, R., Pujari, R., Shiras, A. and Shastry, P.  Laminin-1 induces neurite outgrowth in human mesenchymal stem cells in serum/differentiation factors-free conditions through activation of FAK-MEK/ERK signaling pathways. Biochemical and Biophysical Research Communications. 2010.  391, 43-48. [PubMed]
14. Sudheerkumar, P., Shiras, A., Das, G., Jagtap, J. C., Prasad, V. and Shastry, P.  Independent activation of Akt and NF-kappaB pathways and their role in resistance to TNF-alpha mediated cytotoxicity in gliomas. Molecular Carcinogenesis. 2008.  47, 126-136. [PubMed]
15. Kumar, P. S., Shiras, A., Das, G., Jagtap, J. C., Prasad, V. and Shastry, P.  Differential expression and role of p21cip/waf1 and p27kip1 in TNF-alpha-induced inhibition of proliferation in human glioma cells. Molecular Cancer. 2007.  6, 42. [PubMed]
16. Shiras, A., Chettiar, S. T., Shepal, V., Rajendran, G., Prasad, G. R. and Shastry, P.  Spontaneous transformation of human adult nontumorigenic stem cells to cancer stem cells is driven by genomic instability in a human model of glioblastoma. Stem Cells. 2007.  25, 1478-1489. [PubMed]
17. Prasad, V., Chandele, A., Jagtap, J. C., Sudheer, K. and Shastry, P.  ROS-triggered caspase 2 activation and feedback amplification loop in beta-carotene-induced apoptosis. Free Radical Biology & Medicine. 2006.  41, 431-442. [PubMed]
18. Deshpande, P. and Shastry, P.  Modulation of cytokine profiles by malaria pigment--hemozoin: role of IL-10 in suppression of proliferative responses of mitogen stimulated human PBMC. Cytokine. 2004.  28, 205-213. [PubMed]
19. Chandele, A., Prasad, V., Jagtap, J. C., Shukla, R. and Shastry, P. R.  Upregulation of survivin in G2/M cells and inhibition of caspase 9 activity enhances resistance in staurosporine-induced apoptosis. Neoplasia. 2004.  6, 29-40. [PubMed]
20. Shiras, A., Bhosale, A., Shepal, V., Shukla, R., Baburao, V. S., Prabhakara, K. and Shastry, P.  A unique model system for tumor progression in GBM comprising two developed human neuro-epithelial cell lines with differential transforming potential and coexpressing neuronal and glial markers. Neoplasia. 2003.  5, 520-532. [PubMed]
21. Jagtap, J. C., Chandele, A., Chopde, B. A. and Shastry, P.  Sodium pyruvate protects against H(2)O(2) mediated apoptosis in human neuroblastoma cell line-SK-N-MC. Journal of Chemical Neuroanatomy. 2003.  26, 109-118. [PubMed]
22. Mahajan, R. G., Patil, S. I., Mohan, D. R. and Shastry, P.  Pleurotus Eous mushroom lectin (PEL) with mixed carbohydrate inhibition and antiproliferative activity on tumor cell lines. Journal of Biochemistry, Molecular Biology, and Biophysics : JBMBB : the Official Journal of the Federation of Asian and Oceanian Biochemists and Molecular. 2002.  6, 341-345. [PubMed]
23. Shiras, A., Bhosale, A., Patekar, A., Shepal, V. and Shastry, P.  Differential expression of CD44(S) and variant isoforms v3, v10 in three-dimensional cultures of mouse melanoma cell lines. Clinical & Experimental Metastasis. 2002.  19, 445-455. [PubMed]
24. Jacob, S. S., Shastry, P. and Sudhakaran, P. R.  Monocyte-macrophage differentiation in vitro: modulation by extracellular matrix protein substratum. Molecular and Cellular Biochemistry. 2002.  233, 9-17. [PubMed]
Grant Support:
Project Title Role Funding Agency Sanction Number Sanction Date
Role of Prostrate Apoptosis Response-4 (Par-4 )and its interactive proteins in chemo resistance/ sensitivity in gliomas using multi-cellular spheroids (MCS) as model Principal Investigator Indian Council of Medical Research, Government of India 2010-2013
Exploring the potential of Tf antigen binding property of lectin from sclerotium rolfsii for anticancer effect Department of Biotechnology, Government of India 2010-2013
Differentiation of human Mesenchymal stem cells (MSC) towards neuronal lineages Department of Biotechnology, Government of India 2005-2008


  Last modified on : Dec 9, 2015
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