INCREDB ID : 446
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Surajit Dhara, Ph.D.
Scientist 
 
National Institute of Biomedical Genomics
Netaji Subhas Sanatorium (T.B. Hospital)
2nd Floor P.O.: N.S.S.
Kalyani - 741 251   
West Bengal   
 
E-mail: sdl@nibmg.ac.in
 
URL: http://www.nibmg.ac.in/?q=content/sd1-research
 
Positions Held:
Position Affiliation Time Period
Faculty Johns Hopkins School of Medicine, Baltimore, MD, USA. 2010-2010
Post Doctoral Fellow Johns Hopkins School of Medicine, Baltimore, MD, USA. 2003-2009
Post Doctoral Fellow University of Minnesota, Twin Cities Saint Paul, MN, USA. 2002-2003
Senior Demonstrator All India Institue of Medical Sciences, New Delhi, India 2000-2002
 
Area of Specialization:
Genomics
Publications:
1. Chandra, V., Das, T., Gulati, P., Biswas, N. K., Rote, S., Chatterjee, U., Ghosh, S. N., Deb, S., Saha, S. K., Chowdhury, A. K., Ghosh, S., Rudin, C. M., Mukherjee, A., Basu, A. and Dhara, S.  Hedgehog signaling pathway is active in GBM with GLI1 mRNA expression showing a single continuous distribution rather than discrete high/low clusters. PloS One. 2015.  10, e0116390. [PubMed]
2. Biswas, N. K., Chandra, V., Sarkar-Roy, N., Das, T., Bhattacharya, R. N., Tripathy, L. N., Basu, S. K., Kumar, S., Das, S., Chatterjee, A., Mukherjee, A., Basu, P., Maitra, A., Chattopadhyay, A., Basu, A. and Dhara, S.  Variant allele frequency enrichment analysis in vitro reveals sonic hedgehog pathway to impede sustained temozolomide response in GBM. Scientific Reports. 2015.  5, 7915. [PubMed]
3. Di, C., Dhara, S., Hristov, A. C., Kowalski, J., Elbahloul, O., Hillion, J., Roy, S., Meijerink, J. P., Winter, S. S., Larson, R. S., Huso, D. L. and Resar, L.  Inactivation of the Cdkn2a locus cooperates with HMGA1 to drive T-cell leukemogenesis. Leukemia & Lymphoma. 2013.  54, 1762-1768. [PubMed]
4. Shim, J. S., Matsui, Y., Bhat, S., Nacev, B. A., Xu, J., Bhang, H. E., Dhara, S., Han, K. C., Chong, C. R., Pomper, M. G., So, A. and Liu, J. O.  Effect of nitroxoline on angiogenesis and growth of human bladder cancer. Journal of the National Cancer Institute. 2010.  102, 1855-1873. [PubMed]
5. Hillion, J., Wood, L. J., Mukherjee, M., Bhattacharya, R., Di, C., Kowalski, J., Elbahloul, O., Segal, J., Poirier, J., Rudin, C. M., Dhara, S., Belton, A., Joseph, B., Zucker, S. and Resar, L. M.  Upregulation of MMP-2 by HMGA1 promotes transformation in undifferentiated, large-cell lung cancer. Molecular Cancer Research : MCR. 2009.  7, 1803-1812. [PubMed]
6. Chen, Y., Dhara, S., Banerjee, S. R., Byun, Y., Pullambhatla, M., Mease, R. C. and Pomper, M. G.  A low molecular weight PSMA-based fluorescent imaging agent for cancer. Biochemical and Biophysical Research Communications. 2009.  390, 624-629. [PubMed]
7. Hillion, J., Dhara, S., Sumter, T. F., Mukherjee, M., Di, C., Belton, A., Turkson, J., Jaganathan, S., Cheng, L., Ye, Z., Jove, R., Aplan, P., Lin, Y. W., Wertzler, K., Reeves, R., Elbahlouh, O., Kowalski, J., Bhattacharya, R. and Resar, L. M.  The high-mobility group A1a/signal transducer and activator of transcription-3 axis: an achilles heel for hematopoietic malignancies? Cancer Research. 2008.  68, 10121-10127. [PubMed]
8. Feldmann, G., Habbe, N., Dhara, S., Bisht, S., Alvarez, H., Fendrich, V., Beaty, R., Mullendore, M., Karikari, C., Bardeesy, N., Ouellette, M. M., Yu, W. and Maitra, A.  Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer. Gut. 2008.  57, 1420-1430. [PubMed]
9. Winnard, P. T., Pathak, A. P., Dhara, S., Cho, S. Y., Raman, V. and Pomper, M. G.  Molecular imaging of metastatic potential. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 2008.  49 Suppl 2, 96S-112. [PubMed]
10. Tesfaye, A., Di, C., Hillion, J., Ronnett, B. M., Elbahloul, O., Ashfaq, R., Dhara, S., Prochownik, E., Tworkoski, K., Reeves, R., Roden, R., Ellenson, L. H., Huso, D. L. and Resar, L. M.  The high-mobility group A1 gene up-regulates cyclooxygenase 2 expression in uterine tumorigenesis. Cancer Research. 2007.  67, 3998-4004. [PubMed]
11. Feldmann, G., Dhara, S., Fendrich, V., Bedja, D., Beaty, R., Mullendore, M., Karikari, C., Alvarez, H., Iacobuzio-Donahue, C., Jimeno, A., Gabrielson, K. L., Matsui, W. and Maitra, A.  Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers. Cancer Research. 2007.  67, 2187-2196. [PubMed]
12. Bonde, P., Sui, G., Dhara, S., Wang, J., Broor, A., Kim, I. F., Wiley, J. E., Marti, G., Duncan, M., Jaffee, E., Montgomery, E., Maitra, A. and Harmon, J. W.  Cytogenetic characterization and gene expression profiling in the rat reflux-induced esophageal tumor model. The Journal of Thoracic and Cardiovascular Surgery. 2007.  133, 763-769. [PubMed]
13. Sui, G., Bonde, P., Dhara, S., Broor, A., Wang, J., Marti, G., Feldmann, G., Duncan, M., Montgomery, E., Maitra, A. and Harmon, J. W.  Epidermal growth factor receptor and hedgehog signaling pathways are active in esophageal cancer cells from rat reflux model. The Journal of Surgical Research. 2006.  134, 1-9. [PubMed]
14. Prasad, N. B., Biankin, A. V., Fukushima, N., Maitra, A., Dhara, S., Elkahloun, A. G., Hruban, R. H., Goggins, M. and Leach, S. D.  Gene expression profiles in pancreatic intraepithelial neoplasia reflect the effects of Hedgehog signaling on pancreatic ductal epithelial cells. Cancer Research. 2005.  65, 1619-1626. [PubMed]
15. Hansel, D. E., Dhara, S., Huang, R. C., Ashfaq, R., Deasel, M., Shimada, Y., Bernstein, H. S., Harmon, J., Brock, M., Forastiere, A., Washington, M. K., Maitra, A. and Montgomery, E.  CDC2/CDK1 expression in esophageal adenocarcinoma and precursor lesions serves as a diagnostic and cancer progression marker and potential novel drug target. The American Journal of Surgical Pathology. 2005.  29, 390-399. [PubMed]
16. Karhadkar, S. S., Bova, G. S., Abdallah, N., Dhara, S., Gardner, D., Maitra, A., Isaacs, J. T., Berman, D. M. and Beachy, P. A.  Hedgehog signalling in prostate regeneration, neoplasia and metastasis. Nature. 2004.  431, 707-712. [PubMed]
17. Parker, A. R., Leonard, C. P., Hua, L., Francis, R. O., Dhara, S., Maitra, A. and Eshleman, J. R.  A subgroup of microsatellite stable colorectal cancers has elevated mutation rates and different responses to alkylating and oxidising agents. British Journal of Cancer. 2004.  90, 1666-1671. [PubMed]
18. Ghosh, D., Sharkey, A. M., Charnock-Jones, D. S., Dhawan, L., Dhara, S., Smith, S. K. and Sengupta, J.  Expression of vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) in conceptus and endometrium during implantation in the rhesus monkey. Molecular Human Reproduction. 2000.  6, 935-941. [PubMed]
19. Ghosh, D., Dhara, S., Kumar, A. and Sengupta, J.  Immunohistochemical localization of receptors for progesterone and oestradiol-17 beta in the implantation site of the rhesus monkey. Human Reproduction. 1999.  14, 505-514. [PubMed]
20. Ghosh, D., Nayak, N. R., Kumar, P. G., Dhara, S. and Sengupta, J.  Hormonal requirement for blastocyst implantation and a new approach for anti-implantation strategy. Indian Journal of Physiology and Pharmacology. 1997.  41, 101-108. [PubMed]
21.
Martin ST, Sato N, Dhara S, Hustinx SR, Abe T, Maitra A, Hruban RH, Goggins M. The Human Hedgehog Interacting Protein gene, HHIP, is aberrantly methylated in pancreatic cancer and is a mediator of hedgehog pathway activity in pancreatic carcinogenesis. Cancer Biology Therapy. 2005 4:728-733
 

 
Book Chapters:
Dhara S. (2008). Tumor Biology. Textbook of Molecular Imaging in Oncology. Pomper, M.G., Ed. New York: Taylor & Francis, pp. 1-26
 
My CV:   Download
 
Education 
::
Ph.D. in Genomics, All India Institute of Medical Sciences, New Delhi, India
::
M.Sc. in Biochemistry, Calcutta University
Honors and Awards
::
DBT-NIBMG Fellowship award, 2010
::
Best Young Scientist Award by ISSRF (Indian Society for the Study of Reproduction and Fertility), India, 1996
::
Junior Research Fellowship award by University Grants Commission, Govt. of India, 1993
Member
::
Associate member of AACR (American Association for Cancer Research)
::
Life member of the ISSRF (Indian Society for the Study of Reproduction and Fertility)
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Life member of the APPI (Association of Physiologists and Pharmacologists of India)
  Last modified on : Dec 9, 2015
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