INCREDB ID : 434
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Vani Santosh, M.D.
Professor 
 
National Institute of Mental Health and Neuro Sciences
Hosur Road / Marigowda Road, (Lakkasandra, Wilson Garden)
Bangalore - 560 029   
Karnataka   
 
E-mail: vani@nimhans.kar.nic.in, vani.santosh@gmail.com
Phone: +91-080-26995132
 
URL: http://www.nimhans.kar.nic.in/neuropathology/faculty.htm
 
Area of Specialization:
Pathology
Neuro-Oncology
Research Summary:
Neuro-oncology with emphasis on Biology of Glial Tumors
Developmental Neuropathology
Neuro infections
 
Publications:

 

1. Ambekar, S., Ranjan, M., Prasad, C., Santosh, V. and Somanna, S.  Fourth ventricular ependymoma with a distant intraventricular metastasis: Report of a rare case. Journal of Neurosciences in Rural Practice. 2013.  4, S121-4. [PubMed]
2. Shukla, S., Pia, P., Thinagararjan, S., Srinivasan, S., Mondal, B., Hegde, A. S., Chandramouli, B. A., Santosh, V., Arivazhagan, A. and Somasundaram, K.  A DNA Methylation Prognostic Signature of Glioblastoma: Identification of NPTX2-PTEN-NF-kappaB Nexus. Cancer Research. 2013.  [PubMed]
3. Naz, S., Bashir, M., Ranganathan, P., Bodapati, P., Santosh, V. and Kondaiah, P.  Protumorigenic actions of S100A2 involve regulation of PI3/Akt signaling and functional interaction with Smad3. Carcinogenesis. 2013.  [PubMed]
4. Rao, S. A., Arimappamagan, A., Pandey, P., Santosh, V., Hegde, A. S., Chandramouli, B. A. and Somasundaram, K.  miR-219-5p inhibits receptor tyrosine kinase pathway by targeting EGFR in glioblastoma. PloS One. 2013.  8, e63164. [PubMed]
5. Arimappamagan, A., Somasundaram, K., Thennarasu, K., Peddagangannagari, S., Srinivasan, H., Shailaja, B. C., Samuel, C., Patric, I. R., Shukla, S., Thota, B., Prasanna, K. V., Pandey, P., Balasubramaniam, A., Santosh, V., Chandramouli, B. A., Hegde, A. S., Kondaiah, P. and Sathyanarayana, R. a. o.  A fourteen gene GBM prognostic signature identifies association of immune response pathway and mesenchymal subtype with high risk group. PloS One. 2013.  8, e62042. [PubMed]
6. Baldawa, S., Kasegaonkar, P., Vani, S. and Kelkar, G.  Primary intraventricular gliosarcoma. Clinical Neuropathology. 2013.  32, 525-528. [PubMed]
7. Madhugiri, V. S., Gundamaneni, S. K., Santosh, V., Jagadisan, B., Sasidharan, G. M., Roopesh-Kumar, R. V., Yadav, A. K., Singh, M., Ananthakrishnan, R., Pariarath, N. and Biswal, N.  Acute pyogenic necrotizing encephalomyelitis: a fulminant and fatal infection. Journal of Neurosurgery. Pediatrics. 2013.  11, 591-595. [PubMed]
8. Chikkannaiah, P., Bharath, R. D., Sampath, S. and Santosh, V.  De novo gliosarcoma occurring in the posterior fossa of a 11-year-old girl. Clinical Neuropathology. 2012.  31, 389-391. [PubMed]
9. Thota, B., Shukla, S. K., Srividya, M. R., Shwetha, S. D., Arivazhagan, A., Thennarasu, K., Chickabasaviah, Y. T., Hegde, A. S., Chandramouli, B. A., Somasundaram, K. and Santosh, V.  IDH1 mutations in diffusely infiltrating astrocytomas: grade specificity, association with protein expression, and clinical relevance. American Journal of Clinical Pathology. 2012.  138, 177-184. [PubMed]
10. Krishnamoorthy, N., Santosh, V., Yasha, T. C., Mahadevan, A., Shankar, S. K., Jethwani, D., Taly, A. B., Bhanu, K. and Gayathri, N.  Glycogen storage disease type V (Mc Ardle's disease): a report on three cases. Neurology India. 2011.  59, 884-886. [PubMed]
11. Nalini, A., Jitender, S., Anantaram, G. and Santosh, V.  Rosai Dorfman disease: case with extensive dural involvement and cerebrospinal fluid pleocytosis. Journal of the Neurological Sciences. 2012.  314, 152-154. [PubMed]
12. Madhugiri, V. S., Pandey, P., Indira, D., Santosh, V. and Yasha, T. C.  Intramedullary metastasis in a case of vermian medulloblastoma. British Journal of Neurosurgery. 2012.  26, 278-280. [PubMed]
13. Chakraborti, S., Govindan, A., Alapatt, J. P., Radhakrishnan, M. and Santosh, V.  Primary myxopapillary ependymoma of the fourth ventricle with cartilaginous metaplasia: a case report and review of the literature. Brain Tumor Pathology. 2012.  29, 25-30. [PubMed]
14. Govindan, A., Chakraborti, S., Mahadevan, A., Chickabasavaiah, Y. T., Santosh, V. and Shankar, S. K.  Histopathologic and immunohistochemical profile of spinal glioblastoma: a study of six cases. Brain Tumor Pathology. 2011.  28, 297-303. [PubMed]
15. Gayathri, N., Alefia, R., Nalini, A., Yasha, T. C., Anita, M., Santosh, V. and Shankar, S. K.  Dysferlinopathy: spectrum of pathological changes in skeletal muscle tissue. Indian Journal of Pathology & Microbiology. 2011.  54, 350-354. [PubMed]
16. Suvasini, R., Shruti, B., Thota, B., Shinde, S. V., Friedmann-Morvinski, D., Nawaz, Z., Prasanna, K. V., Thennarasu, K., Hegde, A. S., Arivazhagan, A., Chandramouli, B. A., Santosh, V. and Somasundaram, K.  Insulin growth factor-2 binding protein 3 (IGF2BP3) is a glioblastoma-specific marker that activates phosphatidylinositol 3-kinase/mitogen-activated protein kinase (PI3K/MAPK) pathways by modulating IGF-2. The Journal of Biological Chemistry. 2011.  286, 25882-25890. [PubMed]
17. Thakar, S., Santosh, V., Ghosal, N., Furtado, S. V. and Hegde, A. S.  Metachronous occurrence of a temporal ganglioglioma and a bifrontal anaplastic ependymoma: coincidence or an explainable pathological curiosity? British Journal of Neurosurgery. 2011.  25, 741-743. [PubMed]
18. Ranjan, M., Santosh, V., Tandon, A., Anandh, B., Sampath, S., Devi, B. I. and Chandramouli, B. A.  Factors predicting progression of low-grade diffusely infiltrating astrocytoma. Neurology India. 2011.  59, 248-253. [PubMed]
19. Jain, A., Sharma, M. C., Suri, V., Kale, S. S., Mahapatra, A. K., Tatke, M., Chacko, G., Pathak, A., Santosh, V., Nair, P., Husain, N. and Sarkar, C.  Spectrum of pediatric brain tumors in India: a multi-institutional study. Neurology India. 2011.  59, 208-211. [PubMed]
20. Mohanty, A., Santosh, V., Devi, B. I., Satish, S. and Biswas, A.  Efficacy of simultaneous single-trajectory endoscopic tumor biopsy and endoscopic cerebrospinal fluid diversion procedures in intra- and paraventricular tumors. Neurosurgical Focus. 2011.  30, E4. [PubMed]
21. Chandrashekhar, T. N., Mahadevan, A., Vani, S., Yasha, T. C., Sampath, S., Chandramouli, B. A., Devi, B. I., Arvinda, H. R. and Shankar, S. K.  Pathological spectrum of neuronal/glioneuronal tumors from a tertiary referral neurological Institute. Neuropathology.  2012.  32, 1-12. [PubMed]
22. Srividya, M. R., Thota, B., Shailaja, B. C., Arivazhagan, A., Thennarasu, K., Chandramouli, B. A., Hegde, A. S. and Santosh, V.  Homozygous 10q23/PTEN deletion and its impact on outcome in glioblastoma: a prospective translational study on a uniformly treated cohort of adult patients. Neuropathology : Official Journal of the Japanese Society of Neuropathology. 2011.  31, 376-383. [PubMed]
23. Ghosh, A., Narayanappa, G., Taly, A. B., Chickbasavaiya, Y. T., Mahadevan, A., Vani, S., Atchayaram, N., Mohapatra, I. and Susarala, K. S.  Tubular aggregate myopathy: a phenotypic spectrum and morphological study. Neurology India. 2010.  58, 747-751. [PubMed]
24. Santosh, V., Mahadevan, A., Chickabasaviah, Y. T., Bharath, R. D. and Krishna, S. S.  Infectious lesions mimicking central nervous system neoplasms. Seminars in Diagnostic Pathology. 2010.  27, 122-135. [PubMed]
25. Kumar, D. M., Thota, B., Shinde, S. V., Prasanna, K. V., Hegde, A. S., Arivazhagan, A., Chandramouli, B. A., Santosh, V. and Somasundaram, K.  Proteomic identification of haptoglobin alpha2 as a glioblastoma serum biomarker: implications in cancer cell migration and tumor growth. Journal of Proteome Research. 2010.  9, 5557-5567. [PubMed]
26. Chakraborti, S., Mahadevan, A., Govindan, A., Yasha, T. C., Santosh, V., Kovoor, J. M., Ramamurthi, R., Alapatt, J. P., Hedge, T. and Shankar, S. K.  Supratentorial and cerebellar liponeurocytomas: report of four cases with review of literature. Journal of Neuro-oncology. 2011.  103, 121-127. [PubMed]
27. Rao, S. A., Santosh, V. and Somasundaram, K.  Genome-wide expression profiling identifies deregulated miRNAs in malignant astrocytoma. Modern Pathology . 2010.  23, 1404-1417. [PubMed]
28. Ladha, J., Donakonda, S., Agrawal, S., Thota, B., Srividya, M. R., Sridevi, S., Arivazhagan, A., Thennarasu, K., Balasubramaniam, A., Chandramouli, B. A., Hegde, A. S., Kondaiah, P., Somasundaram, K., Santosh, V. and Rao, S. M.  Glioblastoma-specific protein interaction network identifies PP1A and CSK21 as connecting molecules between cell cycle-associated genes. Cancer Research. 2010.  70, 6437-6447. [PubMed]
29. Sreekanthreddy, P., Srinivasan, H., Kumar, D. M., Nijaguna, M. B., Sridevi, S., Vrinda, M., Arivazhagan, A., Balasubramaniam, A., Hegde, A. S., Chandramouli, B. A., Santosh, V., Rao, M. R., Kondaiah, P. and Somasundaram, K.  Identification of potential serum biomarkers of glioblastoma: serum osteopontin levels correlate with poor prognosis. Cancer Epidemiology, Biomarkers & Prevention. 2010.  19, 1409-1422. [PubMed]
30. Santosh, V., Arivazhagan, A., Sreekanthreddy, P., Srinivasan, H., Thota, B., Srividya, M. R., Vrinda, M., Sridevi, S., Shailaja, B. C., Samuel, C., Prasanna, K. V., Thennarasu, K., Balasubramaniam, A., Chandramouli, B. A., Hegde, A. S., Somasundaram, K., Kondaiah, P. and Rao, M. R.  Grade-specific expression of insulin-like growth factor-binding proteins-2, -3, and -5 in astrocytomas: IGFBP-3 emerges as a strong predictor of survival in patients with newly diagnosed glioblastoma. Cancer Epidemiology, Biomarkers & Prevention. 2010. 19, 1399-1408. [PubMed]
31. Srikantha, U., Balasubramaniam, A., Santosh, V., Somanna, S., Bhagavatula, I. D. and Ashwathnarayana, C. B.  Recurrence in medulloblastoma - influence of clinical, histological and immunohistochemical factors. British Journal of Neurosurgery. 2010.  24, 280-288. [PubMed]
32. Mohapatra, I., Santosh, V., Chickabasaviah, Y. T., Mahadevan, A., Tandon, A., Ghosh, A., Chidambaram, B., Sampath, S., Bhagavatula, I. D., Chandramouli, B. A., Kolluri, S. V. and Shankar, S. K.  Histological and immunohistochemical characterization of AT/RT: a report of 15 cases from India. Neuropathology. 2010.  30, 251-259. [PubMed]
33. Chakraborti, S., Mahadevan, A., Govindan, A., Nagarathna, S., Santosh, V., Yasha, T. C., Devi, B. I., Chandramouli, B. A., Kovoor, J. M., Chandramuki, A. and Shankar, S. K.  Clinicopathological study of tuberculous brain abscess. Pathology, Research and Practice. 2009.  205, 815-822. [PubMed]
34. Nalini, A., Gayathri, N. and Santosh, V.  Ullrich congenital muscular dystrophy: report of nine cases from India. Neurology India. 2009.  57, 41-45. [PubMed]
35. Reddy, P. S., Umesh, S., Thota, B., Tandon, A., Pandey, P., Hegde, A. S., Balasubramaniam, A., Chandramouli, B. A., Santosh, V., Rao, M. R., Kondaiah, P. and Somasundaram, K.  PBEF1/NAmPRTase/Visfatin: a potential malignant astrocytoma/glioblastoma serum marker with prognostic value. Cancer Biology & Therapy. 2008.  7, 663-668. [PubMed]
36. Moiyadi, A. V., Satish, S., Rao, G. and Santosh, V.  Multicompartmental trigeminal schwannoma--a clinical report. The Journal of Craniofacial Surgery. 2008.  19, 1177-1180. [PubMed]
37. Gayathri, N., Yasha, T. C., Kanjalkar, M., Agarwal, S., Sagar, B. K., Santosh, V. and Shankar, S. K.  Fabry's disease: An ultrastructural study of nerve biopsy. Annals of Indian Academy of Neurology. 2008.  11, 182-184. [PubMed]
38. Reddy, S. P., Britto, R., Vinnakota, K., Aparna, H., Sreepathi, H. K., Thota, B., Kumari, A., Shilpa, B. M., Vrinda, M., Umesh, S., Samuel, C., Shetty, M., Tandon, A., Pandey, P., Hegde, S., Hegde, A. S., Balasubramaniam, A., Chandramouli, B. A., Santosh, V., Kondaiah, P., Somasundaram, K. and Rao, M. R.  Novel glioblastoma markers with diagnostic and prognostic value identified through transcriptome analysis. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 2008.  14, 2978-2987. [PubMed]
39. Mahadevan, A., Vaidya, S. R., Wairagkar, N. S., Khedekar, D., Kovoor, J. M., Santosh, V., Yasha, T. C., Satishchandra, P., Ravi, V. and Shankar, S. K.  Case of fulminant-SSPE associated with measles genotype D7 from India: an autopsy study. Neuropathology : Official Journal of the Japanese Society of Neuropathology. 2008.  28, 621-626. [PubMed]
40. Shankar, S. K., Mahadevan, A., Sundaram, C., Sarkar, C., Chacko, G., Lanjewar, D. N., Santosh, V., Yasha, T. C. and Radhakrishnan, V. V.  Pathobiology of fungal infections of the central nervous system with special reference to the Indian scenario. Neurology India. 2007.  55, 198-215. [PubMed]
41. Rumana, M., Santosh, V., Khursheed, N., Yasha, T. C., Kolluri, V. R., Shetty, S. and Ravi, K. C.  Primary spinal paragangliomas: a clinicopathological and immunohistochemical study of six cases. Indian Journal of Pathology & Microbiology. 2007.  50, 528-532. [PubMed]
42. Mahadevan, A., Shankar, S. K., Satishchandra, P., Ranga, U., Chickabasaviah, Y. T., Santosh, V., Vasanthapuram, R., Pardo, C. A., Nath, A. and Zink, M. C.  Characterization of human immunodeficiency virus (HIV)-infected cells in infiltrates associated with CNS opportunistic infections in patients with HIV clade C infection. Journal of Neuropathology and Experimental Neurology. 2007.  66, 799-808. [PubMed]
43. Ghosal, N., Furtado, S. V., Santosh, V., Sridhar, M. and Hegde, A. S.  Co-existing fibrous dysplasia and atypical lymphoplasmacyte-rich meningioma. Neuropathology . 2007.  27, 269-272. [PubMed]
44. Maramattom, B. V., Kumar, U., Deepti, A. N. and Santosh, V.  Indolent extranodal marginal zone lymphoma of the meninges producing chronic cerebral venous occlusion. Neurology India. 2007.  55, 179-180. [PubMed]
45. Roopesh, K., Mohanty, A., Santosh, V., Satish, S., Devi, B. I., Praharaj, S. S. and Kolluri, S. V.  Endoscopic options in management of posterior third ventricular tumors. Child's Nervous System : ChNS : Official Journal of the International Society For Pediatric Neurosurgery. 2007.  23, 1135-1145. [PubMed]
46. Nandeesh, B. N., Mahadevan, A., Santosh, V., Yasha, T. C. and Shankar, S. K.  Acute aortic dissection presenting as painful paraplegia. Clinical Neurology and Neurosurgery. 2007.  109, 531-534. [PubMed]
47. Britto, R., Umesh, S., Hegde, A. S., Hegde, S., Santosh, V., Chandramouli, B. A. and Somasundaram, K.  Shift in AP-2alpha localization characterizes astrocytoma progression. Cancer Biology & Therapy. 2007.  6, 413-418. [PubMed]
48. Mahadevan, A., Satishchandra, P., Prachet, K. K., Sidappa, N. B., Ranga, U., Santosh, V., Yasha, T. C., Desai, A., Ravi, V. and Shankar, S. K.  Optic nerve axonal pathology is related to abnormal visual evoked responses in AIDS. Acta Neuropathologica. 2006.  112, 461-469. [PubMed]
49. Yasha, T. C., Anandh, B., Srikanth, S. G., Mahadevan, A., Santosh, V. and Shankar, S. K.  A 30-year-old male with diffuse white matter lesions. Neurology India. 2005.  53, 358-360. [PubMed]
50. Somasundaram, K., Reddy, S. P., Vinnakota, K., Britto, R., Subbarayan, M., Nambiar, S., Hebbar, A., Samuel, C., Shetty, M., Sreepathi, H. K., Santosh, V., Hegde, A. S., Hegde, S., Kondaiah, P. and Rao, M. R.  Upregulation of ASCL1 and inhibition of Notch signaling pathway characterize progressive astrocytoma. Oncogene. 2005.  24, 7073-7083. [PubMed]
51. Shankar, S. K., Mahadevan, A., Satishchandra, P., Kumar, R. U., Yasha, T. C., Santosh, V., Chandramuki, A., Ravi, V. and Nath, A.  Neuropathology of HIV/AIDS with an overview of the Indian scene. The Indian Journal of Medical Research. 2005.  121, 468-488. [PubMed]
52. Chumbalkar, V. C., Subhashini, C., Dhople, V. M., Sundaram, C. S., Jagannadham, M. V., Kumar, K. N., Srinivas, P. N., Mythili, R., Rao, M. K., Kulkarni, M. J., Hegde, S., Hegde, A. S., Samual, C., Santosh, V., Singh, L. and Sirdeshmukh, R.  Differential protein expression in human gliomas and molecular insights. Proteomics. 2005.  5, 1167-1177. [PubMed]
53. Dubey, A., Patwardhan, R. V., Sampth, S., Santosh, V., Kolluri, S. and Nanda, A.  Intracranial fungal granuloma: analysis of 40 patients and review of the literature. Surgical Neurology. 2005.  63, 254-60. [PubMed]
54. Sarkar, C., Sharma, M. C., Deb, P., Singh, R., Santosh, V. and Shankar, S. K.  Primary central nervous system lymphoma--a hospital based study of incidence and clinicopathological features from India (1980-2003). Journal of Neuro-oncology. 2005.  71, 199-204. [PubMed]
55. Aditya, G. S., Mahadevan, A., Santosh, V., Chickabasaviah, Y. T., Ashwathnarayanarao, C. B. and Krishna, S. S.  Cysticercal chronic basal arachnoiditis with infarcts, mimicking tuberculous pathology in endemic areas. Neuropathology : Official Journal of the Japanese Society of Neuropathology. 2004.  24, 320-325. [PubMed]
56. Sharma, M. C., Ralte, A. M., Gaekwad, S., Santosh, V., Shankar, S. K. and Sarkar, C.  Subependymal giant cell astrocytoma--a clinicopathological study of 23 cases with special emphasis on histogenesis. Pathology Oncology Research : POR. 2004.  10, 219-224. [PubMed]
57. Suresh, T. N., Mahadevan, A., Santosh, V. and Shankar, S. K.  Subarachnoid spread of germinoma mimicking tuberculous meningitis. Neurology India. 2004.  52, 251-253. [PubMed]
58. Sharma, M., Ralte, A., Arora, R., Santosh, V., Shankar, S. K. and Sarkar, C.  Subependymal giant cell astrocytoma: a clinicopathological study of 23 cases with special emphasis on proliferative markers and expression of p53 and retinoblastoma gene proteins. Pathology. 2004.  36, 139-144. [PubMed]
59. Sinha, S., Satishchandra, P., Santosh, V., Gayatri, N. and Shankar, S. K.  Neuronal ceroid lipofuscinosis: a clinicopathological study. Seizure : the Journal of the British Epilepsy Association. 2004.  13, 235-240. [PubMed]
60. Aditya, G. S., Santosh, V., Yasha, T. C. and Shankar, S. K.  Epithelioid and retiform hemangioendothelioma of the skull bone--report of four cases. Indian Journal of Pathology & Microbiology. 2003.  46, 645-649. [PubMed]
61. Koyye, R. T., Mahadevan, A., Santosh, V., Chickabasaviah, Y. T., Govindappa, S. S., Hegde, T. and Shankar, S. K.  A rare case of cellular schwannoma involving the trigeminal ganglion. Brain Tumor Pathology. 2003.  20, 79-83. [PubMed]
62. Rout, P., Santosh, V., Mahadevan, A., Kolluri, V. R., Yasha, T. C. and Shankar, S. K.  Desmoplastic infantile ganglioglioma--clinicopathological and immunohistochemical study of four cases. Child's Nervous System : ChNS : Official Journal of the International Society For Pediatric Neurosurgery. 2002.  18, 463-467. [PubMed]
 
 
Education 
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M.D. in Pathology
  Last modified on : Nov 14, 2013
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