INCREDB ID : 431
Home >> Investigator Page Previous      Next
Rana P Singh, Ph.D.
Associate Professor 
 
Jawaharlal Nehru University
School of Life Sciences
# 104
New Delhi - 110 067   
New Delhi   
 
E-mail: rana_singh@mail.jnu.ac.in
Phone: 91-11-26704503
Fax: 91-11-26742558
 
URL: http://www.jnu.ac.in/FacultyStaff/ShowProfile.asp?SendUserName=ranapsingh
 
Positions Held:
Position Affiliation Time Period
Adjunct Professor School of Life Sciences, Central University of Gujarat, Gandhinagar, Gujarat, India. 2012
Professor and Dean School of Life Sciences, Central University of Gujarat, Gandhinagar, Gujarat, India. 2010-2012
Associate Professor School of Life Sciences, Jawaharlal Nehru University, New Delhi, India. 2006
Assistant Professor Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Denver, CO, USA. 2003-2006
Research Associate Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Denver, CO, USA. 2001-2003
 
Area of Specialization:
Radiology
Oncology
cell cycle progression
mitogenic and cell survival signaling
and apoptosis
tumor angiogenesis
DNA damage/repair in UVB-skin carcinogenesis
inflammation and oxidative stress.
Research Summary:
Carcinogenesis, Tumor Microenvironment, Tumor Angiogenesis, Cancer Prevention and Therapeutics, Radiation Carcinogenesis and Radiotherapy.
 
Publications:
1. Varghese, L., Agarwal, C., Tyagi, A., Singh, R. P. and Agarwal, R.  Silibinin efficacy against human hepatocellular carcinoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 2005.  11, 8441-8448. [PubMed]
2. Tyagi, A., Singh, R. P., Agarwal, C., Siriwardana, S., Sclafani, R. A. and Agarwal, R.  Resveratrol causes Cdc2-tyr15 phosphorylation via ATM/ATR-Chk1/2-Cdc25C pathway as a central mechanism for S phase arrest in human ovarian carcinoma Ovcar-3 cells. Carcinogenesis. 2005.  26, 1978-1987. [PubMed]
3. Gu, M., Dhanalakshmi, S., Mohan, S., Singh, R. P. and Agarwal, R.  Silibinin inhibits ultraviolet B radiation-induced mitogenic and survival signaling, and associated biological responses in SKH-1 mouse skin. Carcinogenesis. 2005.  26, 1404-1413. [PubMed]
4. Dhanalakshmi, S., Agarwal, C., Singh, R. P. and Agarwal, R.  Silibinin up-regulates DNA-protein kinase-dependent p53 activation to enhance UVB-induced apoptosis in mouse epithelial JB6 cells. The Journal of Biological Chemistry. 2005.  280, 20375-20383. [PubMed]
5. Gu, M., Dhanalakshmi, S., Singh, R. P. and Agarwal, R.  Dietary feeding of silibinin prevents early biomarkers of UVB radiation-induced carcinogenesis in SKH-1 hairless mouse epidermis. Cancer Epidemiology, Biomarkers & Prevention : A Publication of the American Association For Cancer Research, Cosponsored By the American Society Of. 2005.  14, 1344-1349. [PubMed]
6. Singh, R. P., Agrawal, P., Yim, D., Agarwal, C. and Agarwal, R.  Acacetin inhibits cell growth and cell cycle progression, and induces apoptosis in human prostate cancer cells: structure-activity relationship with linarin and linarin acetate. Carcinogenesis. 2005.  26, 845-854. [PubMed]
7. Padmavathi, B., Upreti, M., Singh, V., Rao, A. R., Singh, R. P. and Rath, P. C.  Chemoprevention by Hippophae rhamnoides: effects on tumorigenesis, phase II and antioxidant enzymes, and IRF-1 transcription factor. Nutrition and Cancer. 2005.  51, 59-67. [PubMed]
8. Padmavathi, B., Rath, P. C., Rao, A. R. and Singh, R. P.  Roots of Withania somnifera Inhibit Forestomach and Skin Carcinogenesis in Mice. Evidence-based Complementary and Alternative Medicine : ECAM. 2005.  2, 99-105. [PubMed]
9. Yim, D., Singh, R. P., Agarwal, C., Lee, S., Chi, H. and Agarwal, R.  A novel anticancer agent, decursin, induces G1 arrest and apoptosis in human prostate carcinoma cells. Cancer Research. 2005.  65, 1035-1044. [PubMed]
10. Singh, R. P., Dhanalakshmi, S., Agarwal, C. and Agarwal, R.  Silibinin strongly inhibits growth and survival of human endothelial cells via cell cycle arrest and downregulation of survivin, Akt and NF-kappaB: implications for angioprevention and antiangiogenic therapy. Oncogene. 2005.  24, 1188-1202. [PubMed]
11. Kaur, M., Agarwal, C., Singh, R. P., Guan, X., Dwivedi, C. and Agarwal, R.  Skin cancer chemopreventive agent, {alpha}-santalol, induces apoptotic death of human epidermoid carcinoma A431 cells via caspase activation together with dissipation of mitochondrial membrane potential and cytochrome c release. Carcinogenesis. 2005.  26, 369-380. [PubMed]
12. Singh, R. P. and Agarwal, R.  Mechanisms and preclinical efficacy of silibinin in preventing skin cancer. European Journal of Cancer. 2005.  41, 1969-1979. [PubMed]
13. Singh, R. P. and Agarwal, R.  Prostate cancer and inositol hexaphosphate: efficacy and mechanisms. Anticancer Research. 2005.  25, 2891-2903. [PubMed]
14. Agarwal, C., Dhanalakshmi, S., Singh, R. P. and Agarwal, R.  Inositol hexaphosphate inhibits growth and induces G1 arrest and apoptotic death of androgen-dependent human prostate carcinoma LNCaP cells. Neoplasia. 2004.  6, 646-659. [PubMed]
15. Singh, R. P., Mallikarjuna, G. U., Sharma, G., Dhanalakshmi, S., Tyagi, A. K., Chan, D. C., Agarwal, C. and Agarwal, R.  Oral silibinin inhibits lung tumor growth in athymic nude mice and forms a novel chemocombination with doxorubicin targeting nuclear factor kappaB-mediated inducible chemoresistance. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 2004.  10, 8641-8647. [PubMed]
16. Mallikarjuna, G., Dhanalakshmi, S., Singh, R. P., Agarwal, C. and Agarwal, R.  Silibinin protects against photocarcinogenesis via modulation of cell cycle regulators, mitogen-activated protein kinases, and Akt signaling. Cancer Research. 2004.  64, 6349-6356. [PubMed]
17. Mohan, S., Dhanalakshmi, S., Mallikarjuna, G. U., Singh, R. P. and Agarwal, R.  Silibinin modulates UVB-induced apoptosis via mitochondrial proteins, caspases activation, and mitogen-activated protein kinase signaling in human epidermoid carcinoma A431 cells. Biochemical and Biophysical Research Communications. 2004.  320, 183-189. [PubMed]
18. Singh, R. P. and Agarwal, R.  Prostate cancer prevention by silibinin. Current Cancer Drug Targets. 2004.  4, 1-11. [PubMed]
19. Singh, R. P. and Agarwal, R.  A cancer chemopreventive agent silibinin, targets mitogenic and survival signaling in prostate cancer. Mutation Research. 2004.  555, 21-32. [PubMed]
20. Dhanalakshmi, S., Mallikarjuna, G. U., Singh, R. P. and Agarwal, R.  Silibinin prevents ultraviolet radiation-caused skin damages in SKH-1 hairless mice via a decrease in thymine dimer positive cells and an up-regulation of p53-p21/Cip1 in epidermis. Carcinogenesis. 2004.  25, 1459-1465. [PubMed]
21. Sharma, G., Tyagi, A. K., Singh, R. P., Chan, D. C. and Agarwal, R.  Synergistic anti-cancer effects of grape seed extract and conventional cytotoxic agent doxorubicin against human breast carcinoma cells. Breast Cancer Research and Treatment. 2004.  85, 1-12. [PubMed]
22. Singh, R. P., Sharma, G., Mallikarjuna, G. U., Dhanalakshmi, S., Agarwal, C. and Agarwal, R.  In vivo suppression of hormone-refractory prostate cancer growth by inositol hexaphosphate: induction of insulin-like growth factor binding protein-3 and inhibition of vascular endothelial growth factor. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 2004.  10, 244-250. [PubMed]
23. Agarwal, C., Singh, R. P., Dhanalakshmi, S. and Agarwal, R.  Anti-angiogenic efficacy of grape seed extract in endothelial cells. Oncology Reports. 2004.  11, 681-685. [PubMed]
24. Singh, R. P., Tyagi, A. K., Dhanalakshmi, S., Agarwal, R. and Agarwal, C.  Grape seed extract inhibits advanced human prostate tumor growth and angiogenesis and upregulates insulin-like growth factor binding protein-3. International Journal of Cancer. Journal International Du Cancer. 2004.  108, 733-740. [PubMed]
25. Dhanalakshmi, S., Mallikarjuna, G. U., Singh, R. P. and Agarwal, R.  Dual efficacy of silibinin in protecting or enhancing ultraviolet B radiation-caused apoptosis in HaCaT human immortalized keratinocytes. Carcinogenesis. 2004.  25, 99-106. [PubMed]
26. Agarwal, C., Singh, R. P., Dhanalakshmi, S., Tyagi, A. K., Tecklenburg, M., Sclafani, R. A. and Agarwal, R.  Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells. Oncogene. 2003.  22, 8271-8282. [PubMed]
27. Tyagi, A. K., Agarwal, C., Singh, R. P., Shroyer, K. R., Glode, L. M. and Agarwal, R.  Silibinin down-regulates survivin protein and mRNA expression and causes caspases activation and apoptosis in human bladder transitional-cell papilloma RT4 cells. Biochemical and Biophysical Research Communications. 2003.  312, 1178-1184. [PubMed]
28. Agarwal, C., Dhanalakshmi, S., Singh, R. P. and Agarwal, R.  Inositol hexaphosphate inhibits constitutive activation of NF- kappa B in androgen-independent human prostate carcinoma DU145 cells. Anticancer Research. 2003.  23, 3855-3861. [PubMed]
29. Qi, L., Singh, R. P., Lu, Y., Agarwal, R., Harrison, G. S., Franzusoff, A. and Glode, L. M.  Epidermal growth factor receptor mediates silibinin-induced cytotoxicity in a rat glioma cell line. Cancer Biology & Therapy. 2003.  2, 526-531. [PubMed]
30. Singh, R. P., Sharma, G., Dhanalakshmi, S., Agarwal, C. and Agarwal, R.  Suppression of advanced human prostate tumor growth in athymic mice by silibinin feeding is associated with reduced cell proliferation, increased apoptosis, and inhibition of angiogenesis. Cancer Epidemiology, Biomarkers & Prevention : A Publication of the American Association For Cancer Research, Cosponsored By the American Society Of. 2003.  12, 933-939. [PubMed]
31. Sharma, G., Singh, R. P. and Agarwal, R.  Growth inhibitory and apoptotic effects of inositol hexaphosphate in transgenic adenocarcinoma of mouse prostate (TRAMP-C1) cells. International Journal of Oncology. 2003.  23, 1413-1418. [PubMed]
32. Sharma, G., Singh, R. P., Chan, D. C. and Agarwal, R.  Silibinin induces growth inhibition and apoptotic cell death in human lung carcinoma cells. Anticancer Research. 2003.  23, 2649-2655. [PubMed]
33. Singh, R. P., Agarwal, C. and Agarwal, R.  Inositol hexaphosphate inhibits growth, and induces G1 arrest and apoptotic death of prostate carcinoma DU145 cells: modulation of CDKI-CDK-cyclin and pRb-related protein-E2F complexes. Carcinogenesis. 2003.  24, 555-563. [PubMed]
34. Singh, R. P. and Agarwal, R.  Tumor angiogenesis: a potential target in cancer control by phytochemicals. Current Cancer Drug Targets. 2003.  3, 205-217. [PubMed]
35. Agarwal, C., Singh, R. P. and Agarwal, R.  Grape seed extract induces apoptotic death of human prostate carcinoma DU145 cells via caspases activation accompanied by dissipation of mitochondrial membrane potential and cytochrome c release. Carcinogenesis. 2002.  23, 1869-1876. [PubMed]
36. Singh, R. P. and Agarwal, R.  Flavonoid antioxidant silymarin and skin cancer. Antioxidants & Redox Signaling. 2002.  4, 655-663. [PubMed]
37. Singh, R. P., Dhanalakshmi, S. and Agarwal, R.  Phytochemicals as cell cycle modulators--a less toxic approach in halting human cancers. Cell Cycle. 2002.  1, 156-161. [PubMed]
38. Tyagi, A. K., Singh, R. P., Agarwal, C., Chan, D. C. and Agarwal, R.  Silibinin strongly synergizes human prostate carcinoma DU145 cells to doxorubicin-induced growth Inhibition, G2-M arrest, and apoptosis. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 2002.  8, 3512-3519. [PubMed]
39. Singh, R. P., Dhanalakshmi, S., Tyagi, A. K., Chan, D. C., Agarwal, C. and Agarwal, R.  Dietary feeding of silibinin inhibits advance human prostate carcinoma growth in athymic nude mice and increases plasma insulin-like growth factor-binding protein-3 levels. Cancer Research. 2002.  62, 3063-3069. [PubMed]
40. Singh, R. P., Tyagi, A. K., Zhao, J. and Agarwal, R.  Silymarin inhibits growth and causes regression of established skin tumors in SENCAR mice via modulation of mitogen-activated protein kinases and induction of apoptosis. Carcinogenesis. 2002.  23, 499-510. [PubMed]
41. Dhanalakshmi, S., Singh, R. P., Agarwal, C. and Agarwal, R.  Silibinin inhibits constitutive and TNFalpha-induced activation of NF-kappaB and sensitizes human prostate carcinoma DU145 cells to TNFalpha-induced apoptosis. Oncogene. 2002.  21, 1759-1767. [PubMed]
42. Singh, R. P., Banerjee, S. and Rao, A. R.  Modulatory influence of Andrographis paniculata on mouse hepatic and extrahepatic carcinogen metabolizing enzymes and antioxidant status. Phytotherapy Research : PTR. 2001.  15, 382-390. [PubMed]
43. Zi, X., Singh, R. P. and Agarwal, R.  Impairment of erbB1 receptor and fluid-phase endocytosis and associated mitogenic signaling by inositol hexaphosphate in human prostate carcinoma DU145 cells. Carcinogenesis. 2000.  21, 2225-2235. [PubMed]
44. Singh, R. P., Padmavathi, B. and Rao, A. R.  Modulatory influence of Adhatoda vesica (Justicia adhatoda) leaf extract on the enzymes of xenobiotic metabolism, antioxidant status and lipid peroxidation in mice. Molecular and Cellular Biochemistry. 2000.  213, 99-109. [PubMed]
45. Singh, R. P., Banerjee, S. and Rao, A. R.  Effect of Aegle marmelos on biotransformation enzyme systems and protection against free-radical-mediated damage in mice. The Journal of Pharmacy and Pharmacology. 2000.  52, 991-1000. [PubMed]
46. Singh, R. P., Dhanalakshmi, S. and Rao, A. R.  Chemomodulatory action of Aloe vera on the profiles of enzymes associated with carcinogen metabolism and antioxidant status regulation in mice. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. 2000.  7, 209-219. [PubMed]
1. Singh, N., Nambiar, D., Kale, R. K. and Singh, R. P.  Usnic acid inhibits growth and induces cell cycle arrest and apoptosis in human lung carcinoma A549 cells. Nutrition and Cancer. 2013.  65 Suppl 1, 36-43. [PubMed]
2. Nambiar, D., Prajapati, V., Agarwal, R. and Singh, R. P.  In vitro and in vivo anticancer efficacy of silibinin against human pancreatic cancer BxPC-3 and PANC-1 cells. Cancer Letters. 2012.  [PubMed]
3. Nambiar, D. and Singh, R. P.  Advances in prostate cancer chemoprevention: a translational perspective. Nutrition and Cancer. 2013.  65 Suppl 1, 12-25. [PubMed]
4. Bhat, T. A., Nambiar, D., Pal, A., Agarwal, R. and Singh, R. P.  Fisetin inhibits various attributes of angiogenesis in vitro and in vivo--implications for angioprevention. Carcinogenesis. 2012.  33, 385-393. [PubMed]
5. Tyagi, A., Agarwal, C., Dwyer-Nield, L. D., Singh, R. P., Malkinson, A. M. and Agarwal, R.  Silibinin modulates TNF-alpha and IFN-gamma mediated signaling to regulate COX2 and iNOS expression in tumorigenic mouse lung epithelial LM2 cells. Molecular Carcinogenesis. 2012.  51, 832-842. [PubMed]
6. Nambiar, D., Rajamani, P. and Singh, R. P.  Effects of phytochemicals on ionization radiation-mediated carcinogenesis and cancer therapy. Mutation Research. 2011.  728, 139-157. [PubMed]
7. Kaur, M., Tyagi, A., Singh, R. P., Sclafani, R. A., Agarwal, R. and Agarwal, C.  Grape seed extract upregulates p21 (Cip1) through redox-mediated activation of ERK1/2 and posttranscriptional regulation leading to cell cycle arrest in colon carcinoma HT29 cells. Molecular Carcinogenesis. 2011.  50, 553-562. [PubMed]
8. Ramasamy, K., Dwyer-Nield, L. D., Serkova, N. J., Hasebroock, K. M., Tyagi, A., Raina, K., Singh, R. P., Malkinson, A. M. and Agarwal, R.  Silibinin prevents lung tumorigenesis in wild-type but not in iNOS-/- mice: potential of real-time micro-CT in lung cancer chemoprevention studies. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 2011.  17, 753-761. [PubMed]
9. Bhat, T. A., Moon, J. S., Lee, S., Yim, D. and Singh, R. P.  Inhibition of angiogenic attributes by decursin in endothelial cells and ex vivo rat aortic ring angiogenesis model. Indian Journal of Experimental Biology. 2011.  49, 848-856. [PubMed]
10. Prajapati, V., Kale, R. K. and Singh, R. P.  Arsenic and its combinations in cancer therapeutics. Therapeutic Delivery. 2011.  2, 793-806. [PubMed]
11. Ravichandran, K., Velmurugan, B., Gu, M., Singh, R. P. and Agarwal, R.  Inhibitory effect of silibinin against azoxymethane-induced colon tumorigenesis in A/J mice. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 2010.  16, 4595-4606. [PubMed]
12. Rajamanickam, S., Velmurugan, B., Kaur, M., Singh, R. P. and Agarwal, R.  Chemoprevention of intestinal tumorigenesis in APCmin/+ mice by silibinin. Cancer Research. 2010.  70, 2368-2378. [PubMed]
13. Velmurugan, B., Singh, R. P., Agarwal, R. and Agarwal, C.  Dietary-feeding of grape seed extract prevents azoxymethane-induced colonic aberrant crypt foci formation in fischer 344 rats. Molecular Carcinogenesis. 2010.  49, 641-652. [PubMed]
14. Kaur, M., Velmurugan, B., Tyagi, A., Agarwal, C., Singh, R. P. and Agarwal, R.  Silibinin suppresses growth of human colorectal carcinoma SW480 cells in culture and xenograft through down-regulation of beta-catenin-dependent signaling. Neoplasia. 2010.  12, 415-424. [PubMed]
15. Mateen, S., Tyagi, A., Agarwal, C., Singh, R. P. and Agarwal, R.  Silibinin inhibits human nonsmall cell lung cancer cell growth through cell-cycle arrest by modulating expression and function of key cell-cycle regulators. Molecular Carcinogenesis. 2010.  49, 247-258. [PubMed]
16. Velmurugan, B., Singh, R. P., Kaul, N., Agarwal, R. and Agarwal, C.  Dietary feeding of grape seed extract prevents intestinal tumorigenesis in APCmin/+ mice. Neoplasia. 2010.  12, 95-102. [PubMed]
17. Singh, R. P., Raina, K., Deep, G., Chan, D. and Agarwal, R.  Silibinin suppresses growth of human prostate carcinoma PC-3 orthotopic xenograft via activation of extracellular signal-regulated kinase 1/2 and inhibition of signal transducers and activators of transcription signaling. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 2009.  15, 613-621. [PubMed]
18. Rajamanickam, S., Kaur, M., Velmurugan, B., Singh, R. P. and Agarwal, R.  Silibinin suppresses spontaneous tumorigenesis in APC min/+ mouse model by modulating beta-catenin pathway. Pharmaceutical Research. 2009.  26, 2558-2567. [PubMed]
19. Roy, S., Gu, M., Ramasamy, K., Singh, R. P., Agarwal, C., Siriwardana, S., Sclafani, R. A. and Agarwal, R.  p21/Cip1 and p27/Kip1 Are essential molecular targets of inositol hexaphosphate for its antitumor efficacy against prostate cancer. Cancer Research. 2009.  69, 1166-1173. [PubMed]
20. Singh, R. P. and Agarwal, R.  Cosmeceuticals and silibinin. Clinics in Dermatology. 2009.  27, 479-484. [PubMed]
21. Tyagi, A., Singh, R. P., Ramasamy, K., Raina, K., Redente, E. F., Dwyer-Nield, L. D., Radcliffe, R. A., Malkinson, A. M. and Agarwal, R.  Growth inhibition and regression of lung tumors by silibinin: modulation of angiogenesis by macrophage-associated cytokines and nuclear factor-kappaB and signal transducers and activators of transcription 3. Cancer Prevention Research. 2009.  2, 74-83. [PubMed]
22. Kang, T. J., Lee, S. Y., Singh, R. P., Agarwal, R. and Yim, D. S.  Anti-tumor activity of oxypeucedanin from Ostericum koreanum against human prostate carcinoma DU145 cells. Acta Oncologica. 2009.  48, 895-900. [PubMed]
23. Singh, R. P., Gu, M. and Agarwal, R.  Silibinin inhibits colorectal cancer growth by inhibiting tumor cell proliferation and angiogenesis. Cancer Research. 2008.  68, 2043-2050. [PubMed]
24. Raina, K., Rajamanickam, S., Singh, R. P., Deep, G., Chittezhath, M. and Agarwal, R.  Stage-specific inhibitory effects and associated mechanisms of silibinin on tumor progression and metastasis in transgenic adenocarcinoma of the mouse prostate model. Cancer Research. 2008.  68, 6822-6830. [PubMed]
25. Singh, R. P., Raina, K., Sharma, G. and Agarwal, R.  Silibinin inhibits established prostate tumor growth, progression, invasion, and metastasis and suppresses tumor angiogenesis and epithelial-mesenchymal transition in transgenic adenocarcinoma of the mouse prostate model mice. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 2008.  14, 7773-7780. [PubMed]
26. Velmurugan, B., Singh, R. P., Tyagi, A. and Agarwal, R.  Inhibition of azoxymethane-induced colonic aberrant crypt foci formation by silibinin in male Fisher 344 rats. Cancer Prevention Research. 2008.  1, 376-384. [PubMed]
27. Deep, G., Raina, K., Singh, R. P., Oberlies, N. H., Kroll, D. J. and Agarwal, R.  Isosilibinin inhibits advanced human prostate cancer growth in athymic nude mice: comparison with silymarin and silibinin. International Journal of Cancer. Journal International Du Cancer. 2008.  123, 2750-2758. [PubMed]
28. Chittezhath, M., Deep, G., Singh, R. P., Agarwal, C. and Agarwal, R.  Silibinin inhibits cytokine-induced signaling cascades and down-regulates inducible nitric oxide synthase in human lung carcinoma A549 cells. Molecular Cancer Therapeutics. 2008.  7, 1817-1826. [PubMed]
29. Roy, S., Singh, R. P., Agarwal, C., Siriwardana, S., Sclafani, R. and Agarwal, R.  Downregulation of both p21/Cip1 and p27/Kip1 produces a more aggressive prostate cancer phenotype. Cell Cycle. 2008.  7, 1828-1835. [PubMed]
30. Raina, K., Rajamanickam, S., Singh, R. P. and Agarwal, R.  Chemopreventive efficacy of inositol hexaphosphate against prostate tumor growth and progression in TRAMP mice. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 2008.  14, 3177-3184. [PubMed]
31. Bhat, T. A. and Singh, R. P.  Tumor angiogenesis--a potential target in cancer chemoprevention. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. 2008.  46, 1334-1345. [PubMed]
32. Singh, R. P., Tyagi, A., Sharma, G., Mohan, S. and Agarwal, R.  Oral silibinin inhibits in vivo human bladder tumor xenograft growth involving down-regulation of survivin. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 2008.  14, 300-308. [PubMed]
33. Tyagi, A., Raina, K., Singh, R. P., Gu, M., Agarwal, C., Harrison, G., Glode, L. M. and Agarwal, R.  Chemopreventive effects of silymarin and silibinin on N-butyl-N-(4-hydroxybutyl) nitrosamine induced urinary bladder carcinogenesis in male ICR mice. Molecular Cancer Therapeutics. 2007.  6, 3248-3255. [PubMed]
34. Singh, R. P., Deep, G., Blouin, M. J., Pollak, M. N. and Agarwal, R.  Silibinin suppresses in vivo growth of human prostate carcinoma PC-3 tumor xenograft. Carcinogenesis. 2007.  28, 2567-2574. [PubMed]
35. Raina, K., Blouin, M. J., Singh, R. P., Majeed, N., Deep, G., Varghese, L., Glode, L. M., Greenberg, N. M., Hwang, D., Cohen, P., Pollak, M. N. and Agarwal, R.  Dietary feeding of silibinin inhibits prostate tumor growth and progression in transgenic adenocarcinoma of the mouse prostate model. Cancer Research. 2007.  67, 11083-11091. [PubMed]
36. Raina, K., Singh, R. P., Agarwal, R. and Agarwal, C.  Oral grape seed extract inhibits prostate tumor growth and progression in TRAMP mice. Cancer Research. 2007.  67, 5976-5982. [PubMed]
37. Gu, M., Singh, R. P., Dhanalakshmi, S., Agarwal, C. and Agarwal, R.  Silibinin inhibits inflammatory and angiogenic attributes in photocarcinogenesis in SKH-1 hairless mice. Cancer Research. 2007.  67, 3483-3491. [PubMed]
38. Singh, R. P. and Agarwal, R.  Inducible nitric oxide synthase-vascular endothelial growth factor axis: a potential target to inhibit tumor angiogenesis by dietary agents. Current Cancer Drug Targets. 2007.  7, 475-483. [PubMed]
39. Singh, R. P. and Agarwal, R.  Mechanisms of action of novel agents for prostate cancer chemoprevention. Endocrine-related Cancer. 2006.  13, 751-778. [PubMed]
40. Singh, R. P. and Agarwal, R.  Prostate cancer chemoprevention by silibinin: bench to bedside. Molecular Carcinogenesis. 2006.  45, 436-442. [PubMed]
41. Agarwal, R., Agarwal, C., Ichikawa, H., Singh, R. P. and Aggarwal, B. B.  Anticancer potential of silymarin: from bench to bed side. Anticancer Research. 2006.  26, 4457-4498. [PubMed]
42. Kaur, M., Singh, R. P., Gu, M., Agarwal, R. and Agarwal, C.  Grape seed extract inhibits in vitro and in vivo growth of human colorectal carcinoma cells. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 2006.  12, 6194-6202. [PubMed]
43. Singh, R. P., Deep, G., Chittezhath, M., Kaur, M., Dwyer-Nield, L. D., Malkinson, A. M. and Agarwal, R.  Effect of silibinin on the growth and progression of primary lung tumors in mice. Journal of the National Cancer Institute. 2006.  98, 846-855. [PubMed]
44. Gu, M., Singh, R. P., Dhanalakshmi, S., Mohan, S. and Agarwal, R.  Differential effect of silibinin on E2F transcription factors and associated biological events in chronically UVB-exposed skin versus tumors in SKH-1 hairless mice. Molecular Cancer Therapeutics. 2006.  5, 2121-2129. [PubMed]
45. Singh, R. P. and Agarwal, R.  Natural flavonoids targeting deregulated cell cycle progression in cancer cells. Current Drug Targets. 2006.  7, 345-354. [PubMed]
46. Tyagi, A., Singh, R. P., Agarwal, C. and Agarwal, R.  Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase 2. Carcinogenesis. 2006.  27, 2269-2280. [PubMed]
47. Singh, R. P., Dhanalakshmi, S., Mohan, S., Agarwal, C. and Agarwal, R.  Silibinin inhibits UVB- and epidermal growth factor-induced mitogenic and cell survival signaling involving activator protein-1 and nuclear factor-kappaB in mouse epidermal JB6 cells. Molecular Cancer Therapeutics. 2006.  5, 1145-1153. [PubMed]
48. Veluri, R., Singh, R. P., Liu, Z., Thompson, J. A., Agarwal, R. and Agarwal, C.  Fractionation of grape seed extract and identification of gallic acid as one of the major active constituents causing growth inhibition and apoptotic death of DU145 human prostate carcinoma cells. Carcinogenesis. 2006.  27, 1445-1453. [PubMed]
49. Deep, G., Singh, R. P., Agarwal, C., Kroll, D. J. and Agarwal, R.  Silymarin and silibinin cause G1 and G2-M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: a comparison of flavanone silibinin with flavanolignan mixture silymarin. Oncogene. 2006.  25, 1053-1069. [PubMed]
50. Singh, R. P., Banerjee, S., Kumar, P. V., Raveesha, K. A. and Rao, A. R.  Tinospora cordifolia induces enzymes of carcinogen/drug metabolism and antioxidant system, and inhibits lipid peroxidation in mice. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. 2006.  13, 74-84. [PubMed]
 
Book Chapters:
Singh N, Tailor D, Kale RK, Singh RP. Antioxidant phytochemicals in cancer chemoprevention. In Phytochemicals of Nutraceutical Importance and their Role in Human Health. Eds. Sharma G., Prakash D. CABI-UK publication (2013, in press).
Kartha A, Kale RK, Singh RP. Current trends in diagnosis, prevention and treatment of cancer. In Recent Trend in Life Sciences. Eds. Fulekar MH, Kale RK. IK International, New Delhi, pp. 265-319, 2013.
Taylor D, Singh RP. Dietary and non-dietary phytochemicals in cancer control. In Nutrition, Diet and Cancer. Eds. R. Srivastava & S. Shankar, Springer, pp. 573-610, 2012.
Bhat TA, Mittal A, Singh RP. Prevention of angiogenesis and metastasis. In Chemoprevention of cancer and DNA damage by dietary factors. Eds. S. Knasmuller, D.M. DeMarini, I. Johnson, C. Gerhauser. Wiley-VCH VerlagGmbH & Co. KgaA, Weinheim. pp. 163-182, April 2009.
Mittal A, Singh RP. Anticancer and immunomodulatory properties of Tinospora. In Herbal drugs: Ethnomedicine to modern medicine. Ed. K.G. Ramawat. Springer-Verlag Berlin Heidelberg, pp. 195-204, Dec, 2008.
Velmurugan B, Agarwal R, Singh RP. Role of bioactive natural compounds in cancer control. In Recent progresses in medicinal plant (phytopharmacology & therapeutic value III). Eds. J.N. Govil & V.K. Singh. Studium Press, LLC, Houston, TX, USA, vol. 21, pp. 367-93, Jan 2008.
 
Grant Support:
Project Title Role Funding Agency Sanction Number Sanction Date
Study of Antiangiogenic and Anti-tumor Effects of Fisetin in Lung Cancer: Implication for Intervention of Cancer. Principal Investigator Indian Council of Medical Research, Government of India 2012-2015
To study the role of protein glycosylation in cell-extracellular matrix interaction and cancer progression. Principal Investigator University Grants Commission, India 2012-2015
Antiangiogenic effects and mechanisms of Acacetin- a potential role in cancer control. Principal Investigator Council of Scientific and Industrial Research, Government of India 2009-2012
Targeting cell signaling and cell cycle progression for the intervention of prostate cancer by decursin. Principal Investigator Department of Science & Technology, Government of India 2008-2011

 
 
My CV:   Download
 
Education 
::
Ph.D. in Cancer biology
::
M.Sc. in Life Sciences
Honors and Awards
::
Post-doctoral Trainee Award for Prostate Cancer Research, U.S. Army Medical Research and Materiel Command, Department of Defense, USA. (2003, for 2 years).
::
Scholar-in-Training Award, American Association for Cancer Research, Philadelphia, PA, USA. (2002).
::
JRF and SRF, University Grant Commission/School of Life Sciences, JNU, New Delhi, India. (1993-95-98).
::
National Eligibilty Test for Junior Research Fellowship and Lecturership, UGC/CSIR, New Delhi, India. (1993).
::
All India JNU Entrance examination for M.Phil./Ph.D. admission in Life Sciences, JNU, New Delhi, India. (First Rank, 1993).
Member
::
Life member, Indian Association for Cancer Research.
::
Active member, American Association for Cancer Research.
::
Life member, Society for Reproductive Biology and Comparative Endocrinology.
Type of Neoplasms
 
Head and Neck
Pulmonary system
Lung
Breast
Gastrointestinal tract
Stomach, Pancreas, Small intestine, Colon
Male genital system
Prostate
  Last modified on : Dec 21, 2015
India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.