Sher Ali, Ph.D., B.Sc profile in India Cancer Research Database

INCREDB ID : 428

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Sher Ali, Ph.D., B.Sc
Head, Molecular Genetics Laboratory

National Institute of Immunology, New Delhi

Aruna Asaf Ali Marg

New Delhi - 110 067

New Delhi

E-mail: alisher@nii.res.in

Phone: +91-11-26703753

Fax: 011-26742125

Positions Held:

Position	Affiliation	Time Period
Staff Scientist VI and Chief	Molecular Genetics Laboratory, NII, New Delhi	2004-2008
Staff Scientist V and Chief	Molecular Genetics Laboratory, NII, New Delhi	1998-2004
Staff Scientist IV and Chief	Molecular Genetics Laboratory, NII, New Delhi	1993-1998
Staff Scientist III and Chief	Molecular Genetics Laboratory, NII, New Delhi	1989-1993

Area of Specialization:

	Genetics
	Toxicogenomics
	Genomics of Endangered Species
	Cancer Genetics

Research Summary:

Genome Analysis, Molecular Human and Animal Genetics, Germline Genetics, Toxicogenomics, Gene Regulation and Expression, Genomics of Endangered Species, DNA Diagnosis, Cancer Genetics

Publications:

1.	Yadav, S. K., Kumari, A. and Ali, S. Fate of the human Y chromosome linked genes and loci in prostate cancer cell lines DU145 and LNCaP. BMC Genomics. 2013. 14, 323. [PubMed]
2.	Kamle, S. and Ali, S. Genetically modified crops: detection strategies and biosafety issues. Gene. 2013. 522, 123-132. [PubMed]
3.	Kumari, A., Yadav, S. K. and Ali, S. Organizational and functional status of the Y-linked genes and loci in the infertile patients having normal spermiogram. PloS One. 2012. 7, e41488. [PubMed]
4.	Saini, M., Jha, A. N., Abrari, A. and Ali, S. Expression of proto-oncogene KIT is up-regulated in subset of human meningiomas. BMC Cancer. 2012. 12, 212. [PubMed]
5.	Saini, M., Jha, A. N., Abrari, A. and Ali, S. A subset of human gliomas shows over-expression of KIT without its amplification. Gene. 2012. 497, 155-163. [PubMed]
6.	Rawal, L., Ali, S. and Ali, S. Molecular mining of GGAA tagged transcripts and their expression in water buffalo Bubalus bubalis. Gene. 2012. 492, 290-295. [PubMed]
7.	Kumar, S., Gupta, R., Kumar, S. and Ali, S. Molecular mining of alleles in water buffalo Bubalus bubalis and characterization of the TSPY1 and COL6A1 genes. PloS One. 2011. 6, e24958. [PubMed]
8.	Pathak, D. and Ali, S. RsaI repetitive DNA in Buffalo Bubalus bubalis representing retrotransposons, conserved in bovids, are part of the functional genes. BMC Genomics. 2011. 12, 338. [PubMed]
9.	Raina, A., Yadav, B., Ali, S. and Das, D. Misinterpretation of results in medico-legal cases due to microdeletion in the Y-chromosome. Molecular and Cellular Probes. 2010. 24, 418-420. [PubMed]
10.	Ali, S. and Ali, S. Genetic integrity of the human Y chromosome exposed to groundwater arsenic. BMC Medical Genomics. 2010. 3, 35. [PubMed]
11.	Pathak, D., Srivastava, J., Samad, R., Parwez, I., Kumar, S. and Ali, S. Genome-wide search of the genes tagged with the consensus of 33.6 repeat loci in buffalo Bubalus bubalis employing minisatellite-associated sequence amplification. Chromosome Research : An International Journal On the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology. 2010. 18, 441-458. [PubMed]
12.	Premi, S., Srivastava, J., Epplen, J. T. and Ali, S. AZFc region of the Y chromosome shows singular structural organization. Chromosome Research : An International Journal On the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology. 2010. 18, 419-430. [PubMed]
13.	Srivastava, J., Premi, S., Kumar, S. and Ali, S. Expressional dynamics of minisatellite 33.15 tagged spermatozoal transcriptome in Bubalus bubalis. BMC Genomics. 2009. 10, 303. [PubMed]
14.	Premi, S., Srivastava, J., Chandy, S. P. and Ali, S. Unique signatures of natural background radiation on human Y chromosomes from Kerala, India. PloS One. 2009. 4, e4541. [PubMed]
15.	Premi, S., Srivastava, J., Panneer, G. and Ali, S. Startling mosaicism of the Y-chromosome and tandem duplication of the SRY and DAZ genes in patients with Turner Syndrome. PloS One. 2008. 3, e3796. [PubMed]
16.	Srivastava, J., Premi, S., Kumar, S. and Ali, S. Organization and differential expression of the GACA/GATA tagged somatic and spermatozoal transcriptomes in Buffalo Bubalus bubalis. BMC Genomics. 2008. 9, 132. [PubMed]
17.	Ali, S. and Ali, S. Multidimensional approaches in dealing with prostate cancer. Gene. 2008. 410, 1-8. [PubMed]
18.	Srivastava, J., Premi, S., Kumar, S., Parwez, I. and Ali, S. Characterization of Smoc-1 uncovers two transcript variants showing differential tissue and age specific expression in Bubalus bubalis. BMC Genomics. 2007. 8, 436. [PubMed]
19.	Ali, S. and Ali, S. Role of c-kit/SCF in cause and treatment of gastrointestinal stromal tumors (GIST). Gene. 2007. 401, 38-45. [PubMed]
20.	Premi, S., Srivastava, J., Chandy, S. P. and Ali, S. AZFc somatic microdeletions and copy number polymorphism of the DAZ genes in human males exposed to natural background radiation. Human Genetics. 2007. 121, 337-346. [PubMed]
21.	Pathak, D., Premi, S., Srivastava, J., Chandy, S. P. and Ali, S. Genomic instability of the DYZ1 repeat in patients with Y chromosome anomalies and males exposed to natural background radiation. DNA Research : An International Journal For Rapid Publication of Reports On Genes and Genomes. 2006. 13, 103-109. [PubMed]
22.	Srivastava, J., Premi, S., Garg, L. C. and Ali, S. Organizational and expressional uniqueness of a testis-specific mRNA transcript of protooncogene c-kit receptor in water buffalo Bubalus bubalis. DNA and Cell Biology. 2006. 25, 501-513. [PubMed]
23.	Premi, S., Srivastava, J., Chandy, S. P., Ahmad, J. and Ali, S. Tandem duplication and copy number polymorphism of the SRY gene in patients with sex chromosome anomalies and males exposed to natural background radiation. Molecular Human Reproduction. 2006. 12, 113-121. [PubMed]
24.	Pathak, D., Srivastava, J., Premi, S., Tiwari, M., Garg, L. C., Kumar, S. and Ali, S. Chromosomal localization, copy number assessment, and transcriptional status of BamHI repeat fractions in water buffalo Bubalus bubalis. DNA and Cell Biology. 2006. 25, 206-214. [PubMed]
25.	Srivastava, J., Premi, S., Pathak, D., Ahsan, Z., Tiwari, M., Garg, L. C. and Ali, S. Transcriptional status of known and novel genes tagged with consensus of 33.15 repeat loci employing minisatellite-associated sequence amplification (MASA) and real-time PCR in water buffalo, Bubalus bubalis. DNA and Cell Biology. 2006. 25, 31-48. [PubMed]
26.	Bashamboo, A., Rahman, M. M., Prasad, A., Chandy, S. P., Ahmad, J. and Ali, S. Fate of SRY, PABY, DYS1, DYZ3 and DYZ1 loci in Indian patients harbouring sex chromosomal anomalies. Molecular Human Reproduction. 2005. 11, 117-127. [PubMed]
27.	Rahman, M. M., Bashamboo, A., Prasad, A., Pathak, D. and Ali, S. Organizational variation of DYZ1 repeat sequences on the human Y chromosome and its diagnostic potentials. DNA and Cell Biology. 2004. 23, 561-571. [PubMed]
28.	Prasanth, S. G., Chattopadhyay, M., Bhat, K. V. and Ali, S. Expression of protooncogene c-kit receptor in rat testis and uniqueness of extracellular domain across the species with potential in molecular phylogeny. DNA and Cell Biology. 2004. 23, 35-43. [PubMed]
29.	Bhatnagar, S., Bashamboo, A., Chattopadhyay, M., Gangadharan, S. and Ali, S. A 1.3 kb satellite DNA from Bubalus bubalis not conserved evolutionarily is transcribed. Zeitschrift Fur Naturforschung. C, Journal of Biosciences. 2004. 59, 874-879. [PubMed]
30.	Ali, S. and Hasnain, S. E. Genomics of the human Y-chromosome. 1. Association with male infertility. Gene. 2003. 321, 25-37. [PubMed]
31.	Prasanth, S. G. and Ali, S. Expression of proto-oncogene c-kit receptor in rats (Rattus norvegicus) and identification of a mutant mRNA transcript implicated in spermatogenic failure. DNA and Cell Biology. 2003. 22, 447-456. [PubMed]
32.	Kapur, V., Prasanth, S. G., O'Ryan, C., Azfer, M. A. and Ali, S. Development of a DNA marker by minisatellite associated sequence amplification (MASA) from the endangered Indian rhino (Rhinoceros unicornis). Molecular and Cellular Probes. 2003. 17, 1-4. [PubMed]
33.	Kumar, A., Arora, V., Bashamboo, A. and Ali, S. Detection of Salmonella typhi by polymerase chain reaction: implications in diagnosis of typhoid fever. Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases. 2002. 2, 107-110. [PubMed]
34.	Ali, S. and Hasnain, S. E. Molecular dissection of the human Y-chromosome. Gene. 2002. 283, 1-10. [PubMed]
35.	Mohmmed, A., Sharma, R. S., Ali, S. and Babu, C. R. Molecular diversity of the plasmid genotypes among Rhizobium gene pools of sesbanias from different habitats of a semi-arid region (Delhi). FEMS Microbiology Letters. 2001. 205, 171-178. [PubMed]
36.	Chattopadhyay, M., Gangadharan, S., Kapur, V., Azfer, M. A., Prakash, B. and Ali, S. Satellite-tagged transcribing sequences in Bubalus bubalis genome undergo programmed modulation in meiocytes: possible implications for transcriptional inactivation. DNA and Cell Biology. 2001. 20, 587-593. [PubMed]

1. Sher Ali. Animal DNA Fingerprinting- Beyond Dolly. Biotech News. 2012. 7(1-2), 5-7.

2. Rana Samad, Deepali Pathak, Farhan Ali, Leena Rawal and Sher Ali. Uniqueness of the Extracellular Domain of Protooncogene c-kit Receptor across the Species: Implications in Conservation of Biodiversity. Proc. Indian Natn. Sci Acad. 2012. 78 (4), 651-670.

3. Soma Sarkar, Babita Kumari and Sher Ali. Effect of Radiofrequency Electromagnetic Field on Human DNA. Defence Science Journal. 2006. 56, 199-208.

4. Ramadhar Singh, Jitendra Kumar, Amarjeet Kaur, K.L. Yadav, R. Bhattacharyya, Ejaz Hussain and Sher Ali. Mechanism of dc electrical conduction and human endothelial cell proliferation in polypyrrole-sodium nitrate membrane. POLYMER. 2006. 47, 6042-6047.

5. Jyoti Srivastava, Sanjay Premi, Deepali Pathak, Sudhir Kumar and Sher Ali. Molecular Markers for Characterization of Stem Cell Lineages. PINSA (B). 2006. 72:83-89.

6. Supriya Gangadharan Prasanth, Harleen Mangat Giran and Sher Ali. Biology of Protooncogene c-kit Receptor and Spermatogenesis. Current Pharmacogenomics. 2004. 2, 47-60.

7. Anu Bashamboo, Harleen Mangat Giran, MD. Asim Azfer and Sher Ali. Genomics of the Human Y Chromosome and Molecular Diagnosis. Proc. Ind. Nat. Sci. Acad. 2003. B69, 525-538.

8. Anu Bashamboo, Sunita Bhatnagar, Anupam Kaur, Virinder Kaur Sarhadi, Jai Rup Singh and Sher Ali. Molecular characterization of a Y- derived marker chromosome and identification of indels in the DYS1 region in a patient with stigmata of Turner syndrome. 2003. Curr. Sci. 84, 219-224.

9. Kapur V, Bashamboo A and Ali S. Development of Genetic Markers Specific for Highly Endangered Species Rhinoceros unicornis: Strategies and Implications in Conservation. 2002. Ind J Biotech. 1, 96-100.

10. Supriya Gangadharan, Vipra Kapur and Sher Ali. GATA/GACA repeat sequences are transcribed in the normal fertile rat Rattus norvegicus but not in the infertile ones. 2001. Curr. Sci. 81,1-5.

Book Chapters:

	Sher Ali (2007) “Genomics of Y chromosome” In Recurrent pregnancy loss: Edited by Mala Arora; Co-editor Justin C. Konje. Jaypee Brothers, Medical Publisher, Pvt. Ltd. New Delhi. Pages 32-42.
	Safdar Ali and Sher Ali (2011) “Differential gene expression and its possible therapeutic implications”, In: Gene Therapy-Developments and Future Perspectives, ISBN 978-953-307-617-1. INTECH Open Access Publisher, Rijeka, Croatia.
	Deepali Pathak and Sher Ali (2012) “Repetitive DNA: A Tool to Explore Animal Genomes/Transcriptomes” In: Functional Genomics, ISBN 978-953-51-0727-9. INTECH Open Access Publisher, Rijeka, Croatia.

Grant Support:

Project Title	Role	Funding Agency	Sanction Number	Sanction Date
Development of DNA Probes for Detecting Monomorphic and Polymorphic loci in the Bubalus bubalis genome.	Principal Investigator	Department of Science & Technology, Government of India		1996-1999
Studies on Mutagenic and Carcinogenic Potentials of Microwaves.	Principal Investigator	Defence Research and Development Organisation, New Delhi, India		1990-1993
DNA Sequence Diversity in the Human Y chromosome and Its Implications in Molecular Diagnosis	Principal Investigator	Department of Biotechnology, Government of India		2002-2005
Molecular Analysis of the mRNA Transcripts from the Germline of Buffalo (Bubalus bubalis) tagged with Minisatellites and their Possible Functional Status in Somatic Tissues	Principal Investigator	Department of Biotechnology, Government of India		2007-2010
Molecular characterization of satellite tagged genes in water buffalo Bubalus bubalis	Principal Investigator	Department of Biotechnology, Government of India		2010-2013
Analysis of the Y-linked Genes and Loci in Patients with Sex Chromosome Related Anomalies	Principal Investigator	Department of Biotechnology, Government of India		2010-2013

My CV: Download

Education
::	Ph.D. in Genetics, University of Delhi
::	M.Sc. in Genetics, Aligarh Muslim University, Aligarh, India
::	B.Sc in Zoology, Aligarh Muslim University, Aligarh, India
Honors and Awards
::	Indo-Australia Senior Scientist Visiting Fellowship, February 13-25, 2013 awarded by INSA, New Delhi-110002
::	J.C. Bose National Fellowship, India (January 2012 to December 31, 2016).
::	INSA/DFG Exchange Visiting Fellowship, Ruhr University, Bochum, Germany, February 15- March 15, 2009
::	Royal Society Fellowship from Indian National Science Academy, New Delhi and Royal Society, London to work in the laboratory of Professor Sir Alec John Jeffreys, University of Leicester, Leicester UK, September – November, 1997.
Member
::	Life Member, Society of Biological Chemists, Bangalore (India
::	Member, International Society of Animal Genetics (I.S.A.G.), Iowa, U.S.A.
::	Life Member, Indian Academy of Forensic Sciences, Calcutta.
::	Fellow, Indian National Science Academy, (INSA) New Delhi, India

Type of Neoplasms

Gastrointestinal tract

Male genital system

Prostate

Last modified on : Jul 2, 2013

India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.