Raghunadharao Digumarti, M.D., D.M. profile in India Cancer Research Database

INCREDB ID : 424

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Raghunadharao Digumarti, M.D., D.M.
Professor

Nizam Institute of Medical Sciences, Hyderabad

Punjagutta

Hyderabad - 500 082

Andhra Pradesh

E-mail: rdigumarti@gmail.com

Phone: 91 40 23489368

Mobile: 91 9246571537

Fax: 91 40 23371747

URL: http://nims.ap.nic.in/facmonc.html

Positions Held:

Position	Affiliation	Time Period
Additional Professor	Nizam Institute of Medical Sciences, Hyderabad	1998-2003
Assistant Professor	Nizam Institute of Medical Sciences, Hyderabad	1989-1998
Senior Resident	Tata Memorial Hospital, Mumbai, India	1985-1987

Area of Specialization:

	Genomics
	Haematology
	Molecular Biology
	Oncology

Research Summary:

Early phase clinical trials in cancer and febrile neutropenia - from design through execution and report compiling.

Publications:

1.	Cortes, J., Lipton, J. H., Rea, D., Digumarti, R., Chuah, C., Nanda, N., Benichou, A. C., Craig, A. R., Michallet, M., Nicolini, F. E. and Kantarjian, H. Phase 2 study of subcutaneous omacetaxine mepesuccinate after TKI failure in patients with chronic-phase CML with T315I mutation. Blood. 2012. 120, 2573-2580. [PubMed]
2.	Pettengell, R., Coiffier, B., Narayanan, G., de, M., Digumarti, R., Gomez, H., Zinzani, P. L., Schiller, G., Rizzieri, D., Boland, G., Cernohous, P., Wang, L., Kuepfer, C., Gorbatchevsky, I. and Singer, J. W. Pixantrone dimaleate versus other chemotherapeutic agents as a single-agent salvage treatment in patients with relapsed or refractory aggressive non-Hodgkin lymphoma: a phase 3, multicentre, open-label, randomised trial. The Lancet Oncology. 2012. 13, 696-706. [PubMed]
3.	Dorababu, P., Nagesh, N., Linga, V. G., Gundeti, S., Kutala, V. K., Reddanna, P. and Digumarti, R. Epistatic interactions between thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) variations determine 6-mercaptopurine toxicity in Indian children with acute lymphoblastic leukemia. European Journal of Clinical Pharmacology. 2012. 68, 379-387. [PubMed]
4.	Naushad, S. M., Pavani, A., Rupasree, Y., Divyya, S., Deepti, S., Digumarti, R. R., Gottumukkala, S. R., Prayaga, A. and Kutala, V. K. Association of aberrations in one-carbon metabolism with molecular phenotype and grade of breast cancer. Molecular Carcinogenesis. 2012. 51 Suppl 1, E32-41. [PubMed]
5.	Coca, P., Gundeti, S., Uppin, S. and Digumarti, R. Metastatic adenocarcinoma in a young male, 12 years after treatment of primary non seminomatous germ cell tumor. Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical & Paediatric Oncology. 2011. 32, 115-117. [PubMed]
6.	Surekha, D., Sailaja, K., Rao, D. N., Padma, T., Raghunadharao, D. and Vishnupriya, S. Association of a CYP17 gene polymorphism with development of breast cancer in India. Asian Pacific Journal of Cancer Prevention : APJCP. 2010. 11, 1653-1657. [PubMed]
7.	Dunna, N. R., Rajappa, S., Digumarti, R., Vure, S., Kagita, S., Damineni, S., Rao, V. R., Yadav, S. K., Ravuri, R. R. and Satti, V. Fms like tyrosine kinase (FLT3) and nucleophosmin 1 (NPM1) mutations in de novo normal karyotype acute myeloid leukemia (AML). Asian Pacific Journal of Cancer Prevention : APJCP. 2010. 11, 1811-1816. [PubMed]
8.	Naushad, S. M., Pavani, A., Digumarti, R. R., Gottumukkala, S. R. and Kutala, V. K. Epistatic interactions between loci of one-carbon metabolism modulate susceptibility to breast cancer. Molecular Biology Reports. 2011. 38, 4893-4901. [PubMed]
9.	Mohammad, N. S., Yedluri, R., Addepalli, P., Gottumukkala, S. R., Digumarti, R. R. and Kutala, V. K. Aberrations in one-carbon metabolism induce oxidative DNA damage in sporadic breast cancer. Molecular and Cellular Biochemistry. 2011. 349, 159-167. [PubMed]
10.	Rajender, S., Francis, A., Pooja, S., Krupakar, N., Surekha, D., Reddy, G., Rao, D. R., Rao, L., Ramachandra, S., Vishnupriya, S., Ramalingam, K., Satyamoorthy, K. and Thangaraj, K. CAG repeat length polymorphism in the androgen receptor gene and breast cancer risk: data on Indian women and survey from the world. Breast Cancer Research and Treatment. 2011. 127, 751-760. [PubMed]
11.	Paul, T. R., Uppin, S. G., Uppin, M. S., Jacob, R. T., Rao, D. R. and Rajappa, S. J. Evaluation of Cytopenias Occurring in Imatinib Treated Chronic Myeloid Leukemia (CML) Patients. Indian Journal of Hematology & Blood Transfusion : An Official Journal of Indian Society of Hematology and Blood Transfusion. 2010. 26, 56-61. [PubMed]
12.	Jadhav, M. P., Bamba, A., Shinde, V. M., Gogtay, N., Kshirsagar, N. A., Bichile, L. S., Mathai, D., Sharma, A., Varma, S. and Digumarathi, R. Liposomal amphotericin B (Fungisome) for the treatment of cryptococcal meningitis in HIV/AIDS patients in India: a multicentric, randomized controlled trial. Journal of Postgraduate Medicine. 2010. 56, 71-75. [PubMed]
13.	Tandon, A., Challa, S., Shanmugam, M., Gopalan, S., Paul, R. T. and Digumarthi, R. Epstein-Barr virus as a possible etiologic agent in primary central nervous system lymphoma in immunocompetent individuals. Neurology India. 2009. 57, 36-40. [PubMed]
14.	Surekha, D., Sailaja, K., Rao, D. N., Padma, T., Raghunadharao, D. and Vishnupriya, S. Association of CYP1A1*2 polymorphisms with breast cancer risk: a case control study. Indian Journal of Medical Sciences. 2009. 63, 13-20. [PubMed]
15.	Pappas, P. G., Rotstein, C. M., Betts, R. F., Nucci, M., Talwar, D., De, W., Vazquez, J. A., Dupont, B. F., Horn, D. L., Ostrosky-Zeichner, L., Reboli, A. C., Suh, B., Digumarti, R., Wu, C., Kovanda, L. L., Arnold, L. J. and Buell, D. N. Micafungin versus caspofungin for treatment of candidemia and other forms of invasive candidiasis. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 2007. 45, 883-893. [PubMed]
16.	Dirix, L. Y., Ignacio, J., Nag, S., Bapsy, P., Gomez, H., Raghunadharao, D., Paridaens, R., Jones, S., Falcon, S., Carpentieri, M., Abbattista, A. and Lobelle, J. P. Treatment of advanced hormone-sensitive breast cancer in postmenopausal women with exemestane alone or in combination with celecoxib. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 2008. 26, 1253-1259. [PubMed]
17.	Rajappa, S., Gundeti, S., Talluri, M. R. and Digumarti, R. Chemotherapy for advanced lung cancer: a 5-year experience. Indian Journal of Cancer. 2008. 45, 20-26. [PubMed]
18.	Rajappa, S., Varadpande, L., Paul, T., Jacob, R. and Digumarti, R. Imatinib mesylate in early chronic phase chronic myeloid leukemia: Experience from a developing country. Leukemia & Lymphoma. 2008. 49, 554-558. [PubMed]
19.	Rajappa, S. J., Uppin, S. G. and Digumarti, R. Testicular relapse of primary central nervous system lymphoma. Leukemia & Lymphoma. 2007. 48, 1023-1025. [PubMed]
20.	Rajappa, S., Digumarti, R., Immaneni, S. R. and Parage, M. Primary renal lymphoma presenting with paraneoplastic limbic encephalitis. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 2007. 25, 3783-3785. [PubMed]
21.	Rajappa, S., Varadpande, L., Paul, T. R. and Digumarti, R. Imatinib mesylate induced immune thrombocytopenia. Leukemia & Lymphoma. 2007. 48, 2261-2263. [PubMed]
22.	Rajappa, S., Varadpande, L., Paul, T., Jacob, R. and Digumarti, R. Imatinib mesylate in early chronic phase chronic myeloid leukemia: Experience from a developing country. Leukemia & Lymphoma. 2008. 49, 554-558. [PubMed]
23.	Rajappa, S., Muppavarapu, K. M., Uppin, S. and Digumarti, R. Gastrointestinal stromal tumors: a single institution experience of 50 cases. Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology. 2007. 26, 225-229. [PubMed]
24.	Parikh, P. M., Vaid, A., Advani, S. H., Digumarti, R., Madhavan, J., Nag, S., Bapna, A., Sekhon, J. S., Patil, S., Ismail, P. M., Wang, Y., Varadhachary, A., Zhu, J. and Malik, R. Randomized, double-blind, placebo-controlled phase II study of single-agent oral talactoferrin in patients with locally advanced or metastatic non-small-cell lung cancer that progressed after chemotherapy. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 2011. 29, 4129-4136. [PubMed]
25.	Digumarti, R., Wang, Y., Raman, G., Doval, D. C., Advani, S. H., Julka, P. K., Parikh, P. M., Patil, S., Nag, S., Madhavan, J., Bapna, A., Ranade, A. A., Varadhachary, A. and Malik, R. A randomized, double-blind, placebo-controlled, phase II study of oral talactoferrin in combination with carboplatin and paclitaxel in previously untreated locally advanced or metastatic non-small cell lung cancer. Journal of Thoracic Oncology : Official Publication of the International Association For the Study of Lung Cancer. 2011. 6, 1098-1103. [PubMed]
26.	Kumar, L., Gangadharan, V. P., Rao, D. R., Saikia, T., Shah, S., Malhotra, H., Bapsy, P. P., Singh, K. and Rao, R. Safety and efficacy of an indigenous recombinant interferon-alpha-2b in patients with chronic myelogenous leukaemia: results of a multicentre trial from India. The National Medical Journal of India. 2005. 18, 66-70. [PubMed]
27.	Chatterjee, A., Digumarti, R., Mamidi, R. N., Katneni, K., Upreti, V. V., Surath, A., Srinivas, M. L., Uppalapati, S., Jiwatani, S., Subramaniam, S. and Srinivas, N. R. Safety, tolerability, pharmacokinetics, and pharmacodynamics of an orally active novel camptothecin analog, DRF-1042, in refractory cancer patients in a phase I dose escalation study. Journal of Clinical Pharmacology. 2004. 44, 723-736. [PubMed]
28.	Jacob, R. T., Gayathri, K., Surath, A. and Rao, D. R. Cytogenetic profile of chronic myeloid leukemias. Indian Journal of Cancer. 2002. 39, 61-65. [PubMed]

1. Manjula G, Prajitha EM, Sailaja K, Raghunadharao D, Anuradha C, Sugunakar V, Sandhya A, Nageswara Rao S, Vishnupriya S. JAK2 V617F mutation: a marker for CML progression. Journal of Cell and Tissue Research. 2013. 13(1), 3439-3443.

2. Srinivas B.H, Roshni Paul T, Shantveer G Uppin, Megha S Uppin, Rachel T Jacob and Raghunadharao D. Morphologic Changes in the Bone Marrow in Patients of Chronic Myeloid Leukemia (CML) treated with Imatinib Mesylate. Indian J Hematol Blood Transfus. 2012. 28, 162-169.

3. Patchva Dorababu, Shaik Mohammad Naushad, Vijay Kumar Kutala and Raghunadharao Digumarti. Impact of age, gender and haplotypes pf thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) genes on 6-mercaptopurine toxicity in children with acute lymphoblastic leukemia. European Journal od Clinical Pharmocology. 2012. 68(5), 885-886.

4. Dorababu P, Naushad SM, Linga VG, Gundeti S, Nagesh N, Kutala VK, Reddanna P, Digumarti R. Interaction between thipurine and folate metabolic pathway genetic variants determines 6-MP mediated hematological toxicity in children with acute lymphoblastic leukemia. Pharmacogenomics Journal. 2012. (Inpress).

5. Dunna NR, Anuradha C, Vure S, Sailaja K, Surekha D, Raghunadharao D, Rajappa S and Vishnupriya S. NQO1*2 [NAD(P)H: quinone oxidoreductase 1] polymorphism and its influence on acute leukemia risk. Biology and Medicine. 2011. 3 (3), 19-25.

6. Anitha S, Waliyar F, Reddy A.S, Ratna Rao, Raghunadharao D and Lava Kumar P. The development of a simple enzyme-linked immunosorbent assay for quantitative estimation of aflatoxin B1 albumin adduct in humans. Current Science. 2011. 101(7), 844-846.

7. Surekha D, Sailaja K, Nageswararao D, Padma T, Raghunadharao D and Vishnupriya S. CYP2D6*4 polymorphisms and breast cancer risk. Biology and Medicine. 2010. 2 (4), 49-55.

8. Nageswararao D, Manjulla G, Sailaja K, Surekha D, Raghunadharao D, Senthil R and Vishnupriya S. Association of CYP2D6*4 polymorphism with acute leukemia. J Cell and Tissue Research. 2010. 10 (2), 2201 – 2205 – Best paper award.

9. Surekha D, Vishnupriya S, Sailaja K, Nageswara Rao D and Raghunadharao D Influence of Apolipoprotein E Gene Polymorphism on the Risk for Breast Cancer. Int J Hum Genet. 2008. 8(3), 277-282.

10. Surekha D, Vishnupriya S, Sailaja K, Nageswararao D, Padma T and Raghunadharao D. Role of GSTP1 gene polymorphism in the development of breast cancer: a case control study. Journal of Cell and Tissue Research. 2008. 8(3), 1613-1616.

11. Senthil Rajappa, Norman Bethune, Sadasivudu G, Lalit Varadpande, Raghunadharao Digumarti. Acute coronary syndrome as the presenting feature of Cardiac rhabdomyosarcoma. J Clin Oncol. 2007. 25(4), 449-51.

12. Senthil Rajappa, Norman Bethune, Shantiveer Uppin, Aruna Prayaga, Rupam Borgohain and Raghunadharao D. Reversible paraneoplastic syndrome as the presenting feature of ovarian teratoma-A clinicopathological correlate. Annals of the Indian Academy of Neurology. 2007.10, 52-4.

13. Senthil Rajappa, Unni Krishnan, Satish Rao, D. Raghunadharao, Anjna Surath and Aruna Prayaga. Renal metastasis from Primary hepatocellular carcinoma - A case report. Indian Journal of Medical and Pediatric Oncology. 2005. 26(2), 37-39.

14. Senthil Rajappa, Anand Loya, Satish Rao, Raghunadharao D, Anjna Surath, Srihari U. Metastasis to oral cavity - A report of 2 cases and review of literature, Indian Journal of Medical and Pediatric Oncology. 2005. 26(2), 43-46.

15. Senthil Rajappa, Satish Rao, Raghunadharao D, Anjna Surath, Sundaram C, Uma Devi. Melanotic Progonoma – A case report and review of literature. Indian Journal of Medical and Pediatric Oncology. 2005. 26(2), 33-36.

16. Senthil Rajappa, Sirisha Senthil and Raghunadharao D. Choroidal metastasis from lung cancer-A case report and review of literature. Indian Journal of Medical and Pediatric oncology. 2005. 26(3), 44-46.

17. Sundaram Challa, Aruna Kumari Prayaga, Lakshmi Vemuri, Jaishankar Sadasivan, Murali Krishna Murthy Jagarlapudi, Raghunadharao Digumarti and Rajagopal Prabhala. Fungal Endocarditis: An autopsy study. Asian Cardiovascular and Thoracic Annals. 2004.12, 95-98.

My CV: Download

Education
::	M.B.B.S. Andhra Medical College, Andhra University, Visakhapatnam, India, 1976-1981
::	M.D. in Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India, 1982-1985
::	D.M. in Medical Oncology, Cancer Institute, Madras, India, 1987-1989
Honors and Awards
::	2009 Dhanwantri Foundation – Sushruta Award for public service in medicine
::	2007 ANR Swarna kankanam for public service and professional excellence
::	2005 Madras Telugu Academy Samaikhya Bharat Gaurav Puraskar
::	Honorary Senior Research Fellow of the Department of Clinical Pharmacology, University of Oxford, United Kingdom 2005 -2009
Member
::	Fellow & Life Member, International Union Against Cancer - UICC
::	Indian Society for Clinical Research – Executive Member
::	Indian Association of Cancer Research
::	American Association for Cancer Research

Type of Neoplasms

Pulmonary system

Breast

Female

Gastrointestinal tract

Hemato-lymphoid system

Blood

Last modified on : Jun 18, 2013

India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.