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Harikumar K.B., Ph.D.
Scientist C 
Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India
Thycaud Post
Thiruvananthapuram - 695 014   
Phone: 91-471-252-9465
Fax: 91-471-234-6333
Positions Held:
Position Affiliation Time Period
Post Doctoral Fellow Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA, USA. 2008-2012
Post Doctoral Fellow Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, TX. USA. 2007-2008
Area of Specialization:
Research Summary:
Role of inflammation in carcinogenesis and tumor progression
Role of sphingolipids in innate immune response and pathogen induced inflammation
1.Liang, J., Nagahashi, M., Kim, E. Y., Harikumar, K. B., Yamada, A., Huang, W. C., Hait, N. C., Allegood, J. C., Price, M. M., Avni, D., Takabe, K., Kordula, T., Milstien, S. and Spiegel, S.  Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer. Cancer Cell. 2013.  23, 107-120. [PubMed]
2.Price, M. M., Oskeritzian, C. A., Falanga, Y. T., Harikumar, K. B., Allegood, J. C., Alvarez, S. E., Conrad, D., Ryan, J. J., Milstien, S. and Spiegel, S.  A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell-dependent murine model of allergic asthma. The Journal of Allergy and Clinical Immunology. 2013.  131, 501-110. [PubMed]
3.Van, D. N., Roberts, C. F., Marion, J. D., Lepine, S., Harikumar, K. B., Schreiter, J., Dumur, C. I., Fang, X., Spiegel, S. and Bell, J. K.  Innate immune agonist, dsRNA, induces apoptosis in ovarian cancer cells and enhances the potency of cytotoxic chemotherapeutics. FASEB Journal : Official Publication of the Federation of American Societies For Experimental Biology. 2012.  26, 3188-3198. [PubMed]
4.Alvarez, S. E., Harikumar, K. B., Hait, N. C., Allegood, J., Strub, G. M., Kim, E. Y., Maceyka, M., Jiang, H., Luo, C., Kordula, T., Milstien, S. and Spiegel, S.  Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2. Nature. 2010.  465, 1084-1088. [PubMed]
5.Harikumar, K. B., Kunnumakkara, A. B., Sethi, G., Diagaradjane, P., Anand, P., Pandey, M. K., Gelovani, J., Krishnan, S., Guha, S. and Aggarwal, B. B.  Resveratrol, a multitargeted agent, can enhance antitumor activity of gemcitabine in vitro and in orthotopic mouse model of human pancreatic cancer. International Journal of Cancer. Journal International Du Cancer. 2010.  127, 257-268. [PubMed]
6.Harikumar, K. B., Sung, B., Tharakan, S. T., Pandey, M. K., Joy, B., Guha, S., Krishnan, S. and Aggarwal, B. B.  Sesamin manifests chemopreventive effects through the suppression of NF-kappa B-regulated cell survival, proliferation, invasion, and angiogenic gene products. Molecular Cancer Research : MCR. 2010.  8, 751-761. [PubMed]
7.Harikumar, K. B., Kunnumakkara, A. B., Ochi, N., Tong, Z., Deorukhkar, A., Sung, B., Kelland, L., Jamieson, S., Sutherland, R., Raynham, T., Charles, M., Bagherzadeh, A., Foxton, C., Boakes, A., Farooq, M., Maru, D., Diagaradjane, P., Matsuo, Y., Sinnett-Smith, J., Gelovani, J., Krishnan, S., Aggarwal, B. B., Rozengurt, E., Ireson, C. R. and Guha, S.  A novel small-molecule inhibitor of protein kinase D blocks pancreatic cancer growth in vitro and in vivo. Molecular Cancer Therapeutics. 2010.  9, 1136-1146. [PubMed]
8.Harikumar, K. B., Sung, B., Pandey, M. K., Guha, S., Krishnan, S. and Aggarwal, B. B.  Escin, a pentacyclic triterpene, chemosensitizes human tumor cells through inhibition of nuclear factor-kappaB signaling pathway. Molecular Pharmacology. 2010.  77, 818-827. [PubMed]
9.Takabe, K., Kim, R. H., Allegood, J. C., Mitra, P., Ramachandran, S., Nagahashi, M., Harikumar, K. B., Hait, N. C., Milstien, S. and Spiegel, S.  Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2. The Journal of Biological Chemistry. 2010.  285, 10477-10486. [PubMed]
10.Anchoori, R. K., Harikumar, K. B., Batchu, V. R., Aggarwal, B. B. and Khan, S. R.  Inhibition of IkB kinase and NF-kappaB by a novel synthetic compound SK 2009. Bioorganic & Medicinal Chemistry. 2010.  18, 229-235. [PubMed]
11.Kunnumakkara, A. B., Diagaradjane, P., Anand, P., Harikumar, K. B., Deorukhkar, A., Gelovani, J., Guha, S., Krishnan, S. and Aggarwal, B. B.  Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model. International Journal of Cancer. Journal International Du Cancer. 2009.  125, 2187-2197. [PubMed]
12.Harikumar, K. B., Kuttan, G. and Kuttan, R.  Phyllanthus amarus inhibits cell growth and induces apoptosis in Dalton's lymphoma ascites cells through activation of caspase-3 and downregulation of Bcl-2. Integrative Cancer Therapies. 2009.  8, 190-194. [PubMed]
13.  Harikumar KB, Kunnumakkara AB, Ahn KS, Anand P, Krishnan S, Guha S, Aggarwal BB. Modification of the cysteine residues in IkappaBalpha kinase and NF-kappaB (p65) by xanthohumol leads to suppression of NF-kappaB-regulated gene products and potentiation of apoptosis in leukemia cells. Blood. 2009;113(9):2003-2013. Blood. 2013.  121, 3778. [PubMed]
14.Harikumar, K. B., Kuttan, G. and Kuttan, R.  Inhibition of progression of erythroleukemia induced by Friend virus in BALB/c mice by natural products--berberine, curcumin and picroliv. Journal of Experimental Therapeutics & Oncology. 2008.  7, 275-284. [PubMed]
15.Anand, P., Kunnumakkara, A. B., Harikumar, K. B., Ahn, K. S., Badmaev, V. and Aggarwal, B. B.  Modification of cysteine residue in p65 subunit of nuclear factor-kappaB (NF-kappaB) by picroliv suppresses NF-kappaB-regulated gene products and potentiates apoptosis. Cancer Research. 2008.  68, 8861-8870. [PubMed]
16.Tong, Z., Kunnumakkara, A. B., Wang, H., Matsuo, Y., Diagaradjane, P., Harikumar, K. B., Ramachandran, V., Sung, B., Chakraborty, A., Bresalier, R. S., Logsdon, C., Aggarwal, B. B., Krishnan, S. and Guha, S.  Neutrophil gelatinase-associated lipocalin: a novel suppressor of invasion and angiogenesis in pancreatic cancer. Cancer Research. 2008.  68, 6100-6108. [PubMed]
17.Harikumar, K. B., Nimita, C. V., Preethi, K. C., Kuttan, R., Shankaranarayana, M. L. and Deshpande, J.  Toxicity profile of lutein and lutein ester isolated from marigold flowers (Tagetes erecta). International Journal of Toxicology. 2008.  27, 1-9. [PubMed]
18.Harikumar, K. B. and Kuttan, R.  An extract of Phyllanthus amarus protects mouse chromosomes and intestine from radiation induced damages. Journal of Radiation Research. 2007.  48, 469-476. [PubMed]
19.Ajith, T. A., Harikumar, K. B., Thasna, H., Sabu, M. C. and Babitha, N. V.  Proapoptotic and antitumor activities of the HMG-CoA reductase inhibitor, lovastatin, against Dalton's lymphoma ascites tumor in mice. Clinica Chimica Acta; International Journal of Clinical Chemistry. 2006.  366, 322-328. [PubMed]
20.Harikumar, K. B., Jesil, A. M., Sabu, M. C. and Kuttan, R.  A preliminary assessment of the acute and subchronic toxicity profile of phase2: an alpha-amylase inhibitor. International Journal of Toxicology. 2005.  24, 95-102. [PubMed]
21.Kumar, K. B. and Kuttan, R.  Chemoprotective activity of an extract of Phyllanthus amarus against cyclophosphamide induced toxicity in mice. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. 2005.  12, 494-500. [PubMed]
22.Hari, K., Sabu, M. C., Lima, P. S. and Kuttan, R.  Modulation of haematopoetic system and antioxidant enzymes by Emblica officinalis gaertn and its protective role against gamma-radiation induced damages in mice. Journal of Radiation Research. 2004.  45, 549-555. [PubMed]
23.Kumar, K. B. and Kuttan, R.  Protective effect of an extract of Phyllanthus amarus against radiation-induced damage in mice. Journal of Radiation Research. 2004.  45, 133-139. [PubMed]
  1. Harikumar K.B*, Kuttan G and Kuttan R. Inhibition of viral carcinogenesis by Phyllanthus amarus Schumach & Thonn. Integrative Cancer Therapies. 2009. 8, 254-260.
  2. Hait N.C, Allegood J, Maceyka M, Strub G.M, Harikumar K.B, Singh S.K, Luo C, Marmorstein R, Kordula T, Milstien S, and Spiegel S. Sphingosine Kinase 2 and S1P in the nucleus regulate histone acetylation by inhibition of histone deacetylases. Science. 2009. 325,1254-1257.
  3. Hari Kumar K.B, Sunila E.S, Kuttan G, Preethi K.C, Nimita C.V and Kuttan R (2007). Inhibition of chemically induced carcinogenesis by potentiated homeopathic drugs. Asian Pacific Journal of Cancer Prevention. 2007. 8, 98-102.
  4. Raphael R.K, Sabu M.C, Hari Kumar K.B, and Kuttan R. Inhibition of N-methyl N’-nitro-N-nitrosoguanidine (MNNG) induced gastric carcinogenesis by Phyllanthus amarus extract. Asian Pacific Journal of Cancer Prevention. 2006. 7, 299-302.
  5. Hari Kumar K.B and Kuttan R. Inhibitory effect of an extract of Phyllanthus amarus on drug metabolizing enzymes in vitro as well as in vivo.  Biological and Pharmaceutical Bulletin. 2006. 29, 1310-1313.
  6. Hari Kumar K.B and Kuttan R. Radioprotective and anticlastogenic activity of Phyllanthus amarus. The Indian Journal of Medical Research. 2005. 121(Suppl), 129-130.


Book Chapters:
Aggarwal BB, Harikumar KB, Dey S. (2009) Prevention and Treatment of Neurodegenerative Diseases by Spice-Derived Phytochemicals. In Packer L, Sies H, Eggersdorfer M, Cadenas E (eds), Micronutrients and Brain Health, CRC Press, Boca Raton, Pages 281-307.
Preethi KC, Harikumar KB, Kuttan R (2009). Therapy for hepatic carcinoma using herbal drugs. In Mukherjee P (eds), Evaluation of Herbal Medicinal Products [Perspective on quality, safety and efficacy], Pharmaceutical Press, London, Pages 122-132.
Kunnumakkara AB, Anand P, Harikumar KB, Aggarwal BB. (2009) DNA damage and cancer chemoprevention by polyphenols. In Knasmuller S, DeMarini DM, Johnson IT, Gerhauser C (eds), Chemoprevention of cancer and DNA damage by dietary factors, 2009 WILEY-VCH Verlag GmbH & Co, Weinheim. Pages 455-482.
Kuttan R, Kuttan G, Sunila ES, Preethi KC, Nimita Venugopal C, Hari Kumar KB.(2008) An experimental evaluation to the anticancer activity of Homeopathic medicines. In Pushpangadan P, George V, Janardhanan KK (eds), Ethnopharmacology : Recent advances, Daya Publications, New Delhi. Pages 34-37.
Grant Support:
Project Title Role Funding Agency Sanction Number Sanction Date
Spice derived phytochemicals Sesamin and Cardamonin- for colorectal cancer chemoprevention Principal Investigator Department of Biotechnology (DBT)-Ramalingaswami fellowship 2012-2017
Novel aspects of sphingosine 1-phosphate (S1P) in innate immune responses and host defense mechanism Principal Investigator Department of Science & Technology, Government of India 2013-2016


My CV:   Download
Ph.D. in Cancer Biology, Department of Biochemistry, Amala Cancer Research Center, Amala Nagar, India., 2001-2007
M.Sc. in Biochemistry, Nagpur University, Nagpur, India, 1999-2001
Honors and Awards
Senior Research Fellowship from Indian Council of Medical Research (ICMR), New Delhi.
Received travel award from Indian Association for Cancer Research (IACR) in 2004 and 2005.
Best poster award at the Integrated cellular and molecular signaling (ICAMS)/LCRD research retreat, Virginia Commonwealth University, Richmond, USA, October 2010.
Most cited paper award from International Journal of Biochemistry and Cell Biology (2008-2010 period).
European Federation of Biotechnology
American Association of Indian Scientists in Cancer Research
Indian Association for Cancer Research
American Association for the Advancement of Science
Type of Neoplasms
Gastrointestinal tract
  Last modified on : Jun 17, 2013
India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.