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Partho Sarothi Ray, Ph.D.
Assistant Professor 
Indian Institute of Science Education and Research, Kolkata
P. O Mohanpur
Kolkata - 741 246   
West Bengal   
Phone: 91 03473 279130, Extn. 228
Positions Held:
Position Affiliation Time Period
Post Doctoral Fellow Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 2004-2008
Visiting Research Scholar Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 2008-2008
Area of Specialization:
Molecular Biology
Research Summary:
Role of microRNAs and regulatory proteins in chronic inflammation and cancer
1. Yao, P., Potdar, A. A., Arif, A., Ray, P. S., Mukhopadhyay, R., Willard, B., Xu, Y., Yan, J., Saidel, G. M. and Fox, P. L.  Coding region polyadenylation generates a truncated tRNA synthetase that counters translation repression. Cell. 2012.  149, 88-100. [PubMed]
2. Bhat, P., Gnanasundram, S. V., Mani, P., Ray, P. S., Sarkar, D. P. and Das, S.  Targeting ribosome assembly on the HCV RNA using a small RNA molecule. RNA Biology. 2012.  9, 1110-1119. [PubMed]
3. Ray, P. S., Sullivan, J. C., Jia, J., Francis, J., Finnerty, J. R. and Fox, P. L.  Evolution of function of a fused metazoan tRNA synthetase. Molecular Biology and Evolution. 2011.  28, 437-447. [PubMed]
4. Chaudhury, A., Hussey, G. S., Ray, P. S., Jin, G., Fox, P. L. and Howe, P. H.  TGF-beta-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI. Nature Cell Biology. 2010.  12, 286-293. [PubMed]
5. Ray, P. S., Jia, J., Yao, P., Majumder, M., Hatzoglou, M. and Fox, P. L.  A stress-responsive RNA switch regulates VEGFA expression. Nature. 2009.  457, 915-919. [PubMed]
6. Mukhopadhyay, R., Jia, J., Arif, A., Ray, P. S. and Fox, P. L.  The GAIT system: a gatekeeper of inflammatory gene expression. Trends in Biochemical Sciences. 2009.  34, 324-331. [PubMed]
7. Mukhopadhyay, R., Ray, P. S., Arif, A., Brady, A. K., Kinter, M. and Fox, P. L.  DAPK-ZIPK-L13a axis constitutes a negative-feedback module regulating inflammatory gene expression. Molecular Cell. 2008.  32, 371-382. [PubMed]
8. Jia, J., Arif, A., Ray, P. S. and Fox, P. L.  WHEP domains direct noncanonical function of glutamyl-Prolyl tRNA synthetase in translational control of gene expression. Molecular Cell. 2008.  29, 679-690. [PubMed]
9. Grover, R., Ray, P. S. and Das, S.  Polypyrimidine tract binding protein regulates IRES-mediated translation of p53 isoforms. Cell Cycle. 2008.  7, 2189-2198. [PubMed]
10. Ray, P. S. and Fox, P. L.  A post-transcriptional pathway represses monocyte VEGF-A expression and angiogenic activity. The EMBO Journal. 2007.  26, 3360-3372. [PubMed]
11. Ray, P. S., Arif, A. and Fox, P. L.  Macromolecular complexes as depots for releasable regulatory proteins. Trends in Biochemical Sciences. 2007.  32, 158-164. [PubMed]
12. Ray, P. S., Grover, R. and Das, S.  Two internal ribosome entry sites mediate the translation of p53 isoforms. EMBO Reports. 2006.  7, 404-410. [PubMed]
13. Ray, P. S. and Fox, P. L.  Equality of the sexes: found in translation. Cell. 2005.  122, 492-493. [PubMed]
14. Ray, P. S. and Das, S.  Inhibition of hepatitis C virus IRES-mediated translation by small RNAs analogous to stem-loop structures of the 5'-untranslated region. Nucleic Acids Research. 2004.  32, 1678-1687. [PubMed]
15. Venkatramana, M., Ray, P. S., Chadda, A. and Das, S.  A 25 kDa cleavage product of polypyrimidine tract binding protein (PTB) present in mouse tissues prevents PTB binding to the 5' untranslated region and inhibits translation of hepatitis A virus RNA. Virus Research. 2003.  98, 141-149. [PubMed]
16. Seshagiri, P. B., Thomas, M., Sreekumar, A., Ray, P. and Mariappa, D.  Pentoxifylline induced signalling events during capacitation of hamster spermatozoa: significance of protein tyrosine phosphorylation. Cellular and Molecular Biology. 2003.  49, 371-380. [PubMed]
17. Ray, P. S. and Das, S.  La autoantigen is required for the internal ribosome entry site-mediated translation of Coxsackievirus B3 RNA. Nucleic Acids Research. 2002.  30, 4500-4508. [PubMed]

1. Fox P.L. Ray P.S., Arif A. and Jie J. Non-canonical functions of Aminoacyl-tRNA synthesases in translational control. In Translational Control in Biology and Medicine. Eds. Sonenberg N., Hershey J. and Mathews M. Cold Spring Harbor Library press. 2006. 829-854.

Grant Support:
Project Title Role Funding Agency Sanction Number Sanction Date
Molecular interactions in the post-transcriptional regulation of inflammatory gene expression Principal Investigator DBT-Wellcome Trust India Alliance Intermediate Fellowship 2011-2016


My CV:   Download
Ph.D. in Cancer Biology, Indian Institute of Science, Bangalore, India
M.Sc. in Life Sciences, Indian Institute of Science, Bangalore, India
Honors and Awards
DBT-Wellcome Trust India Alliance Intermediate Fellowship, 2011.
Associate, Indian Academy of Sciences, 2010.
Symposium Fellowship Award at the 74th Cold Spring Harbor Symposium on Quantitative Biology: Evolution, the Molecular Landscape, 2009.
The Elsa Albrecht Fellow Award, 2008, from the Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, USA.
  Last modified on : Dec 9, 2015
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