INCREDB ID : 415
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Sagar Sengupta, Ph.D.
Scientist 
 
National Institute of Immunology
Aruna Asaf Ali Marg
New Delhi - 110 067   
 
E-mail: sagar@nii.res.in
Phone: +91-11- 26703786
 
URL: http://202.54.226.233/jsp/faculty/scientist_sagar.html
 
Positions Held:
Position Affiliation Time Period
Post Doctoral Fellow IGBMC, Strasbourg, France 1997-2001
Post Doctoral Fellow National Institutes of Health, Bethesda, Maryland, USA. 2001-2004
 
Publications:
1. Srivastava, V., Modi, P., Tripathi, V., Mudgal, R., De, S. and Sengupta, S.  BLM helicase stimulates the ATPase and chromatin-remodeling activities of RAD54. Journal of Cell Science. 2009.  122, 3093-3103. [PubMed]
2. Tripathi, V., Kaur, S. and Sengupta, S.  Phosphorylation-dependent interactions of BLM and 53BP1 are required for their anti-recombinogenic roles during homologous recombination. Carcinogenesis. 2008.  29, 52-61. [PubMed]
3. Tripathi, V., Nagarjuna, T. and Sengupta, S.  BLM helicase-dependent and -independent roles of 53BP1 during replication stress-mediated homologous recombination. The Journal of Cell Biology. 2007.  178, 9-14. [PubMed]
4. Pedeux, R., Sengupta, S., Shen, J. C., Demidov, O. N., Saito, S., Onogi, H., Kumamoto, K., Wincovitch, S., Garfield, S. H., McMenamin, M., Nagashima, M., Grossman, S. R., Appella, E. and Harris, C. C.  ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation. Molecular and Cellular Biology. 2005.  25, 6639-6648. [PubMed]
5. Zhang, R., Sengupta, S., Yang, Q., Linke, S. P., Yanaihara, N., Bradsher, J., Blais, V., McGowan, C. H. and Harris, C. C.  BLM helicase facilitates Mus81 endonuclease activity in human cells. Cancer Research. 2005.  65, 2526-2531. [PubMed]
6. Sengupta, S., Shimamoto, A., Koshiji, M., Pedeux, R., Rusin, M., Spillare, E. A., Shen, J. C., Huang, L. E., Lindor, N. M., Furuichi, Y. and Harris, C. C.  Tumor suppressor p53 represses transcription of RECQ4 helicase. Oncogene. 2005.  24, 1738-1748. [PubMed]
7. Sengupta, S., Robles, A. I., Linke, S. P., Sinogeeva, N. I., Zhang, R., Pedeux, R., Ward, I. M., Celeste, A., Nussenzweig, A., Chen, J., Halazonetis, T. D. and Harris, C. C.  Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest. The Journal of Cell Biology. 2004.  166, 801-813. [PubMed]
8. Yang, Q., Zhang, R., Wang, X. W., Linke, S. P., Sengupta, S., Hickson, I. D., Pedrazzi, G., Perrera, C., Stagljar, I., Littman, S. J., Modrich, P. and Harris, C. C.  The mismatch DNA repair heterodimer, hMSH2/6, regulates BLM helicase. Oncogene. 2004.  23, 3749-3756. [PubMed]
9. Hussain, S. P., Amstad, P., He, P., Robles, A., Lupold, S., Kaneko, I., Ichimiya, M., Sengupta, S., Mechanic, L., Okamura, S., Hofseth, L. J., Moake, M., Nagashima, M., Forrester, K. S. and Harris, C. C.  p53-induced up-regulation of MnSOD and GPx but not catalase increases oxidative stress and apoptosis. Cancer Research. 2004.  64, 2350-2356. [PubMed]
10. Linke, S. P., Sengupta, S., Khabie, N., Jeffries, B. A., Buchhop, S., Miska, S., Henning, W., Pedeux, R., Wang, X. W., Hofseth, L. J., Yang, Q., Garfield, S. H., Sturzbecher, H. W. and Harris, C. C.  p53 interacts with hRAD51 and hRAD54, and directly modulates homologous recombination. Cancer Research. 2003.  63, 2596-2605. [PubMed]
11. Sengupta, S., Linke, S. P., Pedeux, R., Yang, Q., Farnsworth, J., Garfield, S. H., Valerie, K., Shay, J. W., Ellis, N. A., Wasylyk, B. and Harris, C. C.  BLM helicase-dependent transport of p53 to sites of stalled DNA replication forks modulates homologous recombination. The EMBO Journal. 2003.  22, 1210-1222. [PubMed]
12. Ganguli, G., Back, J., Sengupta, S. and Wasylyk, B.  The p53 tumour suppressor inhibits glucocorticoid-induced proliferation of erythroid progenitors. EMBO Reports. 2002.  3, 569-574. [PubMed]
 

 
Grant Support:
Project Title Role Funding Agency Sanction Number Sanction Date
Determining the role of BLM helicase during signal transduction in humans Principal Investigator
Investigating the role of BLM helicase and signal transducer, 53BP1, during homologous recombination in human Principal Investigator Department of Science & Technology, Government of India 2010-2013
Establishment of an advanced microscopy cum flow cytometry unit Principal Investigator Department of Biotechnology, Government of India 2010-2013
Regulatory mechanisms for BLM helicase Principal Investigator Department of Biotechnology, Government of India 2007-2009
Determining the role of BLM helicase in DNA damage signal recognition and transduction due to double strand breaks in human Principal Investigator Department of Science & Technology, Government of India 2006-2009
how BLM helicase regulates RAD54 functions during recombination in human Co-PI Department of Biotechnology, Government of India 2007-2010
Regulatory mechanisms for BLM helicase Principal Investigator National Institute of Health, Maryland, USA 2006-2011
Determining the role of BLM helicase in DNA damage signal recognition and transduction due to double strand breaks in human Principal Investigator Department of Biotechnology, Government of India 2008-2011
how BLM helicase regulates RAD54 functions during recombination in human Principal Investigator Council of Scientific and Industrial Research, Government of India 2008-2011

 
 
My CV:   Download
 
Education 
::
Ph.D. in Microbiology, Indian Institute of Science, Bangalore, India, 1991-1997
Honors and Awards
::
2011, Awarded National Bioscience award for Career Development
Member
::
Elected as a member of Guha Research Conference
::
Editorial Board member of IRSN Cell Biology
::
Member of Indian Association of Cancer Research
::
Editorial Board member of Genome Integrity
  Last modified on : May 9, 2012
India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.