Ellora Sen, Ph.D.
National Brain Research Centre
NH-8, Nainwal Mode
Guargaon - 122 050
Haryana
E-mail: ellora@nbrc.ac.in
Phone: +91-124-2845200
Fax: +91-124-2338910
URL: http://www.nbrc.ac.in/view_profile.php?id=MTA=
Research Summary:
Cell signaling
Publications:
1.
Sen E . Targeting inflammation-induced transcription factor activation: an open frontier for glioma therapy. Drug Discovery Today. 2011. 16, 1044-1051. [PubMed]
2.
Tewari, R., Choudhury, S. R., Ghosh, S., Mehta, V. S. and Sen, E. Involvement of TNFalpha-induced TLR4-NF-kappaB and TLR4-HIF-1alpha feed-forward loops in the regulation of inflammatory responses in glioma. Journal of Molecular Medicine. 2011. [PubMed]
3.
Sharma, V., Dixit, D., Ghosh, S. and Sen, E. COX-2 regulates the proliferation of glioma stem like cells. Neurochemistry International. 2011. 59, 567-571. [PubMed]
4.
Sinha, S., Koul, N., Dixit, D., Sharma, V. and Sen, E. IGF-1 induced HIF-1alpha-TLR9 cross talk regulates inflammatory responses in glioma. Cellular Signalling. 2011. 23, 1869-1875. [PubMed]
5.
Sen, E. , Basu, A., Willing, L. B., Uliasz, T. F., Myrkalo, J. L., Vannucci, S. J., Hewett, S. J. and Levison, S. W. Pre-conditioning induces the precocious differentiation of neonatal astrocytes to enhance their neuroprotective properties. ASN Neuro. 2011. 3, e00062. [PubMed]
6.
Sharma, V., Shaheen, S. S., Dixit, D. and Sen, E. Farnesyltransferase Inhibitor Manumycin Targets IL1beta-Ras-HIF-1alpha Axis in Tumor Cells of Diverse Origin. Inflammation. 2011. [PubMed]
7.
Sharma, V., Dixit, D., Koul, N., Mehta, V. S. and Sen, E. Ras regulates interleukin-1beta-induced HIF-1alpha transcriptional activity in glioblastoma. Journal of Molecular Medicine. 2011. 89, 123-136. [PubMed]
8.
Koul, N., Sharma, V., Dixit, D., Ghosh, S. and Sen, E. Bicyclic triterpenoid Iripallidal induces apoptosis and inhibits Akt/mTOR pathway in glioma cells. BMC Cancer. 2010. 10, 328. [PubMed]
9.
Bain, J. M., Ziegler, A., Yang, Z., Levison, S. W. and Sen, E. TGFbeta1 stimulates the over-production of white matter astrocytes from precursors of the "brain marrow" in a rodent model of neonatal encephalopathy. PloS One. 2010. 5, e9567. [PubMed]
10.
Ghosh, S., Tewari, R., Dixit, D. and Sen, E. TNFalpha induced oxidative stress dependent Akt signaling affects actin cytoskeletal organization in glioma cells. Neurochemistry International. 2010. 56, 194-201. [PubMed]
11.
Sharma, V., Koul, N., Joseph, C., Dixit, D., Ghosh, S. and Sen, E. HDAC inhibitor, scriptaid, induces glioma cell apoptosis through JNK activation and inhibits telomerase activity. Journal of Cellular and Molecular Medicine. 2010. 14, 2151-2161. [PubMed]
12.
Tewari, R., Sharma, V., Koul, N. and Sen, E. Involvement of miltefosine-mediated ERK activation in glioma cell apoptosis through Fas regulation. Journal of Neurochemistry. 2008. 107, 616-627. [PubMed]
13.
Agarwal, A., Sharma, V., Tewari, R., Koul, N., Joseph, C. and Sen, E. Epigallocatechin-3-gallate exhibits anti-tumor effect by perturbing redox homeostasis, modulating the release of pro-inflammatory mediators and decreasing the invasiveness of glioblastoma cells. Molecular Medicine Reports. 2008. 1, 511-515. [PubMed]
14.
Sharma, V., Joseph, C., Ghosh, S., Agarwal, A., Mishra, M. K. and Sen, E. Kaempferol induces apoptosis in glioblastoma cells through oxidative stress. Molecular Cancer Therapeutics. 2007. 6, 2544-2553. [PubMed]
15.
Sharma, V., Mishra, M., Ghosh, S., Tewari, R., Basu, A., Seth, P. and Sen, E. Modulation of interleukin-1beta mediated inflammatory response in human astrocytes by flavonoids: implications in neuroprotection. Brain Research Bulletin. 2007. 73, 55-63. [PubMed]
16.
Ghoshal, A., Das, S., Ghosh, S., Mishra, M. K., Sharma, V., Koli, P., Sen, E. and Basu, A. Proinflammatory mediators released by activated microglia induces neuronal death in Japanese encephalitis. Glia. 2007. 55, 483-496. [PubMed]
17.
Sen, E. and Levison, S. W. Astrocytes and developmental white matter disorders. Mental Retardation and Developmental Disabilities Research Reviews. 2006. 12, 97-104. [PubMed]
18.
Alam, S., Sen, E. , Brashear, H. and Meyers, C. Adeno-associated virus type 2 increases proteosome-dependent degradation of p21WAF1 in a human papillomavirus type 31b-positive cervical carcinoma line. Journal of Virology. 2006. 80, 4927-4939. [PubMed]
19.
Sen, E. , McLaughlin-Drubin, M. and Meyers, C. Efficacy of two commercial preparations of interferon-alpha on human papillomavirus replication. Anticancer Research. 2005. 25, 1091-1100. [PubMed]
20.
Alam, S., Bromberg-White, J., McLaughlin-Drubin, M., Sen, E. , Bodily, J. M. and Meyers, C. Activity and therapeutic potential of ORI-1001 antisense oligonucleotide on human papillomavirus replication utilizing a model of dysplastic human epithelium. Anticancer Research. 2005. 25, 765-777. [PubMed]
21.
Sen, E. , Alam, S. and Meyers, C. Genetic and biochemical analysis of cis regulatory elements within the keratinocyte enhancer region of the human papillomavirus type 31 upstream regulatory region during different stages of the viral life cycle. Journal of Virology. 2004. 78, 612-629. [PubMed]
22.
Bromberg-White, J. L., Sen, E. , Alam, S., Bodily, J. M. and Meyers, C. Induction of the upstream regulatory region of human papillomavirus type 31 by dexamethasone is differentiation dependent. Journal of Virology. 2003. 77, 10975-10983. [PubMed]
23.
Sen, E. , Bromberg-White, J. L. and Meyers, C. Genetic analysis of cis regulatory elements within the 5' region of the human papillomavirus type 31 upstream regulatory region during different stages of the viral life cycle. Journal of Virology. 2002. 76, 4798-4809. [PubMed]
Education
::
Ph.D. in Immunology and Infectous diseases,
Indian Institute of Chemical Biology, Calcutta, India
Honors and Awards
::
2007, Innovative Young Biotechnologist Award (IYBA) Department of Biotechnology, Government of India
::
NASI–SCOPUS Young Scientist Award conferred jointly by National Academy of Science and Elseviers