INCREDB ID : 402
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Shyamal K. Goswami, Ph.D.
Professor 
 
Jawaharlal Nehru University
Room No.: 220, 217,
School of Life Sciences
New Delhi - 110 067   
New Delhi   
 
E-mail: skgoswami@mail.jnu.ac.in
Phone: 011-26704115, 26197230
 
URL: http://www.jnu.ac.in/Faculty/skgoswami/
 
Area of Specialization:
Molecular Cardiology
Research Summary:
Cell signaling and Gene Expression in Cardiovascular System
Transcription Control of Cardiovascular Development and Diseases
Redox biology of cardiovascular diseases
 
Publications:
1. Thakur, A., Alam, M. J., Ajayakumar, M. R., Ghaskadbi, S., Sharma, M. and Goswami, S. K.  Norepinephrine-induced apoptotic and hypertrophic responses in H9c2 cardiac myoblasts are characterized by different repertoire of reactive oxygen species generation. Redox Biology. 2015.  5, 243-252. [PubMed]
2. Tanti, G. K., Pandey, S. and Goswami, S. K.  SG2NA enhances cancer cell survival by stabilizing DJ-1 and thus activating Akt. Biochemical and Biophysical Research Communications. 2015.  463, 524-531. [PubMed]
3. Jain, B. P., Chauhan, P., Tanti, G. K., Singarapu, N., Ghaskadbi, S. and Goswami, S. K.  Tissue specific expression of SG2NA is regulated by differential splicing, RNA editing and differential polyadenylation. Gene. 2015.  556, 119-126. [PubMed]
4. Tanti, G. K. and Goswami, S. K.  SG2NA recruits DJ-1 and Akt into the mitochondria and membrane to protect cells from oxidative damage. Free Radical Biology & Medicine. 2014.  75, 1-13. [PubMed]
5. Soni, S., Tyagi, C., Grover, A. and Goswami, S. K.  Molecular modeling and molecular dynamics simulations based structural analysis of the SG2NA protein variants. BMC Research Notes. 2014.  7, 446. [PubMed]
6. Tanti, G. K., Singarapu, N., Muthuswami, R. and Goswami, S. K.  Among the three striatin family members, SG2NA was first to arise during evolution. Frontiers in Bioscience. 2014.  6, 1-15. [PubMed]
7. Dutta, P., Tanti, G. K., Sharma, S., Goswami, S. K., Komath, S. S., Mayo, M. W., Hockensmith, J. W. and Muthuswami, R.  Global epigenetic changes induced by SWI2/SNF2 inhibitors characterize neomycin-resistant mammalian cells. PloS One. 2012.  7, e49822. [PubMed]

 

8. Jindal, E. and Goswami, S. K.  In cardiac myoblasts, cellular redox regulates FosB and Fra-1 through multiple cis-regulatory modules. Free Radical Biology & Medicine. 2011.  51, 1512-1521. [PubMed]
9. Hameed, S., Dhamgaye, S., Singh, A., Goswami, S. K. and Prasad, R.  Calcineurin signaling and membrane lipid homeostasis regulates iron mediated multidrug resistance mechanisms in Candida albicans. PloS One. 2011.  6, e18684. [PubMed]
10. Prasad, T., Hameed, S., Manoharlal, R., Biswas, S., Mukhopadhyay, C. K., Goswami, S. K. and Prasad, R.  Morphogenic regulator EFG1 affects the drug susceptibilities of pathogenic Candida albicans. FEMS Yeast Research. 2010.  10, 587-596. [PubMed]
11. Goswami, S. K. and Das, D. K.  Autophagy in the myocardium: Dying for survival? Experimental and Clinical Cardiology. 2006.  11, 183-188. [PubMed]
12. Sanghamitra, M., Talukder, I., Singarapu, N., Sindhu, K. V., Kateriya, S. and Goswami, S. K.  WD-40 repeat protein SG2NA has multiple splice variants with tissue restricted and growth responsive properties. Gene. 2008.  420, 48-56. [PubMed]
13. Hameed, S., Prasad, T., Banerjee, D., Chandra, A., Mukhopadhyay, C. K., Goswami, S. K., Lattif, A. A., Chandra, J., Mukherjee, P. K., Ghannoum, M. A. and Prasad, R.  Iron deprivation induces EFG1-mediated hyphal development in Candida albicans without affecting biofilm formation. FEMS Yeast Research. 2008.  8, 744-755. [PubMed]
14. Das, D., Tapryal, N., Goswami, S. K., Fox, P. L. and Mukhopadhyay, C. K.  Regulation of ceruloplasmin in human hepatic cells by redox active copper: identification of a novel AP-1 site in the ceruloplasmin gene. The Biochemical Journal. 2007.  402, 135-141. [PubMed]
15. Gupta, M. K., Neelakantan, T. V., Sanghamitra, M., Tyagi, R. K., Dinda, A., Maulik, S., Mukhopadhyay, C. K. and Goswami, S. K.  An assessment of the role of reactive oxygen species and redox signaling in norepinephrine-induced apoptosis and hypertrophy of H9c2 cardiac myoblasts. Antioxidants & Redox Signaling. 2006.  8, 1081-1093. [PubMed]
16. Sindhu, K. V., Rani, V., Gupta, M. K., Ghaskadbi, S., Choudhury, D. and Goswami, S. K.  Isolation of a library of target-sites for sequence specific DNA binding proteins from chick embryonic heart: a potential tool for identifying novel transcriptional regulators involved in embryonic development. Biochemical and Biophysical Research Communications. 2004.  323, 912-919. [PubMed]
17. Karnani, N., Gaur, N. A., Jha, S., Puri, N., Krishnamurthy, S., Goswami, S. K., Mukhopadhyay, G. and Prasad, R.  SRE1 and SRE2 are two specific steroid-responsive modules of Candida drug resistance gene 1 (CDR1) promoter. Yeast. 2004.  21, 219-239. [PubMed]
18. Gaur, N. A., Puri, N., Karnani, N., Mukhopadhyay, G., Goswami, S. K. and Prasad, R.  Identification of a negative regulatory element which regulates basal transcription of a multidrug resistance gene CDR1 of Candida albicans. FEMS Yeast Research. 2004.  4, 389-399. [PubMed]
19. Meenakshi, J., Goswami, S. K. and Datta, K.  Constitutive expression of hyaluronan binding protein 1 (HABP1/p32/gC1qR) in normal fibroblast cells perturbs its growth characteristics and induces apoptosis. Biochemical and Biophysical Research Communications. 2003.  300, 686-693. [PubMed]
20. Majumdar, M., Meenakshi, J., Goswami, S. K. and Datta, K.  Hyaluronan binding protein 1 (HABP1)/C1QBP/p32 is an endogenous substrate for MAP kinase and is translocated to the nucleus upon mitogenic stimulation. Biochemical and Biophysical Research Communications. 2002.  291, 829-837. [PubMed]
21. Nijhara, R., Jana, S. S., Goswami, S. K., Rana, A., Majumdar, S. S., Kumar, V. and Sarkar, D. P.  Sustained activation of mitogen-activated protein kinases and activator protein 1 by the hepatitis B virus X protein in mouse hepatocytes in vivo. Journal of Virology. 2001.  75, 10348-10358. [PubMed]
22. Nijhara, R., Jana, S. S., Goswami, S. K., Kumar, V. and Sarkar, D. P.  An internal segment (residues 58-119) of the hepatitis B virus X protein is sufficient to activate MAP kinase pathways in mouse liver. FEBS Letters. 2001.  504, 59-64. [PubMed]
23. Puri, N., Krishnamurthy, S., Habib, S., Hasnain, S. E., Goswami, S. K. and Prasad, R.  CDR1, a multidrug resistance gene from Candida albicans, contains multiple regulatory domains in its promoter and the distal AP-1 element mediates its induction by miconazole. FEMS Microbiology Letters. 1999.  180, 213-219. [PubMed]
24. Goswami, S. K. and Gould, R. M.  Prostanoid synthesis in peripheral nerve. Biochimica et Biophysica Acta. 1985.  834, 263-266. [PubMed]
25. Goswami, S. K. and Gould, R. M.  Effect of electrical stimulation on phosphoinositide metabolism in rat sciatic nerve in vivo. Journal of Neurochemistry. 1985.  44, 941-946. [PubMed]
26. Goswami, S. K. and Bose, S. K.  Isolation of mycobacillin from the culture filtrate of a mutant derivative of Bacillus subtilis B3. Indian Journal of Biochemistry & Biophysics. 1982.  19, 57-58. [PubMed]
27. Goswami, S. K. and Majumdar, S. K.  Water soluble fluorescent pigment production by a strain of Pseudomonas aeruginosa. Indian Journal of Experimental Biology. 1970.  8, 346. [PubMed]
 

 
Grant Support:
Project Title Role Funding Agency Sanction Number Sanction Date
Development of a database on transcription factor binding sites from developing chick heart Investigator Council of Scientific and Industrial Research, Government of India 1999-2003
Role of AP-1 and its associate proteins in cardiac muscle gene expression Investigator Department of Biotechnology, Government of India 2000-2003
Identification of Novel Gene Expression Pathways in Cardiac Diseases Investigator University Grants Commission, India 2002-2007
Identification and characterization of novel transcriptional regulators from developing heart Investigator Council of Scientific and Industrial Research, Government of India 2004-2006
Biochemical and Molecular Analysis of Redox Signaling in Cardiac Myocytes under Adrenergic Stress Investigator Council of Scientific and Industrial Research, Government of India 2007-2010
Identification and Functional Characterization of the Splice Variants of the Tumor Antigen SG2NA Investigator Department of Biotechnology, Government of India 2007-2011
Analysis of intracellular redox dynamics in H9C2 cardiac myoblasts under adrenergic stress: a tool for studying the biology of heart failure Investigator Council of Scientific and Industrial Research, Government of India 2011-2014
The role of SG2NA in Tissue Differentiation during Chick Development Investigator Department of Science & Technology, Government of India 2011-2013

 
 
 
Education 
::
Ph.D. in Biochemistry , 1979-1984
  Last modified on : Jan 24, 2016
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