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Shyamal K. Goswami, Ph.D.
Jawaharlal Nehru University
Room No.: 220, 217,
School of Life Sciences
New Delhi - 110 067   
New Delhi   
Phone: 011-26704115, 26197230
Area of Specialization:
Molecular Cardiology
Research Summary:
Cell signaling and Gene Expression in Cardiovascular System
Transcription Control of Cardiovascular Development and Diseases
Redox biology of cardiovascular diseases
1. Thakur, A., Alam, M. J., Ajayakumar, M. R., Ghaskadbi, S., Sharma, M. and Goswami, S. K.  Norepinephrine-induced apoptotic and hypertrophic responses in H9c2 cardiac myoblasts are characterized by different repertoire of reactive oxygen species generation. Redox Biology. 2015.  5, 243-252. [PubMed]
2. Tanti, G. K., Pandey, S. and Goswami, S. K.  SG2NA enhances cancer cell survival by stabilizing DJ-1 and thus activating Akt. Biochemical and Biophysical Research Communications. 2015.  463, 524-531. [PubMed]
3. Jain, B. P., Chauhan, P., Tanti, G. K., Singarapu, N., Ghaskadbi, S. and Goswami, S. K.  Tissue specific expression of SG2NA is regulated by differential splicing, RNA editing and differential polyadenylation. Gene. 2015.  556, 119-126. [PubMed]
4. Tanti, G. K. and Goswami, S. K.  SG2NA recruits DJ-1 and Akt into the mitochondria and membrane to protect cells from oxidative damage. Free Radical Biology & Medicine. 2014.  75, 1-13. [PubMed]
5. Soni, S., Tyagi, C., Grover, A. and Goswami, S. K.  Molecular modeling and molecular dynamics simulations based structural analysis of the SG2NA protein variants. BMC Research Notes. 2014.  7, 446. [PubMed]
6. Tanti, G. K., Singarapu, N., Muthuswami, R. and Goswami, S. K.  Among the three striatin family members, SG2NA was first to arise during evolution. Frontiers in Bioscience. 2014.  6, 1-15. [PubMed]
7. Dutta, P., Tanti, G. K., Sharma, S., Goswami, S. K., Komath, S. S., Mayo, M. W., Hockensmith, J. W. and Muthuswami, R.  Global epigenetic changes induced by SWI2/SNF2 inhibitors characterize neomycin-resistant mammalian cells. PloS One. 2012.  7, e49822. [PubMed]


8. Jindal, E. and Goswami, S. K.  In cardiac myoblasts, cellular redox regulates FosB and Fra-1 through multiple cis-regulatory modules. Free Radical Biology & Medicine. 2011.  51, 1512-1521. [PubMed]
9. Hameed, S., Dhamgaye, S., Singh, A., Goswami, S. K. and Prasad, R.  Calcineurin signaling and membrane lipid homeostasis regulates iron mediated multidrug resistance mechanisms in Candida albicans. PloS One. 2011.  6, e18684. [PubMed]
10. Prasad, T., Hameed, S., Manoharlal, R., Biswas, S., Mukhopadhyay, C. K., Goswami, S. K. and Prasad, R.  Morphogenic regulator EFG1 affects the drug susceptibilities of pathogenic Candida albicans. FEMS Yeast Research. 2010.  10, 587-596. [PubMed]
11. Goswami, S. K. and Das, D. K.  Autophagy in the myocardium: Dying for survival? Experimental and Clinical Cardiology. 2006.  11, 183-188. [PubMed]
12. Sanghamitra, M., Talukder, I., Singarapu, N., Sindhu, K. V., Kateriya, S. and Goswami, S. K.  WD-40 repeat protein SG2NA has multiple splice variants with tissue restricted and growth responsive properties. Gene. 2008.  420, 48-56. [PubMed]
13. Hameed, S., Prasad, T., Banerjee, D., Chandra, A., Mukhopadhyay, C. K., Goswami, S. K., Lattif, A. A., Chandra, J., Mukherjee, P. K., Ghannoum, M. A. and Prasad, R.  Iron deprivation induces EFG1-mediated hyphal development in Candida albicans without affecting biofilm formation. FEMS Yeast Research. 2008.  8, 744-755. [PubMed]
14. Das, D., Tapryal, N., Goswami, S. K., Fox, P. L. and Mukhopadhyay, C. K.  Regulation of ceruloplasmin in human hepatic cells by redox active copper: identification of a novel AP-1 site in the ceruloplasmin gene. The Biochemical Journal. 2007.  402, 135-141. [PubMed]
15. Gupta, M. K., Neelakantan, T. V., Sanghamitra, M., Tyagi, R. K., Dinda, A., Maulik, S., Mukhopadhyay, C. K. and Goswami, S. K.  An assessment of the role of reactive oxygen species and redox signaling in norepinephrine-induced apoptosis and hypertrophy of H9c2 cardiac myoblasts. Antioxidants & Redox Signaling. 2006.  8, 1081-1093. [PubMed]
16. Sindhu, K. V., Rani, V., Gupta, M. K., Ghaskadbi, S., Choudhury, D. and Goswami, S. K.  Isolation of a library of target-sites for sequence specific DNA binding proteins from chick embryonic heart: a potential tool for identifying novel transcriptional regulators involved in embryonic development. Biochemical and Biophysical Research Communications. 2004.  323, 912-919. [PubMed]
17. Karnani, N., Gaur, N. A., Jha, S., Puri, N., Krishnamurthy, S., Goswami, S. K., Mukhopadhyay, G. and Prasad, R.  SRE1 and SRE2 are two specific steroid-responsive modules of Candida drug resistance gene 1 (CDR1) promoter. Yeast. 2004.  21, 219-239. [PubMed]
18. Gaur, N. A., Puri, N., Karnani, N., Mukhopadhyay, G., Goswami, S. K. and Prasad, R.  Identification of a negative regulatory element which regulates basal transcription of a multidrug resistance gene CDR1 of Candida albicans. FEMS Yeast Research. 2004.  4, 389-399. [PubMed]
19. Meenakshi, J., Goswami, S. K. and Datta, K.  Constitutive expression of hyaluronan binding protein 1 (HABP1/p32/gC1qR) in normal fibroblast cells perturbs its growth characteristics and induces apoptosis. Biochemical and Biophysical Research Communications. 2003.  300, 686-693. [PubMed]
20. Majumdar, M., Meenakshi, J., Goswami, S. K. and Datta, K.  Hyaluronan binding protein 1 (HABP1)/C1QBP/p32 is an endogenous substrate for MAP kinase and is translocated to the nucleus upon mitogenic stimulation. Biochemical and Biophysical Research Communications. 2002.  291, 829-837. [PubMed]
21. Nijhara, R., Jana, S. S., Goswami, S. K., Rana, A., Majumdar, S. S., Kumar, V. and Sarkar, D. P.  Sustained activation of mitogen-activated protein kinases and activator protein 1 by the hepatitis B virus X protein in mouse hepatocytes in vivo. Journal of Virology. 2001.  75, 10348-10358. [PubMed]
22. Nijhara, R., Jana, S. S., Goswami, S. K., Kumar, V. and Sarkar, D. P.  An internal segment (residues 58-119) of the hepatitis B virus X protein is sufficient to activate MAP kinase pathways in mouse liver. FEBS Letters. 2001.  504, 59-64. [PubMed]
23. Puri, N., Krishnamurthy, S., Habib, S., Hasnain, S. E., Goswami, S. K. and Prasad, R.  CDR1, a multidrug resistance gene from Candida albicans, contains multiple regulatory domains in its promoter and the distal AP-1 element mediates its induction by miconazole. FEMS Microbiology Letters. 1999.  180, 213-219. [PubMed]
24. Goswami, S. K. and Gould, R. M.  Prostanoid synthesis in peripheral nerve. Biochimica et Biophysica Acta. 1985.  834, 263-266. [PubMed]
25. Goswami, S. K. and Gould, R. M.  Effect of electrical stimulation on phosphoinositide metabolism in rat sciatic nerve in vivo. Journal of Neurochemistry. 1985.  44, 941-946. [PubMed]
26. Goswami, S. K. and Bose, S. K.  Isolation of mycobacillin from the culture filtrate of a mutant derivative of Bacillus subtilis B3. Indian Journal of Biochemistry & Biophysics. 1982.  19, 57-58. [PubMed]
27. Goswami, S. K. and Majumdar, S. K.  Water soluble fluorescent pigment production by a strain of Pseudomonas aeruginosa. Indian Journal of Experimental Biology. 1970.  8, 346. [PubMed]


Grant Support:
Project Title Role Funding Agency Sanction Number Sanction Date
Development of a database on transcription factor binding sites from developing chick heart Investigator Council of Scientific and Industrial Research, Government of India 1999-2003
Role of AP-1 and its associate proteins in cardiac muscle gene expression Investigator Department of Biotechnology, Government of India 2000-2003
Identification of Novel Gene Expression Pathways in Cardiac Diseases Investigator University Grants Commission, India 2002-2007
Identification and characterization of novel transcriptional regulators from developing heart Investigator Council of Scientific and Industrial Research, Government of India 2004-2006
Biochemical and Molecular Analysis of Redox Signaling in Cardiac Myocytes under Adrenergic Stress Investigator Council of Scientific and Industrial Research, Government of India 2007-2010
Identification and Functional Characterization of the Splice Variants of the Tumor Antigen SG2NA Investigator Department of Biotechnology, Government of India 2007-2011
Analysis of intracellular redox dynamics in H9C2 cardiac myoblasts under adrenergic stress: a tool for studying the biology of heart failure Investigator Council of Scientific and Industrial Research, Government of India 2011-2014
The role of SG2NA in Tissue Differentiation during Chick Development Investigator Department of Science & Technology, Government of India 2011-2013


Ph.D. in Biochemistry , 1979-1984
  Last modified on : Jan 24, 2016
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