INCREDB ID : 40
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Mammen Chandy, M.D., F.R.A.C.P., F.R.A.C.P.A.
Director 
 
Tata Medical Center
1, Bishop Lefroy Road, Rajarhat
Kolkata - 700 020   
West Bengal   
 
E-mail: mammen.chandy@tatatea.co.in
Mobile: +91-9878659525
Fax: +91-161-2609958
 
Positions Held:
Position Affiliation Time Period
Director Tata Medical Center, Kolkata, India 2010-Present
Head of Department Christian Medical College and Hospital, Vellore, India 1987-2010
 
Area of Specialization:
Oncology
Haematology
Research Summary:
Aplastic anemia
Thalassemia
Acute leukemia and stem cell transplantation
 
Publications:
1. Gupta, M., Ashok, K., Sitaram, U., Neeraj, S., Nancy, A., Balasubramanian, P., Abraham, A., Mathews, V., Viswabandya, A., George, B., Chandy, M., Srivastava, A. and Srivastava, V. M.  The t(6;9)(p22;q34) in myeloid neoplasms: a retrospective study of 16 cases. Cancer Genetics and Cytogenetics. 2010.  203, 297-302. [PubMed]
2. Mathews, V., George, B., Chendamarai, E., Lakshmi, K. M., Desire, S., Balasubramanian, P., Viswabandya, A., Thirugnanam, R., Abraham, A., Shaji, R. V., Srivastava, A. and Chandy, M.  Single-agent arsenic trioxide in the treatment of newly diagnosed acute promyelocytic leukemia: long-term follow-up data. Journal of Clinical Oncology. 2010.  28, 3866-3871. [PubMed]
3. Viswabandya, A., Baidya, S., Nair, S. C., Lakshmi, K. M., Mathews, V., George, B., Chandy, M. and Srivastava, A.  Clinical manifestations of combined factor V and VIII deficiency: a series of 37 cases from a single center in India. American Journal of Hematology. 2010.  85, 538-539. [PubMed]
4. George, B., Mathews, V., Viswabandya, A., Lakshmi, K. M., Srivastava, A. and Chandy, M.  Allogeneic hematopoietic stem cell transplantation is superior to immunosuppressive therapy in Indian children with aplastic anemia--a single-center analysis of 100 patients. Pediatric Hematology and Oncology. 2010.  27, 122-131. [PubMed]
5. Rajasekar, R., Lakshmi, K. M., George, B., Viswabandya, A., Thirugnanam, R., Abraham, A., Chandy, M., Srivastava, A. and Mathews, V.  Dendritic cell count in the graft predicts relapse in patients with hematologic malignancies undergoing an HLA-matched related allogeneic peripheral blood stem cell transplant. Biology of Blood and Marrow Transplantation. 2010.  16, 854-860. [PubMed]
6. Desire, S., Balasubramanian, P., Bajel, A., George, B., Viswabandya, A., Mathews, V., Srivastava, A. and Chandy, M.  Frequency of TPMT alleles in Indian patients with acute lymphatic leukemia and effect on the dose of 6-mercaptopurine. Medical Oncology. 2010.  27, 1046-1049. [PubMed]
7. Thirugnanam, R., George, B., Chendamarai, E., Lakshmi, K. M., Balasubramanian, P., Viswabandya, A., Srivastava, A., Chandy, M. and Mathews, V.  Comparison of clinical outcomes of patients with relapsed acute promyelocytic leukemia induced with arsenic trioxide and consolidated with either an autologous stem cell transplant or an arsenic trioxide-based regimen. Biology of Blood and Marrow Transplantation. 2009.  15, 1479-1484. [PubMed]
8. Edison, E. S., Athiyarath, R., Rajasekar, T., Westerman, M., Srivastava, A. and Chandy, M.  A novel splice site mutation c.2278 (-1) G>C in the TMPRSS6 gene causes deletion of the substrate binding site of the serine protease resulting in refractory iron deficiency anaemia. British Journal of Haematology. 2009.  147, 766-769. [PubMed]
9. George, B., Mathews, V., Viswabandya, A., Srivastava, A. and Chandy, M.  Fludarabine-based reduced intensity conditioning regimens for allogeneic hematopoietic stem cell transplantation in patients with aplastic anemia and fungal infections. Clinical Transplantation. 2009.  23, 228-232. [PubMed]
10. Rajasekar, R., Mathews, V., Lakshmi, K. M., George, B., Viswabandya, A., Chandy, M. and Srivastava, A.  Cellular immune reconstitution and its impact on clinical outcome in children with beta thalassemia major undergoing a matched related myeloablative allogeneic bone marrow transplant. Biology of Blood and Marrow Transplantation. 2009.  15, 597-609. [PubMed]
11. Chandy M.  Innovative supportive care practices for stem cell transplantation in India. Biology of Blood and Marrow Transplantation. 2009.  15, 95-98. [PubMed]
12. Edison, E. S., Bajel, A. and Chandy, M.  Iron homeostasis: new players, newer insights. European Journal of Haematology. 2008.  81, 411-424. [PubMed]
13. Bajel, A., George, B., Mathews, V., Viswabandya, A., Kavitha, M. L., Srivastava, A. and Chandy, M.  Treatment of children with acute lymphoblastic leukemia in India using a BFM protocol. Pediatric Blood & Cancer. 2008.  51, 621-625. [PubMed]
14. Mathews, V., George, B., Lakshmi, K. M., Viswabandya, A., John, J. M., Sitaram, U., Daniel, D., Chandy, M. and Srivastava, A.  Impact of pretransplant splenectomy on patients with beta-thalassemia major undergoing a matched-related allogeneic stem cell transplantation. Pediatric Transplantation. 2009.  13, 171-176. [PubMed]
15. Rajasekar, R., Mathews, V., Lakshmi, K. M., Sellathamby, S., George, B., Viswabandya, A., Daniel, D., Chandy, M. and Srivastava, A.  Plasmacytoid dendritic cell count on day 28 in HLA-matched related allogeneic peripheral blood stem cell transplant predicts the incidence of acute and chronic GVHD. Biology of Blood and Marrow Transplantation. 2008.  14, 344-350. [PubMed]
16. George, B., Mathews, V., Viswabandya, A., Kavitha, M. L., Srivastava, A. and Chandy, M.  Fludarabine based reduced intensity conditioning regimens in children undergoing allogeneic stem cell transplantation for severe aplastic anemia. Pediatric Transplantation. 2008.  12, 14-19. [PubMed]
17. Mathews, V., George, B., Deotare, U., Lakshmi, K. M., Viswabandya, A., Daniel, D., Chandy, M. and Srivastava, A.  A new stratification strategy that identifies a subset of class III patients with an adverse prognosis among children with beta thalassemia major undergoing a matched related allogeneic stem cell transplantation. Biology of Blood and Marrow Transplantation. 2007.  13, 889-894. [PubMed]
18. Jayandharan, G. R., Viswabandya, A., Nair, S. C., Chandy, M. and Srivastava, A.  Molecular basis of hereditary factor VII deficiency in India: five novel mutations including a double missense mutation (Ala191Glu; Trp364Cys) in 11 unrelated patients. Haematologica. 2007.  92, 1002-1003. [PubMed]
19. Mathews, V., Thomas, M., Srivastava, V. M., George, B., Srivastava, A. and Chandy, M.  Impact of FLT3 mutations and secondary cytogenetic changes on the outcome of patients with newly diagnosed acute promyelocytic leukemia treated with a single agent arsenic trioxide regimen. Haematologica. 2007.  92, 994-995. [PubMed]
20. Sundaresan, S., Eapen, C. E., Shaji, R. V., Chandy, M., Kurian, G. and Chandy, G.  Screening for mutations in ATP7B gene using conformation-sensitive gel electrophoresis in a family with Wilson's disease. Medical Science Monitor. 2007.  13, CS38-40. [PubMed]
21. Edison, E. S., Melinkeri, S. R. and Chandy, M.  A novel missense mutation in glucose-6-phosphate dehydrogenase gene causing chronic nonspherocytic hemolytic anemia in an Indian family. Annals of Hematology. 2006.  85, 879-880. [PubMed]
22. Jayandharan, G. R., Viswabandya, A., Baidya, S., Nair, S. C., George, B., Mathews, V., Chandy, M. and Srivastava, A.  Mutations in coagulation factor XIII A gene in eight unrelated Indians. Five novel mutations identified by a novel PCR-CSGE approach. Thrombosis and Haemostasis. 2006.  95, 551-556. [PubMed]
23. George, B., Mathews, V., Viswabandya, A., Srivastava, A. and Chandy, M.  Infections in children undergoing allogeneic bone marrow transplantation in India. Pediatric Transplantation. 2006.  10, 48-54. [PubMed]
24. Mathews, V., George, B., Lakshmi, K. M., Viswabandya, A., Bajel, A., Balasubramanian, P., Shaji, R. V., Srivastava, V. M., Srivastava, A. and Chandy, M.  Single-agent arsenic trioxide in the treatment of newly diagnosed acute promyelocytic leukemia: durable remissions with minimal toxicity. Blood. 2006.  107, 2627-2632. [PubMed]
25. Mathews, V., Viswabandya, A., Baidya, S., George, B., Nair, S., Chandy, M. and Srivastava, A.  Surgery for hemophilia in developing countries. Seminars in Thrombosis and Hemostasis. 2005.  31, 538-543. [PubMed]
26. Chandy M.  Management of hemophilia with minimal factor replacement in developing countries: role of ancillary therapy. Seminars in Thrombosis and Hemostasis. 2005.  31, 501-506. [PubMed]
27. Jayandharan, G. R., Shaji, R. V., Baidya, S., Nair, S. C., Chandy, M. and Srivastava, A.  Molecular characterization of factor IX gene mutations in 53 patients with haemophilia B in India. Thrombosis and Haemostasis. 2005.  94, 883-886. [PubMed]
28. Damodar, S., Viswabandya, A., George, B., Mathews, V., Chandy, M. and Srivastava, A.  Dapsone for chronic idiopathic thrombocytopenic purpura in children and adults--a report on 90 patients. European Journal of Haematology. 2005.  75, 328-331. [PubMed]
29. Edison, E. S., Shaji, R. V., Srivastava, A. and Chandy, M.  Compound heterozygosity for Hb E and Hb Lepore-Hollandia in India; first report and potential diagnostic pitfalls. Hemoglobin. 2005.  29, 221-224. [PubMed]
30. Edison, E. S., Shaji, R. V., Srivastava, A. and Chandy, M.  Hyperbilirubinemia in homozygous HbE disease is associated with the UGT1A1 gene polymorphism. Hemoglobin. 2005.  29, 189-195. [PubMed]
31. George, B., Mathews, L., Balasubramanian, P., Shaji, R. V., Srivastava, A. and Chandy, M.  Molecular remission with arsenic trioxide in patients with newly diagnosed acute promyelocytic leukemia. Haematologica. 2004.  89, 1266-1267. [PubMed]
32. George, B., Mathews, L., Balasubramanian, P., Shaji, R. V., Srivastava, A. and Chandy, M.  Molecular remission with arsenic trioxide in patients with newly diagnosed acute promyelocytic leukemia. Haematologica. 2004.  89, 1266-1267. [PubMed]
33. Srivastava, A., Poonkuzhali, B., Shaji, R. V., George, B., Mathews, V., Chandy, M. and Krishnamoorthy, R.  Glutathione S-transferase M1 polymorphism: a risk factor for hepatic venoocclusive disease in bone marrow transplantation. Blood. 2004.  104, 1574-1577. [PubMed]
34. Srivastava, A., Usher, S., Nelson, E. J., Jayandharan, G., Shaji, R. V., Chandy, M., Seligsohn, U. and Peretz, H.  Prenatal diagnosis of Glanzmann thrombasthenia. The National Medical Journal of India. 2003.  16, 207-208. [PubMed]
35. Shaji, R. V., Edison, E. S., Poonkuzhali, B., Srivastava, A. and Chandy, M.  Rapid detection of beta-globin gene mutations and polymorphisms by temporal temperature gradient gel electrophoresis. Clinical Chemistry. 2003.  49, 777-781. [PubMed]
36. Shaji, R. V., Edison, E. S., Krishnamoorthy, R., Chandy, M. and Srivastava, A.  Hb Lepore in the Indian population. Hemoglobin. 2003.  27, 7-14. [PubMed]
37. Simon, A., Pillai, S., Raghupathy, P. and Chandy, M.  Leucocyte adhesion deficiency-1. Indian Pediatrics. 2002.  39, 963-966. [PubMed]
38. Shaji, R. V., Srivastava, A., Krishnamoorthy, R. and Chandy, M.  Coexistence of a novel beta-globin gene deletion (codons 81-87) with the codon 30 (G-->C) mutation in an Indian patient with beta0-thalassemia. Hemoglobin. 2002.  26, 237-243. [PubMed]
39. Shivakumar, S., Mathew, S., Dalton, J., Chandy, M. and Srivastava, A.  A complex karyotype involving chromosomes 3, 6, 11, 12, and 22 in adult acute lymphoblastic leukemia. Leukemia & Lymphoma. 2002.  43, 1673-1677. [PubMed]
40. Mathews, V., Balasubramanian, P., Shaji, R. V., George, B., Chandy, M. and Srivastava, A.  Arsenic trioxide in the treatment of newly diagnosed acute promyelocytic leukemia: a single center experience. American Journal of Hematology. 2002.  70, 292-299. [PubMed]
41. Naina, H. V., Nair, S. C., Daniel, D., George, B. and Chandy, M.  Asymptomatic constitutional macrothrombocytopenia among West Bengal blood donors. The American Journal of Medicine. 2002.  112, 742-743. [PubMed]
42. Kang, G., Srivastava, A., Pulimood, A. B., Dennison, D. and Chandy, M.  Etiology of diarrhea in patients undergoing allogeneic bone marrow transplantation in South India. Transplantation. 2002.  73, 1247-1251. [PubMed]
43. Shaji, R. V., Gerard, N., Krishnamoorthy, R., Srivastava, A. and Chandy, M.  A novel beta-thalassemia mutation in an Asian Indian. Hemoglobin. 2002.  26, 49-57. [PubMed]
44. Srivastava, A., Mathews, V., Bhurani, D., Baidya, S. and Chandy, M.  Successful surgical hemostasis in patients with von Willebrand disease following infusion of KoateDVI. Thrombosis and Haemostasis. 2002.  87, 541-543. [PubMed]

 
 
Education 
::
M.D. in Medicine, Christian Medical College and Hospital, Vellore, India
::
F.R.A.C.P.
::
F.R.A.C.P.A.
Honors and Awards
::
2010, International Healthcare Volunteer Award
::
2010, Fellowship from the Royal College of Physicians, London
Member
::
Hemophilia Federation of India
  Last modified on : Jul 5, 2011
India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.