INCREDB ID : 399
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Sartaj Tabassum, Ph.D.
Professor 
 
Aligarh Muslim University, Uttar Pradesh
Department of Chemistry
Aligarh Muslim University
Aligarh - 202 002   
Uttar Pradesh   
 
E-mail: tsartaj62@yahoo.com
Phone: +91571-2703893
Mobile: +91935-825-5791
 
URL: http://members.nanosociety.us/tsartaj62# , http://www.amu.ac.in/dshowfacultydata2.jsp?did=2&eid=217
 
Area of Specialization:
Cancer Nanotechnology
Research Summary:
Design and Synthesis of Nano Metal based drugs for cancer
 
Publications:

 

1. Tabassum, S., Zaki, M., Ahmad, M., Afzal, M., Srivastav, S., Srikrishna, S. and Arjmand, F.  Synthesis and crystal structure determination of copper(II)-complex: In vitro DNA and HSA binding, pBR322 plasmid cleavage, cell imaging and cytotoxic studies. European Journal of Medicinal Chemistry. 2014.  83, 141-154. [PubMed]
2. Tabassum, S., Zaki, M., Afzal, M. and Arjmand, F.  Synthesis and characterization of Cu(II)-based anticancer chemotherapeutic agent targeting topoisomerase Ialpha: in vitro DNA binding, pBR322 cleavage, molecular docking studies and cytotoxicity against human cancer cell lines. European Journal of Medicinal Chemistry. 2014.  74, 509-523. [PubMed]
3. Tabassum, S., Afzal, M. and Arjmand, F.  New modulated design, docking and synthesis of carbohydrate-conjugate heterobimetallic CuII-SnIV complex as potential topoisomerase II inhibitor: in vitro DNA binding, cleavage and cytotoxicity against human cancer cell lines. European Journal of Medicinal Chemistry. 2014.  74, 694-702. [PubMed]
4. Ahmad, M., Afzal, M., Tabassum, S., Kalinska, B., Mrozinski, J. and Bharadwaj, P. K.  Synthesis and structure elucidation of a cobalt(II) complex as topoisomerase I inhibitor: in vitro DNA binding, nuclease and RBC hemolysis. European Journal of Medicinal Chemistry. 2014.  74, 683-693. [PubMed]
5. Khan, R. A., Yadav, S., Hussain, Z., Arjmand, F. and Tabassum, S.  Carbohydrate linked organotin(IV) complexes as human topoisomerase Ialpha inhibitor and their antiproliferative effects against the human carcinoma cell line. Dalton Transactions. 2014.  43, 2534-2548. [PubMed]
6. Tabassum, S., Asim, A., Khan, R. A., Hussain, Z., Srivastav, S., Srikrishna, S. and Arjmand, F.  Chiral heterobimetallic complexes targeting human DNA-topoisomerase Ialpha. Dalton Transactions. 2013.  42, 16749-16761. [PubMed]
7. Tabassum, S., Zaki, M., Afzal, M. and Arjmand, F.  New modulated design and synthesis of quercetin-Cu(II)/Zn(II)-Sn2(IV) scaffold as anticancer agents: in vitro DNA binding profile, DNA cleavage pathway and Topo-I activity. Dalton Transactions. 2013.  42, 10029-10041. [PubMed]
8. Tabassum, S., Amir, S., Arjmand, F., Pettinari, C., Marchetti, F., Masciocchi, N., Lupidi, G. and Pettinari, R.  Mixed-ligand Cu(II)-vanillin Schiff base complexes; effect of coligands on their DNA binding, DNA cleavage, SOD mimetic and anticancer activity. European Journal of Medicinal Chemistry. 2013.  60, 216-232. [PubMed]
9. Arjmand, F., Sayeed, F., Parveen, S., Tabassum, S., Juvekar, A. S. and Zingde, S. M.  Design and synthesis of (S)- and (R)-enantiomers of [4-(2-hydroxy-1-phenylethylimino)pent-2-ol]dimethyltin(iv) and 2,2-dimethyl-4-phenyl-1,3,2-oxazastannolidine: in vitro antitumor activity against human tumor cell lines and in vivo assay of (S)-enantiomers. Dalton Transactions. 2013.  42, 3390-3401. [PubMed]
10. Tabassum, S., Asim, A., Arjmand, F., Afzal, M. and Bagchi, V.  Synthesis and characterization of copper(II) and zinc(II)-based potential chemotherapeutic compounds: their biological evaluation viz. DNA binding profile, cleavage and antimicrobial activity. European Journal of Medicinal Chemistry. 2012.  58, 308-316. [PubMed]
11. Arjmand, F., Jamsheera, A., Afzal, M. and Tabassum, S.  Enantiomeric specificity of biologically significant Cu(II) and Zn(II) chromone complexes towards DNA. Chirality. 2012.  24, 977-986. [PubMed]
12. Tabassum, S., Afzal, M. and Arjmand, F.  New heterobimetallic Cu(II)-Sn2(IV) complex as potential topoisomerase I inhibitor: in vitro DNA binding, cleavage and cytotoxicity against human cancer cell lines. Journal of Photochemistry and Photobiology. B, Biology. 2012.  115, 63-72. [PubMed]
13. Tabassum, S., Al-Asbahy, W. M., Afzal, M., Arjmand, F. and Khan, R. H.  Interaction and photo-induced cleavage studies of a copper based chemotherapeutic drug with human serum albumin: spectroscopic and molecular docking study. Molecular BioSystems. 2012.  8, 2424-2433. [PubMed]
14. Tabassum, S., Zaki, M., Arjmand, F. and Ahmad, I.  Synthesis of heterobimetallic complexes: in vitro DNA binding, cleavage and antimicrobial studies. Journal of Photochemistry and Photobiology. B, Biology. 2012.  114, 108-118. [PubMed]
15. Tabassum, S., Al-Asbahy, W. M., Afzal, M. and Arjmand, F.  Synthesis, characterization and interaction studies of copper based drug with Human Serum Albumin (HSA): spectroscopic and molecular docking investigations. Journal of Photochemistry and Photobiology. B, Biology. 2012.  114, 132-139. [PubMed]
16. Tabassum, S., Al-Asbahy, W. M., Afzal, M., Arjmand, F. and Bagchi, V.  Molecular drug design, synthesis and structure elucidation of a new specific target peptide based metallo drug for cancer chemotherapy as topoisomerase I inhibitor. Dalton Transactions. 2012.  41, 4955-4964. [PubMed]
17. Tabassum, S., Sharma, G. C. and Arjmand, F.  New modulated design and synthesis of chiral CuII/SnIV bimetallic potential anticancer drug entity: in vitro DNA binding and pBR322 DNA cleavage activity. Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy. 2012.  90, 208-217. [PubMed]
18. Tabassum, S., Mathur, S., Arjmand, F., Mishra, K. and Banerjee, K.  Design, synthesis, characterization and DNA-binding studies of a triphenyltin(IV) complex of N-glycoside (GATPT), a sugar based apoptosis inducer: in vitro and in vivo assessment of induction of apoptosis by GATPT. Metallomics : Integrated Biometal Science. 2012.  4, 205-217. [PubMed]
19. Arjmand, F., Sharma, G. C., Sayeed, F., Muddassir, M. and Tabassum, S.  De novo design of chiral organotin cancer drug candidates: validation of enantiopreferential binding to molecular target DNA and 5'-GMP by UV-visible, fluorescence, (1)H and (31)P NMR. Journal of Photochemistry and Photobiology. B, Biology. 2011.  105, 167-174. [PubMed]
20. Tabassum, S., Khan, R. A., Arjmand, F., Aziz, M., Juvekar, A. S. and Zingde, S. M.  Carbohydrate-conjugate heterobimetallic complexes: synthesis, DNA binding studies, artificial nuclease activity and in vitro cytotoxicity. Carbohydrate Research. 2011.  [PubMed]
21. Arjmand, F., Sharma, G. C., Sayeed, F., Muddassir, M. and Tabassum, S.  De novo design of chiral organotin cancer drug candidates: Validation of enantiopreferential binding to molecular target DNA and 5'-GMP by UV-visible, fluorescence, (1)H and (31)P NMR. Journal of Photochemistry and Photobiology. B, Biology. 2011.  105, 167-174. [PubMed]
22. Arjmand, F., Sharma, G. C., Muddassir, M. and Tabassum, S.  Synthesis and enantiopreferential DNA-binding profile of late 3d transition metal R- and S-enantiomeric complexes derived from N,N-bis-(1-benzyl-2-ethoxyethane): Validation of R-enantiomer of copper(II) complex as a human topoisomerase II inhibitor. Chirality. 2011.  23, 557-567. [PubMed]
23. Tabassum, S., Khan, R. A., Arjmand, F., Juvekar, A. S. and Zingde, S. M.  Synthesis of carbohydrate-conjugate heterobimetallic Cu(II)-Sn(2)(IV) and Zn(II)-Sn(2)(IV) complexes; their interactions with CT DNA and nucleotides; DNA cleavage, in-vitro cytotoxicity. European Journal of Medicinal Chemistry. 2010.  45, 4797-4806. [PubMed]
24. Lupidi, G., Marchetti, F., Masciocchi, N., Reger, D. L., Tabassum, S., Astolfi, P., Damiani, E. and Pettinari, C.  Synthesis, structural and spectroscopic characterization and biomimetic properties of new copper, manganese, zinc complexes: identification of possible superoxide-dismutase mimics bearing hydroxyl radical generating/scavenging abilities. Journal of Inorganic Biochemistry. 2010.  104, 820-830. [PubMed]
25. Tabassum, S., Chandra, S., Arjmand, F. and Azam, A.  DNA interaction studies of new nano metal based anticancer agent: validation by spectroscopic methods. Nanotechnology. 2010.  21, 195102. [PubMed]
26. Tabassum, S. and Bhat, I. U.  Synthesis and characterization of glucose-bis(pyrazole)-Cu(II)/Ni(II) complexes and their in vitro DNA binding studies. Chemical & Pharmaceutical Bulletin. 2010.  58, 318-325. [PubMed]
27. Tabassum, S., Bhat, I. U. and Arjmand, F.  Synthesis of new heterometallic macromolecules: their DNA binding, cleavage activity and in vitro model electrochemotherapy study. Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy. 2009.  74, 1152-1159. [PubMed]
28. Bhat, I. U. and Tabassum, S.  Synthesis of new piperazine derived Cu(II)/Zn(II) metal complexes, their DNA binding studies, electrochemistry and anti-microbial activity: validation for specific recognition of Zn(II) complex to DNA helix by interaction with thymine base. Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy. 2009.  72, 1026-1033. [PubMed]
29. Tak, A. A., Arjmand, F. and Tabassum, S.  Synthesis of New Five Coordinated Copper(II) and Nickel(II) Complexes of L-Valine and Kinetic Study of Copper(II) with Calf Thymus DNA. Metal-based Drugs. 2002.  9, 81-90. [PubMed]
30. Mathur, S. and Tabassum, S.  Template synthesis of novel carboxamide dinuclear copper (II) complex: spectral characterization and reactivity towards calf-thymus DNA. Biometals : An International Journal On the Role of Metal Ions in Biology, Biochemistry, and Medicine. 2008.  21, 299-310. [PubMed]
31. Shi, Z., Tabassum, S., Jiang, W., Zhang, J., Mathur, S., Wu, J. and Shi, Y.  Identification of a potent inhibitor of human dual-specific phosphatase, VHR, from computer-aided and NMR-based screening to cellular effects. Chembiochem : A European Journal of Chemical Biology. 2007.  8, 2092-2099. [PubMed]
32. Mathur, S. and Tabassum, S.  Synthesis and characterization of a new macrocyclic copper(II) complex with an N-glycosidic pendant arm: in vitro cytotoxicity and binding studies with calf-thymus DNA. Chemistry & Biodiversity. 2006.  3, 312-325. [PubMed]
33. Tabassum, S., Parveen, S. and Arjmand, F.  New modulated metallic macrocycles: Electrochemistry and their interaction with calf thymus DNA. Acta Biomaterialia. 2005.  1, 677-689. [PubMed]
34. Hoti, N., Zhu, D. E., Song, Z., Wu, Z., Tabassum, S. and Wu, M.  p53-dependent apoptotic mechanism of a new designer bimetallic compound tri-phenyl tin benzimidazolethiol copper chloride (TPT-CuCl2): in vivo studies in Wistar rats as well as in vitro studies in human cervical cancer cells. The Journal of Pharmacology and Experimental Therapeutics. 2004.  311, 22-33. [PubMed]
35. Hoti, N., Ma, J., Tabassum, S., Wang, Y. and Wu, M.  Triphenyl tin benzimidazolethiol, a novel antitumor agent, induces mitochondrial-mediated apoptosis in human cervical cancer cells via suppression of HPV-18 encoded E6. Journal of Biochemistry. 2003.  134, 521-528. [PubMed]
 

 
 
Education 
::
Ph.D.
Honors and Awards
::
2004-2005, Biotechnology Overseas Associateship Award
Member
::
Member of Nanosociety
  Last modified on : Dec 9, 2015
India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.