Susanta Roychowdhury, Ph.D.
Indian Institute of Chemical Biology
Molecular & Human Genetics Division
Kolkata - 700 032
West Bengal
E-mail: susanta@iicb.res.in, susanta_rc@yahoo.co.in
URL: http://www.iicb.res.in/divisionwiselistofscientists/mhg/sroychoudhury.html
Area of Specialization:
Genetics
Research Summary:
Genetic and epigenetic alterations of mismatch repair and spindle assembly checkpoint genes in oral cancer are being analysed to understand the molecular basis of genomic instability. The mechanism of spindle assembly checkpoint is being investigated to understand its role in aneuploidy.
Systematic search for the single nucleotide polymorphisms in DNA repair genes is being carried out to identify the susceptibility alleles for the development of oral cancer.
Studying the association between cytokine and chemokine genes polymorphisms and Helicobacter pylori mediated gastroduodenal diseases. Also functional analysis of disease-associated polymorphisms to understand the biochemical basis of disease susceptibility.
Publications:
1.
Mitra, S., Mazumder, I., Basu, P. S., Mondal, R. K., Roy, A., Roychoudhury, S . and Panda, C. K. Alterations of RASSF1A in premalignant cervical lesions: Clinical and prognostic significance. Molecular Carcinogenesis. 2011. [PubMed]
2.
Sinha, S., Singh, R. K., Bhattacharya, N., Mukherjee, N., Ghosh, S., Alam, N., Roy, A., Roychoudhury, S . and Panda, C. K. Frequent alterations of LOH11CR2A, PIG8 and CHEK1 genes at chromosomal 11q24.1-24.2 region in breast carcinoma: Clinical and prognostic implications. Molecular Oncology. 2011. [PubMed]
3.
Mandal, C., Roychoudhury, S . and Roy, S. Cancer research: India meets the West. Research (CSIR)-Indian Institute of Chemical Biology (IICB), Kolkata, India. Cell Death and Differentiation. 2011. [PubMed]
4.
Mazumder, I., Mitra, S., Roy, A., Mondal, R. K., Basu, P. S., Roychoudhury, S ., Chakravarty, R. and Panda, C. K. Alterations of ATM and CADM1 in chromosomal 11q22.3-23.2 region are associated Human Genetics. 2011. [PubMed]
5.
Nath, S., Banerjee, T., Sen, D., Das, T. and Roychoudhury, S . Spindle assembly checkpoint protein Cdc20 transcriptionally activates expression of ubiquitin carrier protein UbcH10. The Journal of Biological Chemistry. 2011. 286, 15666-15677. [PubMed]
6.
Datta, D. e., Bhattacharjya, S., Maitra, M., Datta, A., Choudhury, A., Dhali, G. K. and Roychoudhury, S . IL1B induced Smad 7 negatively regulates gastrin expression. PloS One. 2011. 6, e14775. [PubMed]
7.
Mazumder, '., Mitra, S., Singh, R. K., Dutta, S., Roy, A., Mondal, R. K., Basu, P. S., Roychoudhury, S . and Panda, C. K. Inactivation of CHEK1 and EI24 are associated with the development of invasive cervical carcinoma: Clinical and prognostic implications. International Journal of Cancer. Journal International Du Cancer. 2010. [PubMed]
8.
Mitra, S., Mazumder, I., Basu, P. S., Mondal, R. K., Roy, A., Roychoudhury, S . and Panda, C. K. Amplification of CyclinL1 in uterine cervical carcinoma has prognostic implications. Molecular Carcinogenesis. 2010. 49, 935-943. [PubMed]
9.
Ghosh, A., Ghosh, S., Maiti, G. P., Sabbir, M. G., Zabarovsky, E. R., Roy, A., Roychoudhury, S . and Panda, C. K. Frequent alterations of the candidate genes hMLH1, ITGA9 and RBSP3 in early dysplastic lesions of head and neck: clinical and prognostic significance. Cancer Science. 2010. 101, 1511-1520. [PubMed]
10.
Mitra, S., Mazumder, I., Bhattacharya, N., Singh, R. K., Basu, P. S., Mondal, R. K., Roy, A., Zabarovsky, E. R., Roychoudhury, S . and Panda, C. K. RBSP3 is frequently altered in premalignant cervical lesions: clinical and prognostic significance. Genes, Chromosomes & Cancer. 2010. 49, 155-170. [PubMed]
11.
Klug, S. J., Ressing, M., Koenig, J., Abba, M. C., Agorastos, T., Brenna, S. M., Ciotti, M., Das, B. R., Del, M., Dybikowska, A., Giuliano, A. R., Gudleviciene, Z., Gyllensten, U., Haws, A. L., Helland, A., Herrington, C. S., Hildesheim, A., Humbey, O., Jee, S. H., Kim, J. W., Madeleine, M. M., Menczer, J., Ngan, H. Y., Nishikawa, A., Niwa, Y., Pegoraro, R., Pillai, M. R., Ranzani, G., Rezza, G., Rosenthal, A. N., Roychoudhury, S ., Saranath, D., Schmitt, V. M., Sengupta, S., Settheetham-Ishida, W., Shirasawa, H., Snijders, P. J., Stoler, M. H., Suarez-Rincon, A. E., Szarka, K., Tachezy, R., Ueda, M., van, d. e. r., von, K., Wu, M. T., Yamashita, T., Zehbe, I. and Blettner, M. TP53 codon 72 polymorphism and cervical cancer: a pooled analysis of individual data from 49 studies. The Lancet Oncology. 2009. 10, 772-784. [PubMed]
12.
Bhattacharya, N., Roy, A., Roy, B., Roychoudhury, S . and Panda, C. K. MYC gene amplification reveals clinical association with head and neck squamous cell carcinoma in Indian patients. Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. 2009. 38, 759-763. [PubMed]
13.
Banerjee, T., Nath, S. and Roychoudhury, S . DNA damage induced p53 downregulates Cdc20 by direct binding to its promoter causing chromatin remodeling. Nucleic Acids Research. 2009. 37, 2688-2698. [PubMed]
14.
Chakravorty, M., Datta, D. e., Choudhury, A. and Roychoudhury, S . IL1B promoter polymorphism regulates the expression of gastric acid stimulating hormone gastrin. The International Journal of Biochemistry & Cell Biology. 2009. 41, 1502-1510. [PubMed]
15.
Ghosh, S., Ghosh, A., Maiti, G. P., Alam, N., Roy, A., Roychoudhury, S . and Panda, C. K. Alterations of ROBO1/DUTT1 and ROBO2 loci in early dysplastic lesions of head and neck: clinical and prognostic implications. Human Genetics. 2009. 125, 189-198. [PubMed]
16.
Ghosh, A., Ghosh, S., Maiti, G. P., Sabbir, M. G., Alam, N., Sikdar, N., Roy, B., Roychoudhury, S . and Panda, C. K. SH3GL2 and CDKN2A/2B loci are independently altered in early dysplastic lesions of head and neck: correlation with HPV infection and tobacco habit. The Journal of Pathology. 2009. 217, 408-419. [PubMed]
17.
Sinha, S., Singh, R. K., Alam, N., Roy, A., Roychoudhury, S . and Panda, C. K. Frequent alterations of hMLH1 and RBSP3/HYA22 at chromosomal 3p22.3 region in early and late-onset breast carcinoma: clinical and prognostic significance. Cancer Science. 2008. 99, 1984-1991. [PubMed]
18.
Sinha, S., Singh, R. K., Alam, N., Roy, A., Roychoudhury, S . and Panda, C. K. Alterations in candidate genes PHF2, FANCC, PTCH1 and XPA at chromosomal 9q22.3 region: pathological significance in early- and late-onset breast carcinoma. Molecular Cancer. 2008. 7, 84. [PubMed]
19.
Genetic landscape of the people of India: a canvas for disease gene exploration. Journal of Genetics. 2008. 87, 3-20. [PubMed]
20.
De, C., Ghosh, P., Sarma, N., Majumdar, P., Sau, T. J., Basu, S., Roychoudhury, S ., Ray, K. and Giri, A. K. Genetic variants associated with arsenic susceptibility: study of purine nucleoside phosphorylase, arsenic (+3) methyltransferase, and glutathione S-transferase omega genes. Environmental Health Perspectives. 2008. 116, 501-505. [PubMed]
21.
De, C., Kundu, M., Banerjee, M., Das, J. K., Majumdar, P., Basu, S., Roychoudhury, S ., Singh, K. K. and Giri, A. K. Arsenic-induced health effects and genetic damage in keratotic individuals: involvement of p53 arginine variant and chromosomal aberrations in arsenic susceptibility. Mutation Research. 2008. 659, 118-125. [PubMed]
22.
Sinha, S., Chunder, N., Mukherjee, N., Alam, N., Roy, A., Roychoudhury, S . and Kumar, P. Frequent deletion and methylation in SH3GL2 and CDKN2A loci are associated with early- and late-onset breast carcinoma. Annals of Surgical Oncology. 2008. 15, 1070-1080. [PubMed]
23.
Reshmi, S. C., Roychoudhury, S ., Yu, Z., Feingold, E., Potter, D., Saunders, W. S. and Gollin, S. M. Inverted duplication pattern in anaphase bridges confirms the breakage-fusion-bridge (BFB) cycle model for 11q13 amplification. Cytogenetic and Genome Research. 2007. 116, 46-52. [PubMed]
24.
Mitra, S., Banerjee, S., Misra, C., Singh, R. K., Roy, A., Sengupta, A., Panda, C. K. and Roychoudhury, S . Interplay between human papilloma virus infection and p53 gene alterations in head and neck squamous cell carcinoma of an Indian patient population. Journal of Clinical Pathology. 2007. 60, 1040-1047. [PubMed]
25.
De, C., Mahata, J., Das, J. K., Mukherjee, A., Ghosh, P., Sau, T. J., Mondal, L., Basu, S., Giri, A. K. and Roychoudhury, S . Association of specific p53 polymorphisms with keratosis in individuals exposed to arsenic through drinking water in West Bengal, India. Mutation Research. 2006. 601, 102-112. [PubMed]
26.
Mondal, G., Sengupta, S., Panda, C. K., Gollin, S. M., Saunders, W. S. and Roychoudhury, S . Overexpression of Cdc20 leads to impairment of the spindle assembly checkpoint and aneuploidization in oral cancer. Carcinogenesis. 2007. 28, 81-92. [PubMed]
27.
Sabbir, M. G., Roy, A., Mandal, S., Dam, A., Roychoudhury, S . and Panda, C. K. Deletion mapping of chromosome 13q in head and neck squamous cell carcinoma in Indian patients: correlation with prognosis of the tumour. International Journal of Experimental Pathology. 2006. 87, 151-161. [PubMed]
28.
Chakravorty, M., Ghosh, A., Choudhury, A., Santra, A., Hembrum, J. and Roychoudhury, S . Interaction between IL1B gene promoter polymorphisms in determining susceptibility to Helicobacter pylori associated duodenal ulcer. Human Mutation. 2006. 27, 411-419. [PubMed]
29.
Sabbir, M. G., Dasgupta, S., Roy, A., Bhoumik, A., Dam, A., Roychoudhury, S . and Panda, C. K. Genetic alterations (amplification and rearrangement) of D-type cyclins loci in head and neck squamous cell carcinoma of Indian patients: prognostic significance and clinical implications. Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B. 2006. 15, 7-16. [PubMed]
30.
Chakrabarti, S., Sengupta, S., Sengupta, A., Basak, S. N., Roy, A., Panda, C. and Roychoudhury, S . Genomic instabilities in squamous cell carcinoma of head and neck from the Indian population. Molecular Carcinogenesis. 2006. 45, 270-277. [PubMed]
31.
Bhattacharya, N., Sabbir, M. G., Roy, A., Dam, A., Roychoudhury, S . and Panda, C. K. Approximately 580 Kb surrounding the MYC gene is amplified in head and neck squamous cell carcinoma of Indian patients. Pathology, Research and Practice. 2005. 201, 691-697. [PubMed]
32.
Roychoudhury, S . and Mitra, S. Gene symbol: TP53. Disease: squamous cell carcinoma of head and neck. Human Genetics. 2005. 116, 233. [PubMed]
33.
Chunder, N., Roy, A., Roychoudhury, S . and Panda, C. K. Molecular study of clonality in multifocal and bilateral breast tumors. Pathology, Research and Practice. 2004. 200, 735-741. [PubMed]
34.
Mitra, S., Misra, C., Singh, R. K., Panda, C. K. and Roychoudhury, S . Association of specific genotype and haplotype of p53 gene with cervical cancer in India. Journal of Clinical Pathology. 2005. 58, 26-31. [PubMed]
35.
Chunder, N., Mandal, S., Roy, A., Roychoudhury, S . and Panda, C. K. Differential association of BRCA1 and BRCA2 genes with some breast cancer-associated genes in early and late onset breast tumors. Annals of Surgical Oncology. 2004. 11, 1045-1055. [PubMed]
36.
Chunder, N., Mandal, S., Roy, A., Roychoudhury, S . and Panda, C. K. Analysis of different deleted regions in chromosome 11 and their interrelations in early- and late-onset breast tumors: association with cyclin D1 amplification and survival. Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B. 2004. 13, 172-182. [PubMed]
37.
Gupta, A., Neogi, R., Mukherjea, M., Mukhopadhyay, A., Roychoudhury, S ., Senapati, A., Gangopadhyay, P. K. and Ray, K. DNA linkage based diagnosis of Wilson disease in asymptomatic siblings. The Indian Journal of Medical Research. 2003. 118, 208-214. [PubMed]
38.
Chattopadhyay, B., Basu, P., Gangopadhyay, P. K., Mukherjee, S. C., Sinha, K. K., Chakraborty, A., Roy, T., Roychoudhury, S ., Majumder, P. P. and Bhattacharyya, N. P. Variation of CAG repeats and two intragenic polymorphisms at SCA3 locus among Machado-Joseph disease/SCA3 patients and diverse normal populations from eastern India. Acta Neurologica Scandinavica. 2003. 108, 407-414. [PubMed]
39.
Basu, A., Mukherjee, N., Roy, S., Sengupta, S., Banerjee, S., Chakraborty, M., Dey, B., Roy, M., Roy, B., Bhattacharyya, N. P., Roychoudhury, S . and Majumder, P. P. Ethnic India: a genomic view, with special reference to peopling and structure. Genome Research. 2003. 13, 2277-2290. [PubMed]
40.
Chunder, N., Mandal, S., Basu, D., Roy, A., Roychoudhury, S . and Panda, C. K. Deletion mapping of chromosome 1 in early onset and late onset breast tumors--a comparative study in eastern India. Pathology, Research and Practice. 2003. 199, 313-321. [PubMed]
41.
Mondal, G., Tripathi, A., Bhattacharya, N., Sikdar, N., Roy, A., Sengupta, A., Roy, B., Panda, C. K. and Roychoudhury, S . Allelic imbalance at chromosome 11 in head and neck squamous cell carcinoma in an Indian patient population. Journal of Clinical Pathology. 2003. 56, 512-518. [PubMed]
42.
Mitra, S., Chatterjee, S., Panda, C. K., Chaudhuri, K., Ray, K., Bhattacharyya, N. P., Sengupta, A. and Roychoudhury, S . Haplotype structure of TP53 locus in Indian population and possible association with head and neck cancer. Annals of Human Genetics. 2003. 67, 26-34. [PubMed]
43.
Acharya, M., Mitra, S., Mukhopadhyay, A., Khan, M., Roychoudhury, S . and Ray, K. Distribution of p53 codon 72 polymorphism in Indian primary open angle glaucoma patients. Molecular Vision. 2002. 8, 367-371. [PubMed]
44.
Basu, P., Majumder, P. P., Roychoudhury, S . and Bhattacharyya, N. P. Haplotype analysis of genomic polymorphisms in and around the myotonic dystrophy locus in diverse populations of India. Human Genetics. 2001. 108, 310-317. [PubMed]
45.
Chakrabarti, S., Dasgupta, S., Roy, S., Bhar, A., Sengupta, A., Roy, A., Ray, K., Bhattacharyya, N. P., Roy, B., Panda, C. K. and Roychoudhury, S . Microsatellite instability in squamous cell carcinoma of head and neck from the Indian patient population. International Journal of Cancer. Journal International Du Cancer. 2001. 92, 555-561. [PubMed]
46.
Das, S., Chakrabortty, A., Banerjee, R., Roychoudhury, S . and Chaudhuri, K. Comparison of global transcription responses allows identification of Vibrio cholerae genes differentially expressed following infection. FEMS Microbiology Letters. 2000. 190, 87-91. [PubMed]
47.
Basu, P., Chattopadhyay, B., Gangopadhaya, P. K., Mukherjee, S. C., Sinha, K. K., Das, S. K., Roychoudhury, S ., Majumder, P. P. and Bhattacharyya, N. P. Analysis of CAG repeats in SCA1, SCA2, SCA3, SCA6, SCA7 and DRPLA loci in spinocerebellar ataxia patients and distribution of CAG repeats at the SCA1, SCA2 and SCA6 loci in nine ethnic populations of eastern India. Human Genetics. 2000. 106, 597-604. [PubMed]
48.
Chatterjee, S., Mondal, A. K., Begum, N. A., Roychoudhury, S . and Das, J. Ordered cloned DNA map of the genome of Vibrio cholerae 569B and localization of genetic markers. Journal of Bacteriology. 1998. 180, 901-908. [PubMed]
49.
Nandi, S., Khetawat, G., Sengupta, S., Majumder, R., Kar, S., Bhadra, R. K., Roychoudhury, S . and Das, J. Rearrangements in the genomes of Vibrio cholerae strains belonging to different serovars and biovars. International Journal of Systematic Bacteriology. 1997. 47, 858-862. [PubMed]
50.
Majumder, R., Sengupta, S., Khetawat, G., Bhadra, R. K., Roychoudhury, S . and Das, J. Physical map of the genome of Vibrio cholerae 569B and localization of genetic markers. Journal of Bacteriology. 1996. 178, 1105-1112. [PubMed]
51.
Bhadra, R. K., Roychoudhury, S ., Banerjee, R. K., Kar, S., Majumdar, R., Sengupta, S., Chatterjee, S., Khetawat, G. and Das, J. Cholera toxin (CTX) genetic element in Vibrio cholerae O139. Microbiology. 1995. 141 ( Pt 8), 1977-1983. [PubMed]
52.
Shih, C. H., Li, L. S., Roychoudhury, S . and Ho, M. H. In vitro propagation of human hepatitis B virus in a rat hepatoma cell line. Proceedings of the National Academy of Sciences of the United States of America. 1989. 86, 6323-6327. [PubMed]
53.
Faruqi, A. F., Roychoudhury, S ., Greenberg, R., Israel, J. and Shih, C. H. Replication-defective missense mutations within the terminal protein and spacer/intron regions of the polymerase gene of human hepatitis B virus. Virology. 1991. 183, 764-768. [PubMed]
54.
Roychoudhury, S ., Faruqi, A. F. and Shih, C. Pregenomic RNA encapsidation analysis of eleven missense and nonsense polymerase mutants of human hepatitis B virus. Journal of Virology. 1991. 65, 3617-3624. [PubMed]
55.
Roychoudhury, S . and Shih, C. cis rescue of a mutated reverse transcriptase gene of human hepatitis B virus by creation of an internal ATG. Journal of Virology. 1990. 64, 1063-1069. [PubMed]
Last modified on : Sep 8, 2011