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Shyamala Mani, M.S., Ph.D.
Associate Professor 
Indian Institute of Science
Centre for Neuroscience
Room No. 106, Old TIFR building
Bangalore - 560 012   
Phone: +91-80-22933431
Fax: +91-80-23603323
Positions Held:
Position Affiliation Time Period
Associate Professor Indian Institute of Science, Bangalore, India Present
Assistant Professor National Brain Research Centre, Gurgaon, India 2000
Post Doctoral Fellowship Princeton University, New Jersey, USA
Area of Specialization:
Research Summary:
To delineate the role of neural basic-helix-loop-helix family of transcription factors in neuronal subtype determination in human and mouse ES cells
To characterize how extrinsic factors influence centrosome orientation in proliferating GCPs
1. Ranade, S. C., Nawaz, S., Chakrabarti, A., Gressens, P. and Mani, S.  Spatial memory deficits in maternal iron deficiency paradigms are associated with altered glucocorticoid levels. Hormones and Behavior. 2013.  64, 26-36. [PubMed]
2. Srivastava, R., Kumar, M., Peineau, S., Csaba, Z., Mani, S., Gressens, P. and El, G.  Conditional induction of Math1 specifies embryonic stem cells to cerebellar granule neuron lineage and promotes differentiation into mature granule neurons. Stem Cells. 2013.  31, 652-665. [PubMed]
3. Haldipur, P., Bharti, U., Alberti, C., Sarkar, C., Gulati, G., Iyengar, S., Gressens, P. and Mani, S.  Preterm delivery disrupts the developmental program of the cerebellum. PloS One. 2011.  6, e23449. [PubMed]
4. Titomanlio, L., Kavelaars, A., Dalous, J., Mani, S., El, G., Heijnen, C., Baud, O. and Gressens, P.  Stem cell therapy for neonatal brain injury: perspectives and challenges. Annals of Neurology. 2011.  70, 698-712. [PubMed]
5. Haldipur, P., Bharti, U., Govindan, S., Sarkar, C., Iyengar, S., Gressens, P. and Mani, S.  Expression of Sonic hedgehog during cell proliferation in the human cerebellum. Stem Cells and Development. 2012.  21, 1059-1068. [PubMed]
6. Passemard, S., El, G., Nasser, H., Verney, C., Vodjdani, G., Lacaud, A., Lebon, S., Laburthe, M., Robberecht, P., Nardelli, J., Mani, S., Verloes, A., Gressens, P. and Lelievre, V.  VIP blockade leads to microcephaly in mice via disruption of Mcph1-Chk1 signaling. The Journal of Clinical Investigation. 2011.  121, 3071-3087. [PubMed]
7. Kraemer, N., Issa, L., Hauck, S. C., Mani, S., Ninnemann, O. and Kaindl, A. M.  What's the hype about CDK5RAP2? Cellular and Molecular Life Sciences : CMLS. 2011.  68, 1719-1736. [PubMed]
8. Gupta, S. K., Meiri, K. F., Mahfooz, K., Bharti, U. and Mani, S.  Coordination between extrinsic extracellular matrix cues and intrinsic responses to orient the centrosome in polarizing cerebellar granule neurons. The Journal of Neuroscience. 2010.  30, 2755-2766. [PubMed]
9. Kaindl, A. M., Passemard, S., Kumar, P., Kraemer, N., Issa, L., Zwirner, A., Gerard, B., Verloes, A., Mani, S. and Gressens, P.  Many roads lead to primary autosomal recessive microcephaly. Progress in Neurobiology. 2010.  90, 363-383. [PubMed]
10. Destot-Wong, K. D., Liang, K., Gupta, S. K., Favrais, G., Schwendimann, L., Pansiot, J., Baud, O., Spedding, M., Lelievre, V., Mani, S. and Gressens, P.  The AMPA receptor positive allosteric modulator, S18986, is neuroprotective against neonatal excitotoxic and inflammatory brain damage through BDNF synthesis. Neuropharmacology. 2009.  57, 277-286. [PubMed]
11. Moran, J. L., Shifley, E. T., Levorse, J. M., Mani, S., Ostmann, K., Perez-Balaguer, A., Walker, D. M., Vogt, T. F. and Cole, S. E.  Manic fringe is not required for embryonic development, and fringe family members do not exhibit redundant functions in the axial skeleton, limb, or hindbrain. Developmental Dynamics. 2009.  238, 1803-1812. [PubMed]
12. Gupta, S. K., Gressens, P. and Mani, S.  NRSF downregulation induces neuronal differentiation in mouse embryonic stem cells. Differentiation; Research in Biological Diversity. 2009.  77, 19-28. [PubMed]
13. Kumar, M., Kaushalya, S. K., Gressens, P., Maiti, S. and Mani, S.  Optimized derivation and functional characterization of 5-HT neurons from human embryonic stem cells. Stem Cells and Development. 2009.  18, 615-627. [PubMed]
14. Shen, Y., Mishra, R., Mani, S. and Meiri, K. F.  Both cell-autonomous and cell non-autonomous functions of GAP-43 are required for normal patterning of the cerebellum in vivo. Cerebellum. 2008.  7, 451-466. [PubMed]
15. Verma, L. K., Mani, S., Sinha, N. and Rana, S.  Biomedical waste management in nursing homes and smaller hospitals in Delhi. Waste Management. 2008.  28, 2723-2734. [PubMed]
16. Mishra, R., Gupta, S. K., Meiri, K. F., Fong, M., Thostrup, P., Juncker, D. and Mani, S.  GAP-43 is key to mitotic spindle control and centrosome-based polarization in neurons. Cell Cycle. 2008.  7, 348-357. [PubMed]
17. Kumar, M., Bagchi, B., Gupta, S. K., Meena, A. S., Gressens, P. and Mani, S.  Neurospheres derived from human embryoid bodies treated with retinoic Acid show an increase in nestin and ngn2 expression that correlates with the proportion of tyrosine hydroxylase-positive cells. Stem Cells and Development. 2007.  16, 667-681. [PubMed]
18. Bagchi, B., Kumar, M. and Mani, S.  CMV promotor activity during ES cell differentiation: potential insight into embryonic stem cell differentiation. Cell Biology International. 2006.  30, 505-513. [PubMed]
19. Cazillis, M., Rasika, S., Mani, S., Gressens, P. and Lelievre, V.  In vitro induction of neural differentiation of embryonic stem (ES) cells closely mimics molecular mechanisms of embryonic brain development. Pediatric Research. 2006.  59, 48R-53. [PubMed]
20. Shen, Y., Mani, S. and Meiri, K. F.  Failure to express GAP-43 leads to disruption of a multipotent precursor and inhibits astrocyte differentiation. Molecular and Cellular Neurosciences. 2004.  26, 390-405. [PubMed]
21. Shen, Y., Mani, S., Donovan, S. L., Schwob, J. E. and Meiri, K. F.  Growth-associated protein-43 is required for commissural axon guidance in the developing vertebrate nervous system. The Journal of Neuroscience. 2002.  22, 239-247. [PubMed]


M.S. in Clinical Psychology, Marquette University, Wisconsin, USA
Ph.D. in Neuroscience, Upstate Medical University, New York, USA
Honors and Awards
2010, Knight of the Order of Academic Palms, French Government
  Last modified on : Jan 25, 2016
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