INCREDB ID : 367
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D. Sakthisekaran, Ph.D.
Professor and Head 
 
University of Madras
Department of Medical Biochemistry
Chennai - 600 025   
Tamil Nadu   
 
E-mail: dsakthisekaran@unom.ac.in
Phone: +91-44-24415941
 
URL: http://www.unom.ac.in/index.php?route=department/department/profile&deptid=49&facultyid=157
 
Positions Held:
Position Affiliation Time Period
Professor and Head University of Madras, Chennia, India Present
 
Area of Specialization:
Medical Biochemistry
Research Summary:
Cancer Biology
 
Publications:
1. Kalpana, D., Gayathri, R. and Sakthisekaran, D.  Role of sulforaphane in the anti-initiating mechanism of lung carcinogenesis in vivo by modulating the metabolic activation and detoxification of benzo(a)pyrene. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 2011.  65, 9-16. [PubMed]
2. Priya, D. K., Gayathri, R., Gunassekaran, G. R. and Sakthisekaran, D.  Protective role of sulforaphane against oxidative stress mediated mitochondrial dysfunction induced by benzo(a)pyrene in female Swiss albino mice. Pulmonary Pharmacology & Therapeutics. 2011.  24, 110-117. [PubMed]
3. Gayathri, R., Priya, D. K., Gunassekaran, G. R. and Sakthisekaran, D.  Ursolic acid attenuates oxidative stress-mediated hepatocellular carcinoma induction by diethylnitrosamine in male Wistar rats. Asian Pacific Journal of Cancer Prevention : APJCP. 2009.  10, 933-938. [PubMed]
4. Ekambaram, G., Rajendran, P., Magesh, V. and Sakthisekaran, D.  Naringenin reduces tumor size and weight lost in N-methyl-N'-nitro-N-nitrosoguanidine-induced gastric carcinogenesis in rats. Nutrition Research. 2008.  28, 106-112. [PubMed]
5. Magesh, V., DurgaBhavani, K., Senthilnathan, P., Rajendran, P. and Sakthisekaran, D.  In vivo protective effect of crocetin on benzo(a)pyrene-induced lung cancer in Swiss albino mice. Phytotherapy Research : PTR. 2009.  23, 533-539. [PubMed]
6. Prasanna, R., Harish, C. C., Pichai, R., Sakthisekaran, D. and Gunasekaran, P.  Anti-cancer effect of Cassia auriculata leaf extract in vitro through cell cycle arrest and induction of apoptosis in human breast and larynx cancer cell lines. Cell Biology International. 2009.  33, 127-134. [PubMed]
7. Varalakshmi, P., Panneerselvam, C. and Sakthisekaran, D.  A "simple" method for spurious biostatistics: response to the manuscript submitted to the FASEB Journal by Hudes, et al. The FASEB Journal : Official Publication of the Federation of American Societies For Experimental Biology. 2009.  23, 704-709. [PubMed]
8. Rajendran, P., Ekambaram, G. and Sakthisekaran, D.  Cytoprotective effect of mangiferin on benzo(a)pyrene-induced lung carcinogenesis in swiss albino mice. Basic & Clinical Pharmacology & Toxicology. 2008.  103, 137-142. [PubMed]
9. Venkatesan, P. N., Rajendran, P., Ekambaram, G. and Sakthisekaran, D.  Combination therapeutic effect of cisplatin along with Solanum trilobatum on benzo(a)pyrene induced experimental lung carcinogenesis. Natural Product Research. 2008.  22, 1094-1106. [PubMed]
10. Ekambaram, G., Rajendran, P., Devaraja, R., Muthuvel, R. and Sakthisekaran, D.  Impact of naringenin on glycoprotein levels in N-methyl-N'-nitro-N-nitrosoguanidine-induced gastric carcinogenesis in rats. Anti-cancer Drugs. 2008.  19, 885-890. [PubMed]
11. Rajendran, P., Ekambaram, G. and Sakthisekaran, D.  Effect of mangiferin on benzo(a)pyrene induced lung carcinogenesis in experimental Swiss albino mice. Natural Product Research. 2008.  22, 672-680. [PubMed]
12. Rajendran, P., Ekambaram, G. and Sakthisekaran, D.  Protective role of mangiferin against Benzo(a)pyrene induced lung carcinogenesis in experimental animals. Biological & Pharmaceutical Bulletin. 2008.  31, 1053-1058. [PubMed]
13. Thirunavukkarasu, C., Premkumar, K., Sheriff, A. K. and Sakthisekaran, D.  Sodium selenite enhances glutathione peroxidase activity and DNA strand breaks in hepatoma induced by N-nitrosodiethylamine and promoted by phenobarbital. Molecular and Cellular Biochemistry. 2008.  310, 129-139. [PubMed]
14. Chodon, D., Ramamurty, N. and Sakthisekaran, D.  Preliminary studies on induction of apoptosis by genistein on HepG2 cell line. Toxicology in Vitro : An International Journal Published in Association With BIBRA. 2007.  21, 887-891. [PubMed]
15. Chodon, D., Banu, S. M., Padmavathi, R. and Sakthisekaran, D.  Inhibition of cell proliferation and induction of apoptosis by genistein in experimental hepatocellular carcinoma. Molecular and Cellular Biochemistry. 2007.  297, 73-80. [PubMed]
16. Senthilnathan, P., Padmavathi, R., Magesh, V. and Sakthisekaran, D.  Stabilization of membrane bound enzyme profiles and lipid peroxidation by Withania somnifera along with paclitaxel on benzo(a)pyrene induced experimental lung cancer. Molecular and Cellular Biochemistry. 2006.  292, 13-17. [PubMed]
17. Senthilnathan, P., Padmavathi, R., Magesh, V. and Sakthisekaran, D.  Chemotherapeutic efficacy of paclitaxel in combination with Withania somnifera on benzo(a)pyrene-induced experimental lung cancer. Cancer Science. 2006.  97, 658-664. [PubMed]
18. Padmavathi, R., Senthilnathan, P. and Sakthisekaran, D.  Therapeutic effect of propolis and paclitaxel on hepatic phase I and II enzymes and marker enzymes in dimethylbenz(a)anthracene-induced breast cancer in female rats. Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP. 2006.  143, 349-354. [PubMed]
19. Magesh, V., Singh, J. P., Selvendiran, K., Ekambaram, G. and Sakthisekaran, D.  Antitumour activity of crocetin in accordance to tumor incidence, antioxidant status, drug metabolizing enzymes and histopathological studies. Molecular and Cellular Biochemistry. 2006.  287, 127-135. [PubMed]
20. Padmavathi, R., Senthilnathan, P., Chodon, D. and Sakthisekaran, D.  Therapeutic effect of paclitaxel and propolis on lipid peroxidation and antioxidant system in 7,12 dimethyl benz(a)anthracene-induced breast cancer in female Sprague Dawley rats. Life Sciences. 2006.  78, 2820-2825. [PubMed]
21. Senthilnathan, P., Padmavathi, R., Banu, S. M. and Sakthisekaran, D.  Enhancement of antitumor effect of paclitaxel in combination with immunomodulatory Withania somnifera on benzo(a)pyrene induced experimental lung cancer. Chemico-biological Interactions. 2006.  159, 180-185. [PubMed]
22. Thirunavukkarasu, C., Premkumar, K., Jagadeeswaran, R. and Sakthisekaran, D.  The inhibitory effect of sodium selenite on N-nitrosodiethylamine-induced and phenobarbital promoted liver tumourigenesis in rats based on the modulation of polyamine levels. Molecular and Cellular Biochemistry. 2005.  280, 165-172. [PubMed]
23. Senthilnathan, P., Padmavathi, R., Magesh, V. and Sakthisekaran, D.  Modulation of TCA cycle enzymes and electron transport chain systems in experimental lung cancer. Life Sciences. 2006.  78, 1010-1014. [PubMed]
24. Selvendiran, K., Prince, V. and Sakthisekaran, D.  In vivo effect of piperine on serum and tissue glycoprotein levels in benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice. Pulmonary Pharmacology & Therapeutics. 2006.  19, 107-111. [PubMed]
25. Jeyabal, P. V., Syed, M. B., Venkataraman, M., Sambandham, J. K. and Sakthisekaran, D.  Apigenin inhibits oxidative stress-induced macromolecular damage in N-nitrosodiethylamine (NDEA)-induced hepatocellular carcinogenesis in Wistar albino rats. Molecular Carcinogenesis. 2005.  44, 11-20. [PubMed]
26. Selvendiran, K., Padmavathi, R., Magesh, V. and Sakthisekaran, D.  Preliminary study on inhibition of genotoxicity by piperine in mice. Fitoterapia. 2005.  76, 296-300. [PubMed]
27. Selvendiran, K., Thirunavukkarasu, C., Singh, J. P., Padmavathi, R. and Sakthisekaran, D.  Chemopreventive effect of piperine on mitochondrial TCA cycle and phase-I and glutathione-metabolizing enzymes in benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice. Molecular and Cellular Biochemistry. 2005.  271, 101-106. [PubMed]
28. Selvendiran, K., Banu, S. M. and Sakthisekaran, D.  Oral supplementation of piperine leads to altered phase II enzymes and reduced DNA damage and DNA-protein cross links in Benzo(a)pyrene induced experimental lung carcinogenesis. Molecular and Cellular Biochemistry. 2005.  268, 141-147. [PubMed]
29. Banu, S. M., Selvendiran, K., Singh, J. P. and Sakthisekaran, D.  Protective effect of Emblica officinalis ethanolic extract against 7,12-dimethylbenz(a) anthracene (DMBA) induced genotoxicity in Swiss albino mice. Human & Experimental Toxicology. 2004.  23, 527-531. [PubMed]
30. Selvendiran, K., Banu, S. M. and Sakthisekaran, D.  Protective effect of piperine on benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice. Clinica Chimica Acta; International Journal of Clinical Chemistry. 2004.  350, 73-78. [PubMed]
31. Thirunavukkarasu, C., Babu, E., Ebrahim, A. S., Chandramohan, N. and Sakthisekaran, D.  Antioxidant-associated chemoprevention by sodium selenite in N-nitrosodiethylamine-induced and phenobarbital-promoted hepatocarcinogenesis in rats. Cell Biochemistry and Function. 2004.  22, 265-271. [PubMed]
32. Singh, J. P., Selvendiran, K., Banu, S. M., Padmavathi, R. and Sakthisekaran, D.  Protective role of Apigenin on the status of lipid peroxidation and antioxidant defense against hepatocarcinogenesis in Wistar albino rats. Phytomedicine. 2004.  11, 309-314. [PubMed]
33. Selvendiran, K. and Sakthisekaran, D.  Chemopreventive effect of piperine on modulating lipid peroxidation and membrane bound enzymes in benzo(a)pyrene induced lung carcinogenesis. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 2004.  58, 264-267. [PubMed]
34. Selvendiran, K., Senthilnathan, P., Magesh, V. and Sakthisekaran, D.  Modulatory effect of Piperine on mitochondrial antioxidant system in Benzo(a)pyrene-induced experimental lung carcinogenesis. Phytomedicine. 2004.  11, 85-89. [PubMed]
35. Thirunavukkarasu, C. and Sakthisekaran, D.  Effect of dietary selenite on N-nitrosodiethylamine-induced and phenobarbital promoted multistage hepatocarcinogenesis in rat: reflection in some minerals. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 2003.  57, 416-421. [PubMed]
36. Thirunavukkarasu, C. and Sakthisekaran, D.  Stabilization of membrane bound enzyme profiles by sodium selenite in N-nitrosodiethylamine induced and phenobarbital promoted hepatocarcinogenesis in rats. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 2003.  57, 117-123. [PubMed]
37. Thirunavukkarasu, C. and Sakthisekaran, D.  Influence of sodium selenite on glycoprotein contents in normal and N-nitrosodiethylamine initiated and phenobarbital promoted rat liver tumors. Pharmacological Research. 2003.  48, 167-173. [PubMed]
38. Thirunavukkarasu, C. and Sakthisekaran, D.  Sodium selenite modulates tumour marker indices in N-nitrosodiethylamine-initiated and phenobarbital-promoted rat liver carcinogenesis. Cell Biochemistry and Function. 2003.  21, 147-153. [PubMed]
39. Selvendiran, K., Singh, J. P., Krishnan, K. B. and Sakthisekaran, D.  Cytoprotective effect of piperine against benzo[a]pyrene induced lung cancer with reference to lipid peroxidation and antioxidant system in Swiss albino mice. Fitoterapia. 2003.  74, 109-115. [PubMed]
40. Thirunavukkarasu, C. and Sakthisekaran, D.  Sodium selenite, dietary micronutrient, prevents the lymphocyte DNA damage induced by N-nitrosodiethylamine and phenobarbital promoted experimental hepatocarcinogenesis. Journal of Cellular Biochemistry. 2003.  88, 578-588. [PubMed]
41. Thirunavukkarasu, C., Prince, V., Thangavel, M., Selvendiran, K. and Sakthisekaran, D.  Dietary influence of selenium on the incidence of N-nitrosodiethylamine-induced hepatoma with reference to drug and glutathione metabolizing enzymes. Cell Biochemistry and Function. 2002.  20, 347-356. [PubMed]
42. Palanivel, R. and Sakthisekaran, D.  Immunomodulatory effect of tungstate on streptozotocin-induced experimental diabetes in rats. Annals of the New York Academy of Sciences. 2002.  958, 382-386. [PubMed]
43. Thirunavukkarasu, C., Singh, J. P., Selvendiran, K. and Sakthisekaran, D.  Chemopreventive efficacy of selenium against N-nitrosodiethylamine-induced hepatoma in albino rats. Cell Biochemistry and Function. 2001.  19, 265-271. [PubMed]
44. Ebrahim, A. S., Babu, E., Thirunavukkarasu, C. and Sakthisekaran, D.  Protective role of vitamin E, 2-deoxy-D-glucose, and taurine on perchloroethylene induced alterations in ATPases. Drug and Chemical Toxicology. 2001.  24, 429-437. [PubMed]
45. Thirunavukkarasu, C. and Sakthisekaran, D.  Effect of selenium on N-nitrosodiethylamine-induced multistage hepatocarcinogenesis with reference to lipid peroxidation and enzymic antioxidants. Cell Biochemistry and Function. 2001.  19, 27-35. [PubMed]
46. Jagadeeswaran, R., Thirunavukkarasu, C., Gunasekaran, P., Ramamurty, N. and Sakthisekaran, D.  In vitro studies on the selective cytotoxic effect of crocetin and quercetin. Fitoterapia. 2000.  71, 395-399. [PubMed]
47. Babu, E., Ebrahim, A. S., Chandramohan, N. and Sakthisekaran, D.  Rehabilitating role of glutathione ester on cisplatin induced nephrotoxicity. Renal Failure. 1999.  21, 209-217. [PubMed]
48. Ebrahim, A. S., Babakrishnan, K. and Sakthisekaran, D.  Perchloroethylene-induced alterations in glucose metabolism and their prevention by 2-deoxy-D-glucose and vitamin E in mice. Journal of Applied Toxicology : JAT. 1996.  16, 339-348. [PubMed]
49. Babu, E., Gopalakrishnan, V. K., Sriganth, I. N., Gopalakrishnan, R. and Sakthisekaran, D.  Cisplatin induced nephrotoxicity and the modulating effect of glutathione ester. Molecular and Cellular Biochemistry. 1995.  144, 7-11. [PubMed]
50. Ebrahim, A. S., Gopalakrishnan, R., Murugesan, A. and Sakthisekaran, D.  In vivo effect of vitamin E on serum and tissue glycoprotein levels in perchloroethylene induced cytotoxicity. Molecular and Cellular Biochemistry. 1995.  144, 13-18. [PubMed]
51. Gopalakrishnan, V. K. and Sakthisekaran, D.  Effect of patulin on albumin fraction of plasma proteins studied in rats. Biochemistry International. 1991.  25, 461-475. [PubMed]
52. Sakthisekaran, D. and Shanmugasundaram, E. R.  Effect of patulin on the kinetic properties of the enzyme aldolase studied in rat liver. Biochemistry International. 1990.  21, 117-134. [PubMed]
53. Sakthisekaran, D., Shanmugasundaram, K. R. and Shanmugasundaram, E. R.  Effect of patulin on some enzymes of carbohydrate metabolism studied in rats. Biochemistry International. 1989.  19, 37-51. [PubMed]
 

 
Book Chapters:
Antioxidants and Cancer chemotherapy
 
Grant Support:
Project Title Role Funding Agency Sanction Number Sanction Date
Biochemical and molecular studies on the therapeutic efficacy of ellagic acid along with paclitaxel against DMBA induced breast cancer in aged Sprague dawley rats Principal Investigator 2009-2011

 
 
 
Education 
::
Ph.D.
Member
::
Co-ordinator - UGC, SAP (Phase II programme)
::
President - Indian Association of Biomedical Scientists.
::
Chairperson - PG Board of Studies in Biochemistry, University of Madras
::
Scientific Advisory Committee, TICEL BIO PARK Ltd., Chennai
::
UGC XI plan, Expert Committee, Mohanlal Sukhadia University, Udaipur, Rajasthan.
::
UG - Board of studies in Biochemistry, Pondicherry University
::
PG - Board of studies in Biochemistry - Bharathidasan University
  Last modified on : Dec 10, 2015
India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.