S.  Kannan,                               Ph.D. 
                               
                              Additional Professor  
                           
                         
                                  
         
                                                    
                                                    
                            Regional Cancer Centre 
                           
                                                                              
                            Division of Cancer Research 
                           
                                                                              
                            Trivandrum - 695 011                                 
                           
                                                    
                            Kerala                                 
                           						  
                                                            
                           
                                                    
                            E-mail: kannan@rcctvm.org 
                           
                                                                              
                            Phone: +91-471-2522338 
                           
                          
                               
                           
                          
                            URL:   http://rcctvm.org/kannan.htm  
                           
                          
                          						  
                              
                           
						  
	                                                       
                            Area of Specialization:  
                           
                          
                          
                          
  
     
    Molecular Oncology 
   
    
                          
                        
                           
                           
                         
                         
                                                    
                                                    
                          
                             
                           
                                                    
                            Publications:  
                           
                          
                            
	
		
			
				1. 
			
				Sailasree, R., Nalinakumari, K. R., Sebastian, P. and Kannan, S.   Influence of methylenetetrahydrofolate reductase polymorphisms in oral cancer patients. Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.  2011.  40, 61-66. [PubMed]  
		 
		
			
				2. 
			
				Sathyan, K. M., Nalinakumari, K. R., Abraham, T. and Kannan, S.   CCND1 polymorphisms (A870G and C1722G) modulate its protein expression and survival in oral carcinoma. Oral Oncology.  2008.  44, 689-697. [PubMed]  
		 
		
			
				3. 
			
				Sathyan, K. M., Nalinakumari, K. R. and Kannan, S.   H-Ras mutation modulates the expression of major cell cycle regulatory proteins and disease prognosis in oral carcinoma. Modern Pathology, Inc.  2007.  20, 1141-1148. [PubMed]  
		 
		
			
				4. 
			
				Sathyan, K. M., Sailasree, R., Jayasurya, R., Lakshminarayanan, K., Abraham, T., Nalinakumari, K. R., Abraham, E. K. and Kannan, S.   Carcinoma of tongue and the buccal mucosa represent different biological subentities of the oral carcinoma. Journal of Cancer Research and Clinical Oncology.  2006.  132, 601-609. [PubMed]  
		 
		
			
				5. 
			
				Sathyan, K. M., Nalinakumari, K. R., Abraham, T. and Kannan, S.   Influence of single nucleotide polymorphisms in H-Ras and cyclin D1 genes on oral cancer susceptibility. Oral Oncology.  2006.  42, 607-613. [PubMed]  
		 
		
			
				6. 
			
				Jayasurya, R., Sathyan, K. M., Lakshminarayanan, K., Abraham, T., Nalinakumari, K. R., Abraham, E. K., Nair, M. K. and Kannan, S.   Phenotypic alterations in Rb pathway have more prognostic influence than p53 pathway proteins in oral carcinoma. Modern Pathology , Inc.  2005.  18, 1056-1066. [PubMed]  
		 
		
			
				7. 
			
				Jayasurya, R., Francis, G., Kannan, S. , Lekshminarayanan, K., Nalinakumari, K. R., Abraham, T., Abraham, E. K. and Nair, M. K.  p53, p16 and cyclin D1: molecular determinants of radiotherapy treatment response in oral carcinoma. International Journal of Cancer. Journal International Du Cancer.  2004.  109, 710-716. [PubMed]  
		 
		
			
				8. 
			
				Kannan, S. , Yokozaki, H., Jayasree, K., Sebastian, P., Mathews, A., Abraham, E. K., Nair, M. K. and Tahara, E.  Infrequent loss of heterozygosity of the major tumour suppressor genes in Indian oral cancers. International Journal of Oral and Maxillofacial Surgery.  2002.  31, 414-418. [PubMed]  
		 
		
			
				9. 
			
				Kannan, S. , Tahara, H., Yokozaki, H., Mathew, B., Nalinakumari, K. R., Nair, M. K. and Tahara, E.  Telomerase activity in premalignant and malignant lesions of human oral mucosa. Cancer Epidemiology, Biomarkers & Prevention .  1997.  6, 413-420. [PubMed]  
		 
		
			
				10. 
			
				Sujathan, K., Kannan, S. , Pillai, K. R., Chandralekha, B., Amma, N. S. and Nair, M. K.  Significance of AgNOR count in differentiating malignant cells from reactive mesothelial cells in serous effusions. Acta Cytologica.  1996.  40, 724-728. [PubMed]  
		 
		
			
				11. 
			
				Kannan, S. , Chandran, G. J., Pillai, K. R., Mathew, B., Sujathan, K., Nalinakumary, K. R. and Nair, M. K.  Expression of p53 in leukoplakia and squamous cell carcinoma of the oral mucosa: correlation with expression of Ki67. Clinical Molecular Pathology.  1996.  49, M170-5. [PubMed]  
		 
		
			
				12. 
			
				Kannan, S. , Chandran, G. J., Balaram, P., Chidambaram, S. and Nair, M. K.  Potential biological markers for the staging of tumor progression in oral mucosa: a multivariate analysis. The International Journal of Biological Markers.  1996.  11, 67-76. [PubMed]  
		 
		
			
				13. 
			
				Pillai, K. R., Remani, P., Kannan, S. , Sujathan, K., Mathew, B., Vijayakumar, T., Nair, M. K. and Menon, V. P.  Lectin histochemistry of oral premalignant and malignant lesions: correlation of JFL and PNA binding pattern with tumour progression. European Journal of Cancer. Part B, Oral Oncology.  1996.  32B, 32-37. [PubMed]  
		 
		
			
				14. 
			
				Sujathan, K., Kannan, S. , Remani, P., Pillai, K. R., Chandralekha, B., Amma, N. S. and Nair, M. K.  Differential expression of jackfruit-lectin-specific glycoconjugates in metastatic adenocarcinoma and reactive mesothelial cells-a diagnostic aid in effusion cytology. Journal of Cancer Research and Clinical Oncology.  1996.  122, 433-436. [PubMed]  
		 
		
			
				15. 
			
				Sujathan, K., Kannan, S. , Pillai, K. R., Mathew, A., Joseph, M., Symalakumari, B. and Nair, M. K.  Implications of gynaecological abnormalities in pre-selection criteria for cervical screening: preliminary evaluation of 3602 subjects in south India.  1995.  6, 75-87. [PubMed]  
		 
		
			
				16. 
			
				Kannan, S. , Gabius, H. J., Chandran, G. J., Pillai, M. R., Nalinakumari, K. R. and Nair, M. K.  Expression of galactoside-specific endogenous lectins and their ligands in human oral squamous cell carcinoma. Cancer Letters.  1994.  85, 1-7. [PubMed]  
		 
		
			
				17. 
			
				Kannan, S. , Balaram, P., Chandran, G. J., Pillai, M. R., Mathew, B., Nalinakumari, K. R. and Nair, M. K.  Alterations in expression of basement membrane proteins during tumour progression in oral mucosa. Histopathology.  1994.  24, 531-537. [PubMed]  
		 
		
			
				18. 
			
				Kannan, S. , Kartha, C. C., Chandran, G. J., Pillai, M. R., Sudha, L., Nalinakumari, K. R., Nair, M. K. and Balaram, P.  Ultrastructure of oral squamous cell carcinoma: a comparative analysis of different histological types. European Journal of Cancer. Part B, Oral Oncology.  1994.  30B, 32-42. [PubMed]  
		 
		
			
				19. 
			
				Kannan, S. , Balaram, P., Chandran, G. J., Pillai, M. R., Mathew, B. and Nair, M. K.  Co-expression of ras p21 and epidermal growth factor receptor during various stages of tumour progression in oral mucosa. Tumour Biology.  1994.  15, 73-81. [PubMed]  
		 
		
			
				20. 
			
				Pillai, K. R., Remani, P., Kannan, S. , Mathew, A., Sujathan, K., Vijayakumar, T. and Nair, M. K.  Jack fruit lectin-specific glycoconjugate expression during the progression of cervical intraepithelial neoplasia: a study on exfoliated cells. Diagnostic Cytopathology.  1994.  10, 342-346. [PubMed]  
		 
		
			
				21. 
			
				Pillai, K. R., Sujathan, K., Kannan, S. , Abraham, E. K., Mathew, B., Amma, N. S., Nair, M. K. and Menon, V. P.  Argyrophilic nucleolar organizer regions in the evaluation of tumour progression in the oral mucosa: correlation with tissue pathology. Journal of Cancer Research and Clinical Oncology.  1994.  120, 723-726. [PubMed]  
		 
		
			
				22. 
			
				Kannan, S. , Balaram, P., Chandran, G. J., Pillai, M. R., Mathew, B., Nalinakumari, K. R. and Nair, M. K.  Differential expression of cytokeratin proteins during tumour progression in oral mucosa. Epithelial Cell Biology.  1994.  3, 61-69. [PubMed]  
		 
		
			
				23. 
			
				Kannan, S.,  Balaram, P., Chandran, G. J., Pillai, M. R., Mathew, B., Nalinakumari, K. R. and Nair, M. K.  Alterations in expression of terminal differentiation markers of keratinocytes during oral carcinogenesis. Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology.  1994.  62, 127-133. [PubMed]  
		 
		
			
				24. 
			
				Kannan, S. , Balaram, P., Pillai, M. R., Chandran, G. J., Nair, M. K., Kartha, C. C., Augustine, J., Sudha, L. and Mangalam, M. K.  Ultrastructural variations and assessment of malignant transformation risk in oral leukoplakia. Pathology, Research and Practice.  1993.  189, 1169-1180. [PubMed]  
		 
		
			
				25. 
			
				Pillai, M. R., Nair, M. K., Kannan, S. , Chandran, G. J. and Balaram, P.  Immuno-pathological and immunological features of oral precancers. Singapore Dental Journal.  1993.  18, 28-38. [PubMed]  
		 
		
			
				26. 
			
				Pillai, R., Kannan, S.  and Chandran, G. J.  The immunohistochemistry of solid tumours: potential problems for new laboratories. The National Medical Journal of India.  1993.  6, 71-75. [PubMed]  
		 
		
			
				27. 
			
				Pillai, K. R., Kannan, S. , Gangadharan, V. P., Abraham, E. K., Chandralekha, B., Pillai, G. R., Amma, N. S. and Nair, M. K.  Role of sputum cytology in the diagnosis of mediastinal germ cell tumor. Neoplasma.  1993.  40, 193-197. [PubMed]  
		 
		
			
				28. 
			
				Kannan, S. , Balaram, P., Chandran, G. J., Pillai, M. R., Mathew, B. and Nair, M. K.  Expression of lectin-specific cellular glycoconjugates during oral carcinogenesis. Journal of Cancer Research and Clinical Oncology.  1993.  119, 689-694. [PubMed]  
		 
		
			
				29. 
			
				Balaram, P., Pillai, M. R., Abraham, T., Nalinakumari, K. R., Meenattoor, G., Kannan, S. , Hareendran, N. K. and Nair, M. K.  Interferon and interleukin-2 induced spontaneous cell-mediated cytotoxicity: a preliminary evaluation. Journal of Cancer Research and Clinical Oncology.  1992.  118, 408-410. [PubMed]  
		 
		
			
				30. 
			
				Pillai, M. R., Balaram, P., Kannan, S. , Sudha, L., Nalinakumari, K. R., Hareendran, N. K. and Nair, M. K.  Interferon activation of latent natural killer cells and alteration in kinetics of target cell lysis: clinical implications for oral precancerous lesions. Oral Surgery, Oral Medicine, and Oral Pathology.  1990.  70, 458-461. [PubMed]  
		 
	 
	 
  
                           
                         
                                                
 
                      
                          
                            
                                                                 
                                   
                             
                            
                                
                             
                            
                              
                                  
                                     
                                   
                                  
                                                                            
                                        
                                                                                    
                                            Education  
 
                                           
                                                                                    
                                            :: 
 
                                            M.Sc.                                                    				
				 
                                                                                                                            
 
                                           
                                                                                    
                                            :: 
 
                                            Ph.D.