Biplab Bose, M.Pharm, Ph.D.
Indian Institute of Technology
Department of Biotechnology
Guwahati - 781 039
Assam
E-mail: biplabbose@iitg.ernet.in
Phone: +91-361-2582216
Fax: +91-361-2582249, +91-361-2690762
URL: http://www.iitg.ac.in/biotech/B.Bose.htm
Positions Held:
Position Affiliation Time Period
Assistant Professor
Indian Institute of Technology, Guwahati
2006-Present
Lecturer
Birla Institute of Technology & Science Pilani, Rajasthan
2005-2006
Area of Specialization:
Immunology
Research Summary:
Development of recombinant therapeutic antibodies against infectious diseases and in cancer immunotherapy
General interest in different theoretical aspects of biological systems.
Publications:
1.
Loying, P., Manhas, J., Sen, S. and Bose, B. Autoregulation and heterogeneity in expression of human Cripto-1. PloS One. 2015. 10, e0116748. [PubMed]
2.
Thakur, R., Kumar, A., Bose, B. , Panda, D., Saikia, D., Chattopadhyay, P. and Mukherjee, A. K. A new peptide (Ruviprase) purified from the venom of Daboia russelii russelii shows potent anticoagulant activity via non-enzymatic inhibition of thrombin and factor Xa. Biochimie. 2014. 105, 149-158. [PubMed]
3.
Kumar, A., Das, G. and Bose, B. Recombinant receptor-binding domain of diphtheria toxin increases the potency of curcumin by enhancing cellular uptake. Molecular Pharmaceutics. 2014. 11, 208-217. [PubMed]
4.
Bose B. Systems biology: a biologist's viewpoint. Progress in Biophysics and Molecular Biology. 2013. 113, 358-368. [PubMed]
5.
Das, A. B., Loying, P. and Bose, B. Human recombinant Cripto-1 increases doubling time and reduces proliferation of HeLa cells independent of pro-proliferation pathways. Cancer Letters. 2012. 318, 189-198. [PubMed]
6.
Bose, B ., Khanna, N., Acharya, S. K. and Sinha, S. Generation and characterization of a single-gene mouse-human chimeric antibody against hepatitis B surface antigen. Journal of Gastroenterology and Hepatology. 2006. 21, 1439-1447. [PubMed]
7.
Bose, B ., Khanna, N., Acharya, S.K.and Sinha, S. Generation and characterization of a chimeric antibody against Hepatitis B surface antigen. Biotechnology and Applied Biochemistry . 2006. 43(Pt 2):93-101.
8.
Bose, B. , Khanna, N., Acharya, S. K. and Sinha, S. High affinity mouse-human chimeric Fab against hepatitis B surface antigen. World Journal of Gastroenterology : WJG. 2005. 11, 7569-7578. [PubMed]
9.
Bose, B . and Sinha, S. Problems in using statistical analysis of replacement and silent mutations in antibody genes for determining antigen-driven affinity selection. Immunology. 2005. 116, 172-183. [PubMed]
10.
Bose, B ., Chugh, D. A., Kala, M., Acharya, S. K., Khanna, N. and Sinha, S. Characterization and molecular modeling of a highly stable anti-Hepatitis B surface antigen scFv. Molecular Immunology. 2003. 40, 617-631. [PubMed]
Book Chapters:
Bose, B., Acharya, S.K., Khanna, N. and Sinha, S. In Chandra P and Kumar B.V.R (eds) Mathematical Biology: Recent trends.Anamaya Publishers, New Delhi, India. 2005. pp - 218-223.
Grant Support:
Project Title Role Funding Agency Sanction Number Sanction Date
Combination therapy using suicide genes and recombinant antibody
Department of Biotechnology, Government of India
2008-2013
Inhibitor Based Selection of Blocking Antibodies against Heparin-binding EGF-like Growth Factor: Developing Potent Molecules for Antibody-based Cancer Therapy
Department of Biotechnology, Government of India
2007-2010
Development of Therapeutic Human Antibodies Against Cripto-1: Targeting Oncogenic Signaling.
Department of Science & Technology, Government of India
2007-2010
Education
::
M.Pharm
Jadavpur University, Kolkata, India
::
Ph.D.
All India Institute of Medical Sciences, New Delhi, India
Member
::
Member, Indian Immunology Society
::
Member, The Society of Biological Chemists, India