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Biplab Bose, M.Pharm, Ph.D.
Assistant Professor 
Indian Institute of Technology
Department of Biotechnology
Guwahati - 781 039   
Phone: +91-361-2582216
Fax: +91-361-2582249, +91-361-2690762
Positions Held:
Position Affiliation Time Period
Assistant Professor Indian Institute of Technology, Guwahati 2006-Present
Lecturer Birla Institute of Technology & Science Pilani, Rajasthan 2005-2006
Area of Specialization:
Research Summary:
Development of recombinant therapeutic antibodies against infectious diseases and in cancer immunotherapy
General interest in different theoretical aspects of biological systems.
1. Loying, P., Manhas, J., Sen, S. and Bose, B.  Autoregulation and heterogeneity in expression of human Cripto-1. PloS One. 2015.  10, e0116748. [PubMed]
2. Thakur, R., Kumar, A., Bose, B., Panda, D., Saikia, D., Chattopadhyay, P. and Mukherjee, A. K.  A new peptide (Ruviprase) purified from the venom of Daboia russelii russelii shows potent anticoagulant activity via non-enzymatic inhibition of thrombin and factor Xa. Biochimie. 2014.  105, 149-158. [PubMed]
3. Kumar, A., Das, G. and Bose, B.  Recombinant receptor-binding domain of diphtheria toxin increases the potency of curcumin by enhancing cellular uptake. Molecular Pharmaceutics. 2014.  11, 208-217. [PubMed]
4. Bose B.  Systems biology: a biologist's viewpoint. Progress in Biophysics and Molecular Biology. 2013.  113, 358-368. [PubMed]
5. Das, A. B., Loying, P. and Bose, B.  Human recombinant Cripto-1 increases doubling time and reduces proliferation of HeLa cells independent of pro-proliferation pathways. Cancer Letters. 2012.  318, 189-198. [PubMed]
6. Bose, B., Khanna, N., Acharya, S. K. and Sinha, S.  Generation and characterization of a single-gene mouse-human chimeric antibody against hepatitis B surface antigen. Journal of Gastroenterology and Hepatology. 2006.  21, 1439-1447. [PubMed]
7. Bose, B., Khanna, N., Acharya, S.K.and Sinha, S. Generation and characterization of a chimeric antibody against Hepatitis B surface antigen. Biotechnology and Applied Biochemistry. 2006. 43(Pt 2):93-101.
8. Bose, B., Khanna, N., Acharya, S. K. and Sinha, S.  High affinity mouse-human chimeric Fab against hepatitis B surface antigen. World Journal of Gastroenterology : WJG. 2005.  11, 7569-7578. [PubMed]
9. Bose, B. and Sinha, S.  Problems in using statistical analysis of replacement and silent mutations in antibody genes for determining antigen-driven affinity selection. Immunology. 2005.  116, 172-183. [PubMed]
10. Bose, B., Chugh, D. A., Kala, M., Acharya, S. K., Khanna, N. and Sinha, S.  Characterization and molecular modeling of a highly stable anti-Hepatitis B surface antigen scFv. Molecular Immunology. 2003.  40, 617-631. [PubMed]


Book Chapters:
Bose, B., Acharya, S.K., Khanna, N. and Sinha, S. In Chandra P and Kumar B.V.R (eds) Mathematical Biology: Recent trends.Anamaya Publishers, New Delhi, India. 2005. pp - 218-223.
Grant Support:
Project Title Role Funding Agency Sanction Number Sanction Date
Combination therapy using suicide genes and recombinant antibody Department of Biotechnology, Government of India 2008-2013
Inhibitor Based Selection of Blocking Antibodies against Heparin-binding EGF-like Growth Factor: Developing Potent Molecules for Antibody-based Cancer Therapy Department of Biotechnology, Government of India 2007-2010
Development of Therapeutic Human Antibodies Against Cripto-1: Targeting Oncogenic Signaling. Department of Science & Technology, Government of India 2007-2010


M.Pharm Jadavpur University, Kolkata, India
Ph.D. All India Institute of Medical Sciences, New Delhi, India
Member, Indian Immunology Society
Member, The Society of Biological Chemists, India
  Last modified on : Dec 9, 2015
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