INCREDB ID : 322
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Manu Sharma, Ph.D.
Assistant Professor 
 
Jaypee University of Information Technology
Department of Biotechnology and Bioinformatics
Waknaghat, Kandaghat
Solan - 173 234   
Himachal Pradesh   
 
E-mail:  manu.sharma@juit.ac.in, lantadene@hotmail.com
Phone: +91-1792-239 219
 
URL: http://www.juit.ac.in/bio/manu.php#a
 
Positions Held:
Position Affiliation Time Period
Assistant Professor Jaypee University of Information Technology, Solan, Himachal Pradesh
 
Area of Specialization:
Pharmacology
Research Summary:
Anticancer drug development-synthesizing various congeners of naturally occurring pentacyclic triterpenoids to optimize their pharmacophore and to make them more like drug candidates
To synthesize various hybrid molecules which can selectively target cancer cells
To substitute benzimidazoles and conjugate them with various antioxidants to develop them as antitumor agents
 
Publications:
1. Sharma, M., Rakhi, A., Dalal, N. and Sharma, N.  Design, synthesis and evaluation of lantadene A congener with hydroxyl functionality in ring A as an antitumour agent. Natural Product Research. 2011.  25, 387-396. [PubMed]
2. Kaur, J., Sharma, M., Sharma, P. D. and Bansal, M. P.  Chemopreventive activity of lantadenes on two-stage carcinogenesis model in Swiss albino mice: AP-1 (c-jun), NFkappaB (p65) and P53 expression by ELISA and immunohistochemical localization. Molecular and Cellular Biochemistry. 2008.  314, 1-8. [PubMed]
3. Shah, D. I., Sharma, M., Bansal, Y., Bansal, G. and Singh, M.  Angiotensin II--AT1 receptor antagonists: design, synthesis and evaluation of substituted carboxamido benzimidazole derivatives. European Journal of Medicinal Chemistry. 2008.  43, 1808-1812. [PubMed]
4. Vyas, S., Sharma, M., Sharma, P. D. and Singh, T. V.  Design, semisynthesis, and evaluation of O-acyl derivatives of (-)-epigallocatechin-3-gallate as antitumor agents. Journal of Agricultural and Food Chemistry. 2007.  55, 6319-6324. [PubMed]
5. Sharma, M., Sharma, P. D., Bansal, M. P. and Singh, J.  Synthesis, cytotoxicity, and antitumor activity of lantadene-A congeners. Chemistry & Biodiversity. 2007.  4, 932-939. [PubMed]
6. Sharma, M., Sharma, P.D. and Bansal, M.P. Design and development of lantadenes as antitumor agents. Drugs of the Future. (Suppl). 2006. 11, 23-24.
7. Vyas, S., Manon, B., Singh, T.V., Sharma, P.D., Sharma, M. O-Acyl (-)-epicatechin gallate prodrugs as inhibitors of DMBA/TPA induced squamous cell carcinoma of skin in Swiss albino mice. Chemistry Biodiversity (In press).
8. Monga, J., Sharma, M., Tailor, N. and Ganesh, N. Antimelanoma and radioprotective activity of alcoholic aqueous extract of different species of Ocimum in C57BL mice. Pharmaceutical Biology (In press).
9. Sharma, M., Rakhi, A., Dalal, N. and Sharma, N. Design, synthesis and evaluation of Lantadene A congener with hydroxyl functionality in ring A as antitumor agents. Natural Product Research. 2010. 1-10.
10. Kaur, J., Sharma, M., Sharma, P.D. and Bansal, M.P. Antitumor Activity of Lantadenes in DMBA/TPA Induced Skin Tumors in Mice: Expression of Transcription Factors. American J. Biomed. Sci. 2010. 2, 1, 79-90.
11. Sharma, M., Sharma, P.D., Bansal, M.P. and Singh, J. Lantadene A induced apoptosis in human leukemia HL-60 cells. Indian Journal of Pharmacology. 2007. 39, 3, 140-144.
12. Sharma, M., Puri, S. and Sharma, P.D. Antifungal activity of Millingtonia hortensis. Indian Journal of Pharmaceutical Sciences. 2007. 69, 4, 599-601.
13. Sharma, M., Sharma, P.D., Bansal, M.P., Singh, J. Synthesis and antitumor activity of novel pentacyclic triterpenoid Lantadene D. Letters in Drug Design and Discovery. 2007. 4, 3, 201-204.
14. Sharma, M., Sharma, P.D and Bansal, M.P. Chemopreventive effect of Lantana camara L. leaf extract on DMBA-induced squamous cell carcinogenesis in Swiss albino mice. Pharmaceutical Biology. 2007. 45, 2, 145-148.
15. Sharma, M. and Sharma, P.D. Optimization of lantadene isolation and preparation of 22β-hydroxyoleanolic acid. Chemistry of Natural Compounds. 2006. 42, 412-414.
   
 

 
Grant Support:
Project Title Role Funding Agency Sanction Number Sanction Date
Antioxidants and Lantadene A hybrid compounds as anticancer agents Principal Investigator Department of Biotechnology, Government of India 2009-2012
Design, synthesis and evaluation of Lantadene - antioxidant conjugates as anticancer agents Principal Investigator Department of Science & Technology, Government of India 2009-2012

 
 
 
Education 
::
M.Sc. in Pharmaceutical Sciences, Punjabi University, Patiala, India
::
Ph.D. in Pharmaceutical Sciences, Panjab University, Chandigarh, India
Honors and Awards
::
March 2011, US National Cancer Institute (NCI) and European Society of Medical Oncology (ESMO) Fellowship to present paper in International Symposia on Targeted Anticancer Therapies (TAT), Paris, France
::
2010, International YSF Fellowship Australia and invited to present paper in OzBio 2010 conference, Melbourne, September
::
April 2010, International Scholarship of 1,00000 Yen by Japan College of Rheumatology to present paper in Kobe Japan
::
April 2010, Third World Academy of Science and invited to present paper in Young Scientist Programme and Biovision Conference in Alexandria Egypt
::
2009, Rapid Grant for Young Investigator by DBT, Government of India
::
2009, Research grant under Fast track scheme for young scientist, DST, Government of India
::
Young Scientist Fellowship by International Union of Biochemistry and Molecular Biology and invited to present paper in Shanghai China
::
Senior Research Fellowship from Indian Council of Medical Research, New Delhi to carry out Ph.D. research work
::
29th August-2nd September 2006, Presented paper in XIXth International Symposium on Medicinal Chemistry, Istanbul Turkey
::
29th August-2nd September 2006, Prestigious Bentham Science Publication UK, award to attend XIXth International Symposium on Medicinal Chemistry, , Istanbul Turkey
::
May 7-9, 2007, Scholarship by Queensland Medical Research Institute to attend 4th Indo-Australian Biotechnology Conference
::
10-11th March 2007, Best Poster Award in 1st Chandigarh Sciences Congress, Panjab University Chandigarh
::
11th April 2007, Professor A. S. Brar best paper award in National conference on Recent Advances in Analytical Sciences and Applications
::
11th April-16th April 2008, Third World Academy of Science to attend and present paper in 4th International Conference Biovision Alexandria Alexandria, Egypt
Member
::
World Academy of Young Scientists
::
Third World Academy of Young Scientists
::
Reviewer-International Journal of Biological and Chemical Sciences, Journal of Pharmacy and Pharmacology, African Journal of Environment Science and Technology
  Last modified on : Mar 24, 2011
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