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Smrati Bhadauria, Ph.D.
Scientist C 
Central Drug Research Institute
Endocrinology Division
Lucknow - 226 001   
Uttar Pradesh   
Phone: +91-522-2612411-18, Ext. 4274
Fax: +91-522-2623405
Area of Specialization:
Research Summary:
Biochemical and molecular mechanism of drug induced hepatotoxicyty using hepatoma cultures with special reference to involvement of oxidative stress and apoptosis.
Role of Estrogen(s) Induced Redox Alteration in Breast Carcinogenesis.
Regulatory Toxicology
1. Mishra, R., Bhadauria, S., Murthy, P. K. and Murthy, P. S.  Glycine soya diet synergistically enhances the suppressive effect of tamoxifen and inhibits tamoxifen-promoted hepatocarcinogenesis in 7,12-dimethylbenz[alpha]anthracene-induced rat mammary tumor model. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. 2011.  49, 434-440. [PubMed]
2. Bhadauria, S., Mishra, R., Kanchan, R., Tripathi, C., Srivastava, A., Tiwari, A. and Sharma, S.  Isoniazid-induced apoptosis in HepG2 cells: generation of oxidative stress and Bcl-2 down-regulation. Toxicology Mechanisms and Methods. 2010.  20, 242-251. [PubMed]
3. Mishra, R., Tiwari, A., Bhadauria, S., Mishra, J., Murthy, P. K. and Murthy, P. S.  Therapeutic effect of centchroman alone and in combination with glycine soya on 7,12-dimethylbenz[alpha]anthracene-induced breast tumor in rat. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. 2010.  48, 1587-1591. [PubMed]
4. Raghu, K. G., Yadav, G. K., Singh, R., Prathapan, A., Sharma, S. and Bhadauria, S.  Evaluation of adverse cardiac effects induced by arsenic trioxide, a potent anti-APL drug. Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society For Environmental Toxicology and Cancer. 2009.  28, 241-252. [PubMed]
5. Bhadauria, S., Singh, G., Sinha, N. and Srivastava, S.  Isoniazid induces oxidative stress, mitochondrial dysfunction and apoptosis in Hep G2 cells. Cellular and Molecular Biology. 2007.  53, 102-114. [PubMed]
6. Bhadauria, S. and Flora, S. J.  Response of arsenic-induced oxidative stress, DNA damage, and metal imbalance to combined administration of DMSA and monoisoamyl-DMSA during chronic arsenic poisoning in rats. Cell Biology and Toxicology. 2007.  23, 91-104. [PubMed]
7. Flora, S. J., Bhadauria, S., Pant, S. C. and Dhaked, R. K.  Arsenic induced blood and brain oxidative stress and its response to some thiol chelators in rats. Life Sciences. 2005.  77, 2324-2337. [PubMed]
8. Manisha Pande,M., Bhadauria,S., Kannan,G.M. and Flora,S.J.S.Lead Induced Oxidative Stress And Its Response To Combined Administration Of Taurine And Dimercaptosuccinic Acid In Male Rats.Human And Experimental Toxicology.2004. 23: 157-166.
9. Bhadauria,S. and Flora,S.J.S. Arsenic Induced Inhibited ?-Aminolevulinate Dehydratase Activity In Rat Blood And Its Response To Meso 2,3-Dimercaptosuccinic Acid And Monoisoamyl DMSA. Biomedical And Environmental Sciences.2003. 17: 305-313.


  Last modified on : Mar 4, 2011
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