INCREDB ID : 309
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Fayaz Ahmad Malik, Ph.D.
Scientist C 
 
Indian Institute of Integrative Medicine
Department of Cancer Pharmacology
Canal Road
Jammu - 180 001   
Jammu and Kashmir   
 
E-mail: malik_fayaz@yahoo.com, fmalik@iiim.ac.in
Phone: +91-191-2569 000, Ext. 291
Fax: +91-191-2569 333, +91-191-2569019
 
Positions Held:
Position Affiliation Time Period
Scientist C Indian Institute of Integrative Medicine, Jammu, India
 
Area of Specialization:
Pharmacology
Research Summary:
Development of anti-cancer therapeutics from medicinal plants
Identification and validation of new molecularly targeted agents and their translation into clinical applications
Studying the role of natural products in targeting critical tumor promoting pathways involving protein kinase network and tumor microenvironment
Studying immune modifiers for their potential role in the development of immune adjuvants
 
Publications:
1. Kumar, H. M., Singh, P. P., Qazi, N. A., Srinivas, J., Malik, F., Sidiq, T., Gupta, A., Khajuria, A., Suri, K. A., Satti, N. K. and Qazi, G. N.  Development of novel lipidated analogs of picroside as vaccine adjuvants: acylated analogs of picroside-II elicit strong Th1 and Th2 response to ovalbumin in mice. Vaccine. 2010.  28, 8327-8337. [PubMed]
2. Khan, S., Malik, F., Suri, K. A. and Singh, J.  Molecular insight into the immune up-regulatory properties of the leaf extract of Ashwagandha and identification of Th1 immunostimulatory chemical entity. Vaccine. 2009.  27, 6080-6087. [PubMed]
3. Malik, F., Kumar, A., Bhushan, S., Mondhe, D. M., Pal, H. C., Sharma, R., Khajuria, A., Singh, S., Singh, G., Saxena, A. K., Suri, K. A., Qazi, G. N. and Singh, J.  Immune modulation and apoptosis induction: Two sides of antitumoural activity of a standardised herbal formulation of Withania somnifera. European Journal of Cancer. 2009.  45, 1494-1509. [PubMed]
4. Khan, S., Malik, F., Suri, K. A. and Singh, J.  Molecular insight into the immune up-regulatory properties of the leaf extract of Ashwagandha and identification of Th1 immunostimulatory chemical entity. Vaccine. 2009.  27, 6080-6087. [PubMed]
5. Bhushan, S., Malik, F., Kumar, A., Isher, H. K., Kaur, I. P., Taneja, S. C. and Singh, J.  Activation of p53/p21/PUMA alliance and disruption of PI-3/Akt in multimodal targeting of apoptotic signaling cascades in cervical cancer cells by a pentacyclic triterpenediol from Boswellia serrata. Molecular Carcinogenesis. 2009.  48, 1093-1108. [PubMed]
6. Khajuria, A., Gupta, A., Suden, P., Singh, S., Malik, F., Singh, J., Gupta, B. D., Suri, K. A., Srinivas, V. K., Ella, K. and Qazi, G. N.  Immunomodulatory activity of biopolymeric fraction BOS 2000 from Boswellia serrata. Phytotherapy Research : PTR. 2008.  22, 340-348. [PubMed]
7. Kumar, A., Malik, F., Bhushan, S., Sethi, V. K., Shahi, A. K., Kaur, J., Taneja, S. C., Qazi, G. N. and Singh, J.  An essential oil and its major constituent isointermedeol induce apoptosis by increased expression of mitochondrial cytochrome c and apical death receptors in human leukaemia HL-60 cells. Chemico-biological Interactions. 2008.  171, 332-347. [PubMed]
8. Malik, F., Kumar, A., Bhushan, S., Khan, S., Bhatia, A., Suri, K. A., Qazi, G. N. and Singh, J.  Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic cell death of human myeloid leukemia HL-60 cells by a dietary compound withaferin A with concomitant protection by N-acetyl cysteine. Apoptosis. 2007.  12, 2115-2133. [PubMed]
9. Bhushan, S., Kumar, A., Malik, F., Andotra, S. S., Sethi, V. K., Kaur, I. P., Taneja, S. C., Qazi, G. N. and Singh, J.  A triterpenediol from Boswellia serrata induces apoptosis through both the intrinsic and extrinsic apoptotic pathways in human leukemia HL-60 cells. Apoptosis. 2007.  12, 1911-1926. [PubMed]
10. Khajuria, A., Gupta, A., Singh, S., Malik, F., Singh, J., Suri, K. A., Satti, N. K., Qazi, G. N., Srinivas, V. K. and Ella, K.  RLJ-NE-299A: a new plant based vaccine adjuvant. Vaccine. 2007.  25, 2706-2715. [PubMed]
11. Malik, F., Singh, J., Khajuria, A., Suri, K. A., Satti, N. K., Singh, S., Kaul, M. K., Kumar, A., Bhatia, A. and Qazi, G. N.  A standardized root extract of Withania somnifera and its major constituent withanolide-A elicit humoral and cell-mediated immune responses by up regulation of Th1-dominant polarization in BALB/c mice. Life Sciences. 2007.  80, 1525-1538. [PubMed]
12. Khajuria, A., Gupta, A., Malik, F., Singh, S., Singh, J., Gupta, B. D., Suri, K. A., Suden, P., Srinivas, V. K., Ella, K. and Qazi, G. N.  A new vaccine adjuvant (BOS 2000) a potent enhancer mixed Th1/Th2 immune responses in mice immunized with HBsAg. Vaccine. 2007.  25, 4586-4594. [PubMed]
13. Malik, F., Singh, J., Bhatia, A. and Qazi, G.N. Multiple therapeutic target based novel herbal formulation with anticancer and immunostimulatory activities. European Journal of Cancer. Supplements. 2007. 5, 4, 89.
 

 
Book Chapters:
Singh, J., Malik, F. and Qazi, G.N. Protective role of tea against cancer and infectious diseases through immune activation. In: Global advances in Tea Science Book-3. Economic Crisis in Tea Industry, Strategies for scientific management. Jain, N.K., Weisburger, J. and Siddiqi, M., Editors. CABI Publishers, U.K. 2008. 33, 341-351.
 
My CV:   Download
 
Education 
::
M.Sc.
::
Ph.D.
Honors and Awards
::
2009, CSIR Young Scientist Award for Biological Sciences
Member
::
Member of Indian association of Cancer research
  Last modified on : Mar 4, 2011
India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.