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Bramanandam Manavathi, Ph.D.
Assistant Professor 
School of Life Sciences, University of Hyderabad
Department of Biochemistry
Central University
Hyderabad - 500 046   
Andhra Pradesh   
Phone: +91-40-23134546
Mobile: +91-9490932411
Positions Held:
Position Affiliation Time Period
Lecturer School of Life Sciences, University of Hyderabad, Hyderabad, India 2007-Present
Area of Specialization:
Molecular Biology
Research Summary:
Molecular Mechanisms of Oncogenesis
1. Bugide, S., David, D., Nair, A., Kannan, N., Samanthapudi, V. S., Prabhakar, J. and Manavathi, B.  Hematopoietic PBX-interacting protein (HPIP) is over expressed in breast infiltrative ductal carcinoma and regulates cell adhesion and migration through modulation of focal adhesion dynamics. Oncogene. 2015.  34, 4601-4612. [PubMed]
2. Mangamuri, U. K., Vijayalakshmi, M., Poda, S., Manavathi, B., Bhujangarao, C. h. and Venkateswarlu, Y.  Bioactive Metabolites Produced by Pseudonocardia endophytica VUK-10 from Mangrove Sediments: Isolation, Chemical Structure Determination and Bioactivity. Journal of Microbiology and Biotechnology. 2015.  25, 629-636. [PubMed]
3. Manavathi, B., Samanthapudi, V. S. and Gajulapalli, V. N.  Estrogen receptor coregulators and pioneer factors: the orchestrators of mammary gland cell fate and development. Frontiers in Cell and Developmental Biology. 2014.  2, 34. [PubMed]
4. Manavathi, B., Dey, O., Gajulapalli, V. N., Bhatia, R. S., Bugide, S. and Kumar, R.  Derailed estrogen signaling and breast cancer: an authentic couple. Endocrine Reviews. 2013.  34, 1-32. [PubMed]
5. Manavathi, B., Lo, D., Bugide, S., Dey, O., Imren, S., Weiss, M. J. and Humphries, R. K.  Functional regulation of pre-B-cell leukemia homeobox interacting protein 1 (PBXIP1/HPIP) in erythroid differentiation. The Journal of Biological Chemistry. 2012.  287, 5600-5614. [PubMed]
6. Nair, B. C., Nair, S. S., Chakravarty, D., Challa, R., Manavathi, B., Yew, P. R., Kumar, R., Tekmal, R. R. and Vadlamudi, R. K.  Cyclin-dependent kinase-mediated phosphorylation plays a critical role in the oncogenic functions of PELP1. Cancer Research. 2010.  70, 7166-7175. [PubMed]
7. Kumar, R., Balasenthil, S., Manavathi, B., Rayala, S. K. and Pakala, S. B.  Metastasis-associated protein 1 and its short form variant stimulates Wnt1 transcription through promoting its derepression from Six3 corepressor. Cancer Research. 2010.  70, 6649-6658. [PubMed]
8. Manavathi, B., Singh, K. and Kumar, R.  MTA family of coregulators in nuclear receptor biology and pathology. Nuclear Receptor Signaling. 2007.  5, e010. [PubMed]
9. Pandey, J. P., Gorla, P., Manavathi, B. and Siddavattam, D.  mRNA secondary structure modulates the translation of organophosphate hydrolase (OPH) in E. coli. Molecular Biology Reports. 2009.  36, 449-454. [PubMed]
10. Manavathi, B., Peng, S., Rayala, S. K., Talukder, A. H., Wang, M. H., Wang, R. A., Balasenthil, S., Agarwal, N., Frishman, L. J. and Kumar, R.  Repression of Six3 by a corepressor regulates rhodopsin expression. Proceedings of the National Academy of Sciences of the United States of America. 2007.  104, 13128-13133. [PubMed]
11. Manavathi, B., Rayala, S. K. and Kumar, R.  Phosphorylation-dependent regulation of stability and transforming potential of ETS transcriptional factor ESE-1 by p21-activated kinase 1. The Journal of Biological Chemistry. 2007.  282, 19820-19830. [PubMed]
12. Manavathi, B. and Kumar, R.  Metastasis tumor antigens, an emerging family of multifaceted master coregulators. The Journal of Biological Chemistry. 2007.  282, 1529-1533. [PubMed]
13. Acconcia, F., Manavathi, B., Mascarenhas, J., Talukder, A. H., Mills, G. and Kumar, R.  An inherent role of integrin-linked kinase-estrogen receptor alpha interaction in cell migration. Cancer Research. 2006.  66, 11030-11038. [PubMed]
14. Verma, A., Wang, H., Manavathi, B., Fok, J. Y., Mann, A. P., Kumar, R. and Mehta, K.  Increased expression of tissue transglutaminase in pancreatic ductal adenocarcinoma and its implications in drug resistance and metastasis. Cancer Research. 2006.  66, 10525-10533. [PubMed]
15. Manavathi, B., Acconcia, F., Rayala, S. K. and Kumar, R.  An inherent role of microtubule network in the action of nuclear receptor. Proceedings of the National Academy of Sciences of the United States of America. 2006.  103, 15981-15986. [PubMed]
16. Mann, A. P., Verma, A., Sethi, G., Manavathi, B., Wang, H., Fok, J. Y., Kunnumakkara, A. B., Kumar, R., Aggarwal, B. B. and Mehta, K.  Overexpression of tissue transglutaminase leads to constitutive activation of nuclear factor-kappaB in cancer cells: delineation of a novel pathway. Cancer Research. 2006.  66, 8788-8795. [PubMed]
17. Rayala, S. K., den, H., Manavathi, B., Talukder, A. H., Song, C., Peng, S., Barnekow, A., Kremerskothen, J. and Kumar, R.  Essential role of KIBRA in co-activator function of dynein light chain 1 in mammalian cells. The Journal of Biological Chemistry. 2006.  281, 19092-19099. [PubMed]
18. Manavathi, B. and Kumar, R.  Steering estrogen signals from the plasma membrane to the nucleus: two sides of the coin. Journal of Cellular Physiology. 2006.  207, 594-604. [PubMed]
19. Vadlamudi, R. K., Manavathi, B., Balasenthil, S., Nair, S. S., Yang, Z., Sahin, A. A. and Kumar, R.  Functional implications of altered subcellular localization of PELP1 in breast cancer cells. Cancer Research. 2005.  65, 7724-7732. [PubMed]
20. Manavathi, B., Nair, S. S., Wang, R. A., Kumar, R. and Vadlamudi, R. K.  Proline-, glutamic acid-, and leucine-rich protein-1 is essential in growth factor regulation of signal transducers and activators of transcription 3 activation. Cancer Research. 2005.  65, 5571-5577. [PubMed]
21. Vadlamudi, R. K., Manavathi, B., Singh, R. R., Nguyen, D., Li, F. and Kumar, R.  An essential role of Pak1 phosphorylation of SHARP in Notch signaling. Oncogene. 2005.  24, 4591-4596. [PubMed]
22. Siddavattam, D., Khajamohiddin, S., Manavathi, B., Pakala, S. B. and Merrick, M.  Transposon-like organization of the plasmid-borne organophosphate degradation (opd) gene cluster found in Flavobacterium sp. Applied and Environmental Microbiology. 2003.  69, 2533-2539. [PubMed]
23. Somara, S., Manavathi, B., Tebbe, C. C. and Siddavatam, D.  Localisation of identical organophosphorus pesticide degrading (opd) genes on genetically dissimilar indigenous plasmids of soil bacteria: PCR amplification, cloning and sequencing of opd gene from Flavobacterium balustinum. Indian Journal of Experimental Biology. 2002.  40, 774-779. [PubMed]


Ph.D. Sri Krishnadevaraya University, Anantapur, India, 1997-2002
M.Sc. Sri Krishnadevaraya University, Anantapur, India, 1995-1997
Honors and Awards
Young Scientist Award 2009 (Fast Track grant) –DST, India
BOYSCAST Fellow-2009, DST India (visiting scientist at Terry Fox Laboratory, Vancouver, Canada)
Innovative Young Biotechnologist Award (IYBA)-2009, DBT- India
AMZEN Award in Basic Science Research-2007 at MD Anderson Cancer Center, Houston, USA
Type of Neoplasms
  Last modified on : Dec 9, 2015
India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.