Satya N. Das,                               Ph.D. 
                               
                              Additional Professor  
                           
                         
                                  
         
                                                    
                                                    
                            All India Institute of Medical Sciences 
                           
                                                                              
                            Department of Biotechnology 
                           
                                                                              
                            Ansari Nagar 
                           
                                                    
                            New Delhi - 110 029                                 
                           
                          						  
                                                            
                           
                                                    
                            E-mail:  snd@aiims.ernet .in; satyandas@gmail.com; satyandas@hotmail.com 
                           
                                                                              
                            Phone: +91-11-6593548 
                           
                                                    
                            Fax: +91-11-26862663  
                           
                  
                          
                               
                           
                          
                            URL:   http://aiims.edu/aiims/departments/Biotechnology/biotechsndas.htm  
                           
                          
                          						  
                              
                           
						  
	                             
                            Positions Held:  
                           
                                                    
                            
                                
                                  Position  
                                  Affiliation  
                                  Time Period   
                                 
                                                                
                                  Additional Professor  
                                  All India Institute of Medical Sciences, New Delhi, India 
                                  
								  2001-Present 
                                 
                                                                
                                  Associate Professor  
                                  All India Institute of Medical Sciences, New Delhi, India 
                                  
								  1997-2001 
                                 
                                                                
                                  Assistant Professor  
                                  All India Institue of Medical Sciences, New Delhi, India 
                                  
								  1992-1997 
                                 
                                                                
                                  Scientific Officer  
                                  Industrial Toxicology Research Centre, Lucknow, India 
                                  
								  1987-1992 
                                 
                                                                
                                  Pool Officer  
                                  Industrial Toxicology Research Centre, Lucknow, India 
                                  
								  1985-1986 
                                 
                                                                
                                  Research Officer  
                                  Institute of Medical Sciences, Banaras Hindu University,Varanasi,India 
                                  
								  1981-1985 
                                 
                                                            
 
                           
                          
                              
                           
                                                                              
                            Area of Specialization:  
                           
                          
                          
                          
  
     
    Molecuar genetics 
   
    
     
     Immunology 
   
    
     
     Biotechnology 
   
    
                          
                        
                           
                           
                         
                         
                                                    
                                                    
                          
                             
                           
                                                    
                             Research Summary:  
                           
                                                    
                            
                                                                
                                   
                                  Cancer genetics  
                                 
                                                                
                                   
                                  Immunogenetics of cancer and autoimmune diseases  
                                 
                                                            
 
                           
                          
                              
                           
                                                    
                            Publications:  
                           
                          
                            
	
		
			
				1. 
			
				Khanna, N. N., Das, S. N.  and Khanna, S.  Serum immunoglobulins in squamous cell carcinoma of the oral cavity. Journal of Surgical Oncology.  1982.  20, 46-48. [PubMed]  
		 
		
			
				2. 
			
				Das, S. N. , Khanna, N. N. and Khanna, S.  Delayed hypersensitivity in squamous cell carcinoma of the oral cavity. Annals of the Academy of Medicine, Singapore.  1983.  12, 416-419. [PubMed]  
		 
		
			
				3. 
			
				Khanna, N. N., Srivastava, P. K., Khanna, S. and Das, S. N.   Intensive combination chemotherapy for cancer of the oral cavity. Cancer.  1983.  52, 790-793. [PubMed]  
		 
		
			
				4. 
			
				Das, S. N. , Khanna, N. N. and Khanna, S.  A multiparametric observation of immune competence in breast cancer and its correlation with tumour load and prognosis. Annals of the Academy of Medicine, Singapore.  1985.  14, 374-381. [PubMed]  
		 
		
			
				5. 
			
				Singh, G., Das, S. N.  and Khanna, N. N.  Immune status in advanced upper gastrointestinal cancers. Journal of Surgical Oncology.  1985.  29, 43-45. [PubMed]  
		 
		
			
				6. 
			
				Das, S. N. , Khanna, N. N. and Khanna, S.  In vivo and in vitro observation of cellular immune parameters in squamous cell carcinoma of the oral cavity and its correlation with tumor load and prognosis. Cancer Investigation.  1986.  4, 207-216. [PubMed]  
		 
		
			
				7. 
			
				Das, S. N. , Khanna, N. N., Khanna, S. and Gupta, S.  Cell surface antigens in squamous cell carcinoma of the oral cavity. Journal of Surgical Oncology.  1986.  31, 166-169. [PubMed]  
		 
		
			
				8. 
			
				Das, S. N. , Paul, B. N., Saxena, A. K. and Ray, P. K.  Effect of in utero exposure to hexachlorocyclohexane on the developing immune system of mice. Immunopharmacology and Immunotoxicology.  1990.  12, 293-310. [PubMed]  
		 
		
			
				9. 
			
				Saxena, A. K., Paul, B. N., Sinha, M., Dutta, K. K., Das, S. N.  and Ray, P. K.  A study on the B cell activity in protein deficient rats exposed to methyl isocyanate vapour. Immunopharmacology and Immunotoxicology.  1991.  13, 413-424. [PubMed]  
		 
		
			
				10. 
			
				Jain, V., Das, S. N. , Luthra, K., Shukla, N. K. and Ralhan, R.  Differential expression of multidrug resistance gene product, P-glycoprotein, in normal, dysplastic and malignant oral mucosa in India. International Journal of Cancer. Journal International Du Cancer.  1997.  74, 128-133. [PubMed]  
		 
		
			
				11. 
			
				Arora, M., Kumar, A., Das, S. N.  and Srivastava, L. M.  Complement-regulatory protein expression and activation of complement cascade on erythrocytes from patients with rheumatoid arthritis (RA). Clinical and Experimental Immunology.  1998.  111, 102-106. [PubMed]  
		 
		
			
				12. 
			
				Kaur, J., Das, S. N. , Srivastava, A. and Ralhan, R.  Cell surface expression of 70 kDa heat shock protein in human oral dysplasia and squamous cell carcinoma: correlation with clinicopathological features. Oral Oncology.  1998.  34, 93-98. [PubMed]  
		 
		
			
				13. 
			
				Sharma, R. B., Srinivas, M., Mitra, D. K. and Das, S. N.   T-lymphocyte subsets in the contralateral testis after unilateral blunt testicular trauma in pre-pubertal mice. Pediatric Surgery International.  1999.  15, 238-239. [PubMed]  
		 
		
			
				14. 
			
				Srinivas, M., Degaonkar, M., Gupta, D. K., Raghunathan, P., Das, S. N.  and Mitra, D. K.  Evaluation of developing rat testis by phosporus 31P magnetic resonance spectroscopy and DNA flowcytometry. Pediatric Surgery International.  2001.  17, 316-320. [PubMed]  
		 
		
			
				15. 
			
				Grover, J. K., Vats, V., Srinivas, M., Das, S. N. , Jha, P., Gupta, D. K. and Mitra, D. K.  Effect of metronidazole on spermatogenesis and FSH, LH and testosterone levels of pre-pubertal rats. Indian Journal of Experimental Biology.  2001.  39, 1160-1162. [PubMed]  
		 
		
			
				16. 
			
				Srinivas, M., Chandrasekharam, V. V., Degaonkar, M., Gupta, D. K., Jha, P., Jagannathan, N. R. and Das, S. N.   Effects of unilateral grade I testicular injury in rat. Urology.  2002.  60, 548-551. [PubMed]  
		 
		
			
				17. 
			
				Chandrasekharam, V. V., Srinivas, M., Das, S. N. , Jha, P., Bajpai, M., Chaki, S. P. and Misro, M. M.  Prepubertal human chorionic gonadotropin injection affects postpubertal germ cell maturation and androgen production in rat testis. Urology.  2003.  62, 571-574. [PubMed]  
		 
		
			
				18. 
			
				Baniasadi, V., Narain, N., Goswami, R. and Das, S. N.   Promoter region -318 C/ T and -1661 A/G CTLA-4 single nucleotide polymorphisms and type 1 diabetes in North Indians. Tissue Antigens.  2006.  67, 383-389. [PubMed]  
		 
		
			
				19. 
			
				Manchanda, P., Sharma, S. C. and Das, S. N.   Differential regulation of IL-2 and IL-4 in patients with tobacco-related oral squamous cell carcinoma. Oral Diseases.  2006.  12, 455-462. [PubMed]  
		 
	 
	
		
			
				20. 
			
				Khanna, N. N., Das, S. N.  and Khanna, S.  Serum immunoglobulins in squamous cell carcinoma of the oral cavity. Journal of Surgical Oncology.  1982.  20, 46-48. [PubMed]  
		 
		
			
				21. 
			
				Das, S. N. , Khanna, N. N. and Khanna, S.  Delayed hypersensitivity in squamous cell carcinoma of the oral cavity. Annals of the Academy of Medicine, Singapore.  1983.  12, 416-419. [PubMed]  
		 
		
			
				22. 
			
				Khanna, N. N., Srivastava, P. K., Khanna, S. and Das, S. N.   Intensive combination chemotherapy for cancer of the oral cavity. Cancer.  1983.  52, 790-793. [PubMed]  
		 
		
			
				23. 
			
				Das, S. N. , Khanna, N. N. and Khanna, S.  A multiparametric observation of immune competence in breast cancer and its correlation with tumour load and prognosis. Annals of the Academy of Medicine, Singapore.  1985.  14, 374-381. [PubMed]  
		 
		
			
				24. 
			
				Singh, G., Das, S. N.  and Khanna, N. N.  Immune status in advanced upper gastrointestinal cancers. Journal of Surgical Oncology.  1985.  29, 43-45. [PubMed]  
		 
		
			
				25. 
			
				Das, S. N. , Khanna, N. N. and Khanna, S.  In vivo and in vitro observation of cellular immune parameters in squamous cell carcinoma of the oral cavity and its correlation with tumor load and prognosis. Cancer Investigation.  1986.  4, 207-216. [PubMed]  
		 
		
			
				26. 
			
				Das, S. N. , Khanna, N. N., Khanna, S. and Gupta, S.  Cell surface antigens in squamous cell carcinoma of the oral cavity. Journal of Surgical Oncology.  1986.  31, 166-169. [PubMed]  
		 
		
			
				27. 
			
				Das, S. N. , Paul, B. N., Saxena, A. K. and Ray, P. K.  Effect of in utero exposure to hexachlorocyclohexane on the developing immune system of mice. Immunopharmacology and Immunotoxicology.  1990.  12, 293-310. [PubMed]  
		 
		
			
				28. 
			
				Saxena, A. K., Paul, B. N., Sinha, M., Dutta, K. K., Das, S. N.  and Ray, P. K.  A study on the B cell activity in protein deficient rats exposed to methyl isocyanate vapour. Immunopharmacology and Immunotoxicology.  1991.  13, 413-424. [PubMed]  
		 
		
			
				29. 
			
				Jain, V., Das, S. N. , Luthra, K., Shukla, N. K. and Ralhan, R.  Differential expression of multidrug resistance gene product, P-glycoprotein, in normal, dysplastic and malignant oral mucosa in India. International Journal of Cancer. Journal International Du Cancer.  1997.  74, 128-133. [PubMed]  
		 
		
			
				30. 
			
				Arora, M., Kumar, A., Das, S. N.  and Srivastava, L. M.  Complement-regulatory protein expression and activation of complement cascade on erythrocytes from patients with rheumatoid arthritis (RA). Clinical and Experimental Immunology.  1998.  111, 102-106. [PubMed]  
		 
		
			
				31. 
			
				Kaur, J., Das, S. N. , Srivastava, A. and Ralhan, R.  Cell surface expression of 70 kDa heat shock protein in human oral dysplasia and squamous cell carcinoma: correlation with clinicopathological features. Oral Oncology.  1998.  34, 93-98. [PubMed]  
		 
		
			
				32. 
			
				Sharma, R. B., Srinivas, M., Mitra, D. K. and Das, S. N.   T-lymphocyte subsets in the contralateral testis after unilateral blunt testicular trauma in pre-pubertal mice. Pediatric Surgery International.  1999.  15, 238-239. [PubMed]  
		 
		
			
				33. 
			
				Grover, J. K., Vats, V., Srinivas, M., Das, S. N. , Jha, P., Gupta, D. K. and Mitra, D. K.  Effect of metronidazole on spermatogenesis and FSH, LH and testosterone levels of pre-pubertal rats. Indian Journal of Experimental Biology.  2001.  39, 1160-1162. [PubMed]  
		 
		
			
				34. 
			
				Srinivas, M., Chandrasekharam, V. V., Degaonkar, M., Gupta, D. K., Jha, P., Jagannathan, N. R. and Das, S. N.   Effects of unilateral grade I testicular injury in rat. Urology.  2002.  60, 548-551. [PubMed]  
		 
		
			
				35. 
			
				Chandrasekharam, V. V., Srinivas, M., Das, S. N. , Jha, P., Bajpai, M., Chaki, S. P. and Misro, M. M.  Prepubertal human chorionic gonadotropin injection affects postpubertal germ cell maturation and androgen production in rat testis. Urology.  2003.  62, 571-574. [PubMed]  
		 
		
			
				36. 
			
				Baniasadi, V., Narain, N., Goswami, R. and Das, S. N.   Promoter region -318 C/ T and -1661 A/G CTLA-4 single nucleotide polymorphisms and type 1 diabetes in North Indians. Tissue Antigens.  2006.  67, 383-389. [PubMed]  
		 
	 
	
		
			
				37. 
			
				Kapoor, V., Singh, A. K., Dey, S., Sharma, S. C. and Das, S. N.   Circulating cycloxygenase-2 in patients with tobacco-related intraoral squamous cell carcinoma and evaluation of its peptide inhibitors as potential antitumor agent. Journal of Cancer Research and Clinical Oncology.  2010.  136, 1795-1804. [PubMed]  
		 
		
			
				38. 
			
				Gupta, R., Kapuria, V. and Das, S. N.   Single nucleotide polymorphisms in TNF-alpha, TNFR2 gene and TNF-alpha production in Asian Indians. Immunological Investigations.  2009.  38, 240-254. [PubMed]  
		 
		
			
				39. 
			
				Gupta, R., Sharma, S. C. and Das, S. N.   Association of TNF-alpha and TNFR1 promoters and 3' UTR region of TNFR2 gene polymorphisms with genetic susceptibility to tobacco-related oral carcinoma in Asian Indians. Oral Oncology.  2008.  44, 455-463. [PubMed]  
		 
		
			
				40. 
			
				Agarwal, A., Mohanti, B. K. and Das, S. N.   Ex vivo triggering of T-cell-mediated immune responses by autologous tumor cell vaccine in oral cancer patients. Immunopharmacology and Immunotoxicology.  2007.  29, 95-104. [PubMed]  
		 
		
			
				41. 
			
				Devarapu, S. K., Sharma, S. C. and Das, S. N.   Triggering of T cell-mediated immune responses by allogenic tumor cell vaccine in patients with oral cancer. Immunopharmacology and Immunotoxicology.  2006.  28, 387-395. [PubMed]  
		 
		
			
				42. 
			
				Sawhney, M., Mathew, M., Valarmathi, M. T. and Das, S. N.   Age related changes in Fas (CD95) and Fas ligand gene expression and cytokine profiles in healthy Indians. Asian Pacific Journal of Allergy and Immunology.  2006.  24, 47-56. [PubMed]  
		 
		
			
				43. 
			
				Kochupillai, V., Kumar, P., Singh, D., Aggarwal, D., Bhardwaj, N., Bhutani, M. and Das, S. N.   Effect of rhythmic breathing (Sudarshan Kriya and Pranayam) on immune functions and tobacco addiction. Annals of the New York Academy of Sciences.  2005.  1056, 242-252. [PubMed]  
		 
		
			
				44. 
			
				Das, S. N. , Khare, P., Patil, A., Pandey, R. M., Singh, M. K. and Shukla, N. K.  Association of DNA pattern of metastatic lymph node with disease free survival in patients with intraoral squamous cell carcinoma. The Indian Journal of Medical Research.  2005.  122, 216-223. [PubMed]  
		 
		
			
				45. 
			
				Valarmathi, M. T., Sawhney, M., Deo, S. S., Shukla, N. K. and Das, S. N.   Novel germline mutations in the BRCA1 and BRCA2 genes in Indian breast and breast-ovarian cancer families. Human Mutation.  2004.  23, 205. [PubMed]  
		 
		
			
				46. 
			
				Agarwal, A., Rani, M., Saha, G. K., Valarmathi, T. M., Bahadur, S., Mohanti, B. K. and Das, S. N.   Disregulated expression of the Th2 cytokine gene in patients with intraoral squamous cell carcinoma. Immunological Investigations.  2003.  32, 17-30. [PubMed]  
		 
		
			
				47. 
			
				Valarmathi, M. T., A, A., Deo, S. S., Shukla, N. K. and Das, S. N.   BRCA1 germline mutations in Indian familial breast cancer. Human Mutation.  2003.  21, 98-99. [PubMed]  
		 
		
			
				48. 
			
				Mittal, M., Kapoor, V., Mohanti, B. K. and Das, S. N.   Functional variants of COX-2 and risk of tobacco-related oral squamous cell carcinoma in high-risk Asian Indians. Oral Oncology.  2010. 46, 622-626. [PubMed]  
		 
		
			
				49. 
			
				Srinivas, M., Agarwala, S., Datta, G., Das, S. N. , Shaha, C. and Mitra, D. K.  Fertility and unilateral undescended testis in the rat model II. Pediatric Surgery International.  1998. 13, 392-395. [PubMed]  
		 
		
			
				50. 
			
				Srinivas, M., Agarwala, S., Datta, G., Das, S. N. , Jha, P., Misro, M. M. and Mitra, D. K.  Effect of cyclosporine on fertility in male rats. Pediatric Surgery International.  1998. 13, 388-391. [PubMed]  
		 
	 
	 
	 
  
                           
                         
                                                
 
                      
                          
                            
                                                                 
                                   
                             
                            
                                
                             
                            
                              
                                  
                                     
                                   
                                  
                                                                            
                                        
                                                                                    
                                            Education  
 
                                           
                                                                                    
                                            :: 
 
                                            Ph.D.                                                    				
				 
                                                    Banaras Hindu University, Varanasi, India                                                                        
 
                                           
                                                                                    
                                            Honors and Awards  
 
                                           
                                                                                    
                                            :: 
 
                                            2004,  Elected as Joint Secretary, Indian Immunology Society                      
 
                                           
                                                                                    
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                                            2002, Elected as Member of the Executive Committee, Indian Immunology Society                      
 
                                           
                                                                                    
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                                            2000, Elected as Member of the National Academy of Medical Sciences, India                                           
 
                                           
                                                                                    
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                                            1999, Awarded SEERING GmbH- FU Visiting Fellowship, Berlin, Germany                      
 
                                           
                                                                                    
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                                            1998, Fellow, International Academy of Biological Therapy & Modern Cancer treatment                      
 
                                           
                                                                                    
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                                            1997, Awarded DAAD fellowship under Indo-German Exchange Program, Germany                      
 
                                           
                                                                                    
                                            :: 
 
                                            Fellow, National Academy of Medical Sciences, India   
 
                                           
                                                                                    
                                            Member 
 
                                           
                                                                                    
                                            :: 
 
                                            Fellow, International Academy of Biological Therapy                                            
 
                                           
                                                                                    
                                            :: 
 
                                            National Academy of Medical Sciences, India                                           
 
                                           
                                                                                    
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                                            Indian Immunology Society                                            
 
                                           
                                                                                    
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                                            American Association of Cancer Research                                           
 
                                           
                                                                                    
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                                            Task Force group on cancer Cervix (DBT)                                  
 
                                           
                                                                                    
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                                            Task Force Group to establish normal range of Lymphocyte subsets in Indian population                                
 
                                           
                                                                                    
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                                            Reviewer, Research projects of ICMR, DBT etc                               
 
                                           
                                                                                    
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                                            Referee of International Journals- International Journal of Immunogenetics, Clinical & Experimental immunology, Immunology                                 
 
                                           
                                                                                    
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                                            reviewer for Anatomical Records, Cancer Immunology Immunotherapy, Cancer Investigations, Cancer Letters, DNA and Cell Biology, Immunological Investigations, Indian Journal of Medical Research, International Journal of Immunogenetics, Journal of Cellular and Molecular Medicine, Journal of Oral Pathology and Medicine, Life Sciences, Molecular and Cellular Endocrinology, Oral Oncology     
 
                                           
                                                                                    
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                                            Editorial Board: Clinical Reviews and Opinions