INCREDB ID : 3
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Satya N. Das, Ph.D.
Additional Professor 
 
All India Institute of Medical Sciences
Department of Biotechnology
Ansari Nagar
New Delhi - 110 029   
 
E-mail:  snd@aiims.ernet .in; satyandas@gmail.com; satyandas@hotmail.com
Phone: +91-11-6593548
Fax: +91-11-26862663
 
URL: http://aiims.edu/aiims/departments/Biotechnology/biotechsndas.htm
 
Positions Held:
Position Affiliation Time Period
Additional Professor All India Institute of Medical Sciences, New Delhi, India 2001-Present
Associate Professor All India Institute of Medical Sciences, New Delhi, India 1997-2001
Assistant Professor All India Institue of Medical Sciences, New Delhi, India 1992-1997
Scientific Officer Industrial Toxicology Research Centre, Lucknow, India 1987-1992
Pool Officer Industrial Toxicology Research Centre, Lucknow, India 1985-1986
Research Officer Institute of Medical Sciences, Banaras Hindu University,Varanasi,India 1981-1985
 
Area of Specialization:
Molecuar genetics
Immunology
Biotechnology
Research Summary:
Cancer genetics
Immunogenetics of cancer and autoimmune diseases
 
Publications:
1.Kumar, S., Kapoor, V., Gill, K., Singh, K., Xess, I., Das, S. N. and Dey, S.  Antifungal and antiproliferative protein from Cicer arietinum: a bioactive compound against emerging pathogens. BioMed Research International. 2014.  2014, 387203. [PubMed]
2.Aggarwal, S., Devaraja, K., Sharma, S. C. and Das, S. N.  Expression of vascular endothelial growth factor (VEGF) in patients with oral squamous cell carcinoma and its clinical significance. Clinica Chimica Acta; International Journal of Clinical Chemistry. 2014.  436, 35-40. [PubMed]
3.Singh, A. K., Gaur, P., Shukla, N. K. and Das, S. N.  Differential dendritic cell-mediated activation and functions of invariant NKT-cell subsets in oral cancer. Oral Diseases. 2015.  21, e105-13. [PubMed]
4.Gaur, P., Singh, A. K., Shukla, N. K. and Das, S. N.  Inter-relation of Th1, Th2, Th17 and Treg cytokines in oral cancer patients and their clinical significance. Human Immunology. 2014.  75, 330-337. [PubMed]
5.Singh, A. K., Gaur, P. and Das, S. N.  Natural killer T cell anergy, co-stimulatory molecules and immunotherapeutic interventions. Human Immunology. 2014.  75, 250-260. [PubMed]
6.Singh, A. K., Shukla, N. K. and Das, S. N.  Altered invariant natural killer T cell subsets and its functions in patients with oral squamous cell carcinoma. Scandinavian Journal of Immunology. 2013.  78, 468-477. [PubMed]
7.Jha, R., Gaur, P., Sharma, S. C. and Das, S. N.  Single nucleotide polymorphism in hMLH1 promoter and risk of tobacco-related oral carcinoma in high-risk Asian Indians. Gene. 2013.  526, 223-227. [PubMed]
8.Kapoor, V., Paliwal, D., Baskar, S., Mohanti, B. K. and Das, S. N.  Deregulation of Beclin 1 in patients with tobacco-related oral squamous cell carcinoma. Biochemical and Biophysical Research Communications. 2012.  422, 764-769. [PubMed]
9.Bharti, V., Mohanti, B. K. and Das, S. N.  Functional genetic variants of CTLA-4 and risk of tobacco-related oral carcinoma in high-risk North Indian population. Human Immunology. 2013.  74, 348-352. [PubMed]
10.Garg, R., Kapoor, V., Mittal, M., Singh, M. K., Shukla, N. K. and Das, S. N.  Abnormal expression of PI3K isoforms in patients with tobacco-related oral squamous cell carcinoma. Clinica Chimica Acta; International Journal of Clinical Chemistry. 2013.  416, 100-106. [PubMed]
11.Gill, K., Singh, A. K., Kapoor, V., Nigam, L., Kumar, R., Holla, P., Das, S. N., Yadav, S., Subbarao, N., Mohanti, B. K. and Dey, S.  Development of peptide inhibitor as a therapeutic agent against head and neck squamous cell carcinoma (HNSCC) targeting p38alpha MAP kinase. Biochimica et Biophysica Acta. 2013.  1830, 2763-2769. [PubMed]
12.Bharti, V., Mohanti, B. K. and Das, S. N.  Functional genetic variants of CTLA-4 and risk of tobacco-related oral carcinoma in high-risk North Indian population. Human Immunology. 2013.  74, 348-352. [PubMed]
13.Karimi, M. Y., Kapoor, V., Sharma, S. C. and Das, S. N.  Genetic polymorphisms in FAS (CD95) and FAS ligand (CD178) promoters and risk of tobacco-related oral carcinoma: gene-gene interactions in high-risk Indians. Cancer Investigation. 2013.  31, 1-6. [PubMed]
14.Gaur, P., Qadir, G. A., Upadhyay, S., Singh, A. K., Shukla, N. K. and Das, S. N.  Skewed immunological balance between Th17 (CD4(+)IL17A (+)) and Treg (CD4 (+)CD25 (+)FOXP3 (+)) cells in human oral squamous cell carcinoma. Cellular Oncology. 2012.  35, 335-343. [PubMed]
15.Kapoor, V., Zaharieva, M. M., Das, S. N. and Berger, M. R.  Erufosine simultaneously induces apoptosis and autophagy by modulating the Akt-mTOR signaling pathway in oral squamous cell carcinoma. Cancer Letters. 2012.  319, 39-48. [PubMed]
16.Gaur, P., Mittal, M., Mohanti, B. K. and Das, S. N.  Functional genetic variants of TGF-beta1 and risk of tobacco-related oral carcinoma in high-risk Asian Indians. Oral Oncology. 2011.  47, 1117-1121. [PubMed]
17.Gaur, P., Mittal, M., Mohanti, B. and Das, S.  Functional variants of IL4 and IL6 genes and risk of tobacco-related oral carcinoma in high-risk Asian Indians. Oral Diseases. 2011.  17, 720-726. [PubMed]
18.Das, S. N., Khare, P., Singh, M. K. and Sharma, S. C.  Fas receptor (CD95) & Fas ligand (CD178) expression in patients with tobacco-related intraoral squamous cell carcinoma. The Indian Journal of Medical Research. 2011.  134, 54-60. [PubMed]
19.Singh, A. K., Parshad, R., Pasi, S., Madhavan, T., Das, S. N., Mishra, B., Gill, K., Dalal, K. and Dey, S.  Prognostic significance of cyclooxygenase-2 and response to chemotherapy in invasive ductal breast carcinoma patients by real time surface plasmon resonance analysis. DNA and Cell Biology. 2011.  30, 801-807. [PubMed]
20.Das, S. N., Khare, P., Singh, M. K. and Sharma, S. C.  Correlation of cyclin D1 expression with aggressive DNA pattern in patients with tobacco-related intraoral squamous cell carcinoma. The Indian Journal of Medical Research. 2011.  133, 381-386. [PubMed]
21.Mittal, M., Kapoor, V., Mohanti, B. K. and Das, S. N.  Functional variants of COX-2 and risk of tobacco-related oral squamous cell carcinoma in high-risk Asian Indians. Oral Oncology. 2010.  46, 622-626. [PubMed]

 

1. Khanna, N. N., Das, S. N. and Khanna, S.  Serum immunoglobulins in squamous cell carcinoma of the oral cavity. Journal of Surgical Oncology. 1982.  20, 46-48. [PubMed]
2. Das, S. N., Khanna, N. N. and Khanna, S.  Delayed hypersensitivity in squamous cell carcinoma of the oral cavity. Annals of the Academy of Medicine, Singapore. 1983.  12, 416-419. [PubMed]
3. Khanna, N. N., Srivastava, P. K., Khanna, S. and Das, S. N.  Intensive combination chemotherapy for cancer of the oral cavity. Cancer. 1983.  52, 790-793. [PubMed]
4. Das, S. N., Khanna, N. N. and Khanna, S.  A multiparametric observation of immune competence in breast cancer and its correlation with tumour load and prognosis. Annals of the Academy of Medicine, Singapore. 1985.  14, 374-381. [PubMed]
5. Singh, G., Das, S. N. and Khanna, N. N.  Immune status in advanced upper gastrointestinal cancers. Journal of Surgical Oncology. 1985.  29, 43-45. [PubMed]
6. Das, S. N., Khanna, N. N. and Khanna, S.  In vivo and in vitro observation of cellular immune parameters in squamous cell carcinoma of the oral cavity and its correlation with tumor load and prognosis. Cancer Investigation. 1986.  4, 207-216. [PubMed]
7. Das, S. N., Khanna, N. N., Khanna, S. and Gupta, S.  Cell surface antigens in squamous cell carcinoma of the oral cavity. Journal of Surgical Oncology. 1986.  31, 166-169. [PubMed]
8. Das, S. N., Paul, B. N., Saxena, A. K. and Ray, P. K.  Effect of in utero exposure to hexachlorocyclohexane on the developing immune system of mice. Immunopharmacology and Immunotoxicology. 1990.  12, 293-310. [PubMed]
9. Saxena, A. K., Paul, B. N., Sinha, M., Dutta, K. K., Das, S. N. and Ray, P. K.  A study on the B cell activity in protein deficient rats exposed to methyl isocyanate vapour. Immunopharmacology and Immunotoxicology. 1991.  13, 413-424. [PubMed]
10. Jain, V., Das, S. N., Luthra, K., Shukla, N. K. and Ralhan, R.  Differential expression of multidrug resistance gene product, P-glycoprotein, in normal, dysplastic and malignant oral mucosa in India. International Journal of Cancer. Journal International Du Cancer. 1997.  74, 128-133. [PubMed]
11. Arora, M., Kumar, A., Das, S. N. and Srivastava, L. M.  Complement-regulatory protein expression and activation of complement cascade on erythrocytes from patients with rheumatoid arthritis (RA). Clinical and Experimental Immunology. 1998.  111, 102-106. [PubMed]
12. Kaur, J., Das, S. N., Srivastava, A. and Ralhan, R.  Cell surface expression of 70 kDa heat shock protein in human oral dysplasia and squamous cell carcinoma: correlation with clinicopathological features. Oral Oncology. 1998.  34, 93-98. [PubMed]
13. Sharma, R. B., Srinivas, M., Mitra, D. K. and Das, S. N.  T-lymphocyte subsets in the contralateral testis after unilateral blunt testicular trauma in pre-pubertal mice. Pediatric Surgery International. 1999.  15, 238-239. [PubMed]
14. Srinivas, M., Degaonkar, M., Gupta, D. K., Raghunathan, P., Das, S. N. and Mitra, D. K.  Evaluation of developing rat testis by phosporus 31P magnetic resonance spectroscopy and DNA flowcytometry. Pediatric Surgery International. 2001.  17, 316-320. [PubMed]
15. Grover, J. K., Vats, V., Srinivas, M., Das, S. N., Jha, P., Gupta, D. K. and Mitra, D. K.  Effect of metronidazole on spermatogenesis and FSH, LH and testosterone levels of pre-pubertal rats. Indian Journal of Experimental Biology. 2001.  39, 1160-1162. [PubMed]
16. Srinivas, M., Chandrasekharam, V. V., Degaonkar, M., Gupta, D. K., Jha, P., Jagannathan, N. R. and Das, S. N.  Effects of unilateral grade I testicular injury in rat. Urology. 2002.  60, 548-551. [PubMed]
17. Chandrasekharam, V. V., Srinivas, M., Das, S. N., Jha, P., Bajpai, M., Chaki, S. P. and Misro, M. M.  Prepubertal human chorionic gonadotropin injection affects postpubertal germ cell maturation and androgen production in rat testis. Urology. 2003.  62, 571-574. [PubMed]
18. Baniasadi, V., Narain, N., Goswami, R. and Das, S. N.  Promoter region -318 C/ T and -1661 A/G CTLA-4 single nucleotide polymorphisms and type 1 diabetes in North Indians. Tissue Antigens. 2006.  67, 383-389. [PubMed]
19. Manchanda, P., Sharma, S. C. and Das, S. N.  Differential regulation of IL-2 and IL-4 in patients with tobacco-related oral squamous cell carcinoma. Oral Diseases. 2006.  12, 455-462. [PubMed]
20. Khanna, N. N., Das, S. N. and Khanna, S.  Serum immunoglobulins in squamous cell carcinoma of the oral cavity. Journal of Surgical Oncology. 1982.  20, 46-48. [PubMed]
21. Das, S. N., Khanna, N. N. and Khanna, S.  Delayed hypersensitivity in squamous cell carcinoma of the oral cavity. Annals of the Academy of Medicine, Singapore. 1983.  12, 416-419. [PubMed]
22. Khanna, N. N., Srivastava, P. K., Khanna, S. and Das, S. N.  Intensive combination chemotherapy for cancer of the oral cavity. Cancer. 1983.  52, 790-793. [PubMed]
23. Das, S. N., Khanna, N. N. and Khanna, S.  A multiparametric observation of immune competence in breast cancer and its correlation with tumour load and prognosis. Annals of the Academy of Medicine, Singapore. 1985.  14, 374-381. [PubMed]
24. Singh, G., Das, S. N. and Khanna, N. N.  Immune status in advanced upper gastrointestinal cancers. Journal of Surgical Oncology. 1985.  29, 43-45. [PubMed]
25. Das, S. N., Khanna, N. N. and Khanna, S.  In vivo and in vitro observation of cellular immune parameters in squamous cell carcinoma of the oral cavity and its correlation with tumor load and prognosis. Cancer Investigation. 1986.  4, 207-216. [PubMed]
26. Das, S. N., Khanna, N. N., Khanna, S. and Gupta, S.  Cell surface antigens in squamous cell carcinoma of the oral cavity. Journal of Surgical Oncology. 1986.  31, 166-169. [PubMed]
27. Das, S. N., Paul, B. N., Saxena, A. K. and Ray, P. K.  Effect of in utero exposure to hexachlorocyclohexane on the developing immune system of mice. Immunopharmacology and Immunotoxicology. 1990.  12, 293-310. [PubMed]
28. Saxena, A. K., Paul, B. N., Sinha, M., Dutta, K. K., Das, S. N. and Ray, P. K.  A study on the B cell activity in protein deficient rats exposed to methyl isocyanate vapour. Immunopharmacology and Immunotoxicology. 1991.  13, 413-424. [PubMed]
29. Jain, V., Das, S. N., Luthra, K., Shukla, N. K. and Ralhan, R.  Differential expression of multidrug resistance gene product, P-glycoprotein, in normal, dysplastic and malignant oral mucosa in India. International Journal of Cancer. Journal International Du Cancer. 1997.  74, 128-133. [PubMed]
30. Arora, M., Kumar, A., Das, S. N. and Srivastava, L. M.  Complement-regulatory protein expression and activation of complement cascade on erythrocytes from patients with rheumatoid arthritis (RA). Clinical and Experimental Immunology. 1998.  111, 102-106. [PubMed]
31. Kaur, J., Das, S. N., Srivastava, A. and Ralhan, R.  Cell surface expression of 70 kDa heat shock protein in human oral dysplasia and squamous cell carcinoma: correlation with clinicopathological features. Oral Oncology. 1998.  34, 93-98. [PubMed]
32. Sharma, R. B., Srinivas, M., Mitra, D. K. and Das, S. N.  T-lymphocyte subsets in the contralateral testis after unilateral blunt testicular trauma in pre-pubertal mice. Pediatric Surgery International. 1999.  15, 238-239. [PubMed]
33. Grover, J. K., Vats, V., Srinivas, M., Das, S. N., Jha, P., Gupta, D. K. and Mitra, D. K.  Effect of metronidazole on spermatogenesis and FSH, LH and testosterone levels of pre-pubertal rats. Indian Journal of Experimental Biology. 2001.  39, 1160-1162. [PubMed]
34. Srinivas, M., Chandrasekharam, V. V., Degaonkar, M., Gupta, D. K., Jha, P., Jagannathan, N. R. and Das, S. N.  Effects of unilateral grade I testicular injury in rat. Urology. 2002.  60, 548-551. [PubMed]
35. Chandrasekharam, V. V., Srinivas, M., Das, S. N., Jha, P., Bajpai, M., Chaki, S. P. and Misro, M. M.  Prepubertal human chorionic gonadotropin injection affects postpubertal germ cell maturation and androgen production in rat testis. Urology. 2003.  62, 571-574. [PubMed]
36. Baniasadi, V., Narain, N., Goswami, R. and Das, S. N.  Promoter region -318 C/ T and -1661 A/G CTLA-4 single nucleotide polymorphisms and type 1 diabetes in North Indians. Tissue Antigens. 2006.  67, 383-389. [PubMed]
37. Kapoor, V., Singh, A. K., Dey, S., Sharma, S. C. and Das, S. N.  Circulating cycloxygenase-2 in patients with tobacco-related intraoral squamous cell carcinoma and evaluation of its peptide inhibitors as potential antitumor agent. Journal of Cancer Research and Clinical Oncology. 2010.  136, 1795-1804. [PubMed]
38. Gupta, R., Kapuria, V. and Das, S. N.  Single nucleotide polymorphisms in TNF-alpha, TNFR2 gene and TNF-alpha production in Asian Indians. Immunological Investigations. 2009.  38, 240-254. [PubMed]
39. Gupta, R., Sharma, S. C. and Das, S. N.  Association of TNF-alpha and TNFR1 promoters and 3' UTR region of TNFR2 gene polymorphisms with genetic susceptibility to tobacco-related oral carcinoma in Asian Indians. Oral Oncology. 2008.  44, 455-463. [PubMed]
40. Agarwal, A., Mohanti, B. K. and Das, S. N.  Ex vivo triggering of T-cell-mediated immune responses by autologous tumor cell vaccine in oral cancer patients. Immunopharmacology and Immunotoxicology. 2007.  29, 95-104. [PubMed]
41. Devarapu, S. K., Sharma, S. C. and Das, S. N.  Triggering of T cell-mediated immune responses by allogenic tumor cell vaccine in patients with oral cancer. Immunopharmacology and Immunotoxicology. 2006.  28, 387-395. [PubMed]
42. Sawhney, M., Mathew, M., Valarmathi, M. T. and Das, S. N.  Age related changes in Fas (CD95) and Fas ligand gene expression and cytokine profiles in healthy Indians. Asian Pacific Journal of Allergy and Immunology. 2006.  24, 47-56. [PubMed]
43. Kochupillai, V., Kumar, P., Singh, D., Aggarwal, D., Bhardwaj, N., Bhutani, M. and Das, S. N.  Effect of rhythmic breathing (Sudarshan Kriya and Pranayam) on immune functions and tobacco addiction. Annals of the New York Academy of Sciences. 2005.  1056, 242-252. [PubMed]
44. Das, S. N., Khare, P., Patil, A., Pandey, R. M., Singh, M. K. and Shukla, N. K.  Association of DNA pattern of metastatic lymph node with disease free survival in patients with intraoral squamous cell carcinoma. The Indian Journal of Medical Research. 2005.  122, 216-223. [PubMed]
45. Valarmathi, M. T., Sawhney, M., Deo, S. S., Shukla, N. K. and Das, S. N.  Novel germline mutations in the BRCA1 and BRCA2 genes in Indian breast and breast-ovarian cancer families. Human Mutation. 2004.  23, 205. [PubMed]
46. Agarwal, A., Rani, M., Saha, G. K., Valarmathi, T. M., Bahadur, S., Mohanti, B. K. and Das, S. N.  Disregulated expression of the Th2 cytokine gene in patients with intraoral squamous cell carcinoma. Immunological Investigations. 2003.  32, 17-30. [PubMed]
47. Valarmathi, M. T., A, A., Deo, S. S., Shukla, N. K. and Das, S. N.  BRCA1 germline mutations in Indian familial breast cancer. Human Mutation. 2003.  21, 98-99. [PubMed]
48. Mittal, M., Kapoor, V., Mohanti, B. K. and Das, S. N.  Functional variants of COX-2 and risk of tobacco-related oral squamous cell carcinoma in high-risk Asian Indians. Oral Oncology. 2010. 46, 622-626. [PubMed]
49. Srinivas, M., Agarwala, S., Datta, G., Das, S. N., Shaha, C. and Mitra, D. K.  Fertility and unilateral undescended testis in the rat model II. Pediatric Surgery International. 1998. 13, 392-395. [PubMed]
50. Srinivas, M., Agarwala, S., Datta, G., Das, S. N., Jha, P., Misro, M. M. and Mitra, D. K.  Effect of cyclosporine on fertility in male rats. Pediatric Surgery International. 1998. 13, 388-391. [PubMed]

 

 
 
Education 
::
Ph.D. Banaras Hindu University, Varanasi, India
Honors and Awards
::
2004, Elected as Joint Secretary, Indian Immunology Society
::
2002, Elected as Member of the Executive Committee, Indian Immunology Society
::
2000, Elected as Member of the National Academy of Medical Sciences, India
::
1999, Awarded SEERING GmbH- FU Visiting Fellowship, Berlin, Germany
::
1998, Fellow, International Academy of Biological Therapy & Modern Cancer treatment
::
1997, Awarded DAAD fellowship under Indo-German Exchange Program, Germany
::
Fellow, National Academy of Medical Sciences, India
Member
::
Fellow, International Academy of Biological Therapy
::
National Academy of Medical Sciences, India
::
Indian Immunology Society
::
American Association of Cancer Research
::
Task Force group on cancer Cervix (DBT)
::
Task Force Group to establish normal range of Lymphocyte subsets in Indian population
::
Reviewer, Research projects of ICMR, DBT etc
::
Referee of International Journals- International Journal of Immunogenetics, Clinical & Experimental immunology, Immunology
::
reviewer for Anatomical Records, Cancer Immunology Immunotherapy, Cancer Investigations, Cancer Letters, DNA and Cell Biology, Immunological Investigations, Indian Journal of Medical Research, International Journal of Immunogenetics, Journal of Cellular and Molecular Medicine, Journal of Oral Pathology and Medicine, Life Sciences, Molecular and Cellular Endocrinology, Oral Oncology
::
Editorial Board: Clinical Reviews and Opinions
  Last modified on : Dec 10, 2015
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