INCREDB ID : 295
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Suresh Kumar Rayala, M.S., Ph.D.
Associate Professor 
 
Indian Institute of Technology Madras
Department of Biotechnology
Room No. BT 306
Chennai - 600 036   
Tamil Nadu   
 
E-mail: rayala@iitm.ac.in
Phone: +91-44-2257 4137
Fax: +91-44-2257 4102
 
URL: http://www.biotech.iitm.ac.in/Rayala_research
 
Positions Held:
Position Affiliation Time Period
Associate Professor Indian Institute of Technology Madras, Chennai, India
Post Doctoral Fellow MD Anderson Cancer Centre, Houston, Texas, USA
 
Area of Specialization:
Cancer Biology
Publications:
1. Ganesan, K., Banerjee, S., Gunasekaran, P., Tan, P. and Rayala, S.K. Integrative functional genomics in cancer research and its clinical implications. Journal of Cancer Molecules. 2010. In Press.
2. Ohshiro, K., Rayala, S. K., Wigerup, C., Pakala, S. B., Natha, R. S., Gururaj, A. E., Molli, P. R., Mansson, S. S., Ramezani, A., Hawley, R. G., Landberg, G., Lee, N. H. and Kumar, R.  Acetylation-dependent oncogenic activity of metastasis-associated protein 1 co-regulator. EMBO Reports. 2010.  11, 691-697. [PubMed]
3. Kumar, R., Balasenthil, S., Pakala, S. B., Rayala, S. K., Sahin, A. A. and Ohshiro, K.  Metastasis-associated protein 1 short form stimulates Wnt1 pathway in mammary epithelial and cancer cells. Cancer Research. 2010.  70, 6598-6608. [PubMed]
4. Pakala, S. B., Bui-Nguyen, T. M., Reddy, S. D., Li, D. Q., Peng, S., Rayala, S. K., Behringer, R. R. and Kumar, R.  Regulation of NF-kappaB circuitry by a component of the nucleosome remodeling and deacetylase complex controls inflammatory response homeostasis. The Journal of Biological Chemistry. 2010.  285, 23590-23597. [PubMed]
5. Ohshiro, K., Mudvari, P., Meng, Q. C., Rayala, S. K., Sahin, A. A., Fuqua, S. A. and Kumar, R.  Identification of a novel estrogen receptor-alpha variant and its upstream splicing regulator. Molecular Endocrinology. 2010.  24, 914-922. [PubMed]
6. Li, D. Q., Ohshiro, K., Reddy, S. D., Pakala, S. B., Lee, M. H., Zhang, Y., Rayala, S. K. and Kumar, R.  E3 ubiquitin ligase COP1 regulates the stability and functions of MTA1. Proceedings of the National Academy of Sciences of the United States of America. 2009.  106, 17493-17498. [PubMed]
7. Kumar, A., Molli, P. R., Pakala, S. B., Bui, N., Rayala, S. K. and Kumar, R.  PAK thread from amoeba to mammals. Journal of Cellular Biochemistry. 2009.  107, 579-585. [PubMed]
8. Molli, P. R., Li, D. Q., Murray, B. W., Rayala, S. K. and Kumar, R.  PAK signaling in oncogenesis. Oncogene. 2009.  28, 2545-2555. [PubMed]
9. Kumar, R., Zhang, H., Vadlamudi, R.K., Holm, C., Landberg, G., Cardiff, R.D. and Rayala, S.K. Extranuclear Coactivator Signaling Confers Insensitivity to Tamoxifen. Clinical Cancer Research. 2009. 15, 4123-30.
10. Li, D.Q., Reddy, S.D.N., Pakala, S.B., Wu, X., Zhang, Y., Rayala, S. K. and Kumar, R. MTA1 coregulator regulates p53 stability and functions. Journal of Biological Chemistry. 2009. 284, 50, 34545-34552.
11. Reddy, S. D., Pakala, S. B., Ohshiro, K., Rayala, S. K. and Kumar, R.  MicroRNA-661, a c/EBPalpha target, inhibits metastatic tumor antigen 1 and regulates its functions. Cancer Research. 2009.  69, 5639-5642. [PubMed]
12. Song, C., Wen, W., Rayala, S. K., Chen, M., Ma, J., Zhang, M. and Kumar, R.  Serine 88 phosphorylation of the 8-kDa dynein light chain 1 is a molecular switch for its dimerization status and functions. The Journal of Biological Chemistry. 2008.  283, 4004-4013. [PubMed]
13. Reddy, S. D., Ohshiro, K., Rayala, S. K. and Kumar, R.  MicroRNA-7, a homeobox D10 target, inhibits p21-activated kinase 1 and regulates its functions. Cancer Research. 2008.  68, 8195-8200. [PubMed]
14. Ohshiro, K., Rayala, S. K., El-Naggar, A. K. and Kumar, R.  Delivery of cytoplasmic proteins to autophagosomes. Autophagy. 2008.  4, 104-106. [PubMed]
15. Mandal, M., Myers, J. N., Lippman, S. M., Johnson, F. M., Williams, M. D., Rayala, S., Ohshiro, K., Rosenthal, D. I., Weber, R. S., Gallick, G. E. and El-Naggar, A. K.  Epithelial to mesenchymal transition in head and neck squamous carcinoma: association of Src activation with E-cadherin down-regulation, vimentin expression, and aggressive tumor features. Cancer. 2008.  112, 2088-2100. [PubMed]
16. Rayala, S. K., Martin, E., Sharina, I. G., Molli, P. R., Wang, X., Jacobson, R., Murad, F. and Kumar, R.  Dynamic interplay between nitration and phosphorylation of tubulin cofactor B in the control of microtubule dynamics. Proceedings of the National Academy of Sciences of the United States of America. 2007.  104, 19470-19475. [PubMed]
17. Rayala, S. K. and Kumar, R.  Sliding p21-activated kinase 1 to nucleus impacts tamoxifen sensitivity. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 2007.  61, 408-411. [PubMed]
18. Meng, Q., Rayala, S. K., Gururaj, A. E., Talukder, A. H., O'Malley, B. W. and Kumar, R.  Signaling-dependent and coordinated regulation of transcription, splicing, and translation resides in a single coregulator, PCBP1. Proceedings of the National Academy of Sciences of the United States of America. 2007.  104, 5866-5871. [PubMed]
19. Manavathi, B., Rayala, S. K. and Kumar, R.  Phosphorylation-dependent regulation of stability and transforming potential of ETS transcriptional factor ESE-1 by p21-activated kinase 1. The Journal of Biological Chemistry. 2007.  282, 19820-19830. [PubMed]
20. Manavathi, B., Peng, S., Rayala, S. K., Talukder, A. H., Wang, M. H., Wang, R. A., Balasenthil, S., Agarwal, N., Frishman, L. J. and Kumar, R.  Repression of Six3 by a corepressor regulates rhodopsin expression. Proceedings of the National Academy of Sciences of the United States of America. 2007.  104, 13128-13133. [PubMed]
21. Ohshiro, K., Rayala, S. K., Kondo, S., Gaur, A., Vadlamudi, R. K., El-Naggar, A. K. and Kumar, R.  Identifying the estrogen receptor coactivator PELP1 in autophagosomes. Cancer Research. 2007.  67, 8164-8171. [PubMed]
22. Barnes, C. J., Ohshiro, K., Rayala, S. K., El-Naggar, A. K. and Kumar, R.  Insulin-like growth factor receptor as a therapeutic target in head and neck cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 2007.  13, 4291-4299. [PubMed]
23. Rayala, S. K., Talukder, A. H., Balasenthil, S., Tharakan, R., Barnes, C. J., Wang, R. A., Aldaz, C. M., Khan, S. and Kumar, R.  P21-activated kinase 1 regulation of estrogen receptor-alpha activation involves serine 305 activation linked with serine 118 phosphorylation. Cancer Research. 2006.  66, 1694-1701. [PubMed]
24. Rayala, S. K., Hollander, P., Balasenthil, S., Molli, P. R., Bean, A. J., Vadlamudi, R. K., Wang, R. A. and Kumar, R.  Hepatocyte growth factor-regulated tyrosine kinase substrate (HRS) interacts with PELP1 and activates MAPK. The Journal of Biological Chemistry. 2006.  281, 4395-4403. [PubMed]
25. Singh, R. R., Kaluarachchi, K., Chen, M., Rayala, S. K., Balasenthil, S., Ma, J. and Kumar, R.  Solution structure and antiestrogenic activity of the unique C-terminal, NR-box motif-containing region of MTA1s. The Journal of Biological Chemistry. 2006.  281, 25612-25621. [PubMed]
26. den, H., Rayala, S. K., Coverley, D. and Kumar, R.  Ciz1, a Novel DNA-binding coactivator of the estrogen receptor alpha, confers hypersensitivity to estrogen action. Cancer Research. 2006.  66, 11021-11029. [PubMed]
27. Rayala, S. K., Hollander, P.D., Manavathi, B., Talukder, A.H., Song, C., Peng, S., Barnekow, A., Kremerskothen, J. and Kumar, R. Essential role of KIBRA in coactivator function of dynein light chain 1. Journal of Biological Chemistry. 2006. 281, 19092-9.
28. Rayala, S. K., Mascarenhas, J., Vadlamudi, R.K. and Kumar, R. Altered localization of a co-activator sensitizes breast cancer cells to TNF-induced apoptosis. Molecular Cancer Therapeutics. 2006, 5, 230-7.
29. Rayala, S. K., Molli, P.R. and Kumar, R. Signals PAKup to the nucleus in breast cancer. Cancer Research. 2006, 66, 5985-5988.
30. Ohshiro, K., Rayala, S., Williams, D.M., Kumar, R., and El-Naggar, A.K. Biological role of estrogen receptor-b in salivary gland adenocarcinoma cells. Clinical Cancer Research. 2006, 12, 5994-9.
31. Holm, C., Rayala, S., Jirstrom, K., Stal, O., Kumar, R. and Landberg, G. High Pak1 expression and nuclear localization is associated with lack of tamoxifen response in human premenopausal breast cancer and experimental models. J Natl Cancer Inst.  2006, 98, 671-680.
32. Gururaj, A.E., Singh, R.R., Rayala, S. K., Holm, C., Hollander, P., Zhang, H., Balasenthil, S., Landberg, G. and Kumar, R. MTA1, a Novel Transcriptional Activator of Breast Cancer Amplified Sequence 3. PNAS. 2006. 103, 6670 – 6675.
33. Manavathi, B., Acconcia, F., Rayala, S. K. and Kumar, R. Microtubule dependent regulation of estrogen receptor-alpha signaling. PNAS.  2006. 103, 15981-6.
34. Gururaj, A.E., Rayala, S. K., Vadlamudi, R.K. and Kumar, R. Novel Mechanisms of Resistance to Endocrine Therapy – Genomic and non-genomic considerations. Clinical Cancer Research. 2006. 12, 1001S-1007S.
35. Rayala, S. K., den, H., Balasenthil, S., Yang, Z., Broaddus, R. R. and Kumar, R.  Functional regulation of oestrogen receptor pathway by the dynein light chain 1. EMBO Reports. 2005.  6, 538-544. [PubMed]
36. Kumar, R., Gururaj, A. E., Vadlamudi, R. K. and Rayala, S. K.  The clinical relevance of steroid hormone receptor corepressors. Clinical Cancer Research. 2005.  11, 2822-2831. [PubMed]
37. Yang, Z., Rayala, S., Nguyen, D., Vadlamudi, R. K., Chen, S. and Kumar, R.  Pak1 phosphorylation of snail, a master regulator of epithelial-to-mesenchyme transition, modulates snail's subcellular localization and functions. Cancer Research. 2005.  65, 3179-3184. [PubMed]
38. Vadlamudi, R. K., Barnes, C. J., Rayala, S., Li, F., Balasenthil, S., Marcus, S., Goodson, H. V., Sahin, A. A. and Kumar, R.  p21-activated kinase 1 regulates microtubule dynamics by phosphorylating tubulin cofactor B. Molecular and Cellular Biology. 2005.  25, 3726-3736. [PubMed]
39. Gururaj, A. E., Rayala, S. K. and Kumar, R.  p21-activated kinase signaling in breast cancer. Breast Cancer Research : BCR. 2005.  7, 5-12. [PubMed]
40. Balasenthil, S., Barnes, C. J., Rayala, S. K. and Kumar, R.  Estrogen receptor activation at serine 305 is sufficient to upregulate cyclin D1 in breast cancer cells. FEBS Letters. 2004.  567, 243-247. [PubMed]
41. Kothari, K., Bapat, K., Korde, A., Sarma, H.D., Suresh, R., Padma, S., Udayachander, M., Meenakshi, A., Venkatesh, M., Pillai, M.R.A. Radiochemical and biological studies of 188Re labeled monoclonal antibody-CAMA3C8 specific for breast cancer. Indian Journal of Nuclear Medicine. 2004. 19, 6-11.
42. Meenakshi, A., Kumar, R. S., Ganesh, V. and Sivakumar, N.  Immunohistochemical assay (IHC) to study C-erbB-2 status of breast cancer using monoclonal antibody CIBCgp185. Human Antibodies. 2003.  12, 123-127. [PubMed]
43. Meenakshi, A., Ganesh, V., Suresh, K. and Siva, K.  Radioimmuno targetting (99m)technetium labeled anti-epidermal growth factor receptor monoclonal antibodies in experimental tumor models. The Quarterly Journal of Nuclear Medicine. 2003.  47, 139-144. [PubMed]
42.. Meenakshi, A., Kumar, R. S., Siva, K. and Ganesh, V.  Immunofluorescent localization of C-erbB-2 oncoprotein in breast cancer: a preliminary study. Human Antibodies. 2002.  11, 73-77. [PubMed]
43. Meenakshi, A., Kumar, R. S. and Kumar, N. S.  ELISA for quantitation of serum C-erbB-2 oncoprotein in breast cancer patients. Journal of Immunoassay & Immunochemistry. 2002.  23, 293-305. [PubMed]
44. Meenakshi, A., Kumar, R. S., Ganesh, V. and Kumar, N.S. Preliminary study on radioimmuno-diagnosis of experimental tumor models using technetium-99m-labeled anti-C-erbB-2 monoclonal antibody. Tumori. 2002. 88, 507-12.
45. Meenakshi, A., Kumar, R. S. and Kumar, N. S.  Generation of monoclonal antibody CIBCgp185 against C-erbB-2 oncoprotein and its clinical evaluation. Human Antibodies. 2001.  10, 101-107. [PubMed]
46. Subbiah, K., Rayala, S. K., Ananthanarayanan, M. and Thangarajan, R.  Targetted localisation and imaging of a murine lymphoma using 131I-labelled monoclonal antibody. Indian Journal of Experimental Biology. 2001.  39, 993-997. [PubMed]
 

 
 
Education 
::
M.S. Sri Venkateswara University, Tirupati, India
::
Ph.D. The Cancer Institute, Chennai, India, 1999-2002
Honors and Awards
::
2008, Research Biography highlighted in Who’s Who in America
::
2007, AMGEN Award in Basic Science Research
::
2006, Research Biography highlighted on Science Advisory Board
::
2006, Research Biography highlighted on Gene to Drug in August, Monthly Publication for Professionals in the Life Science Industry
::
2004, Outstanding productive Post Doctoral Fellow award
::
2002, Young Scientist Award, 89th Indian Science Congress, Lucknow, India
::
2000, Young Scientist Award, Indian Society of Oncology Conference, Hyderabad, India
  Last modified on : Mar 4, 2011
India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.