Vegesna Radha, Ph.D.
Centre for Cellular and Molecular Biology
Uppal Road
Hyderabad - 500 007
Andhra Pradesh
E-mail: vradha@ccmb.res.in
Phone: +91-40-27192619
URL: http://www.ccmb.res.in/scientistdetails.php?grpid=40
Positions Held:
Position Affiliation Time Period
Scientist
Center for Cellular and Molecular Biology, Hyderabad, India
Present
Area of Specialization:
Molecular Biology
Research Summary:
Characterizing regulatory molecules of signaling pathways leading to cytoskeletal remodeling, cell differentiation and survival
Publications:
1.
Dayma, K. and Radha, V. Cytoskeletal remodeling by C3G to induce neurite-like extensions and inhibit motility in highly invasive breast carcinoma cells. Biochimica et Biophysica Acta. 2011. [PubMed]
2.
Kumar, Y., Radha, V. and Swarup, G. Interaction with Sug1 enables Ipaf ubiquitination leading to caspase 8 activation and cell death. The Biochemical Journal. 2010. 427, 91-104. [PubMed]
3.
Mitra, A. and Radha, V. F-actin-binding domain of c-Abl regulates localized phosphorylation of C3G: role of C3G in c-Abl-mediated cell death. Oncogene. 2010. 29, 4528-4542. [PubMed]
4.
Mantena, S. K., Unnikrishnan, M. K., Joshi, R., Radha, V. , Devi, P. U. and Mukherjee, T. In vivo radioprotection by 5-aminosalicylic acid. Mutation Research. 2008. 650, 63-79. [PubMed]
5.
Radha, V. , Rajanna, A., Gupta, R. K., Dayma, K. and Raman, T. The guanine nucleotide exchange factor, C3G regulates differentiation and survival of human neuroblastoma cells. Journal of Neurochemistry. 2008. 107, 1424-1435. [PubMed]
6.
Chalasani, M. L., Radha, V. , Gupta, V., Agarwal, N., Balasubramanian, D. and Swarup, G. A glaucoma-associated mutant of optineurin selectively induces death of retinal ganglion cells which is inhibited by antioxidants. Investigative Ophthalmology & Visual Science. 2007. 48, 1607-1614. [PubMed]
7.
Paliwal, P., Radha, V. and Swarup, G. Regulation of p73 by Hck through kinase-dependent and independent mechanisms. BMC Molecular Biology. 2007. 8, 45. [PubMed]
8.
Radha, V. , Rajanna, A., Mitra, A., Rangaraj, N. and Swarup, G. C3G is required for c-Abl-induced filopodia and its overexpression promotes filopodia formation. Experimental Cell Research. 2007. 313, 2476-2492. [PubMed]
9.
Thalappilly, S., Sadasivam, S., Radha, V. and Swarup, G. Involvement of caspase 1 and its activator lpaf upstream of mitochondrial events in apoptosis. FEBS Journal . 2006. 273, 2766-2778.
10.
Sadasivam, S., Gupta, S., Radha, V. , Batta, K., Kundu, T. K. and Swarup, G. Caspase-1 activator Ipaf is a p53-inducible gene involved in apoptosis. Oncogene. 2005. 24, 627-636. [PubMed]
11.
Jain, N., Gupta, S., Sudhakar, Ch., Radha, V. and Swarup, G. Role of p73 in regulating human caspase-1 gene transcription induced by interferon-{gamma} and cisplatin. The Journal of Biological Chemistry. 2005. 280, 36664-36673. [PubMed]
12.
Radha, V. , Rajanna, A. and Swarup, G. Phosphorylated guanine nucleotide exchange factor C3G, induced by pervanadate and Src family kinases localizes to the Golgi and subcortical actin cytoskeleton. BMC Cell Biology. 2004. 5, 31. [PubMed]
13.
Shivakrupa, R., Radha, V. , Sudhakar, Ch. and Swarup, G. Physical and functional interaction between Hck tyrosine kinase and guanine nucleotide exchange factor C3G results in apoptosis, which is independent of C3G catalytic domain. The Journal of Biological Chemistry. 2003. 278, 52188-52194. [PubMed]
14.
Radha, V. , Sudhakar, Ch., Ray, P. and Swarup, G. Induction of cytochrome c release and apoptosis by Hck-SH3 domain-mediated signalling requires caspase-3. Apoptosis. 2002. 7, 195-207. [PubMed]
15.
Gupta, S., Radha, V. , Sudhakar, Ch. and Swarup, G. A nuclear protein tyrosine phosphatase activates p53 and induces caspase-1-dependent apoptosis. FEBS Letters. 2002. 532, 61-66. [PubMed]
16.
Gupta, S., Radha, V. , Furukawa, Y. and Swarup, G. Direct transcriptional activation of human caspase-1 by tumor suppressor p53. The Journal of Biological Chemistry. 2001. 276, 10585-10588. [PubMed]
17.
Ganapati, U., Gupta, S., Radha, V. , Sudhakar, Ch., Manogaran, P. S. and Swarup, G. A Nuclear Protein Tyrosine Phosphatase Induces Shortening of G1 Phase and Increase in c-Myc Protien Level. Experimental Cell Research . 2001. 265, 1-10.
18.
Nambirajan, S., Radha, V. , Kamatkar, S. and Swarup, G. PTP-S2, a nuclear tyrosine phosphatase, is phosphorylated and excluded from condensed chromosomes during mitosis. Journal of Biosciences. 2000. 25, 33-40. [PubMed]
Book Chapters:
Swarup, G. and Radha, V. Nuclear Matrix : Methods of Preparation. In: Encyclopedia of Life Sciences. John Wiley & Sons, Inc. 2001. A2708 pp 1-3.
Last modified on : Mar 11, 2011